Pdcd1lg2 (programmed cell death 1 ligand 2) - Rat Genome Database

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Gene: Pdcd1lg2 (programmed cell death 1 ligand 2) Mus musculus
Analyze
Symbol: Pdcd1lg2
Name: programmed cell death 1 ligand 2
RGD ID: 1552436
MGI Page MGI
Description: Involved in negative regulation of T cell proliferation and positive regulation of T cell proliferation. Predicted to localize to external side of plasma membrane. Is expressed in several structures, including alimentary system epithelium; forebrain; nose; retina; and skin. Orthologous to human PDCD1LG2 (programmed cell death 1 ligand 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; carbon nanotube; carboplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B7-DC; Btdc; butyrophilin B7-DC; butyrophilin-like protein; F730015O22Rik; MGC124039; MGC124040; PD-; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; programmed death ligand 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,388,319 - 29,450,327 (+)NCBIGRCm39mm39
GRCm39 Ensembl1929,388,319 - 29,448,561 (+)Ensembl
GRCm381929,410,919 - 29,472,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,410,919 - 29,471,161 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,485,409 - 29,547,417 (+)NCBIGRCm37mm9NCBIm37
MGSCv361929,476,955 - 29,537,158 (+)NCBImm8
Celera1930,187,250 - 30,249,414 (+)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11224527   PMID:11283156   PMID:12161284   PMID:12421930   PMID:12444166   PMID:12477932   PMID:12719480   PMID:12810690  
PMID:12847135   PMID:12909129   PMID:14764726   PMID:15484188   PMID:15897272   PMID:16141072   PMID:16141073   PMID:16236366   PMID:16301644   PMID:16517716   PMID:16606670   PMID:16864790  
PMID:16917960   PMID:17016562   PMID:17182110   PMID:17392506   PMID:17412283   PMID:17683117   PMID:17853943   PMID:17924994   PMID:17938288   PMID:17981145   PMID:18025191   PMID:18212277  
PMID:18641123   PMID:18825752   PMID:19234176   PMID:19342693   PMID:19420345   PMID:19454675   PMID:19497561   PMID:19710692   PMID:19724910   PMID:19741598   PMID:19757438   PMID:20008522  
PMID:20065112   PMID:20453843   PMID:20574047   PMID:20625006   PMID:21147037   PMID:21303364   PMID:21307196   PMID:21357717   PMID:21677750   PMID:21768400   PMID:21813777   PMID:21873635  
PMID:22266281   PMID:23090063   PMID:23149662   PMID:23174661   PMID:23555047   PMID:24030385   PMID:24031027   PMID:24076050   PMID:24098455   PMID:24376539   PMID:24752301   PMID:24880458  
PMID:25053811   PMID:25404361   PMID:25624454   PMID:25924065   PMID:26043977   PMID:26162855   PMID:26599163   PMID:27294527   PMID:27533014   PMID:27783986   PMID:28302645   PMID:28479601  
PMID:28570665   PMID:28768724   PMID:28777458   PMID:28953925   PMID:29144460   PMID:30357491   PMID:30431333   PMID:30567732   PMID:32610128   PMID:32611724  


Genomics

Comparative Map Data
Pdcd1lg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,388,319 - 29,450,327 (+)NCBIGRCm39mm39
GRCm39 Ensembl1929,388,319 - 29,448,561 (+)Ensembl
GRCm381929,410,919 - 29,472,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,410,919 - 29,471,161 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,485,409 - 29,547,417 (+)NCBIGRCm37mm9NCBIm37
MGSCv361929,476,955 - 29,537,158 (+)NCBImm8
Celera1930,187,250 - 30,249,414 (+)NCBICelera
Cytogenetic Map19C1NCBI
PDCD1LG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl95,510,531 - 5,571,282 (+)EnsemblGRCh38hg38GRCh38
GRCh3895,510,438 - 5,571,282 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3795,510,531 - 5,571,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3695,500,570 - 5,560,398 (+)NCBINCBI36hg18NCBI36
Build 3495,500,569 - 5,560,398NCBI
Celera95,436,182 - 5,496,918 (+)NCBI
Cytogenetic Map9p24.1NCBI
HuRef95,466,254 - 5,526,976 (+)NCBIHuRef
CHM1_195,510,742 - 5,571,459 (+)NCBICHM1_1
Pdcd1lg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21227,158,941 - 227,223,938 (+)NCBI
Rnor_6.0 Ensembl1247,562,202 - 247,627,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01247,562,202 - 247,629,279 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01254,810,377 - 254,876,025 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,090,444 - 233,156,412 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11233,273,427 - 233,368,190 (+)NCBI
Celera1224,309,877 - 224,374,794 (+)NCBICelera
Cytogenetic Map1q52NCBI
Pdcd1lg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554349,540,047 - 9,559,335 (+)NCBIChiLan1.0ChiLan1.0
PDCD1LG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.195,514,449 - 5,575,660 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,514,449 - 5,575,688 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v095,313,071 - 5,391,676 (+)NCBIMhudiblu_PPA_v0panPan3
PDCD1LG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,631,676 - 93,698,560 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,631,979 - 93,689,266 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha194,040,062 - 94,127,750 (+)NCBI
ROS_Cfam_1.0194,185,676 - 94,272,591 (+)NCBI
UMICH_Zoey_3.1193,817,857 - 93,905,923 (+)NCBI
UNSW_CanFamBas_1.0193,542,645 - 93,630,714 (+)NCBI
UU_Cfam_GSD_1.0194,306,830 - 94,395,104 (+)NCBI
Pdcd1lg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947141,737,769 - 141,782,738 (+)NCBI
SpeTri2.0NW_004936539190,583 - 229,936 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDCD1LG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,553,101 - 216,682,607 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,564,428 - 216,600,333 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PDCD1LG2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11273,938,194 - 73,998,028 (-)NCBI
ChlSab1.1 Ensembl1273,938,042 - 73,997,770 (-)Ensembl
Pdcd1lg2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473610,049,428 - 10,056,849 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132362870Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132897810Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19167640035676563Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19320000035900000Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19334585237345984Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19334585237345984Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19334585237345984Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19334585237345984Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19533596239336106Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19932831543328421Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19981005343810202Mouse
14928311Manh85_mmandible shape 85 (mouse)191193738945937389Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191494561648945738Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191593520749935319Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191593520749935319Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191831776252317981Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191831776252317981Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192025691554257062Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192025691554257062Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192139025755390480Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192200672732935319Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192233596253923073Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192500000059000000Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192515863842400477Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192543847859438566Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192739715561397266Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192779458535317981Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2815190961431566Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:206
Interacting mature miRNAs:212
Transcripts:ENSMUST00000112576
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF142780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX370315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX420005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX420007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX460800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX460802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY749628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000112576   ⟹   ENSMUSP00000108195
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1929,410,919 - 29,471,161 (+)Ensembl
RefSeq Acc Id: ENSMUST00000235164   ⟹   ENSMUSP00000158422
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1929,422,059 - 29,471,152 (+)Ensembl
RefSeq Acc Id: NM_021396   ⟹   NP_067371
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391929,388,319 - 29,450,327 (+)NCBI
GRCm381929,410,919 - 29,472,927 (+)NCBI
MGSCv371929,485,409 - 29,547,417 (+)RGD
Celera1930,187,250 - 30,249,414 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067371   ⟸   NM_021396
- Peptide Label: precursor
- UniProtKB: Q9WUL5 (UniProtKB/Swiss-Prot),   Q3U304 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000108195   ⟸   ENSMUST00000112576
RefSeq Acc Id: ENSMUSP00000158422   ⟸   ENSMUST00000235164
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Promoters
RGD ID:13679220
Promoter ID:EPDNEW_M23759
Type:initiation region
Name:Pdcd1lg2_1
Description:Mus musculus programmed cell death 1 ligand 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381929,410,980 - 29,411,040EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930125 AgrOrtholog
Ensembl Genes ENSMUSG00000016498 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000108195 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000158422 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000112576 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000235164 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD80_C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58205 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1930125 ENTREZGENE
NCBI Gene 58205 ENTREZGENE
Pfam C2-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdcd1lg2 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PD1L2_MOUSE UniProtKB/Swiss-Prot
  Q3U304 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUL5 ENTREZGENE