Mir34b (microRNA 34b) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mir34b (microRNA 34b) Rattus norvegicus
Analyze
Symbol: Mir34b
Name: microRNA 34b
RGD ID: 2325432
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in miRNA-mediated gene silencing by mRNA destabilization. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; embryonic brain development; and motile cilium assembly. Orthologous to human MIR34B (microRNA 34b); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH bleomycin A2; cisplatin; DDT.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-34b; rno-mir-34b
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8860,306,609 - 60,306,692 (-)NCBIGRCr8
mRatBN7.2851,410,244 - 51,410,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,410,244 - 51,410,327 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,957,870 - 56,957,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0855,236,797 - 55,236,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0853,101,059 - 53,101,142 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,492,542 - 55,492,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,492,542 - 55,492,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,088,899 - 54,088,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera850,956,685 - 50,956,768 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir34bRatParkinson's disease  ISOMIR34B (Homo sapiens)10755477 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir34bRatataxia telangiectasia  ISOMIR34B (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia syndromeClinVarPMID:23807571 more ...
Mir34bRatBH4-deficient hyperphenylalaninemia A  ISOMIR34B (Homo sapiens)8554872ClinVar Annotator: match by term: BH4-deficient hyperphenylalaninemia AClinVarPMID:28492532
Mir34bRatCarney-Stratakis syndrome  ISOMIR34B (Homo sapiens)8554872ClinVar Annotator: match by term: Carney-Stratakis syndromeClinVarPMID:15531530 more ...
Mir34bRatchromosome 11 partial duplication syndrome  ISOMIR34B (Homo sapiens)8554872ClinVar Annotator: match by term: Distal trisomy 11qClinVarPMID:25741868
Mir34bRatintellectual disability  ISOMIR34B (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Mir34bRatPyruvate Dehydrogenase E2 Deficiency  ISOMIR34B (Homo sapiens)8554872ClinVar Annotator: match by term: Pyruvate dehydrogenase E2 deficiencyClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir34bRatCarcinoid Tumor  ISOMIR34B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25105010
Mir34bRatDisease Progression  ISOMIR34B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026881
Mir34bRatExperimental Neoplasms  ISOMIR34B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:22113133
Mir34bRatLung Neoplasms  ISOMIR34B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21339737 and PMID:25105010
Mir34bRatNeoplasm Metastasis  ISOMIR34B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19487542
Mir34bRatNeoplastic Cell Transformation  ISOMIR34B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21339737
Mir34bRattransitional cell carcinoma  ISOMIR34B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026881
Mir34bRaturinary bladder cancer  ISOMIR34B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026881

1 to 20 of 50 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir34bRat(-)-citrinin multiple interactionsISOMIR34B (Homo sapiens)6480464[Citrinin co-treated with ochratoxin A] results in increased expression of MIR34B mRNACTDPMID:30428381
Mir34bRat(-)-citrinin decreases expressionISOMIR34B (Homo sapiens)6480464Citrinin results in decreased expression of MIR34B mRNACTDPMID:30428381
Mir34bRat17beta-estradiol multiple interactionsISOMIR34B (Homo sapiens)6480464[Progesterone co-treated with Estradiol] results in decreased expression of MIR34B mRNA more ...CTDPMID:22113133 and PMID:22950660
Mir34bRat17beta-estradiol decreases expressionISOMir34b (Mus musculus)6480464Estradiol results in decreased expression of MIR34B mRNACTDPMID:22113133
Mir34bRat17beta-estradiol increases expressionISOMIR34B (Homo sapiens)6480464Estradiol results in increased expression of MIR34B mRNACTDPMID:24877718
Mir34bRat17beta-estradiol decreases expressionISOMIR34B (Homo sapiens)6480464Estradiol results in decreased expression of MIR34B mRNACTDPMID:22113133
Mir34bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMIR34B (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of MIR34B mRNACTDPMID:30096437
Mir34bRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMir34b (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MIR34B mRNACTDPMID:37854252
Mir34bRat5-aza-2'-deoxycytidine increases expressionISOMIR34B (Homo sapiens)6480464Decitabine results in increased expression of MIR34B mRNACTDPMID:22113133
Mir34bRat5-aza-2'-deoxycytidine decreases methylationISOMIR34B (Homo sapiens)6480464Decitabine results in decreased methylation of MIR34B promoterCTDPMID:22113133
Mir34bRatalpha-Zearalanol decreases expressionISOMIR34B (Homo sapiens)6480464Zeranol results in decreased expression of MIR34B mRNACTDPMID:22113133
Mir34bRatbenzene multiple interactionsISOMir34b (Mus musculus)6480464[Formaldehyde co-treated with Benzene co-treated with Toluene co-treated with Xylenes] results in decreased expression of MIR34B mRNACTDPMID:24733833
Mir34bRatbenzene decreases expressionISOMir34b (Mus musculus)6480464Benzene results in decreased expression of MIR34B mRNACTDPMID:32105654
Mir34bRatbenzo[a]pyrene increases methylationISOMIR34B (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of MIR34B promoterCTDPMID:27901495
Mir34bRatbifenthrin decreases expressionISOMir34b (Mus musculus)6480464bifenthrin results in decreased expression of MIR34B mRNACTDPMID:32408700
Mir34bRatbis(2-ethylhexyl) phthalate decreases expressionISOMir34b (Mus musculus)6480464Diethylhexyl Phthalate results in decreased expression of MIR34BCTDPMID:31920986
Mir34bRatbleomycin A2 decreases expressionEXP 6480464Bleomycin results in decreased expression of MIR34B mRNACTDPMID:25933445
Mir34bRatcadmium atom multiple interactionsISOMir34b (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MIR34B mRNA and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR34B mRNACTDPMID:28892167
Mir34bRatcadmium dichloride multiple interactionsISOMir34b (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MIR34B mRNA and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR34B mRNACTDPMID:28892167
Mir34bRatcisplatin increases expressionEXP 6480464Cisplatin results in increased expression of MIR34B mRNACTDPMID:24880025

1 to 20 of 50 rows

Biological Process
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir34bRatcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISOMir34b (Mus musculus)1624291 PMID:20439489RGDPMID:20439489
Mir34bRatembryonic brain development acts_upstream_of_or_withinISOMir34b (Mus musculus)1624291MGI:3619365 more ...RGDPMID:24982181
Mir34bRatmiRNA-mediated gene silencing by mRNA destabilization involved_inISOMIR34B (Homo sapiens)1624291 PMID:22336710RGDPMID:22336710
Mir34bRatmiRNA-mediated post-transcriptional gene silencing involved_inISOMIR34B (Homo sapiens)1624291 PMID:24778011 and PMID:26924291RGDPMID:24778011 and PMID:26924291
Mir34bRatmotile cilium assembly acts_upstream_of_or_withinISOMir34b (Mus musculus)1624291MGI:3619365 more ...RGDPMID:24982181
Mir34bRatmulticellular organism growth acts_upstream_of_or_withinISOMir34b (Mus musculus)1624291MGI:3619365 more ...RGDPMID:24982181
Mir34bRatnegative regulation of cell population proliferation acts_upstream_ofISOMIR34B (Homo sapiens)1624291 PMID:24778011RGDPMID:24778011
Mir34bRatnegative regulation of gene expression acts_upstream_of_or_withinISOMir34b (Mus musculus)1624291MGI:3619365 more ...RGDPMID:19895913 and PMID:24982181
Mir34bRatnegative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane acts_upstream_ofISOMIR34B (Homo sapiens)1624291 PMID:26924291RGDPMID:26924291
Mir34bRatossification acts_upstream_of_or_withinISOMir34b (Mus musculus)1624291 PMID:25751060RGDPMID:25751060
Mir34bRatpost-embryonic development acts_upstream_of_or_withinISOMir34b (Mus musculus)1624291MGI:3619365 more ...RGDPMID:24982181
Mir34bRatspermatogenesis acts_upstream_of_or_withinISOMir34b (Mus musculus)1624291MGI:3619365 more ...RGDPMID:24982181
1 to 12 of 12 rows

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir34bRatParkinson's disease pathway   ISOMIR34B (Homo sapiens)10755477 RGD 

#
Reference Title
Reference Citation
1. MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function. Minones-Moyano E, etal., Hum Mol Genet. 2011 Aug 1;20(15):3067-78. doi: 10.1093/hmg/ddr210. Epub 2011 May 10.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12919684   PMID:16381832   PMID:19895913   PMID:20403161   PMID:20439489   PMID:24982181   PMID:25751060   PMID:27503378   PMID:27514646   PMID:28098882   PMID:28498394   PMID:30539753  
PMID:31220137   PMID:39056770  



Mir34b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8860,306,609 - 60,306,692 (-)NCBIGRCr8
mRatBN7.2851,410,244 - 51,410,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,410,244 - 51,410,327 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,957,870 - 56,957,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0855,236,797 - 55,236,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0853,101,059 - 53,101,142 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,492,542 - 55,492,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,492,542 - 55,492,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,088,899 - 54,088,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera850,956,685 - 50,956,768 (-)NCBICelera
Cytogenetic Map8q23NCBI
MIR34B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,512,938 - 111,513,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,512,938 - 111,513,021 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,383,663 - 111,383,746 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,888,872 - 110,888,955 (+)NCBINCBI36Build 36hg18NCBI36
Celera11108,536,852 - 108,536,935 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,307,861 - 107,307,944 (+)NCBIHuRef
CHM1_111111,266,758 - 111,266,841 (+)NCBICHM1_1
T2T-CHM13v2.011111,523,086 - 111,523,169 (+)NCBIT2T-CHM13v2.0
Mir34b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,014,862 - 51,014,945 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl951,014,862 - 51,014,945 (-)EnsemblGRCm39 Ensembl
GRCm38951,103,562 - 51,103,645 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,103,562 - 51,103,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,911,667 - 50,911,750 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera948,390,072 - 48,390,155 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.83NCBI
MIR34B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,558,685 - 21,558,768 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,558,685 - 21,558,768 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha521,480,327 - 21,480,410 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,584,341 - 21,584,424 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1521,645,437 - 21,645,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,545,409 - 21,545,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,594,394 - 21,594,477 (-)NCBIUU_Cfam_GSD_1.0

.

Predicted Targets
Summary Value
Count of predictions:12547
Count of gene targets:7324
Count of transcripts:7949
Interacting mature miRNAs:rno-miR-34b-3p, rno-miR-34b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 61 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat

1 to 10 of 61 rows



endoderm
hemolymphoid system
mesenchyme
mesoderm
reproductive system
respiratory system
5 2 2 2 10 5


RefSeq Transcripts NR_031848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl851,410,244 - 51,410,327 (-)Ensembl
Rnor_6.0 Ensembl855,492,542 - 55,492,625 (-)Ensembl
RefSeq Acc Id: NR_031848
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8860,306,609 - 60,306,692 (-)NCBI
mRatBN7.2851,410,244 - 51,410,327 (-)NCBI
Rnor_6.0855,492,542 - 55,492,625 (-)NCBI
Rnor_5.0854,088,899 - 54,088,982 (-)NCBI
Celera850,956,685 - 50,956,768 (-)NCBI
Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 9 of 9 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-30522 BioCyc
Ensembl Genes ENSRNOG00000035561 Ensembl
miRBase MI0000875 ENTREZGENE
NCBI Gene 100314188 ENTREZGENE
PhenoGen Mir34b PhenoGen
RatGTEx ENSRNOG00000035561 RatGTEx
RNAcentral URS000037E0D9 RNACentral
  URS00004C43E8 RNACentral
  URS000072DC85 RNACentral
1 to 9 of 9 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir34b  microRNA 34b  Mir34b  microRNA mir-34b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir34b  microRNA mir-34b      Symbol and Name status set to provisional 70820 PROVISIONAL