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Gene: Iqgap1 (IQ motif containing GTPase activating protein 1) Mus musculus
Symbol: Iqgap1
Name: IQ motif containing GTPase activating protein 1
Description: Exhibits Rac GTPase binding activity. Involved in several processes, including cellular response to growth factor stimulus; regulation of phosphate metabolic process; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to several cellular components, including cell leading edge; focal adhesion; and lateral plasma membrane. Predicted to colocalize with actin cytoskeleton and microtubule cytoskeleton. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and skin. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1); PARTICIPATES IN E-cadherin signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA682088; Cdc42-Rac1 effector protein; D7Ertd237e; D7Ertd257e; mKIAA0051; ras GTPase-activating-like protein IQGAP1
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl780,711,583 - 80,825,974 (-)EnsemblGRCm38mm10GRCm38
GRCm38780,711,583 - 80,815,549 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37787,856,469 - 87,948,217 (-)NCBIGRCm37mm9NCBIm37
MGSCv36780,586,294 - 80,676,807 (-)NCBImm8
Celera778,116,162 - 78,211,858 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Iqgap1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323574
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.