CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: bifenthrin
Accession: CHEBI:3093
browse the term
Definition: A carboxylic ester obtained by formal condensation of cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylic acid and [(2-methyl-1,1'-biphenyl)-3-yl]methanol.
Synonyms: exact_synonym: (2-methyl-[1,1'-biphenyl]-3-yl)methyl rel-(1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylate
related_synonym: Biphenthrin; Formula=C23H22ClF3O2; InChI=1S/C23H22ClF3O2/c1-14-16(10-7-11-17(14)15-8-5-4-6-9-15)13-29-21(28)20-18(22(20,2)3)12-19(24)23(25,26)27/h4-12,18,20H,13H2,1-3H3/b19-12-/t18-,20-/m0/s1; InChIKey=OMFRMAHOUUJSGP-IRHGGOMRSA-N; SMILES=Cc1c(COC(=O)[C@@H]2[C@H](\\C=C(/Cl)C(F)(F)F)C2(C)C)cccc1-c1ccccc1
xref: Beilstein:8512305; CAS:82657-04-3; KEGG:C10980
xref_mesh: MESH:C099952
xref: PMID:19950221; PMID:20563640; PMID:21104824; PMID:21246035; PMID:21360666; PMID:21370390; PMID:21394881; PMID:21503692; PMID:21520766; PMID:21563678; PMID:21635642; PMID:21718662; PMID:21735922; PMID:21770011; PMID:21819079
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Abcb1b
ATP-binding cassette, sub-family B member 1B
increases expression
ISO
bifenthrin results in increased expression of ABCB1B mRNA
CTD
PMID:26071804
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Ache
acetylcholinesterase
multiple interactions decreases expression
EXP
bifenthrin results in decreased expression of and results in decreased activity of ACHE protein bifenthrin results in decreased expression of ACHE mRNA; bifenthrin results in decreased expression of ACHE protein
CTD
PMID:29775722 PMID:30978409
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
increases expression
ISO
bifenthrin results in increased expression of ADH1 mRNA
CTD
PMID:26071804
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Adh5
alcohol dehydrogenase 5 (class III), chi polypeptide
increases expression
ISO
bifenthrin results in increased expression of ADH5 mRNA
CTD
PMID:26071804
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
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Ahr
aryl hydrocarbon receptor
increases expression
ISO
bifenthrin results in increased expression of AHR mRNA
CTD
PMID:26071804
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
ISO
bifenthrin results in increased expression of ALDH1A1 mRNA
CTD
PMID:26071804
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Alox12
arachidonate 12-lipoxygenase, 12S type
decreases expression
ISO
bifenthrin results in decreased expression of ALOX12 mRNA
CTD
PMID:26071804
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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Alox15
arachidonate 15-lipoxygenase
increases expression
ISO
bifenthrin results in increased expression of ALOX15 mRNA
CTD
PMID:26071804
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
bifenthrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]
CTD
PMID:29149346
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
bifenthrin results in increased expression of APAF1 mRNA
CTD
PMID:26071804 PMID:32408700
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Apoe
apolipoprotein E
increases expression
ISO
bifenthrin results in increased expression of APOE mRNA
CTD
PMID:26071804
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Areg
amphiregulin
multiple interactions
EXP
bifenthrin inhibits the reaction [CGA protein results in increased expression of AREG mRNA]
CTD
PMID:21251947
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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Arnt
aryl hydrocarbon receptor nuclear translocator
increases expression
ISO
bifenthrin results in increased expression of ARNT mRNA
CTD
PMID:26071804
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
bifenthrin results in increased expression of BAX mRNA
CTD
PMID:32408700
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bche
butyrylcholinesterase
decreases activity
EXP
bifenthrin results in decreased activity of BCHE protein
CTD
PMID:30978409
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
bifenthrin results in decreased expression of BCL2 mRNA
CTD
PMID:26071804 PMID:27916261 PMID:32408700
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bid
BH3 interacting domain death agonist
increases expression
ISO
bifenthrin results in increased expression of BID mRNA
CTD
PMID:26071804 PMID:32408700
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Brca1
BRCA1, DNA repair associated
affects binding
ISO
bifenthrin binds to BRCA1 protein
CTD
PMID:32278787
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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Casp3
caspase 3
increases activity increases expression
ISO EXP
bifenthrin results in increased activity of CASP3 protein bifenthrin results in increased expression of CASP3 protein bifenthrin results in increased expression of CASP3 mRNA
CTD
PMID:26071804 PMID:27916261 PMID:30978409 PMID:32408700
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases activity decreases expression
ISO
bifenthrin results in increased activity of CASP8 protein bifenthrin results in decreased expression of CASP8 mRNA
CTD
PMID:26071804
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases expression
ISO
bifenthrin results in increased expression of CASP9 mRNA
CTD
PMID:32408700
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions decreases activity decreases expression increases expression affects activity
ISO EXP
Quercetin inhibits the reaction [bifenthrin results in decreased activity of CAT protein]; Rutin inhibits the reaction [bifenthrin results in decreased activity of CAT protein] bifenthrin results in decreased expression of CAT protein bifenthrin analog results in increased expression of CAT mRNA; bifenthrin results in increased expression of CAT mRNA bifenthrin affects the activity of CAT protein; bifenthrin analog affects the activity of CAT protein
CTD
PMID:19833193 PMID:23172818 PMID:25149237 PMID:27916261 PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760 PMID:32408700 More...
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccne1
cyclin E1
multiple interactions
EXP
bifenthrin inhibits the reaction [CGA protein results in increased expression of CCNE1 mRNA]
CTD
PMID:21251947
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Cd36
CD36 molecule
increases expression
ISO
bifenthrin results in increased expression of CD36 mRNA
CTD
PMID:29554630
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
EXP
bifenthrin inhibits the reaction [CGA protein results in increased expression of CDKN1A mRNA]
CTD
PMID:21251947
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cebpb
CCAAT/enhancer binding protein beta
multiple interactions
EXP
bifenthrin inhibits the reaction [CGA protein results in increased expression of CEBPB mRNA]
CTD
PMID:21251947
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Ces2e
carboxylesterase 2E
affects metabolic processing
ISO
CES2E protein affects the metabolism of bifenthrin
CTD
PMID:15123619
NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856
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Ces2h
carboxylesterase 2H
increases metabolic processing
ISO
CES2 protein results in increased metabolism of bifenthrin
CTD
PMID:19249324
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Cga
glycoprotein hormones, alpha polypeptide
multiple interactions increases secretion
EXP ISO
bifenthrin analog inhibits the reaction [CGA protein results in increased abundance of Progesterone]; bifenthrin analog inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]; bifenthrin analog inhibits the reaction [CGA results in increased expression of CYP11A1 mRNA]; bifenthrin analog inhibits the reaction [CGA results in increased expression of DBI mRNA]; bifenthrin analog inhibits the reaction [CGA results in increased expression of PTGS2 mRNA]; bifenthrin analog inhibits the reaction [CGA results in increased expression of STAR mRNA]; bifenthrin analog inhibits the reaction [CGA results in increased expression of TSPO mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of AREG mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CCNE1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CDKN1A mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CEBPB mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CYP11A1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of EREG mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of PGR mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of PTGS2 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of RUNX1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of STAR mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of SULT1E1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of TGFB1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased secretion of Dinoprostone] fulvestrant inhibits the reaction [bifenthrin results in increased secretion of CGA protein]
CTD
PMID:21251947 PMID:21871944 PMID:24938463
NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
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Chat
choline O-acetyltransferase
decreases expression
EXP
bifenthrin results in decreased expression of CHAT mRNA
CTD
PMID:29775722
NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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Chrm1
cholinergic receptor, muscarinic 1
decreases expression
EXP
bifenthrin results in decreased expression of CHRM1 mRNA
CTD
PMID:29775722 PMID:30978409
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Chrna2
cholinergic receptor nicotinic alpha 2 subunit
decreases expression
EXP
bifenthrin results in decreased expression of CHRNA2 mRNA
CTD
PMID:30978409
NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
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Cpt1a
carnitine palmitoyltransferase 1A
decreases expression
ISO
bifenthrin results in decreased expression of CPT1A mRNA
CTD
PMID:29554630
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression
ISO
bifenthrin results in decreased expression of CXCL1 mRNA
CTD
PMID:28251819
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cyb5r3
cytochrome b5 reductase 3
increases expression
ISO
bifenthrin results in increased expression of CYB5R3 mRNA
CTD
PMID:26071804
NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
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Cycs
cytochrome c, somatic
increases expression
ISO
bifenthrin results in increased expression of CYCS mRNA
CTD
PMID:32408700
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions decreases expression
EXP ISO
bifenthrin analog inhibits the reaction [CGA results in increased expression of CYP11A1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CYP11A1 mRNA] bifenthrin inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA] bifenthrin results in decreased expression of CYP11A1 mRNA
CTD
PMID:21251947 PMID:21871944 PMID:23994515 PMID:24449165 PMID:32408700 PMID:34896276 More...
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
decreases expression multiple interactions
ISO
bifenthrin results in decreased expression of CYP11B1 mRNA bifenthrin inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11B1 mRNA]
CTD
PMID:34896276
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
decreases expression
ISO
bifenthrin results in decreased expression of CYP11B2 mRNA
CTD
PMID:34896276
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
increases expression decreases expression multiple interactions
ISO
bifenthrin results in increased expression of CYP17A1 mRNA bifenthrin results in decreased expression of CYP17A1 mRNA bifenthrin inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]
CTD
PMID:23994515 PMID:24449165 PMID:24938463 PMID:26071804 PMID:32408700 PMID:34896276 More...
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions increases expression
EXP ISO
bifenthrin inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA] bifenthrin results in increased expression of CYP19A1 mRNA
CTD
PMID:21251947 PMID:24938463
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases activity decreases expression
EXP ISO
bifenthrin results in increased activity of CYP1A1 protein bifenthrin results in decreased expression of CYP1A1 mRNA
CTD
PMID:20009351 PMID:26071804
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases expression
ISO
bifenthrin results in increased expression of CYP2C29 mRNA
CTD
PMID:26071804
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
ISO
bifenthrin results in increased expression of CYP2E1 mRNA
CTD
PMID:26071804
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
bifenthrin results in increased expression of CYP3A4 mRNA
CTD
PMID:19249324
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
decreases expression
ISO
bifenthrin results in decreased expression of CYP4B1 mRNA
CTD
PMID:26071804
NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
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Dbi
diazepam binding inhibitor
multiple interactions
EXP
bifenthrin analog inhibits the reaction [CGA results in increased expression of DBI mRNA]
CTD
PMID:21871944
NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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Ephx1
epoxide hydrolase 1
increases expression
ISO
bifenthrin results in increased expression of EPHX1 mRNA
CTD
PMID:26071804
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Erbb2
erb-b2 receptor tyrosine kinase 2
affects binding
ISO
bifenthrin binds to ERBB2 protein
CTD
PMID:32278787
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Ereg
epiregulin
multiple interactions
EXP
bifenthrin inhibits the reaction [CGA protein results in increased expression of EREG mRNA]
CTD
PMID:21251947
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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Esr1
estrogen receptor 1
decreases expression multiple interactions affects binding
ISO
bifenthrin results in decreased expression of ESR1 mRNA bifenthrin binds to and results in increased activity of ESR1 protein bifenthrin binds to ESR1 protein
CTD
PMID:20097460 PMID:32278787 PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
bifenthrin binds to and results in increased activity of ESR2 protein
CTD
PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Faim
Fas apoptotic inhibitory molecule
decreases expression
ISO
bifenthrin results in decreased expression of FAIM mRNA
CTD
PMID:26071804
NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562
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Faslg
Fas ligand
decreases expression
ISO
bifenthrin results in decreased expression of FASL mRNA
CTD
PMID:26071804
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fasn
fatty acid synthase
increases expression decreases expression
ISO
bifenthrin results in increased expression of FASN mRNA bifenthrin results in decreased expression of FASN mRNA
CTD
PMID:29554630 PMID:32408700
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fbp1
fructose-bisphosphatase 1
increases expression
ISO
bifenthrin results in increased expression of FBP1 mRNA
CTD
PMID:26071804
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
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Fgfr2
fibroblast growth factor receptor 2
affects binding
ISO
bifenthrin binds to FGFR2 protein
CTD
PMID:32278787
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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Ggt1
gamma-glutamyltransferase 1
increases expression
ISO
bifenthrin results in increased expression of GGT1 mRNA
CTD
PMID:26071804
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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Gnrh1
gonadotropin releasing hormone 1
increases expression
ISO
bifenthrin results in increased expression of GNRH1 mRNA
CTD
PMID:24938463
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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Gnrhr
gonadotropin releasing hormone receptor
increases expression
ISO
bifenthrin results in increased expression of GNRHR mRNA
CTD
PMID:24938463
NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
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Gpi
glucose-6-phosphate isomerase
increases expression
ISO
bifenthrin results in increased expression of GPI1 mRNA
CTD
PMID:26071804
NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
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Gpx1
glutathione peroxidase 1
increases expression decreases expression
ISO
bifenthrin results in increased expression of GPX1 mRNA bifenthrin results in decreased expression of GPX1 mRNA
CTD
PMID:26071804 PMID:27916261
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Gpx2
glutathione peroxidase 2
increases expression decreases expression
ISO
bifenthrin results in increased expression of GPX2 mRNA bifenthrin results in decreased expression of GPX2 mRNA
CTD
PMID:26071804 PMID:27916261
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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Gpx3
glutathione peroxidase 3
increases expression
ISO
bifenthrin results in increased expression of GPX3 mRNA
CTD
PMID:26071804
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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Gstm1
glutathione S-transferase mu 1
increases expression
ISO
bifenthrin results in increased expression of GSTM1 mRNA
CTD
PMID:26071804
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Gstm2
glutathione S-transferase mu 2
increases expression
ISO
bifenthrin results in increased expression of GSTM2 mRNA; bifenthrin results in increased expression of GSTM5 mRNA
CTD
PMID:26071804
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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Gstp1
glutathione S-transferase pi 1
increases expression
ISO
bifenthrin results in increased expression of GSTP1 mRNA
CTD
PMID:26071804
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Hk2
hexokinase 2
increases expression
ISO
bifenthrin results in increased expression of HK2 mRNA
CTD
PMID:26071804
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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Hmox1
heme oxygenase 1
increases expression
ISO
bifenthrin analog results in increased expression of HMOX1 mRNA; bifenthrin results in increased expression of HMOX1 mRNA
CTD
PMID:25149237 PMID:27916261
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
decreases expression
ISO
bifenthrin results in decreased expression of HSD17B1 mRNA
CTD
PMID:24938463
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
decreases expression
ISO
bifenthrin results in decreased expression of HSD17B3 mRNA
CTD
PMID:26071804
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases expression
ISO
bifenthrin results in decreased expression of HSD3B1 mRNA
CTD
PMID:32408700
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
increases expression decreases expression multiple interactions
ISO
bifenthrin results in increased expression of HSD3B2 mRNA bifenthrin results in decreased expression of HSD3B2 mRNA bifenthrin inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B2 mRNA]
CTD
PMID:24938463 PMID:34896276
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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Hspa1a
heat shock protein family A (Hsp70) member 1A
decreases expression
ISO
bifenthrin results in decreased expression of HSPA1A protein
CTD
PMID:16271832
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
bifenthrin results in increased expression of HSPA5 protein
CTD
PMID:16271832
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Hspa8
heat shock protein family A (Hsp70) member 8
decreases expression
ISO
bifenthrin results in decreased expression of HSPA8 protein
CTD
PMID:16271832
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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Hspb2
heat shock protein family B (small) member 2
decreases expression
ISO
bifenthrin results in decreased expression of HSPB2 protein
CTD
PMID:16271832
NCBI chr 8:51,093,267...51,094,528
Ensembl chr 8:51,081,342...51,094,533
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Il1b
interleukin 1 beta
decreases expression increases expression multiple interactions
ISO EXP
bifenthrin results in decreased expression of IL1B mRNA bifenthrin results in increased expression of IL1B mRNA bifenthrin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]
CTD
PMID:27916261 PMID:28251819 PMID:30102949
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
increases expression
ISO
bifenthrin results in increased expression of IL2 mRNA
CTD
PMID:23172818
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il4
interleukin 4
increases expression
ISO
bifenthrin results in increased expression of IL4 mRNA
CTD
PMID:23172818
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
decreases expression increases expression multiple interactions
ISO EXP
bifenthrin results in decreased expression of IL6 mRNA bifenthrin results in increased expression of IL6 protein bifenthrin results in increased expression of IL6 mRNA bifenthrin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
CTD
PMID:27916261 PMID:28251819 PMID:29793499 PMID:30102949 PMID:32061760
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ldlr
low density lipoprotein receptor
decreases expression
ISO
bifenthrin results in decreased expression of LDLR mRNA
CTD
PMID:24449165 PMID:32408700
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
bifenthrin results in increased lipidation of and results in increased localization of MAP1LC3B protein
CTD
PMID:38040083
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
bifenthrin analog results in increased phosphorylation of MAPK1 protein
CTD
PMID:19442700
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
bifenthrin analog results in increased phosphorylation of MAPK3 protein
CTD
PMID:19442700
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mgst2
microsomal glutathione S-transferase 2
decreases expression
ISO
bifenthrin results in decreased expression of MGST2 mRNA
CTD
PMID:26071804
NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
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Mgst3
microsomal glutathione S-transferase 3
increases expression
ISO
bifenthrin results in increased expression of MGST3 mRNA
CTD
PMID:26071804
NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
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Mir122
microRNA 122
increases expression
ISO
bifenthrin results in increased expression of MIR122 mRNA
CTD
PMID:32408700
NCBI chr18:58,758,703...58,758,787
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Mir17
microRNA 17
decreases expression
ISO
bifenthrin results in decreased expression of MIR17 mRNA
CTD
PMID:32408700
NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
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Mir34b
microRNA 34b
decreases expression
ISO
bifenthrin results in decreased expression of MIR34B mRNA
CTD
PMID:32408700
NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327
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Mir34c
microRNA 34c
decreases expression
ISO
bifenthrin results in decreased expression of MIR34C mRNA
CTD
PMID:32408700
NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802
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Mir449a
microRNA 449a
decreases expression
ISO
bifenthrin results in decreased expression of MIR449A mRNA
CTD
PMID:32408700
NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804
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Mir449c
microRNA 449c
decreases expression
ISO
bifenthrin results in decreased expression of MIR449C mRNA
CTD
PMID:32408700
NCBI chr 2:44,669,179...44,669,277
Ensembl chr 2:44,669,179...44,669,277
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Mt2A
metallothionein 2A
increases expression
ISO
bifenthrin results in increased expression of MT2 mRNA
CTD
PMID:26071804
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mt3
metallothionein 3
increases expression
ISO
bifenthrin results in increased expression of MT3 mRNA
CTD
PMID:26071804
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Mthfr
methylenetetrahydrofolate reductase
increases expression
ISO
bifenthrin results in increased expression of MTHFR mRNA
CTD
PMID:26071804
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Nat1
N-acetyltransferase 1
increases expression
ISO
bifenthrin results in increased expression of NAT1 mRNA
CTD
PMID:26071804
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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Nfe2l2
NFE2 like bZIP transcription factor 2
decreases expression increases expression
EXP ISO
bifenthrin results in decreased expression of NFE2L2 mRNA; bifenthrin results in decreased expression of NFE2L2 protein bifenthrin results in increased expression of NFE2L2 mRNA; bifenthrin results in increased expression of NFE2L2 protein
CTD
PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression affects binding
ISO
bifenthrin results in decreased expression of NQO1 mRNA bifenthrin binds to NQO1 protein
CTD
PMID:27916261 PMID:32278787
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
bifenthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity multiple interactions increases expression affects binding
ISO EXP
bifenthrin results in increased activity of NR1I2 protein bifenthrin binds to and results in increased activity of NR1I2 protein bifenthrin results in increased expression of NR1I2 mRNA; bifenthrin results in increased expression of NR1I2 protein bifenthrin binds to NR1I2 protein
CTD
PMID:19249324 PMID:29554630 PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions
ISO
bifenthrin inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]
CTD
PMID:26647222
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
multiple interactions
ISO
bifenthrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; bifenthrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
CTD
PMID:29149346
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
decreases expression
EXP
bifenthrin results in decreased expression of NR4A2 mRNA; bifenthrin results in decreased expression of NR4A2 protein
CTD
PMID:30978409
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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Pck1
phosphoenolpyruvate carboxykinase 1
multiple interactions
EXP
bifenthrin inhibits the reaction [Hydrocortisone results in increased expression of PCK1 mRNA]
CTD
PMID:26647222
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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Pgr
progesterone receptor
multiple interactions increases expression
EXP ISO
bifenthrin inhibits the reaction [CGA protein results in increased expression of PGR mRNA] fulvestrant inhibits the reaction [bifenthrin results in increased expression of PGR mRNA] bifenthrin results in increased expression of PGR; bifenthrin results in increased expression of PGR mRNA
CTD
PMID:21251947 PMID:24938463
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Pklr
pyruvate kinase L/R
decreases expression
ISO
bifenthrin results in decreased expression of PKLR mRNA
CTD
PMID:26071804
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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Pkm
pyruvate kinase M1/2
increases expression
ISO
bifenthrin results in increased expression of PKM mRNA
CTD
PMID:26071804
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Pon1
paraoxonase 1
increases expression
ISO
bifenthrin results in increased expression of PON1 mRNA
CTD
PMID:26071804
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Pon3
paraoxonase 3
increases expression
ISO
bifenthrin results in increased expression of PON3 mRNA
CTD
PMID:26071804
NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
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Ppard
peroxisome proliferator-activated receptor delta
affects binding
ISO
bifenthrin binds to PPARD protein
CTD
PMID:32278787
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression multiple interactions
ISO
bifenthrin results in increased expression of PPARG mRNA bifenthrin binds to and results in increased activity of PPARG protein
CTD
PMID:29554630 PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ptges
prostaglandin E synthase
increases expression
EXP ISO
bifenthrin results in increased expression of PTGES mRNA; bifenthrin results in increased expression of PTGES protein
CTD
PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760
NCBI chr 3:14,177,892...14,189,236
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
EXP ISO
bifenthrin analog inhibits the reaction [CGA results in increased expression of PTGS2 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of PTGS2 mRNA]; bifenthrin inhibits the reaction [Colforsin results in increased expression of PTGS2 mRNA] bifenthrin results in increased expression of PTGS2 mRNA; bifenthrin results in increased expression of PTGS2 protein
CTD
PMID:21251947 PMID:21871944 PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760 More...
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression
EXP ISO
bifenthrin results in increased expression of RELA mRNA; bifenthrin results in increased expression of RELA protein
CTD
PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rora
RAR-related orphan receptor A
affects binding
ISO
bifenthrin binds to RORA protein
CTD
PMID:32278787
NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
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Rorc
RAR-related orphan receptor C
affects binding
ISO
bifenthrin binds to RORC protein
CTD
PMID:32278787
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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RT1-M3-1
RT1 class Ib, locus M3, gene 1
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [bifenthrin results in increased expression of HLA-G mRNA]
CTD
PMID:24938463
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
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Runx1
RUNX family transcription factor 1
multiple interactions
EXP
bifenthrin inhibits the reaction [CGA protein results in increased expression of RUNX1 mRNA]
CTD
PMID:21251947
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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Scarb1
scavenger receptor class B, member 1
decreases expression
ISO
bifenthrin results in decreased expression of SCARB1 mRNA
CTD
PMID:23994515
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Scd
stearoyl-CoA desaturase
increases expression
ISO
bifenthrin results in increased expression of SCD mRNA
CTD
PMID:29554630
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Scn10a
sodium voltage-gated channel alpha subunit 10
multiple interactions
EXP
bifenthrin affects the reaction [SCN10A protein results in increased transport of Sodium]
CTD
PMID:16051293
NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
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Shbg
sex hormone binding globulin
affects binding
ISO
bifenthrin binds to SHBG protein
CTD
PMID:32278787
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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Sod1
superoxide dismutase 1
multiple interactions increases expression
EXP ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bifenthrin analog results in increased expression of SOD1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [bifenthrin analog results in increased expression of SOD1 protein] bifenthrin analog results in increased expression of SOD1 mRNA; bifenthrin results in increased expression of SOD1 mRNA
CTD
PMID:22718203 PMID:25149237 PMID:27916261
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
multiple interactions increases expression
EXP ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bifenthrin analog results in increased expression of SOD2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [bifenthrin analog results in increased expression of SOD2 protein] bifenthrin results in increased expression of SOD2 mRNA
CTD
PMID:22718203 PMID:27916261
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sqstm1
sequestosome 1
increases expression
ISO
bifenthrin results in increased expression of SQSTM1 protein
CTD
PMID:38040083
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
affects binding
ISO
bifenthrin binds to SRC protein
CTD
PMID:32278787
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Srd5a2
steroid 5 alpha-reductase 2
decreases expression
ISO
bifenthrin results in decreased expression of SRD5A2 mRNA
CTD
PMID:26071804
NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
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Star
steroidogenic acute regulatory protein
multiple interactions decreases expression
EXP ISO
bifenthrin analog inhibits the reaction [CGA results in increased expression of STAR mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of STAR mRNA] bifenthrin inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; bifenthrin inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein] bifenthrin results in decreased expression of STAR mRNA; bifenthrin results in decreased expression of STAR protein
CTD
PMID:21251947 PMID:21871944 PMID:23994515 PMID:34896276
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Sult1e1
sulfotransferase family 1E member 1
multiple interactions
EXP
bifenthrin inhibits the reaction [CGA protein results in increased expression of SULT1E1 mRNA]
CTD
PMID:21251947
NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
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Tff1
trefoil factor 1
increases expression
ISO
bifenthrin results in increased expression of TFF1 mRNA
CTD
PMID:20097460
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
bifenthrin inhibits the reaction [CGA protein results in increased expression of TGFB1 mRNA]
CTD
PMID:21251947
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
increases expression multiple interactions decreases expression
ISO EXP
bifenthrin results in increased expression of TNF mRNA bifenthrin results in increased expression of TNF protein bifenthrin results in increased expression of TNF mRNA; bifenthrin results in increased expression of TNF protein bifenthrin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA] bifenthrin results in decreased expression of TNF mRNA
CTD
PMID:23172818 PMID:26071804 PMID:27916261 PMID:28251819 PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760 PMID:32408700 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
increases expression decreases expression
ISO
bifenthrin results in increased expression of TRP53 mRNA bifenthrin results in decreased expression of TRP53 mRNA
CTD
PMID:20097460 PMID:26071804 PMID:27916261
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tspo
translocator protein
multiple interactions decreases expression
EXP ISO
bifenthrin analog inhibits the reaction [CGA results in increased expression of TSPO mRNA] bifenthrin results in decreased expression of TSPO mRNA
CTD
PMID:21871944 PMID:23994515 PMID:24449165
NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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