Mir449a (microRNA 449a) - Rat Genome Database

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Gene: Mir449a (microRNA 449a) Rattus norvegicus
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Symbol: Mir449a
Name: microRNA 449a
RGD ID: 2325536
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including miRNA-mediated post-transcriptional gene silencing; negative regulation of cell migration; and positive regulation of apoptotic signaling pathway. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; embryonic brain development; and motile cilium assembly. Orthologous to human MIR449A (microRNA 449a); INTERACTS WITH 2-methoxyethanol; atrazine; bisphenol A.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-449a; rno-mir-449a
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8246,403,910 - 46,404,000 (+)NCBIGRCr8
mRatBN7.2244,670,714 - 44,670,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl244,670,714 - 44,670,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx251,781,734 - 51,781,824 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0249,840,092 - 49,840,182 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0244,715,525 - 44,715,615 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0244,897,601 - 44,897,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl244,897,601 - 44,897,691 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0263,935,154 - 63,935,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera240,445,141 - 40,445,231 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:19056356   PMID:20403161   PMID:20439489   PMID:23893957   PMID:24982181   PMID:25480379   PMID:30119293   PMID:30773606   PMID:31646589   PMID:32982175  
PMID:33378032   PMID:36458392  


Genomics

Comparative Map Data
Mir449a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8246,403,910 - 46,404,000 (+)NCBIGRCr8
mRatBN7.2244,670,714 - 44,670,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl244,670,714 - 44,670,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx251,781,734 - 51,781,824 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0249,840,092 - 49,840,182 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0244,715,525 - 44,715,615 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0244,897,601 - 44,897,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl244,897,601 - 44,897,691 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0263,935,154 - 63,935,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera240,445,141 - 40,445,231 (+)NCBICelera
Cytogenetic Map2q14NCBI
MIR449A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38555,170,532 - 55,170,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl555,170,532 - 55,170,622 (-)EnsemblGRCh38hg38GRCh38
GRCh37554,466,360 - 54,466,450 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36554,502,116 - 54,502,206 (-)NCBINCBI36Build 36hg18NCBI36
Celera551,419,206 - 51,419,296 (-)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef551,439,533 - 51,439,623 (-)NCBIHuRef
CHM1_1554,469,853 - 54,469,943 (-)NCBICHM1_1
T2T-CHM13v2.0555,997,819 - 55,997,909 (-)NCBIT2T-CHM13v2.0
Mir449a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913113,174,068 - 113,174,158 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13113,174,068 - 113,174,158 (+)EnsemblGRCm39 Ensembl
GRCm3813113,037,534 - 113,037,624 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13113,037,534 - 113,037,624 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713113,827,742 - 113,827,832 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera13117,355,551 - 117,355,641 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.93NCBI
MIR449A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,541,949 - 42,542,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,541,949 - 42,542,039 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,587,525 - 39,587,615 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0243,003,982 - 43,004,072 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1240,070,025 - 40,070,115 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,884,585 - 40,884,675 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,707,507 - 41,707,597 (-)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:13263
Count of gene targets:7387
Count of transcripts:8014
Interacting mature miRNAs:rno-miR-449a-3p, rno-miR-449a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

reproductive system respiratory system
High
Medium
Low 5 2
Below cutoff 2

Sequence


RefSeq Acc Id: ENSRNOT00000053745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl244,670,714 - 44,670,804 (+)Ensembl
Rnor_6.0 Ensembl244,897,601 - 44,897,691 (+)Ensembl
RefSeq Acc Id: NR_031950
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8246,403,910 - 46,404,000 (+)NCBI
mRatBN7.2244,670,714 - 44,670,804 (+)NCBI
Rnor_6.0244,897,601 - 44,897,691 (+)NCBI
Rnor_5.0263,935,154 - 63,935,244 (+)NCBI
Celera240,445,141 - 40,445,231 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325536 AgrOrtholog
BioCyc Gene G2FUF-54378 BioCyc
Ensembl Genes ENSRNOG00000035622 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053745 ENTREZGENE
miRBase MI0001650 ENTREZGENE
NCBI Gene 100314068 ENTREZGENE
PhenoGen Mir449a PhenoGen
RatGTEx ENSRNOG00000035622 RatGTEx
RNAcentral URS00001F5B39 RNACentral
  URS000065DAF1 RNACentral
  URS000075B5E3 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir449a  microRNA 449a  Mir449a  microRNA mir-449a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir449a  microRNA mir-449a      Symbol and Name status set to provisional 70820 PROVISIONAL