CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: radiation protective agent
Accession: CHEBI:66987
browse the term
Definition: Any compound that is able to protect normal cells from the damage caused by radiation therapy.
Synonyms: related_synonym: radiation mitigation agent; radiation mitigation agents; radiation protective agents; radiation protective drug; radiation protective drugs; radioprotective agent; radioprotective agents; radioprotector; radioprotectors
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation multiple interactions
ISO
16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD
PMID:15578100
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Bax
BCL2 associated X, apoptosis regulator
increases response to substance affects localization
ISO
BAX results in increased susceptibility to 16,16-Dimethylprostaglandin E2 16,16-Dimethylprostaglandin E2 affects the localization of BAX protein
CTD
PMID:15578100
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Egfr
epidermal growth factor receptor
multiple interactions
ISO
EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD
PMID:15578100
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Hpgd
15-hydroxyprostaglandin dehydrogenase
increases activity
ISO
16,16-Dimethylprostaglandin E2 results in increased activity of HPGD protein
CTD
PMID:14736730
NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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Mpo
myeloperoxidase
multiple interactions
EXP
16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:11686837 PMID:11855677 PMID:11991626 PMID:18306037
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]
CTD
PMID:11686837 PMID:11855677 PMID:11991626 PMID:15610444 PMID:18306037
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
ISO EXP
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA] 16,16-Dimethylprostaglandin E2 inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]
CTD
PMID:9099957 PMID:15610444
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Tnf
tumor necrosis factor
multiple interactions
ISO
16,16-Dimethylprostaglandin E2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
CTD
PMID:9298541
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases activity multiple interactions
ISO
5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion
CTD
PMID:26599973
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions decreases activity
ISO
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole
CTD
PMID:26599973
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2d1
cytochrome P450, family 2, subfamily d, polypeptide 1
increases metabolic processing
EXP
CYP2D1 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine
CTD
PMID:18191824
NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084
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Cyp2d2
cytochrome P450, family 2, subfamily d, polypeptide 2
increases metabolic processing
EXP
CYP2D2 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine
CTD
PMID:18191824
NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions decreases activity
ISO
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan
CTD
PMID:26599973
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions decreases activity
ISO
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone
CTD
PMID:26599973
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions
ISO
CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine
CTD
PMID:12777961
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Htr7
5-hydroxytryptamine receptor 7
multiple interactions
ISO
[5-Methoxytryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP
CTD
PMID:14578406
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
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Kmo
kynurenine 3-monooxygenase
increases expression
EXP
5-Methoxytryptamine results in increased expression of KMO mRNA
CTD
PMID:32243540
NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
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Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
decreases phosphorylation increases phosphorylation
ISO
5-Methoxytryptamine results in decreased phosphorylation of PPP1R1B protein 5-Methoxytryptamine results in increased phosphorylation of PPP1R1B protein
CTD
PMID:11880652
NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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Sod2
superoxide dismutase 2
decreases expression
EXP
5-Methoxytryptamine results in decreased expression of SOD2 mRNA
CTD
PMID:32243540
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Taar1
trace-amine-associated receptor 1
increases activity multiple interactions
ISO
5-Methoxytryptamine results in increased activity of TAAR1 protein [5-Methoxytryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD
PMID:19725810
NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
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Tph1
tryptophan hydroxylase 1
decreases expression
EXP
5-Methoxytryptamine results in decreased expression of TPH1 mRNA
CTD
PMID:32243540
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[Amifostine co-treated with Doxorubicin] results in increased expression of BAX mRNA
CTD
PMID:15985719
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[Amifostine co-treated with Doxorubicin] results in decreased expression of BCL2 mRNA
CTD
PMID:15985719
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions
ISO
[Amifostine co-treated with Doxorubicin] results in increased activity of CASP3 protein; Amifostine inhibits the reaction [Idarubicin results in increased activity of CASP3 protein]; Amifostine promotes the reaction [Idarubicin results in increased activity of CASP3 protein]
CTD
PMID:15985719 PMID:18438337
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cdk1
cyclin-dependent kinase 1
decreases phosphorylation multiple interactions
ISO
Amifostine results in decreased phosphorylation of CDK1 protein olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]
CTD
PMID:16628227
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression increases expression
ISO
Amifostine results in decreased expression of CDKN1A mRNA Amifostine results in increased expression of CDKN1A protein
CTD
PMID:12618886 PMID:14555708
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Ei24
EI24, autophagy associated transmembrane protein
decreases expression
ISO
Amifostine results in decreased expression of EI24 mRNA
CTD
PMID:14555708
NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
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Il6
interleukin 6
multiple interactions
ISO
Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein]
CTD
PMID:19010997
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased phosphorylation of MAPK14 protein]
CTD
PMID:19010997
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mdm2
MDM2 proto-oncogene
decreases expression
ISO
Amifostine results in decreased expression of MDM2 mRNA
CTD
PMID:14555708
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mpo
myeloperoxidase
multiple interactions
ISO
Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
CTD
PMID:19010997
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
ISO
[Amifostine co-treated with TP53] results in increased expression of MYC mRNA
CTD
PMID:14555708
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Myl2
myosin light chain 2
multiple interactions
ISO
Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL2 protein] Amifostine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MYL2 protein]; Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein]
CTD
PMID:19010997
NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
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Nfkbia
NFKB inhibitor alpha
decreases expression multiple interactions
ISO
Amifostine results in decreased expression of NFKBIA protein Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD
PMID:10590050 PMID:19010997
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
Amifostine inhibits the reaction [Benzene results in decreased expression of PCNA protein]
CTD
PMID:17661222
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases localization
ISO
Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] Amifostine results in increased localization of RELA protein
CTD
PMID:10590050 PMID:19010997
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tp53
tumor protein p53
multiple interactions increases expression affects response to substance increases activity
ISO
[Amifostine co-treated with TP53] results in increased expression of MYC mRNA; olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein] Amifostine results in increased expression of TP53 protein TP53 affects the susceptibility to Amifostine Amifostine results in increased activity of TP53 protein
CTD
PMID:12618886 PMID:14555708 PMID:16628227
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53i3
tumor protein p53 inducible protein 3
decreases expression
ISO
Amifostine results in decreased expression of TP53I3 mRNA
CTD
PMID:14555708
NCBI chr 6:27,818,327...27,825,753
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Ar
androgen receptor
affects binding
EXP
Androstenediol binds to AR protein
CTD
PMID:14565775
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Dhrs11
dehydrogenase/reductase 11
increases oxidation
ISO
DHRS11 protein results in increased oxidation of Androstenediol
CTD
PMID:30926317
NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
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Esr1
estrogen receptor 1
multiple interactions
ISO
Androstenediol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]
CTD
PMID:9048584
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions increases expression
EXP ISO
Androstenediol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein] Androstenediol results in increased expression of ESR2 protein ESR2 protein alternative form inhibits the reaction [Androstenediol results in increased expression of ESR2 protein]
CTD
PMID:9048584 PMID:27634370
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
affects metabolic processing increases chemical synthesis
ISO
HSD17B1 protein affects the metabolism of Androstenediol HSD17B1 protein results in increased chemical synthesis of Androstenediol
CTD
PMID:16054388
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
increases chemical synthesis
ISO
HSD17B12 protein results in increased chemical synthesis of Androstenediol
CTD
PMID:17641292
NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
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Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
increases chemical synthesis affects metabolic processing
ISO
HSD17B2 protein results in increased chemical synthesis of Androstenediol HSD17B2 protein affects the metabolism of Androstenediol
CTD
PMID:16054388
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
affects metabolic processing increases chemical synthesis
ISO
HSD17B4 protein affects the metabolism of Androstenediol HSD17B4 protein results in increased chemical synthesis of Androstenediol
CTD
PMID:16054388
NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
affects metabolic processing
ISO
HSD3B1 protein affects the metabolism of Androstenediol
CTD
PMID:16054388
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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Sts
steroid sulfatase
decreases activity
ISO
Androstenediol metabolite results in decreased activity of STS protein
CTD
PMID:11600235
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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Acta2
actin alpha 2, smooth muscle
multiple interactions decreases expression
ISO
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA] Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:30551460
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Aifm1
apoptosis inducing factor, mitochondria associated 1
affects localization
ISO
artesunate affects the localization of AIFM1 protein
CTD
PMID:24704559
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Ar
androgen receptor
multiple interactions
ISO
artesunate binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atg12
autophagy related 12
increases expression
ISO
Artesunate results in increased expression of ATG12 mRNA
CTD
PMID:30551460
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atg3
autophagy related 3
increases expression
ISO
Artesunate results in increased expression of ATG3 mRNA
CTD
PMID:30551460
NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224
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Atg5
autophagy related 5
increases expression
ISO
Artesunate results in increased expression of ATG5 mRNA
CTD
PMID:30551460
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO EXP
Artesunate results in increased expression of BAX protein [1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
CTD
PMID:24704559 PMID:29031619 PMID:33002460
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO EXP
Artesunate results in decreased expression of BCL2 protein 3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein] [1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
CTD
PMID:24704559 PMID:29031619 PMID:33002460
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bst1
bone marrow stromal cell antigen 1
increases response to substance
ISO
BST1 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
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Casp3
caspase 3
increases activity increases cleavage multiple interactions
ISO
artesunate results in increased activity of CASP3 protein Artesunate results in increased cleavage of CASP3 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]
CTD
PMID:19513562 PMID:24704559 PMID:33002460
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
affects expression
ISO
artesunate affects the expression of CASP9 protein
CTD
PMID:24704559
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
increases expression decreases response to substance
ISO
artesunate results in increased expression of CAT protein CAT protein results in decreased susceptibility to artesunate
CTD
PMID:19513562 PMID:20144594
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cct2
chaperonin containing TCP1 subunit 2
decreases response to substance
ISO
CCT2 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
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Chek1
checkpoint kinase 1
multiple interactions increases phosphorylation
ISO
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein]
CTD
PMID:31664825
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Chek2
checkpoint kinase 2
multiple interactions increases phosphorylation
ISO
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein]
CTD
PMID:31664825
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Clip4
CAP-GLY domain containing linker protein family, member 4
increases response to substance
ISO
CLIP4 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 6:23,616,280...23,697,625 NCBI chr 6:23,718,580...23,729,231 NCBI chr 6:23,597,729...23,601,000
Ensembl chr 6:23,616,281...23,677,874
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Coq8a
coenzyme Q8A
decreases response to substance
ISO
COQ8A mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
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Ctnnb1
catenin beta 1
multiple interactions
EXP
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]
CTD
PMID:29031619
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Dbh
dopamine beta-hydroxylase
increases response to substance
ISO
DBH mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Des
desmin
multiple interactions decreases expression
ISO
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA] Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
CTD
PMID:30551460
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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Esr1
estrogen receptor 1
multiple interactions
ISO
artesunate binds to and results in decreased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Fas
Fas cell surface death receptor
increases expression
ISO
artesunate results in increased expression of FAS protein
CTD
PMID:19513562
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Flna
filamin A
increases response to substance
ISO
FLNA mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052
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Fn1
fibronectin 1
multiple interactions decreases expression
ISO
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA] Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
CTD
PMID:30551460
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
G
Fth1
ferritin heavy chain 1
decreases expression multiple interactions
ISO
Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
CTD
PMID:30551460
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
G
Fzd7
frizzled class receptor 7
increases response to substance
ISO
FZD7 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
G
Gclc
glutamate-cysteine ligase, catalytic subunit
affects response to substance decreases response to substance
ISO
GCLC mRNA affects the susceptibility to artesunate GCLC mRNA results in decreased susceptibility to artesunate
CTD
PMID:15796179
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
decreases response to substance
ISO
GCLM mRNA results in decreased susceptibility to artesunate
CTD
PMID:15796179
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gpx4
glutathione peroxidase 4
decreases activity multiple interactions
ISO
Artesunate results in decreased activity of GPX4 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
CTD
PMID:30551460
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
G
Gstm4
glutathione S-transferase mu 4
affects response to substance
ISO
GSTM4 mRNA affects the susceptibility to artesunate
CTD
PMID:15796179
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
G
Gstp1
glutathione S-transferase pi 1
decreases expression
ISO
artesunate results in decreased expression of GSTP1 protein
CTD
PMID:19513562
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gstt2
glutathione S-transferase theta 2
affects response to substance
ISO
GSTT2 mRNA affects the susceptibility to artesunate
CTD
PMID:15796179
NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
G
Gstz1
glutathione S-transferase zeta 1
affects response to substance
ISO
GSTZ1 mRNA affects the susceptibility to artesunate
CTD
PMID:15796179
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
G
H2ax
H2A.X variant histone
multiple interactions increases phosphorylation
ISO
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein]
CTD
PMID:31664825
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Il1b
interleukin 1 beta
multiple interactions
EXP
Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein]
CTD
PMID:27474069 PMID:30031708
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
EXP
Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein]
CTD
PMID:27474069 PMID:30031708
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Itgb1
integrin subunit beta 1
increases response to substance
ISO
ITGB1 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions increases lipidation
ISO
3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]
CTD
PMID:33002460
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
G
Mgst3
microsomal glutathione S-transferase 3
affects response to substance
ISO
MGST3 mRNA affects the susceptibility to artesunate
CTD
PMID:15796179
NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
G
Mki67
marker of proliferation Ki-67
multiple interactions
EXP
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]
CTD
PMID:29031619
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
G
Mmp9
matrix metallopeptidase 9
multiple interactions decreases expression
EXP ISO
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein] Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]
CTD
PMID:29031619 PMID:30551460
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mpo
myeloperoxidase
multiple interactions
EXP
artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein]
CTD
PMID:27474069
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
decreases response to substance
ISO
MTHFD2 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
G
Mtor
mechanistic target of rapamycin kinase
multiple interactions decreases phosphorylation
ISO
acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]
CTD
PMID:33002460
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Myd88
MYD88, innate immune signal transduction adaptor
multiple interactions
EXP
artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein]
CTD
PMID:30031708
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
G
Naca
nascent polypeptide associated complex subunit alpha
decreases response to substance
ISO
NACA mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992
G
Nckap1
NCK-associated protein 1
increases response to substance
ISO
NCKAP1 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
G
Ncoa4
nuclear receptor coactivator 4
multiple interactions decreases expression
ISO
Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA] Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
CTD
PMID:30551460
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
G
Nfe2l2
NFE2 like bZIP transcription factor 2
affects localization
ISO
artesunate affects the localization of NFE2L2 protein
CTD
PMID:26340163
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein]
CTD
PMID:30031708
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage multiple interactions
ISO
Artesunate results in increased cleavage of PARP1 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]
CTD
PMID:24704559 PMID:33002460
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]
CTD
PMID:29031619
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Pgr
progesterone receptor
multiple interactions
ISO
artesunate binds to and results in increased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein
CTD
PMID:30551460
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein]
CTD
PMID:27474069 PMID:30031708
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rpa2
replication protein A2
increases phosphorylation
ISO
Artesunate results in increased phosphorylation of RPA2 protein
CTD
PMID:31664825
NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
G
Rpl41
ribosomal protein L41
decreases response to substance
ISO
RPL41 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 7:977,885...978,965
G
Rpl6
ribosomal protein L6
decreases response to substance
ISO
RPL6 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
G
Rpl7
ribosomal protein L7
decreases response to substance
ISO
RPL7 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 5:3,217,184...3,220,192
G
Rps12
ribosomal protein S12
decreases response to substance
ISO
RPS12 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
G
Rps15a
ribosomal protein S15a
decreases response to substance
ISO
RPS15A mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
G
Rps6
ribosomal protein S6
decreases response to substance
ISO
RPS6 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
G
Slc25a19
solute carrier family 25 member 19
decreases response to substance
ISO
SLC25A19 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
G
Sp1
Sp1 transcription factor
decreases expression
ISO
artesunate results in decreased expression of SP1 protein
CTD
PMID:19513562
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
G
Sqstm1
sequestosome 1
multiple interactions decreases expression
ISO
Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein] Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
CTD
PMID:30551460
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
G
Srsf2
serine and arginine rich splicing factor 2
decreases response to substance
ISO
SRSF2 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
G
Timp1
TIMP metallopeptidase inhibitor 1
increases expression multiple interactions
ISO
Artesunate results in increased expression of TIMP1 mRNA Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
CTD
PMID:30551460
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Tlr4
toll-like receptor 4
multiple interactions
EXP
artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein]
CTD
PMID:30031708
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tnf
tumor necrosis factor
multiple interactions
EXP
artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein]
CTD
PMID:27474069 PMID:30031708
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
increases expression multiple interactions
ISO
Artesunate results in increased expression of TP53 protein Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD
PMID:33259807
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Tpt1
tumor protein, translationally-controlled 1
affects response to substance multiple interactions
ISO
TPT1 protein affects the susceptibility to artesunate Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD
PMID:15878303 PMID:33259807
NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
G
Tufm
Tu translation elongation factor, mitochondrial
decreases response to substance
ISO
TUFM mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
G
Ulk1
unc-51 like autophagy activating kinase 1
increases phosphorylation multiple interactions
ISO
Artesunate results in increased phosphorylation of ULK1 protein acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]
CTD
PMID:33002460
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
G
Vegfa
vascular endothelial growth factor A
multiple interactions
EXP
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein]
CTD
PMID:29031619
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Yy1
YY1 transcription factor
decreases expression
ISO
artesunate results in decreased expression of YY1 protein
CTD
PMID:19513562
NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
G
Zbtb4
zinc finger and BTB domain containing 4
increases response to substance
ISO
ZBTB4 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:17708605
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
G
Col1a1
collagen type I alpha 1 chain
multiple interactions
EXP
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
CTD
PMID:17708605
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
G
Tgm2
transglutaminase 2
multiple interactions
EXP
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 protein]
CTD
PMID:17708605
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
G
Timp1
TIMP metallopeptidase inhibitor 1
multiple interactions
EXP
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]
CTD
PMID:17708605
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Adipor2
adiponectin receptor 2
increases expression
EXP
dietary cysteamine increases expression of adipor2 mRNA in soleus muscle and retroperitoneal adipose tissue
RGD
PMID:17696487
RGD:21079417
NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
G
Ctsd
cathepsin D
increases expression multiple interactions
EXP
Cysteamine results in increased expression of CTSD protein Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]; thamira parpam inhibits the reaction [Cysteamine results in increased expression of CTSD protein]
CTD
PMID:20165931
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
increases activity
EXP
Cysteamine results in increased activity of CYP7A1 protein
CTD
PMID:1175606
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Gclc
glutamate-cysteine ligase, catalytic subunit
decreases activity multiple interactions
ISO
Cysteamine results in decreased activity of GCLC protein [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione
CTD
PMID:15282320
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Ghrl
ghrelin and obestatin prepropeptide
decreases expression multiple interactions
EXP
Cysteamine results in decreased expression of GHRL mRNA; Cysteamine results in decreased expression of GHRL protein Cysteamine results in increased expression of and results in increased secretion of GHRL protein
CTD
PMID:15778430
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
G
Hmox1
heme oxygenase 1
increases expression multiple interactions
EXP
[Cysteamine results in increased expression of HMOX1] which results in increased expression of SOD2; Cysteamine results in increased expression of HMOX1 mRNA; Cysteamine results in increased expression of HMOX1 protein [stannous mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Cysteamine results in increased expression of SOD2 protein]
CTD
PMID:10942521
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Mmp12
matrix metallopeptidase 12
increases expression
ISO
Cysteamine results in increased expression of MMP12 mRNA; Cysteamine results in increased expression of MMP12 protein
CTD
PMID:22532830
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
G
Mmp14
matrix metallopeptidase 14
increases expression
ISO
Cysteamine results in increased expression of MMP14 mRNA; Cysteamine results in increased expression of MMP14 protein
CTD
PMID:22532830
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
G
Mmp9
matrix metallopeptidase 9
decreases activity multiple interactions increases expression
ISO
Cysteamine results in decreased activity of MMP9 protein Cysteamine results in increased expression of and results in decreased activity of MMP9 protein Cysteamine results in increased expression of MMP9 mRNA
CTD
PMID:22532830
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mpo
myeloperoxidase
multiple interactions increases expression
EXP
geraniol inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; thamira parpam inhibits the reaction [Cysteamine results in increased expression of MPO protein]
CTD
PMID:20165931 PMID:24337826
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Sod2
superoxide dismutase 2
increases expression multiple interactions
EXP
[Cysteamine results in increased expression of HMOX1] which results in increased expression of SOD2; Cysteamine results in increased expression of SOD2 mRNA; Cysteamine results in increased expression of SOD2 protein [stannous mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Cysteamine results in increased expression of SOD2 protein]
CTD
PMID:10942521
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Sst
somatostatin
decreases expression
EXP
Cysteamine results in decreased expression of SST protein
CTD
PMID:15778430
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
G
Vnn1
vanin 1
increases chemical synthesis multiple interactions
ISO
VNN1 results in increased chemical synthesis of Cysteamine Cysteamine inhibits the reaction [VNN1 gene mutant form results in decreased susceptibility to Paraquat]
CTD
PMID:11042271 PMID:15282320
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
ISO
tocotrienol, delta results in increased expression of ABCB1
CTD
PMID:15269186
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcc1
ATP binding cassette subfamily C member 1
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of ABCC1 mRNA] tocotrienol, delta results in increased expression of ABCC1 mRNA
CTD
PMID:22185406
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
G
Abcd2
ATP binding cassette subfamily D member 2
decreases expression
ISO
tocotrienol, delta results in decreased expression of ABCD2 mRNA
CTD
PMID:22185406
NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
G
Actl6b
actin-like 6B
increases expression
ISO
tocotrienol, delta results in increased expression of ACTL6B mRNA
CTD
PMID:22185406
NCBI chr12:19,124,887...19,141,419
Ensembl chr12:19,124,916...19,141,376
G
Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
multiple interactions increases expression
ISO
tocotrienol, delta promotes the reaction [Lipopolysaccharides results in increased expression of ATP2A2 mRNA] tocotrienol, delta results in increased expression of ATP2A2 mRNA
CTD
PMID:22185406
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Ccnd1
cyclin D1
decreases expression
ISO
tocotrienol, delta results in decreased expression of CCND1 protein
CTD
PMID:21453743
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd2
cyclin D2
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CCND2 mRNA] tocotrienol, delta results in increased expression of CCND2 mRNA
CTD
PMID:22185406
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Cd40
CD40 molecule
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA] tocotrienol, delta results in increased expression of CD40 mRNA
CTD
PMID:22185406
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Cd69
Cd69 molecule
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA] tocotrienol, delta results in increased expression of CD69 mRNA
CTD
PMID:22185406
NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
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Cox7b2
cytochrome c oxidase subunit 7B2
multiple interactions decreases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA] tocotrienol, delta results in decreased expression of COX7B2 mRNA
CTD
PMID:22185406
NCBI chr14:36,693,120...36,805,323
Ensembl chr14:36,693,105...36,805,523
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Crp
C-reactive protein
multiple interactions
ISO
[resveratrol co-treated with pterostilbene co-treated with Quercetin co-treated with tocotrienol, delta co-treated with Niacin] results in decreased expression of CRP protein
CTD
PMID:24319627
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Ctnnb1
catenin beta 1
decreases expression
ISO
tocotrienol, delta results in decreased expression of CTNNB1 protein
CTD
PMID:21453743
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; tocotrienol, delta inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid] tocotrienol, delta results in increased expression of CYP3A4
CTD
PMID:15269186 PMID:31102695
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
multiple interactions affects response to substance
ISO
tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid] CYP3A5 gene polymorphism affects the susceptibility to tocotrienol, delta
CTD
PMID:31102695
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Gimap1
GTPase, IMAP family member 1
multiple interactions decreases expression
ISO
tocotrienol, delta promotes the reaction [Lipopolysaccharides results in decreased expression of GIMAP1 mRNA] tocotrienol, delta results in decreased expression of GIMAP1 mRNA
CTD
PMID:22185406
NCBI chr 4:77,687,581...77,691,468
Ensembl chr 4:77,682,171...77,691,866
G
Icam1
intercellular adhesion molecule 1
decreases expression multiple interactions
ISO
tocotrienol, delta results in decreased expression of ICAM1 mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]
CTD
PMID:22185406
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifnb1
interferon beta 1
multiple interactions
ISO
tocotrienol, delta inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]
CTD
PMID:22185406
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Ifng
interferon gamma
multiple interactions
ISO
tocotrienol, delta inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]
CTD
PMID:22185406
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ifngr1
interferon gamma receptor 1
decreases expression multiple interactions
ISO
tocotrienol, delta results in decreased expression of IFNGR1 mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]
CTD
PMID:22185406
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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Il12b
interleukin 12B
decreases expression multiple interactions
ISO
tocotrienol, delta results in decreased expression of IL12B mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]
CTD
PMID:22185406
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il1a
interleukin 1 alpha
increases expression
ISO
tocotrienol, delta results in increased expression of IL1A mRNA
CTD
PMID:22185406
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] tocotrienol, delta results in increased expression of IL1B mRNA
CTD
PMID:22185406
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
increases expression multiple interactions
ISO
tocotrienol, delta results in increased expression of IL1RN mRNA tocotrienol, delta promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]
CTD
PMID:22185406
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il6
interleukin 6
increases expression multiple interactions
ISO
tocotrienol, delta results in increased expression of IL6 mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:22185406
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
tocotrienol, delta results in decreased expression of JUN protein
CTD
PMID:21453743
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Mmp7
matrix metallopeptidase 7
decreases expression
ISO
tocotrienol, delta results in decreased expression of MMP7 protein
CTD
PMID:21453743
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Ncor1
nuclear receptor co-repressor 1
multiple interactions
ISO
tocotrienol, delta inhibits the reaction [NR1I2 protein binds to NCOR1 protein]
CTD
PMID:15269186
NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
Lipopolysaccharides inhibits the reaction [tocotrienol, delta results in increased expression of NOS2]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD
PMID:21356098 PMID:22185406
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
tocotrienol, delta binds to and results in increased activity of NR1I2 protein; tocotrienol, delta inhibits the reaction [NR1I2 protein binds to NCOR1 protein]
CTD
PMID:15269186
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Phka2
phosphorylase kinase regulatory subunit alpha 2
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PHKA2 mRNA] tocotrienol, delta results in increased expression of PHKA2 mRNA
CTD
PMID:22185406
NCBI chr X:34,170,959...34,293,498
Ensembl chr X:34,171,323...34,293,466
G
Psmb2
proteasome 20S subunit beta 2
decreases expression
ISO
tocotrienol, delta results in decreased expression of PSMB2 mRNA
CTD
PMID:22185406
NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
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Ptbp2
polypyrimidine tract binding protein 2
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA] tocotrienol, delta results in increased expression of PTBP2 mRNA
CTD
PMID:22185406
NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506
G
Rasgrp1
RAS guanyl releasing protein 1
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of RASGRP1 mRNA] tocotrienol, delta results in increased expression of RASGRP1 mRNA
CTD
PMID:22185406
NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
G
Rasgrp3
RAS guanyl releasing protein 3
decreases expression multiple interactions
ISO
tocotrienol, delta results in decreased expression of RASGRP3 mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA]
CTD
PMID:22185406
NCBI chr 6:19,895,361...19,993,945
Ensembl chr 6:19,895,390...19,958,578
G
Socs3
suppressor of cytokine signaling 3
multiple interactions decreases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA] tocotrienol, delta results in decreased expression of SOCS3 mRNA
CTD
PMID:22185406
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
G
Tnf
tumor necrosis factor
multiple interactions decreases expression
ISO
Lipopolysaccharides inhibits the reaction [tocotrienol, delta results in increased expression of TNF]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] tocotrienol, delta results in decreased expression of TNF mRNA
CTD
PMID:21356098 PMID:22185406
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnp1
transition protein 1
multiple interactions decreases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of TNP1 mRNA] tocotrienol, delta results in decreased expression of TNP1 mRNA
CTD
PMID:22185406
NCBI chr 9:74,594,463...74,595,072
Ensembl chr 9:74,594,466...74,595,274
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Traf1
TNF receptor-associated factor 1
multiple interactions increases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA] tocotrienol, delta results in increased expression of TRAF1 mRNA
CTD
PMID:22185406
NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
G
Ube2d2
ubiquitin-conjugating enzyme E2D 2
multiple interactions decreases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of UBE2D2A mRNA] tocotrienol, delta results in decreased expression of UBE2D2A mRNA
CTD
PMID:22185406
NCBI chr18:27,364,325...27,406,322
Ensembl chr18:27,364,303...27,406,181
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
ISO
tocotrienol, delta results in increased expression of UGT1A1
CTD
PMID:15269186
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions decreases expression
ISO
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA] tocotrienol, delta results in decreased expression of VCAM1 mRNA
CTD
PMID:22185406
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Wnt1
Wnt family member 1
decreases expression
ISO
tocotrienol, delta results in decreased expression of WNT1 protein
CTD
PMID:21453743
NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
G
Acta2
actin alpha 2, smooth muscle
affects expression
ISO
diethyl malate affects the expression of ACTA2 mRNA
CTD
PMID:24814887
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
G
Actc1
actin, alpha, cardiac muscle 1
affects expression
ISO
diethyl malate affects the expression of ACTC1 mRNA
CTD
PMID:24814887
NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
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Actn3
actinin alpha 3
affects expression
ISO
diethyl malate affects the expression of ACTN3 mRNA
CTD
PMID:24814887
NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
G
Adcy1
adenylate cyclase 1
affects expression
ISO
diethyl malate affects the expression of ADCY1 mRNA
CTD
PMID:24814887
NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
affects expression
ISO
diethyl malate affects the expression of ADH1 mRNA
CTD
PMID:24814887
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Agt
angiotensinogen
affects expression
ISO
diethyl malate affects the expression of AGT mRNA
CTD
PMID:24814887
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
C3
complement C3
affects expression
ISO
diethyl malate affects the expression of C3 mRNA
CTD
PMID:24814887
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
G
Cacnb2
calcium voltage-gated channel auxiliary subunit beta 2
affects expression
ISO
diethyl malate affects the expression of CACNB2 mRNA
CTD
PMID:24814887
NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
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Cacnb4
calcium voltage-gated channel auxiliary subunit beta 4
affects expression
ISO
diethyl malate affects the expression of CACNB4 mRNA
CTD
PMID:24814887
NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944
G
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions affects expression
ISO
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA]
CTD
PMID:24814887
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Cbr2
carbonyl reductase 2
affects expression
ISO
diethyl malate affects the expression of CBR2 mRNA
CTD
PMID:24814887
NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001
G
Ccl20
C-C motif chemokine ligand 20
affects expression
ISO
diethyl malate affects the expression of CCL20 mRNA
CTD
PMID:24814887
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccl7
C-C motif chemokine ligand 7
affects expression
ISO
diethyl malate affects the expression of CCL7 mRNA
CTD
PMID:24814887
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
G
Ccl9
C-C motif chemokine ligand 9
affects expression
ISO
diethyl malate affects the expression of CCL6 mRNA
CTD
PMID:24814887
NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
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Col11a1
collagen type XI alpha 1 chain
affects expression
ISO
diethyl malate affects the expression of COL11A1 mRNA
CTD
PMID:24814887
NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
G
Col2a1
collagen type II alpha 1 chain
affects expression
ISO
diethyl malate affects the expression of COL2A1 mRNA
CTD
PMID:24814887
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
G
Col3a1
collagen type III alpha 1 chain
affects expression
ISO
diethyl malate affects the expression of COL3A1 mRNA
CTD
PMID:24814887
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Col6a1
collagen type VI alpha 1 chain
affects expression
ISO
diethyl malate affects the expression of COL6A1 mRNA
CTD
PMID:24814887
NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
G
Comp
cartilage oligomeric matrix protein
affects expression
ISO
diethyl malate affects the expression of COMP mRNA
CTD
PMID:24814887
NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845
G
Cxcl12
C-X-C motif chemokine ligand 12
affects expression multiple interactions
ISO
diethyl malate affects the expression of CXCL12 mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]
CTD
PMID:24814887
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
G
Cxcl3
C-X-C motif chemokine ligand 3
affects expression
ISO
diethyl malate affects the expression of CXCL1 mRNA
CTD
PMID:24814887
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
G
Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
affects expression
ISO
diethyl malate affects the expression of CYP2J9 mRNA
CTD
PMID:24814887
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
G
Dapk2
death-associated protein kinase 2
affects expression
ISO
diethyl malate affects the expression of DAPK2 mRNA
CTD
PMID:24814887
NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567
G
Dhrs3
dehydrogenase/reductase 3
affects expression
ISO
diethyl malate affects the expression of DHRS3 mRNA
CTD
PMID:24814887
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
G
Dhx58
DEXH-box helicase 58
affects expression
ISO
diethyl malate affects the expression of DHX58 mRNA
CTD
PMID:24814887
NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
G
Edar
ectodysplasin-A receptor
affects expression
ISO
diethyl malate affects the expression of EDAR mRNA
CTD
PMID:24814887
NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494
G
Ednra
endothelin receptor type A
affects expression
ISO
diethyl malate affects the expression of EDNRA mRNA
CTD
PMID:24814887
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
G
Epas1
endothelial PAS domain protein 1
affects expression
ISO
diethyl malate affects the expression of EPAS1 mRNA
CTD
PMID:24814887
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Epha7
Eph receptor A7
affects expression
ISO
diethyl malate affects the expression of EPHA7 mRNA
CTD
PMID:24814887
NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
G
Ephb2
Eph receptor B2
affects expression
ISO
diethyl malate affects the expression of EPHB2 mRNA
CTD
PMID:24814887
NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
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Ephb6
Eph receptor B6
affects expression
ISO
diethyl malate affects the expression of EPHB6 mRNA
CTD
PMID:24814887
NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230
G
Fgf10
fibroblast growth factor 10
affects expression
ISO
diethyl malate affects the expression of FGF10 mRNA
CTD
PMID:24814887
NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
G
Fgf18
fibroblast growth factor 18
multiple interactions affects expression
ISO
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA]
CTD
PMID:24814887
NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
G
Fgfr2
fibroblast growth factor receptor 2
affects expression
ISO
diethyl malate affects the expression of FGFR2 mRNA
CTD
PMID:24814887
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
G
Fst
follistatin
affects expression
ISO
diethyl malate affects the expression of FST mRNA
CTD
PMID:24814887
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
G
Fzd2
frizzled class receptor 2
affects expression
ISO
diethyl malate affects the expression of FZD2 mRNA
CTD
PMID:24814887
NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
G
Fzd7
frizzled class receptor 7
affects expression
ISO
diethyl malate affects the expression of FZD7 mRNA
CTD
PMID:24814887
NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
G
Gclc
glutamate-cysteine ligase, catalytic subunit
affects expression
ISO
diethyl malate affects the expression of GCLC mRNA
CTD
PMID:24814887
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions affects expression
ISO
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA]
CTD
PMID:24814887
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Ggt6
gamma-glutamyl transferase 6
affects expression
ISO
diethyl malate affects the expression of GGT6 mRNA
CTD
PMID:24814887
NCBI chr10:57,051,977...57,054,900
Ensembl chr10:57,051,825...57,067,260
G
Gli2
GLI family zinc finger 2
affects expression
ISO
diethyl malate affects the expression of GLI2 mRNA
CTD
PMID:24814887
NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
G
Gnao1
G protein subunit alpha o1
affects expression
ISO
diethyl malate affects the expression of GNAO1 mRNA
CTD
PMID:24814887
NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493
G
Gng7
G protein subunit gamma 7
affects expression
ISO
diethyl malate affects the expression of GNG7 mRNA
CTD
PMID:24814887
NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
G
Gsr
glutathione-disulfide reductase
affects expression
ISO
diethyl malate affects the expression of GSR mRNA
CTD
PMID:24814887
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gss
glutathione synthetase
multiple interactions affects expression
ISO
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA]
CTD
PMID:24814887
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
G
Gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
affects expression
ISO
diethyl malate affects the expression of GUCY1A1 mRNA
CTD
PMID:24814887
NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
G
Gucy1b1
guanylate cyclase 1 soluble subunit beta 1
affects expression
ISO
diethyl malate affects the expression of GUCY1B1 mRNA
CTD
PMID:24814887
NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
G
Hck
HCK proto-oncogene, Src family tyrosine kinase
affects expression
ISO
diethyl malate affects the expression of HCK mRNA
CTD
PMID:24814887
NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
G
Hgf
hepatocyte growth factor
affects expression
ISO
diethyl malate affects the expression of HGF mRNA
CTD
PMID:24814887
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Igf1
insulin-like growth factor 1
affects expression
ISO
diethyl malate affects the expression of IGF1 mRNA
CTD
PMID:24814887
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Il15
interleukin 15
affects expression
ISO
diethyl malate affects the expression of IL15 mRNA
CTD
PMID:24814887
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
G
Il18
interleukin 18
affects expression
ISO
diethyl malate affects the expression of IL18 mRNA
CTD
PMID:24814887
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Irag1
inositol 1,4,5-triphosphate receptor associated 1
affects expression
ISO
diethyl malate affects the expression of IRAG1 mRNA
CTD
PMID:24814887
NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176
G
Irf7
interferon regulatory factor 7
affects expression
ISO
diethyl malate affects the expression of IRF7 mRNA
CTD
PMID:24814887
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
G
Isg15
ISG15 ubiquitin-like modifier
affects expression
ISO
diethyl malate affects the expression of ISG15 mRNA
CTD
PMID:24814887
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
G
Itga11
integrin subunit alpha 11
affects expression
ISO
diethyl malate affects the expression of ITGA11 mRNA
CTD
PMID:24814887
NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407
G
Itga3
integrin subunit alpha 3
affects expression
ISO
diethyl malate affects the expression of ITGA3 mRNA
CTD
PMID:24814887
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
G
Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
affects expression
ISO
diethyl malate affects the expression of KCNMB4 mRNA
CTD
PMID:24814887
NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278
G
Lama1
laminin subunit alpha 1
affects expression
ISO
diethyl malate affects the expression of LAMA1 mRNA
CTD
PMID:24814887
NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
G
Lama4
laminin subunit alpha 4
affects expression
ISO
diethyl malate affects the expression of LAMA4 mRNA
CTD
PMID:24814887
NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
G
Mapk1
mitogen activated protein kinase 1
affects phosphorylation multiple interactions
ISO
diethyl malate affects the phosphorylation of MAPK1 protein S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]
CTD
PMID:24814887
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
affects phosphorylation multiple interactions
ISO
diethyl malate affects the phosphorylation of MAPK3 protein S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]
CTD
PMID:24814887
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Myl9
myosin light chain 9
affects expression
ISO
diethyl malate affects the expression of MYL9 mRNA
CTD
PMID:24814887
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
G
Odc1
ornithine decarboxylase 1
affects expression
ISO
diethyl malate affects the expression of ODC1 mRNA
CTD
PMID:24814887
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
G
Pdgfb
platelet derived growth factor subunit B
affects expression multiple interactions
ISO
diethyl malate affects the expression of PDGFB mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]
CTD
PMID:24814887
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
G
Pdgfd
platelet derived growth factor D
affects expression
ISO
diethyl malate affects the expression of PDGFD mRNA
CTD
PMID:24814887
NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395
G
Pf4
platelet factor 4
affects expression
ISO
diethyl malate affects the expression of PF4 mRNA
CTD
PMID:24814887
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
G
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
affects expression
ISO
diethyl malate affects the expression of PIK3IP1 mRNA
CTD
PMID:24814887
NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608
G
Plxnc1
plexin C1
affects expression
ISO
diethyl malate affects the expression of PLXNC1 mRNA
CTD
PMID:24814887
NCBI chr 7:29,390,038...29,543,985
Ensembl chr 7:29,390,048...29,543,779
G
Prkg1
protein kinase cGMP-dependent 1
affects expression
ISO
diethyl malate affects the expression of PRKG1 mRNA
CTD
PMID:24814887
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
G
Ptgis
prostaglandin I2 synthase
affects expression
ISO
diethyl malate affects the expression of PTGIS mRNA
CTD
PMID:24814887
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
G
Ramp2
receptor activity modifying protein 2
affects expression
ISO
diethyl malate affects the expression of RAMP2 mRNA
CTD
PMID:24814887
NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
G
Rgs3
regulator of G-protein signaling 3
affects expression
ISO
diethyl malate affects the expression of RGS3 mRNA
CTD
PMID:24814887
NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
G
Rig1
RNA sensor RIG-1
affects expression
ISO
diethyl malate affects the expression of RIGI mRNA
CTD
PMID:24814887
NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
G
RT1-DMb
RT1 class II, locus DMb
affects expression
ISO
diethyl malate affects the expression of H2-DMB1 mRNA
CTD
PMID:24814887
NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
G
RT1-M3-1
RT1 class Ib, locus M3, gene 1
affects expression
ISO
diethyl malate affects the expression of H2-M3 mRNA
CTD
PMID:24814887
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
G
Runx1t1
RUNX1 partner transcriptional co-repressor 1
affects expression
ISO
diethyl malate affects the expression of RUNX1T1 mRNA
CTD
PMID:24814887
NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592
G
Sema3b
semaphorin 3B
affects expression
ISO
diethyl malate affects the expression of SEMA3B mRNA
CTD
PMID:24814887
NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919
G
Sema4g
semaphorin 4G
affects expression
ISO
diethyl malate affects the expression of SEMA4G mRNA
CTD
PMID:24814887
NCBI chr 1:243,849,979...243,865,343
Ensembl chr 1:243,853,854...243,865,341
G
Sema5a
semaphorin 5A
affects expression
ISO
diethyl malate affects the expression of SEMA5A mRNA
CTD
PMID:24814887
NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084
G
Stat1
signal transducer and activator of transcription 1
affects expression
ISO
diethyl malate affects the expression of STAT1 mRNA
CTD
PMID:24814887
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
G
Tgfb2
transforming growth factor, beta 2
affects expression multiple interactions
ISO
diethyl malate affects the expression of TGFB2 mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]
CTD
PMID:24814887
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
G
Thbs1
thrombospondin 1
affects expression
ISO
diethyl malate affects the expression of THBS1 mRNA
CTD
PMID:24814887
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
G
Thbs2
thrombospondin 2
affects expression
ISO
diethyl malate affects the expression of THBS2 mRNA
CTD
PMID:24814887
NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
G
Tnc
tenascin C
affects expression
ISO
diethyl malate affects the expression of TNC mRNA
CTD
PMID:24814887
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
G
Tnfrsf11b
TNF receptor superfamily member 11B
affects expression
ISO
diethyl malate affects the expression of TNFRSF11B mRNA
CTD
PMID:24814887
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
G
Tnnt1
troponin T1, slow skeletal type
affects expression
ISO
diethyl malate affects the expression of TNNT1 mRNA
CTD
PMID:24814887
NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
G
Tslp
thymic stromal lymphopoietin
affects expression
ISO
diethyl malate affects the expression of TSLP mRNA
CTD
PMID:24814887
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
G
Bcl2
BCL2, apoptosis regulator
increases phosphorylation
ISO
Estramustine results in increased phosphorylation of BCL2 protein
CTD
PMID:11763419
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
Estramustine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD
PMID:11602686
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Krt18
keratin 18
increases expression
ISO
Estramustine results in increased expression of KRT18 protein
CTD
PMID:16685278
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
G
Acsl4
acyl-CoA synthetase long-chain family member 4
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACSL4 protein]; ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ACSL4 protein]; ferrostatin-1 inhibits the reaction [Acrolein results in increased expression of ACSL4 protein]; ferrostatin-1 inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of ACSL4 protein]; ferrostatin-1 inhibits the reaction [monobutyl phthalate results in increased expression of ACSL4 protein] ferrostatin-1 inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of ACSL4 protein]
CTD
PMID:34813903 PMID:34863575 PMID:35870111 PMID:36435477 PMID:37121744
NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
G
Ascl4
achaete-scute family bHLH transcription factor 4
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ASCL4 protein]
CTD
PMID:33737050
NCBI chr 7:17,940,972...17,943,215
Ensembl chr 7:17,941,709...17,942,146
G
Atf6
activating transcription factor 6
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Silicon Dioxide results in increased expression of ATF6 protein]
CTD
PMID:37075931
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
G
Atg5
autophagy related 5
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of ATG5 protein]
CTD
PMID:35195477
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
G
Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of ATP2A2 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of ATP2A2 protein]
CTD
PMID:34864093
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]
CTD
PMID:35195477
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]
CTD
PMID:35195477
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Becn1
beclin 1
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of BECN1 protein]
CTD
PMID:35195477
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
G
Cacna1c
calcium voltage-gated channel subunit alpha1 C
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of CACNA1C mRNA]
CTD
PMID:34864093
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
G
Casp3
caspase 3
multiple interactions
EXP ISO
ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein] [ferrostatin-1 co-treated with sclareol] results in increased cleavage of CASP3 protein
CTD
PMID:35195477 PMID:37850667
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Cdh1
cadherin 1
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [shogaol results in increased expression of CDH1 protein]
CTD
PMID:36341865
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN1A protein]
CTD
PMID:33737050
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN2A protein]
CTD
PMID:33737050
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
G
Col2a1
collagen type II alpha 1 chain
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]
CTD
PMID:36084724
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
G
Cybb
cytochrome b-245 beta chain
multiple interactions
ISO
[ferrostatin-1 co-treated with Benzene] results in increased expression of CYBB protein; ferrostatin-1 inhibits the reaction [Benzene results in increased expression of CYBB mRNA]
CTD
PMID:35661779
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]; FXN protein affects the reaction [ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]]
CTD
PMID:33017621
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Ddit3
DNA-damage inducible transcript 3
multiple interactions
EXP ISO
ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein] ferrostatin-1 inhibits the reaction [Silicon Dioxide results in increased expression of DDIT3 protein]
CTD
PMID:35195477 PMID:37075931
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Fth1
ferritin heavy chain 1
multiple interactions
EXP ISO
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FTH1 protein] ferrostatin-1 inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [Benzene results in increased expression of FTH1 mRNA]; ferrostatin-1 inhibits the reaction [Benzene results in increased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of FTH1 protein]; ferrostatin-1 inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FTH1 protein]
CTD
PMID:33737050 PMID:34863575 PMID:34864093 PMID:35608139 PMID:35661779 PMID:36435477 More...
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
G
Ftl1
ferritin light chain 1
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of FTL1 protein]; ferrostatin-1 inhibits the reaction [Benzene results in increased expression of FTL1 protein]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of FTL1 protein]
CTD
PMID:34864093 PMID:35608139 PMID:35661779
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
G
Fxn
frataxin
multiple interactions
ISO
FXN protein affects the reaction [ferrostatin-1 affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]]
CTD
PMID:33017621
NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540
G
Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GCLC mRNA]
CTD
PMID:35661779
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Glb1
galactosidase, beta 1
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of GLB1 protein]
CTD
PMID:33737050
NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
G
Got1
glutamic-oxaloacetic transaminase 1
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Diethylhexyl Phthalate results in increased expression of GOT1 protein]
CTD
PMID:36438553
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Diethylhexyl Phthalate results in increased expression of GPT protein]; ferrostatin-1 inhibits the reaction [Matrines results in increased expression of GPT protein]
CTD
PMID:36438553 PMID:37716422
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx4
glutathione peroxidase 4
multiple interactions increases expression decreases expression
ISO EXP
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Acrolein results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GPX4 mRNA]; ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein]; ferrostatin-1 inhibits the reaction [Cisplatin results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of GPX4 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [monobutyl phthalate results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Silicon Dioxide results in decreased expression of GPX4 protein] ferrostatin-1 results in increased expression of GPX4 protein ferrostatin-1 results in decreased expression of GPX4 protein ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of GPX4 mRNA]; ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Fluorouracil results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein] [ferrostatin-1 co-treated with sclareol] results in decreased expression of GPX4 protein; ferrostatin-1 inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [1-nitropyrene results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [erastin results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [shogaol results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [sodium arsenite results in decreased expression of GPX4 protein]
CTD
PMID:32416107 PMID:32593899 PMID:33737050 PMID:34302894 PMID:34813903 PMID:34863575 PMID:34864093 PMID:35101590 PMID:35195477 PMID:35608139 PMID:35661779 PMID:35870111 PMID:36084724 PMID:36341865 PMID:36435477 PMID:36438553 PMID:37075931 PMID:37121744 PMID:37648051 PMID:37850667 PMID:37993079 More...
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA]
CTD
PMID:34785303
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Hmox1
heme oxygenase 1
multiple interactions
ISO
ferrostatin-1 affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of HMOX1 protein] ferrostatin-1 inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of HMOX1 protein]
CTD
PMID:34863575 PMID:36450496
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
ferrostatin-1 results in increased expression of HSPA5 protein
CTD
PMID:37075931
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Il1b
interleukin 1 beta
multiple interactions
ISO EXP
ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] ferrostatin-1 inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; ferrostatin-1 inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [IL1B protein results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; ferrostatin-1 inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; ferrostatin-1 inhibits the reaction [IL1B protein results in increased expression of P53 protein]; ferrostatin-1 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]
CTD
PMID:32593899 PMID:36084724
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
CTD
PMID:32593899
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ins1
insulin 1
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Acrolein inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
CTD
PMID:34813903
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Kcna5
potassium voltage-gated channel subfamily A member 5
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCNA5 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCNA5 protein]
CTD
PMID:34864093
NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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Kcnb1
potassium voltage-gated channel subfamily B member 1
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCNB1 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCNB1 protein]
CTD
PMID:34864093
NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
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Kcnd3
potassium voltage-gated channel subfamily D member 3
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Ethanol results in decreased expression of KCND3 mRNA]
CTD
PMID:34864093
NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
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Lcn2
lipocalin 2
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of LCN2 mRNA]
CTD
PMID:34785303
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
EXP
[ferrostatin-1 co-treated with Arsenic Trioxide] results in increased lipidation of MAP1LC3B protein
CTD
PMID:35195477
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Mmp13
matrix metallopeptidase 13
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
CTD
PMID:36084724
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Nfatc2
nuclear factor of activated T-cells 2
increases expression multiple interactions
ISO
ferrostatin-1 results in increased expression of NFATC2 protein ferrostatin-1 inhibits the reaction [Silicon Dioxide results in increased expression of NFATC2 protein]
CTD
PMID:37075931
NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein] ferrostatin-1 inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NFE2L2 protein]
CTD
PMID:32416107 PMID:36450496
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]
CTD
PMID:36084724
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Pln
phospholamban
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Ethanol results in decreased phosphorylation of PLN protein]
CTD
PMID:34864093
NCBI chr20:32,629,537...32,639,559
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO EXP
ferrostatin-1 inhibits the reaction [Acrolein results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Matrines results in increased expression of PTGS2 mRNA]; ferrostatin-1 inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein] ferrostatin-1 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
CTD
PMID:32416107 PMID:32593899 PMID:34785303 PMID:34813903 PMID:34864093 PMID:36084724 PMID:36438553 PMID:37088170 PMID:37716422 More...
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [arsenic disulfide results in decreased phosphorylation of RAF1 protein]
CTD
PMID:36321791
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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Sesn2
sestrin 2
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [erastin results in increased expression of SESN2 protein]
CTD
PMID:31323261
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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Slc40a1
solute carrier family 40 member 1
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]
CTD
PMID:32416107
NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
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Slc7a11
solute carrier family 7 member 11
multiple interactions decreases expression
EXP ISO
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [IL1B protein results in decreased expression of SLC7A11 protein] ferrostatin-1 results in decreased expression of SLC7A11 protein ferrostatin-1 affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [1-nitropyrene results in decreased expression of SLC7A11 protein] ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of SLC7A11 mRNA]; ferrostatin-1 inhibits the reaction [Benzene results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [Cisplatin results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SLC7A11 protein]
CTD
PMID:33737050 PMID:34302894 PMID:34863575 PMID:35661779 PMID:36084724 PMID:36438553 PMID:36450496 PMID:37075931 PMID:37993079 More...
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Snca
synuclein alpha
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]; ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]
CTD
PMID:36435477
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Sqstm1
sequestosome 1
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein]
CTD
PMID:35195477
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Tfrc
transferrin receptor
multiple interactions
EXP ISO
ferrostatin-1 inhibits the reaction [Fluorouracil results in increased expression of TFRC protein] ferrostatin-1 inhibits the reaction [Benzene results in increased expression of TFRC protein]
CTD
PMID:35101590 PMID:35661779
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Th
tyrosine hydroxylase
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]; ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]
CTD
PMID:36435477
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tnf
tumor necrosis factor
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
CTD
PMID:32593899
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions
EXP
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 protein]; ferrostatin-1 inhibits the reaction [Fluorouracil results in increased expression of TRP53 protein]
CTD
PMID:33737050 PMID:35101590
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Vim
vimentin
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [shogaol results in decreased expression of VIM protein]
CTD
PMID:36341865
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Wnt5a
Wnt family member 5A
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [Silicon Dioxide results in increased expression of WNT5A protein]
CTD
PMID:37075931
NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
G
Zfp36
zinc finger protein 36
multiple interactions
ISO
ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of ZFP36 mRNA]; ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of ZFP36 protein]
CTD
PMID:36435477
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
[hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2
CTD
PMID:18347083
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4
CTD
PMID:18347083
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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F2
coagulation factor II, thrombin
affects expression
ISO
hydrocortisone hemisuccinate affects the expression of F2 protein
CTD
PMID:12542493
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
G
Il18
interleukin 18
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of IL18 protein
CTD
PMID:20421217
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of IL1B protein
CTD
PMID:20421217
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of IL6 protein
CTD
PMID:20421217
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Tnf
tumor necrosis factor
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of TNF protein
CTD
PMID:20421217
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Acbd5
acyl-CoA binding domain containing 5
increases expression
ISO
Malathion results in increased expression of ACBD5 mRNA
CTD
PMID:37047231
NCBI chr17:85,206,178...85,248,909
Ensembl chr17:85,206,303...85,248,215
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Ache
acetylcholinesterase
multiple interactions decreases activity
ISO EXP
[Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]; Oximes analog inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein] [Endosulfan co-treated with Malathion] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in increased activity of ACHE protein; Taurine inhibits the reaction [Malathion results in decreased activity of ACHE protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]
CTD
PMID:2380476 PMID:4859365 PMID:14713564 PMID:18617161 PMID:19429256 PMID:19784758 PMID:21628957 PMID:21723318 PMID:21983245 PMID:23774768 PMID:28987951 PMID:30625376 More...
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acot6
acyl-CoA thioesterase 6
decreases expression
ISO
Malathion results in decreased expression of ACOT6 mRNA
CTD
PMID:37047231
NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446
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Acsm1
acyl-CoA synthetase medium-chain family member 1
decreases expression
ISO
Malathion results in decreased expression of ACSM1 mRNA
CTD
PMID:17311802
NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
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Adam11
ADAM metallopeptidase domain 11
increases methylation
ISO
Malathion results in increased methylation of ADAM11 promoter
CTD
PMID:37047231
NCBI chr10:87,724,115...87,742,773
Ensembl chr10:87,724,234...87,741,562
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Adam32
ADAM metallopeptidase domain 32
decreases expression
ISO
Malathion results in decreased expression of ADAM32 mRNA
CTD
PMID:37047231
NCBI chr16:67,102,384...67,212,163
Ensembl chr16:67,102,320...67,212,161
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Adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
decreases expression
ISO
Malathion results in decreased expression of ADAMTS12 mRNA
CTD
PMID:37047231
NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629
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Adamts20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
decreases expression
ISO
Malathion results in decreased expression of ADAMTS20 mRNA
CTD
PMID:37047231
NCBI chr 7:125,396,227...125,528,020
Ensembl chr 7:125,397,734...125,527,777
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Adamts6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
increases expression
ISO
Malathion results in increased expression of ADAMTS6 mRNA
CTD
PMID:37047231
NCBI chr 2:35,421,483...35,633,305
Ensembl chr 2:35,421,510...35,633,298
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Add3
adducin 3
increases expression
EXP
Malathion results in increased expression of ADD3 mRNA
CTD
PMID:19784758
NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
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Adm
adrenomedullin
increases expression
ISO
Malathion results in increased expression of ADM mRNA
CTD
PMID:37047231
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Adra2a
adrenoceptor alpha 2A
increases expression
ISO
Malathion results in increased expression of ADRA2A mRNA
CTD
PMID:37047231
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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Aff1
ALF transcription elongation factor 1
increases expression
ISO
Malathion results in increased expression of AFF1 mRNA mutant form
CTD
PMID:28624474
NCBI chr14:5,861,188...6,024,196
Ensembl chr14:5,863,961...6,024,729
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
[prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein
CTD
PMID:25684042
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akr1c1
aldo-keto reductase family 1, member C1
increases expression
ISO
Malathion results in increased expression of AKR1C1 mRNA
CTD
PMID:16079077 PMID:18214805
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
Malathion results in increased expression of AKR1C2 mRNA
CTD
PMID:16079077
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1e2
aldo-keto reductase family 1, member E2
decreases expression
ISO
Malathion results in decreased expression of AKR1E2 mRNA
CTD
PMID:37047231
NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441
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Alkal2
ALK and LTK ligand 2
increases expression
ISO
Malathion results in increased expression of ALKAL2 mRNA
CTD
PMID:37047231
NCBI chr 6:47,495,645...47,505,235
Ensembl chr 6:47,495,782...47,505,234
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Amot
angiomotin
decreases expression
ISO
Malathion results in decreased expression of AMOT mRNA
CTD
PMID:37047231
NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272
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Angptl2
angiopoietin-like 2
decreases expression
ISO
Malathion results in decreased expression of ANGPTL2 mRNA
CTD
PMID:37047231
NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
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Angptl4
angiopoietin-like 4
decreases methylation increases expression
ISO
Malathion results in decreased methylation of ANGPTL4 promoter Malathion results in increased expression of ANGPTL4 mRNA
CTD
PMID:37047231
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Ank1
ankyrin 1
decreases expression
ISO
Malathion results in decreased expression of ANK1 mRNA
CTD
PMID:37047231
NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759
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Ankrd55
ankyrin repeat domain 55
increases expression
ISO
Malathion results in increased expression of ANKRD55 mRNA
CTD
PMID:37047231
NCBI chr 2:43,883,877...43,983,820
Ensembl chr 2:43,883,857...43,983,680
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Aplf
aprataxin and PNKP like factor
decreases expression
ISO
Malathion results in decreased expression of APLF mRNA
CTD
PMID:37047231
NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633
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Aqp12a
aquaporin 12A
decreases expression
ISO
Malathion results in decreased expression of AQP12A mRNA
CTD
PMID:37047231
NCBI chr 9:93,554,527...93,560,011
Ensembl chr 9:93,554,527...93,560,011
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Aqp9
aquaporin 9
increases expression
ISO
Malathion results in increased expression of AQP9 mRNA
CTD
PMID:37047231
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Ar
androgen receptor
multiple interactions decreases expression
ISO EXP
[terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein Malathion results in decreased expression of AR mRNA
CTD
PMID:23871939 PMID:36336997
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Armc3
armadillo repeat containing 3
decreases expression
ISO
Malathion results in decreased expression of ARMC3 mRNA
CTD
PMID:37047231
NCBI chr17:81,814,087...81,917,534
Ensembl chr17:81,832,518...81,917,531
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Arnt2
aryl hydrocarbon receptor nuclear translocator 2
decreases expression
ISO
Malathion results in decreased expression of ARNT2 mRNA
CTD
PMID:37047231
NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153
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Asic5
acid sensing ion channel subunit family member 5
increases expression
ISO
Malathion results in increased expression of ASIC5 mRNA
CTD
PMID:37047231
NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812
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Atp2b3
ATPase plasma membrane Ca2+ transporting 3
decreases expression
ISO
Malathion results in decreased expression of ATP2B3 mRNA
CTD
PMID:37047231
NCBI chr X:151,216,483...151,289,069
Ensembl chr X:151,216,507...151,286,775
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B4galt1
beta-1,4-galactosyltransferase 1
decreases expression
ISO
Malathion results in decreased expression of B4GALT1 mRNA
CTD
PMID:32069766
NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
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B9d1
B9 domain containing 1
decreases expression
ISO
Malathion results in decreased expression of B9D1 mRNA
CTD
PMID:37047231
NCBI chr10:46,186,222...46,196,309
Ensembl chr10:46,186,691...46,196,008
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Bax
BCL2 associated X, apoptosis regulator
decreases expression increases expression multiple interactions
EXP ISO
Malathion results in decreased expression of BAX mRNA Malathion results in increased expression of BAX protein crocin inhibits the reaction [Malathion results in increased expression of BAX protein] Plant Extracts inhibits the reaction [Malathion results in increased expression of BAX protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of BAX protein] Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]
CTD
PMID:23774768 PMID:30769050 PMID:32120800 PMID:35274200
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bche
butyrylcholinesterase
multiple interactions increases activity decreases activity
ISO EXP
Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of BCHE protein] Malathion results in increased activity of BCHE protein
CTD
PMID:17364237 PMID:18617161 PMID:21983245 PMID:25180440
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Bcl2
BCL2, apoptosis regulator
decreases expression increases expression multiple interactions
EXP ISO
Malathion results in decreased expression of BCL2 mRNA Malathion results in increased expression of BCL2 mRNA Malathion results in increased expression of BCL2 protein Acetylcysteine inhibits the reaction [Malathion results in decreased expression of BCL2 protein]
CTD
PMID:23774768 PMID:30673264 PMID:30769050 PMID:32120800
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bdnf
brain-derived neurotrophic factor
decreases secretion increases methylation
ISO
Malathion results in decreased secretion of BDNF protein Malathion results in increased methylation of BDNF protein
CTD
PMID:35292247
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bmi1
BMI1 proto-oncogene, polycomb ring finger
increases expression
ISO
Malathion results in increased expression of BMI1 mRNA
CTD
PMID:32069766
NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
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Brd7
bromodomain containing 7
increases expression
ISO
Malathion results in increased expression of BRD7 mRNA
CTD
PMID:18214912
NCBI chr19:18,708,792...18,737,497
Ensembl chr19:18,709,022...18,737,494
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Bsnd
barttin CLCNK type accessory subunit beta
increases expression
ISO
Malathion results in increased expression of BSND mRNA
CTD
PMID:37047231
NCBI chr 5:121,251,774...121,260,571
Ensembl chr 5:121,251,774...121,260,571
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Btg1
BTG anti-proliferation factor 1
decreases expression
ISO
Malathion results in decreased expression of BTG1 mRNA
CTD
PMID:32069766
NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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Bub1
BUB1 mitotic checkpoint serine/threonine kinase
decreases expression
ISO
Malathion results in decreased expression of BUB1 mRNA
CTD
PMID:16079077
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
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C16h10orf53
similar to human chromosome 10 open reading frame 53
decreases expression
ISO
Malathion results in decreased expression of C10ORF53 mRNA
CTD
PMID:37047231
NCBI chr16:7,634,207...7,644,876
Ensembl chr16:7,634,207...7,644,876
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C1ql2
complement C1q like 2
decreases expression
ISO
Malathion results in decreased expression of C1QL2 mRNA
CTD
PMID:37047231
NCBI chr13:31,471,150...31,472,685
Ensembl chr13:31,471,150...31,472,689
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C2h3orf80
similar to human chromosome 3 open reading frame 80
decreases expression
ISO
Malathion results in decreased expression of C3ORF80 mRNA
CTD
PMID:37047231
NCBI chr 2:153,125,312...153,128,124
Ensembl chr 2:153,125,676...153,126,419
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C3h11orf96
similar to human chromosome 11 open reading frame 96
increases expression
ISO
Malathion results in increased expression of C11ORF96 mRNA
CTD
PMID:37047231
NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523
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C3h15orf48
similar to human chromosome 15 open reading frame 48
increases expression
ISO
Malathion results in increased expression of C15ORF48 mRNA
CTD
PMID:37047231
NCBI chr 3:109,719,952...109,723,505
Ensembl chr 3:109,719,897...109,724,006 Ensembl chr 3:109,719,897...109,724,006
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C5h8orf34
similar to human chromosome 8 open reading frame 34
decreases expression
ISO
Malathion results in decreased expression of C8ORF34 mRNA
CTD
PMID:37047231
NCBI chr 5:7,237,968...7,777,119
Ensembl chr 5:7,238,853...7,776,769
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C7h12orf54
similar to human chromosome 12 open reading frame 54
decreases expression
ISO
Malathion results in decreased expression of C12ORF54 mRNA
CTD
PMID:37047231
NCBI chr 7:129,529,811...129,548,676
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Cabp7
calcium binding protein 7
decreases expression
ISO
Malathion results in decreased expression of CABP7 mRNA
CTD
PMID:37047231
NCBI chr14:79,598,822...79,609,172
Ensembl chr14:79,598,827...79,609,240
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
increases expression
ISO
Malathion results in increased expression of CACNA1C mRNA
CTD
PMID:37047231
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions
EXP
Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]
CTD
PMID:28385489
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
multiple interactions
EXP
Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA]
CTD
PMID:28385489
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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Capn8
calpain 8
decreases expression
ISO
Malathion results in decreased expression of CAPN8 mRNA
CTD
PMID:37047231
NCBI chr13:94,252,218...94,316,146
Ensembl chr13:94,253,054...94,316,146
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Cartpt
CART prepropeptide
increases expression
ISO
Malathion results in increased expression of CARTPT mRNA
CTD
PMID:37047231
NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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Casp3
caspase 3
increases activity increases cleavage multiple interactions increases expression
ISO EXP
Malathion results in increased activity of CASP3 protein Malathion results in increased cleavage of CASP3 protein Malathion results in increased activity of and results in increased cleavage of CASP3 protein; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein] Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP3 protein] Malathion results in increased expression of CASP3 mRNA [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
CTD
PMID:12505448 PMID:19815060 PMID:21628957 PMID:27941166 PMID:29027213 PMID:30769050 PMID:35274200 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp4
caspase 4
decreases expression
ISO
Malathion results in decreased expression of CASP4 mRNA
CTD
PMID:32069766
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Casp8
caspase 8
increases activity
ISO
Malathion results in increased activity of CASP8 protein
CTD
PMID:12505448
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity increases cleavage multiple interactions increases expression
ISO EXP
Malathion results in increased activity of CASP9 protein Malathion results in increased cleavage of CASP9 protein Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP9 protein] [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP9 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
CTD
PMID:12505448 PMID:21628957 PMID:27941166 PMID:30769050 PMID:35274200
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions decreases expression decreases activity increases activity
EXP ISO
[Dimethoate co-treated with Malathion] results in increased activity of CAT protein; [Selenium co-treated with Vitamin E] inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]; Taurine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of CAT protein] Malathion results in decreased expression of CAT protein [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Malathion results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein] [Malathion co-treated with 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide] results in increased activity of CAT protein; [Malathion co-treated with pralidoxime] results in increased activity of CAT protein; lavender oil inhibits the reaction [Malathion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Malathion results in decreased activity of CAT protein]; Polyphenols inhibits the reaction [Malathion results in decreased activity of CAT protein]
CTD
PMID:11834209 PMID:18655177 PMID:19429256 PMID:20194575 PMID:21628957 PMID:21723318 PMID:24810974 PMID:25180440 PMID:28987951 PMID:30409133 PMID:30673264 PMID:30769050 PMID:32120800 PMID:36336997 More...
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cbfb
core-binding factor subunit beta
increases expression
ISO
Malathion results in increased expression of CBFB mRNA
CTD
PMID:32069766
NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751
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Ccdc126
coiled-coil domain containing 126
increases expression
ISO
Malathion results in increased expression of CCDC126 mRNA
CTD
PMID:37047231
NCBI chr 4:78,297,625...78,318,655
Ensembl chr 4:78,297,551...78,318,655
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Cck
cholecystokinin
increases expression
EXP
Malathion results in increased expression of CCK mRNA
CTD
PMID:19784758
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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Ccl1
C-C motif chemokine ligand 1
increases expression
ISO
Malathion results in increased expression of CCL1 mRNA
CTD
PMID:37047231
NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
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Ccl19
C-C motif chemokine ligand 19
increases expression
ISO
Malathion results in increased expression of CCL19 mRNA
CTD
PMID:37047231
NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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Ccl20
C-C motif chemokine ligand 20
increases expression
ISO
Malathion results in increased expression of CCL20 mRNA
CTD
PMID:37047231
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccl3
C-C motif chemokine ligand 3
increases expression
ISO
Malathion results in increased expression of CCL3 mRNA
CTD
PMID:37047231
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl7
C-C motif chemokine ligand 7
increases expression
ISO
Malathion results in increased expression of CCL7 mRNA
CTD
PMID:37047231
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Ccm2l
CCM2 like scaffold protein
increases expression
ISO
Malathion results in increased expression of CCM2L mRNA
CTD
PMID:37047231
NCBI chr 3:141,533,470...141,549,136
Ensembl chr 3:141,533,511...141,549,140
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Ccna2
cyclin A2
decreases expression
ISO
Malathion results in decreased expression of CCNA2 protein
CTD
PMID:30769050
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression
ISO
Malathion results in decreased expression of CCNB1 protein
CTD
PMID:30769050
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccne1
cyclin E1
decreases expression
ISO
Malathion results in decreased expression of CCNE1 protein
CTD
PMID:30769050
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Ccser1
coiled-coil serine-rich protein 1
increases expression
ISO
Malathion results in increased expression of CCSER1 mRNA
CTD
PMID:37047231
NCBI chr 4:90,153,873...91,391,441
Ensembl chr 4:90,292,780...91,388,786
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Cd14
CD14 molecule
decreases expression
ISO
Malathion results in decreased expression of CD14 mRNA
CTD
PMID:32069766
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd274
CD274 molecule
increases expression
ISO
Malathion results in increased expression of CD274 mRNA
CTD
PMID:37047231
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd36
CD36 molecule
increases expression
ISO
Malathion results in increased expression of CD36 mRNA
CTD
PMID:32069766
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd5
Cd5 molecule
decreases expression
ISO
Malathion results in decreased expression of CD5 mRNA
CTD
PMID:32069766
NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
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Cd69
Cd69 molecule
increases expression
ISO
Malathion results in increased expression of CD69 mRNA
CTD
PMID:37047231
NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
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Cdc20
cell division cycle 20
decreases expression
ISO
Malathion results in decreased expression of CDC20 mRNA
CTD
PMID:18214805
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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Cdk15
cyclin-dependent kinase 15
increases expression
ISO
Malathion results in increased expression of CDK15 mRNA
CTD
PMID:37047231
NCBI chr 9:60,710,787...60,803,638
Ensembl chr 9:60,711,715...60,802,777
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Cdk2
cyclin dependent kinase 2
decreases expression increases expression
ISO
Malathion results in decreased expression of CDK2 protein Malathion results in increased expression of CDK2 mRNA
CTD
PMID:30769050 PMID:32069766
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cebpg
CCAAT/enhancer binding protein gamma
increases expression
ISO
Malathion results in increased expression of CEBPG mRNA
CTD
PMID:32069766
NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
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Cenpf
centromere protein F
decreases expression
ISO
Malathion results in decreased expression of CENPF mRNA
CTD
PMID:16079077
NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
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Ces1d
carboxylesterase 1D
increases expression
ISO
Malathion results in increased expression of CES1 mRNA
CTD
PMID:17311802
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Cfap157
cilia and flagella associated protein 157
decreases expression
ISO
Malathion results in decreased expression of CFAP157 mRNA
CTD
PMID:37047231
NCBI chr 3:16,066,521...16,073,504
Ensembl chr 3:16,066,521...16,073,495
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Cfap91
cilia and flagella associated protein 91
decreases expression
ISO
Malathion results in decreased expression of CFAP91 mRNA
CTD
PMID:37047231
NCBI chr11:62,413,613...62,457,281
Ensembl chr11:62,413,602...62,457,293
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Cfb
complement factor B
increases expression
ISO
Malathion results in increased expression of CFB mRNA
CTD
PMID:37047231
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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Ch25h
cholesterol 25-hydroxylase
increases expression
ISO
Malathion results in increased expression of CH25H mRNA
CTD
PMID:37047231
NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
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Cldn12
claudin 12
increases expression
ISO
Malathion results in increased expression of CLDN12 mRNA
CTD
PMID:37047231
NCBI chr 4:28,522,659...28,533,647
Ensembl chr 4:28,522,678...28,533,801
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Cldn22
claudin 22
decreases expression
ISO
Malathion results in decreased expression of CLDN22 mRNA
CTD
PMID:37047231
NCBI chr16:44,422,344...44,423,370
Ensembl chr16:44,422,345...44,423,354
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Cldn5
claudin 5
multiple interactions decreases expression
EXP
[Malathion co-treated with Lead] results in decreased expression of CLDN5 protein Malathion results in decreased expression of CLDN5 protein
CTD
PMID:20970449
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
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Cma1
chymase 1
decreases expression
ISO
Malathion results in decreased expression of CMA1 mRNA
CTD
PMID:37047231
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
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Cntn4
contactin 4
increases expression
ISO
Malathion results in increased expression of CNTN4 mRNA
CTD
PMID:37047231
NCBI chr 4:138,624,584...139,622,499
Ensembl chr 4:139,099,152...139,621,090
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Col1a2
collagen type I alpha 2 chain
increases expression
ISO
Malathion results in increased expression of COL1A2 mRNA
CTD
PMID:32069766
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Cpne9
copine family member 9
decreases expression
ISO
Malathion results in decreased expression of CPNE9 mRNA
CTD
PMID:37047231
NCBI chr 4:146,429,961...146,454,335
Ensembl chr 4:146,430,792...146,454,333
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Cpz
carboxypeptidase Z
decreases expression
ISO
Malathion results in decreased expression of CPZ mRNA
CTD
PMID:37047231
NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945
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Crh
corticotropin releasing hormone
multiple interactions decreases expression
EXP
caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]
CTD
PMID:20233601 PMID:25404496
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Crisp3
cysteine-rich secretory protein 3
decreases expression
ISO
Malathion results in decreased expression of CRISP3 mRNA
CTD
PMID:37047231
NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658
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Crispld2
cysteine-rich secretory protein LCCL domain containing 2
decreases expression
EXP
Malathion results in decreased expression of CRISPLD2 mRNA
CTD
PMID:19784758
NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465
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Csf2
colony stimulating factor 2
increases expression
EXP ISO
Malathion results in increased expression of CSF2 protein Malathion results in increased expression of CSF2 mRNA
CTD
PMID:34778934 PMID:37047231
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Csf3
colony stimulating factor 3
increases expression
ISO
Malathion results in increased expression of CSF3 mRNA
CTD
PMID:37047231
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Ctsd
cathepsin D
increases expression
ISO
Malathion results in increased expression of CTSD protein
CTD
PMID:8812242
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cxcl11
C-X-C motif chemokine ligand 11
increases expression
ISO
Malathion results in increased expression of CXCL11 mRNA
CTD
PMID:37047231
NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
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Cybb
cytochrome b-245 beta chain
multiple interactions increases expression
ISO
Plant Extracts inhibits the reaction [Malathion results in increased expression of CYBB protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of CYBB protein]
CTD
PMID:32120800
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases expression multiple interactions
ISO
Malathion results in decreased expression of CYP11A1 mRNA lavender oil inhibits the reaction [Malathion results in decreased expression of CYP11A1 mRNA]
CTD
PMID:30409133
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions
EXP
[bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA
CTD
PMID:23954766
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects metabolic processing increases expression
ISO
CYP1A2 protein affects the metabolism of Malathion Malathion results in increased expression of CYP1A2 mRNA
CTD
PMID:15557345 PMID:22310298
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp27b1
cytochrome P450, family 27, subfamily b, polypeptide 1
increases expression
ISO
Malathion results in increased expression of CYP27B1 mRNA
CTD
PMID:37047231
NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
affects metabolic processing multiple interactions increases expression decreases activity
ISO
CYP2B6 protein affects the metabolism of Malathion Malathion promotes the reaction [isomalathion results in increased expression of CYP2B6 mRNA] Malathion results in increased expression of CYP2B6 mRNA Malathion results in decreased activity of CYP2B6 protein
CTD
PMID:15557345 PMID:22310298 PMID:24333466
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions decreases activity
ISO
Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] Malathion results in decreased activity of CYP2E1 protein
CTD
PMID:22634058
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases expression affects metabolic processing
ISO
[Malathion co-treated with isomalathion] results in increased expression of CYP3A4 mRNA Malathion results in increased expression of CYP3A4 mRNA CYP3A4 protein affects the metabolism of Malathion
CTD
PMID:15557345 PMID:17110060 PMID:22310298 PMID:24333466
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
affects metabolic processing increases expression
ISO
CYP3A5 protein affects the metabolism of Malathion Malathion results in increased expression of CYP3A5 mRNA
CTD
PMID:17110060 PMID:37047231
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
multiple interactions
ISO
[Insecticides results in increased abundance of Malathion] which affects the methylation of CYP8B1 gene
CTD
PMID:34516295
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Dcn
decorin
increases expression
ISO
Malathion results in increased expression of DCN mRNA
CTD
PMID:37047231
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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Ddc
dopa decarboxylase
affects binding increases expression
ISO
Malathion binds to [DDC protein binds to Pyridoxal Phosphate]; Malathion binds to DDC protein Malathion results in increased expression of DDC mRNA
CTD
PMID:35151785 PMID:37047231
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Ddr1
discoidin domain receptor tyrosine kinase 1
decreases expression
ISO
Malathion results in decreased expression of DDR1 mRNA
CTD
PMID:37047231
NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
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Ddx11
DEAD/H-box helicase 11
increases expression
ISO
Malathion results in increased expression of DDX11 mRNA
CTD
PMID:32069766
NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550
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Dio1
iodothyronine deiodinase 1
decreases expression
ISO
Malathion results in decreased expression of DIO1 mRNA
CTD
PMID:37047231
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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Disc1
DISC1 scaffold protein
increases expression
ISO
Malathion results in increased expression of DISC1 mRNA
CTD
PMID:37047231
NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
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Dkk2
dickkopf WNT signaling pathway inhibitor 2
increases expression
ISO
Malathion results in increased expression of DKK2 mRNA
CTD
PMID:37047231
NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
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Dlg2
discs large MAGUK scaffold protein 2
increases expression
ISO
Malathion results in increased expression of DLG2 mRNA
CTD
PMID:37047231
NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475
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Dnmt1
DNA methyltransferase 1
decreases expression
EXP
Malathion results in decreased expression of DNMT1 mRNA
CTD
PMID:36370973
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Dnmt3a
DNA methyltransferase 3 alpha
affects expression
EXP
Malathion affects the expression of DNMT3A mRNA
CTD
PMID:36370973
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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Dnmt3b
DNA methyltransferase 3 beta
affects expression
EXP
Malathion affects the expression of DNMT3B mRNA
CTD
PMID:36370973
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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Doc2b
double C2 domain beta
decreases expression
ISO
Malathion results in decreased expression of DOC2B mRNA
CTD
PMID:37047231
NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267
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Dsp
desmoplakin
increases expression
ISO
Malathion results in increased expression of DSP mRNA
CTD
PMID:37047231
NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800
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Dspp
dentin sialophosphoprotein
decreases expression
ISO
Malathion results in decreased expression of DSPP mRNA
CTD
PMID:37047231
NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672
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Dtna
dystrobrevin, alpha
decreases expression
ISO
Malathion results in decreased expression of DTNA mRNA
CTD
PMID:37047231
NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261
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Duox1
dual oxidase 1
multiple interactions increases expression
ISO
Plant Extracts inhibits the reaction [Malathion results in increased expression of DUOX1 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of DUOX1 protein]
CTD
PMID:32120800
NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
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Dusp1
dual specificity phosphatase 1
decreases expression
ISO
Malathion results in decreased expression of DUSP1 mRNA
CTD
PMID:32069766
NCBI chr10:16,680,478...16,683,275
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Dusp5
dual specificity phosphatase 5
increases expression
ISO
Malathion results in increased expression of DUSP5 mRNA
CTD
PMID:37047231
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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Dvl1
dishevelled segment polarity protein 1
increases expression
ISO
Malathion results in increased expression of DVL1 mRNA
CTD
PMID:18204794
NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
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Ebi3
Epstein-Barr virus induced 3
increases expression
ISO
Malathion results in increased expression of EBI3 mRNA
CTD
PMID:37047231
NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544
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Edn1
endothelin 1
increases expression
ISO
Malathion results in increased expression of EDN1 mRNA
CTD
PMID:37047231
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Ednrb
endothelin receptor type B
decreases expression
ISO
Malathion results in decreased expression of EDNRB mRNA
CTD
PMID:37047231
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Efcab9
EF-hand calcium binding domain 9
increases expression
ISO
Malathion results in increased expression of EFCAB9 mRNA
CTD
PMID:37047231
NCBI chr10:17,107,123...17,112,282
Ensembl chr10:17,107,123...17,112,289
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Ehbp1
EH domain binding protein 1
increases response to substance
ISO
EHBP1 gene SNP results in increased susceptibility to Malathion
CTD
PMID:23593118
NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332
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En1
engrailed homeobox 1
decreases expression
ISO
Malathion results in decreased expression of EN1 mRNA
CTD
PMID:37047231
NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943
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Enkur
enkurin, TRPC channel interacting protein
increases expression
ISO
Malathion results in increased expression of ENKUR mRNA
CTD
PMID:37047231
NCBI chr17:83,690,105...83,714,756
Ensembl chr17:83,690,797...83,714,408
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Epha10
EPH receptor A10
increases expression
ISO
Malathion results in increased expression of EPHA10 mRNA
CTD
PMID:37047231
NCBI chr 5:137,139,588...137,175,637
Ensembl chr 5:137,140,735...137,174,157
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Epha4
Eph receptor A4
increases expression
ISO
Malathion results in increased expression of EPHA4 mRNA
CTD
PMID:32069766
NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
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Ephx1
epoxide hydrolase 1
decreases expression
ISO
Malathion results in decreased expression of EPHX1 mRNA
CTD
PMID:17311802
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Epop
elongin BC and polycomb repressive complex 2 associated protein
increases expression
ISO
Malathion results in increased expression of EPOP mRNA
CTD
PMID:37047231
NCBI chr10:82,624,392...82,625,912
Ensembl chr10:82,624,392...82,625,912
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Eps8l1
EPS8-like 1
increases expression
ISO
Malathion results in increased expression of EPS8L1 mRNA
CTD
PMID:32069766
NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524
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Erbb4
erb-b2 receptor tyrosine kinase 4
increases expression
ISO
Malathion results in increased expression of ERBB4 mRNA
CTD
PMID:37047231
NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
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Esr1
estrogen receptor 1
decreases activity
ISO
Malathion results in decreased activity of ESR1 protein
CTD
PMID:22562034
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Etv6
ETS variant transcription factor 6
increases expression
ISO
Malathion results in increased expression of ETV6 mRNA mutant form
CTD
PMID:28624474
NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
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F3
coagulation factor III, tissue factor
increases expression
ISO
Malathion results in increased expression of F3 mRNA
CTD
PMID:37047231
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Fam124a
family with sequence similarity 124 member A
increases expression
ISO
Malathion results in increased expression of FAM124A mRNA
CTD
PMID:37047231
NCBI chr15:36,799,836...36,855,062
Ensembl chr15:36,799,877...36,853,683
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Fam227b
family with sequence similarity 227, member B
decreases expression
ISO
Malathion results in decreased expression of FAM227B mRNA
CTD
PMID:37047231
NCBI chr 3:113,226,662...113,392,396
Ensembl chr 3:113,233,205...113,392,320
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Fam229b
family with sequence similarity 229, member B
decreases expression
ISO
Malathion results in decreased expression of FAM229B mRNA
CTD
PMID:37047231
NCBI chr20:42,538,853...42,552,355
Ensembl chr20:42,538,868...42,552,248
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Fgf22
fibroblast growth factor 22
decreases expression
ISO
Malathion results in decreased expression of FGF22 mRNA
CTD
PMID:37047231
NCBI chr 7:9,947,632...9,956,918
Ensembl chr 7:9,948,071...9,950,486
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Fgf6
fibroblast growth factor 6
increases expression
ISO
Malathion results in increased expression of FGF6 mRNA
CTD
PMID:32069766
NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447
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Fgfbp1
fibroblast growth factor binding protein 1
increases expression
ISO
Malathion results in increased expression of FGFBP1 mRNA
CTD
PMID:37047231
NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496
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Fgfr1
Fibroblast growth factor receptor 1
increases expression
ISO
Malathion results in increased expression of FGFR1 mRNA
CTD
PMID:32069766
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
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Fgg
fibrinogen gamma chain
decreases expression
ISO
Malathion results in decreased expression of FGG mRNA
CTD
PMID:37047231
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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Filip1l
filamin A interacting protein 1-like
increases expression
ISO
Malathion results in increased expression of FILIP1L mRNA
CTD
PMID:37047231
NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
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Flt4
Fms related receptor tyrosine kinase 4
increases expression
ISO
Malathion results in increased expression of FLT4 mRNA
CTD
PMID:37047231
NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
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Foxo1
forkhead box O1
decreases expression increases methylation multiple interactions
EXP
Malathion results in decreased expression of FOXO1 mRNA Malathion results in increased methylation of FOXO1 promoter [Malathion results in increased methylation of FOXO1 promoter] which results in decreased expression of FOXO1 mRNA
CTD
PMID:36370973
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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Foxo4
forkhead box O4
increases expression
ISO
Malathion results in increased expression of FOXO4 mRNA
CTD
PMID:32069766
NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115
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Fshr
follicle stimulating hormone receptor
increases expression
ISO
Malathion results in increased expression of FSHR mRNA
CTD
PMID:32069766
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
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G6pd
glucose-6-phosphate dehydrogenase
multiple interactions increases activity
EXP
[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein] Malathion results in increased activity of G6PD protein
CTD
PMID:27214522
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gad1
glutamate decarboxylase 1
affects binding
ISO
Malathion binds to [GAD1 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD1 protein
CTD
PMID:35151785
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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Gad2
glutamate decarboxylase 2
affects binding
ISO
Malathion binds to [GAD2 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD2 protein
CTD
PMID:35151785
NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
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Galnt16
polypeptide N-acetylgalactosaminyltransferase 16
increases expression
ISO
Malathion results in increased expression of GALNT16 mRNA
CTD
PMID:37047231
NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705
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Garin2
golgi associated RAB2 interactor family member 2
decreases expression
ISO
Malathion results in decreased expression of GARIN2 mRNA
CTD
PMID:37047231
NCBI chr 6:97,489,562...97,534,729
Ensembl chr 6:97,490,368...97,534,763
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Gas2
growth arrest-specific 2
increases expression
ISO
Malathion results in increased expression of GAS2 mRNA
CTD
PMID:37047231
NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
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Gata4
GATA binding protein 4
decreases expression
ISO
Malathion results in decreased expression of GATA4 mRNA
CTD
PMID:37047231
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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Gbp1
guanylate binding protein 1
increases expression
ISO
Malathion results in increased expression of GBP1 mRNA
CTD
PMID:37047231
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
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Gbp3
guanylate binding protein 3
increases expression
ISO
Malathion results in increased expression of GBP3 mRNA
CTD
PMID:37047231
NCBI chr 2:231,460,032...231,500,266
Ensembl chr 2:231,486,062...231,493,098
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Gbp5
guanylate binding protein 5
increases expression
ISO
Malathion results in increased expression of GBP5 mRNA
CTD
PMID:37047231
NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061
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Gk
glycerol kinase
multiple interactions increases activity
EXP
Acetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein]
CTD
PMID:25449180
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
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Gk2
glycerol kinase 2
decreases expression
EXP
Malathion results in decreased expression of GK2 mRNA
CTD
PMID:25449180
NCBI chr14:12,107,071...12,108,923
Ensembl chr14:12,107,020...12,128,473
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Gmnc
geminin coiled-coil domain containing
increases expression
ISO
Malathion results in increased expression of GMNC mRNA
CTD
PMID:37047231
NCBI chr11:73,836,255...73,847,698
Ensembl chr11:73,814,533...73,847,328
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Gnai1
G protein subunit alpha i1
increases expression
ISO
Malathion results in increased expression of GNAI1 mRNA
CTD
PMID:37047231
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
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Gnai2
G protein subunit alpha i2
decreases expression
ISO
Malathion results in decreased expression of GNAI2 mRNA
CTD
PMID:32069766
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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Got1l1
glutamic-oxaloacetic transaminase 1-like 1
increases expression
ISO
Malathion results in increased expression of GOT1L1 mRNA
CTD
PMID:37047231
NCBI chr16:64,860,308...64,873,656
Ensembl chr16:64,860,704...64,866,162
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Gp5
glycoprotein V (platelet)
increases expression
ISO
Malathion results in increased expression of GP5 mRNA
CTD
PMID:37047231
NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705
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Gpr179
G protein-coupled receptor 179
decreases expression
ISO
Malathion results in decreased expression of GPR179 mRNA
CTD
PMID:37047231
NCBI chr10:82,324,568...82,340,448
Ensembl chr10:82,337,771...82,340,448
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Gps2
G protein pathway suppressor 2
decreases expression
ISO
Malathion results in decreased expression of GPS2 mRNA
CTD
PMID:32069766
NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
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Gpt
glutamic--pyruvic transaminase
increases activity
EXP
Malathion results in increased activity of GPT protein
CTD
PMID:25180440 PMID:36370973
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gramd4
GRAM domain containing 4
decreases expression
ISO
Malathion results in decreased expression of GRAMD4 mRNA
CTD
PMID:32069766
NCBI chr 7:117,150,398...117,224,056
Ensembl chr 7:117,150,374...117,224,053
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Grk1
G protein-coupled receptor kinase 1
increases expression
ISO
Malathion results in increased expression of GRK1 mRNA
CTD
PMID:37047231
NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792
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Gsk3b
glycogen synthase kinase 3 beta
increases expression
EXP
Malathion results in increased expression of GSK3B mRNA
CTD
PMID:25449180
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gsr
glutathione-disulfide reductase
multiple interactions decreases activity
ISO EXP
[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein zinc chloride inhibits the reaction [Malathion results in decreased activity of GSR protein]
CTD
PMID:16718366 PMID:19429256
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gstp1
glutathione S-transferase pi 1
decreases expression
ISO
Malathion results in decreased expression of GSTP1 mRNA
CTD
PMID:32069766
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gzmb
granzyme B
decreases expression multiple interactions
ISO
Malathion results in decreased expression of GZMB protein Plant Extracts inhibits the reaction [Malathion results in decreased expression of GZMB protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of GZMB protein]
CTD
PMID:32120800
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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H19
H19 imprinted maternally expressed transcript
increases expression
ISO
Malathion results in increased expression of H19 mRNA
CTD
PMID:37047231
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
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Has1
hyaluronan synthase 1
increases expression
ISO
Malathion results in increased expression of HAS1 mRNA
CTD
PMID:37047231
NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
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Hbegf
heparin-binding EGF-like growth factor
increases expression
ISO
Malathion results in increased expression of HBEGF mRNA
CTD
PMID:37047231
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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Hdc
histidine decarboxylase
affects binding
ISO
Malathion binds to [HDC protein binds to Pyridoxal Phosphate]; Malathion binds to HDC protein
CTD
PMID:35151785
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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Hilpda
hypoxia inducible lipid droplet-associated
increases expression
ISO
Malathion results in increased expression of HILPDA mRNA
CTD
PMID:37047231
NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557
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Hmox1
heme oxygenase 1
increases expression
EXP
Malathion results in increased expression of HMOX1 protein
CTD
PMID:34778934
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hnmt
histamine N-methyltransferase
decreases expression
ISO
Malathion results in decreased expression of HNMT mRNA
CTD
PMID:37047231
NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
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Hras
HRas proto-oncogene, GTPase
multiple interactions increases expression
ISO
[Malathion co-treated with Estrogens] results in increased expression of HRAS mRNA Malathion results in increased expression of HRAS mRNA; Malathion results in increased expression of HRAS protein
CTD
PMID:18204794 PMID:19787260
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
multiple interactions decreases expression
ISO EXP
lavender oil inhibits the reaction [Malathion results in decreased expression of HSD17B3 mRNA]
CTD
PMID:30409133 PMID:36336997
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
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Hsf2bp
heat shock transcription factor 2 binding protein
increases expression
ISO
Malathion results in increased expression of HSF2BP mRNA
CTD
PMID:37047231
NCBI chr20:10,035,562...10,123,059
Ensembl chr20:10,035,562...10,121,242
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Hspb2
heat shock protein family B (small) member 2
increases expression
ISO
Malathion results in increased expression of HSPB2 protein
CTD
PMID:19607909
NCBI chr 8:51,093,267...51,094,528
Ensembl chr 8:51,081,342...51,094,533
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Htatip2
HIV-1 Tat interactive protein 2
decreases expression
ISO
Malathion results in decreased expression of HTATIP2 mRNA
CTD
PMID:32069766
NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
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Htra4
HtrA serine peptidase 4
decreases expression
ISO
Malathion results in decreased expression of HTRA4 mRNA
CTD
PMID:37047231
NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074
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Ido1
indoleamine 2,3-dioxygenase 1
increases expression
ISO
Malathion results in increased expression of IDO1 mRNA
CTD
PMID:37047231
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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Ifi44l
interferon-induced protein 44-like
increases expression
ISO
Malathion results in increased expression of IFI44L mRNA
CTD
PMID:37047231
NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
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Ifnb1
interferon beta 1
multiple interactions
ISO
Malathion inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]
CTD
PMID:18177342
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Ifng
interferon gamma
decreases expression multiple interactions increases expression
EXP ISO
Malathion results in decreased expression of IFNG protein Plant Extracts inhibits the reaction [Malathion results in decreased expression of IFNG protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IFNG protein] Malathion results in increased expression of IFNG mRNA Acetylcysteine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]
CTD
PMID:19145326 PMID:24810974 PMID:25180440 PMID:28987951 PMID:32120800
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il11
interleukin 11
increases expression
ISO
Malathion results in increased expression of IL11 mRNA
CTD
PMID:37047231
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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Il13
interleukin 13
increases expression
ISO
Malathion results in increased expression of IL13 mRNA
CTD
PMID:37047231
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il13ra2
interleukin 13 receptor subunit alpha 2
increases expression
ISO
Malathion results in increased expression of IL13RA2 mRNA
CTD
PMID:32069766
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
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Il1a
interleukin 1 alpha
increases expression
ISO
Malathion results in increased expression of IL1A mRNA
CTD
PMID:37047231
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
multiple interactions increases expression
EXP ISO
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]
CTD
PMID:24810974 PMID:25180440 PMID:28987951 PMID:37047231
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1r2
interleukin 1 receptor type 2
decreases expression
EXP
Malathion results in decreased expression of IL1R2 mRNA
CTD
PMID:19784758
NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
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Il2
interleukin 2
multiple interactions decreases expression
ISO
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL2 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL2 protein]
CTD
PMID:32120800
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il23a
interleukin 23 subunit alpha
increases expression
ISO
Malathion results in increased expression of IL23A mRNA
CTD
PMID:37047231
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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Il24
interleukin 24
increases expression
ISO
Malathion results in increased expression of IL24 mRNA
CTD
PMID:37047231
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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Il36g
interleukin 36, gamma
increases expression
ISO
Malathion results in increased expression of IL36G mRNA
CTD
PMID:37047231
NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480
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Il4
interleukin 4
decreases expression multiple interactions
ISO
Malathion results in decreased expression of IL4 protein Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL4 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL4 protein]
CTD
PMID:32120800
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
multiple interactions increases expression
EXP ISO
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA]
CTD
PMID:24810974 PMID:25180440 PMID:37047231
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Inhba
inhibin subunit beta A
increases expression decreases methylation
ISO
Malathion results in increased expression of INHBA mRNA Malathion results in decreased methylation of INHBA promoter
CTD
PMID:37047231
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Ins1
insulin 1
increases expression
EXP
Malathion results in increased expression of INS1 protein
CTD
PMID:25449180
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Irak1
interleukin-1 receptor-associated kinase 1
increases expression
ISO
Malathion results in increased expression of IRAK1 mRNA
CTD
PMID:32069766
NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
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Irak2
interleukin-1 receptor-associated kinase 2
increases expression
ISO
Malathion results in increased expression of IRAK2 mRNA
CTD
PMID:37047231
NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
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Irx2
iroquois homeobox 2
increases expression
ISO
Malathion results in increased expression of IRX2 mRNA
CTD
PMID:37047231
NCBI chr 1:30,660,960...30,666,378
Ensembl chr 1:30,660,960...30,666,378
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Itgb8
integrin subunit beta 8
decreases methylation increases expression
ISO
Malathion results in decreased methylation of ITGB8 promoter Malathion results in increased expression of ITGB8 mRNA
CTD
PMID:37047231
NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476
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Kazn
kazrin, periplakin interacting protein
decreases expression
ISO
Malathion results in decreased expression of KAZN mRNA
CTD
PMID:37047231
NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074
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Kcnh5
potassium voltage-gated channel subfamily H member 5
increases expression
ISO
Malathion results in increased expression of KCNH5 mRNA
CTD
PMID:37047231
NCBI chr 6:93,615,174...93,908,107
Ensembl chr 6:93,624,529...93,908,107
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Kcnma1
potassium calcium-activated channel subfamily M alpha 1
increases methylation decreases expression
ISO
Malathion results in increased methylation of KCNMA1 promoter Malathion results in decreased expression of KCNMA1 mRNA
CTD
PMID:37047231
NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198
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Kif6
kinesin family member 6
decreases expression
ISO
Malathion results in decreased expression of KIF6 mRNA
CTD
PMID:37047231
NCBI chr 9:11,076,203...11,373,205
Ensembl chr 9:11,072,824...11,373,006
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Kmt2a
lysine methyltransferase 2A
increases mutagenesis increases expression
ISO
Malathion results in increased mutagenesis of KMT2A gene Malathion results in increased expression of KMT2A mRNA mutant form
CTD
PMID:28624474
NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
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Krt14
keratin 14
increases expression
ISO
Malathion results in increased expression of KRT14 mRNA
CTD
PMID:37047231
NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799
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Krt17
keratin 17
increases expression
ISO
Malathion results in increased expression of KRT17 mRNA
CTD
PMID:37047231
NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392
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Krtap27-1
keratin associated protein 27-1
increases expression
ISO
Malathion results in increased expression of KRTAP27-1 mRNA
CTD
PMID:37047231
NCBI chr11:27,980,875...27,982,002
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L1td1
LINE-1 type transposase domain containing 1
affects expression multiple interactions increases methylation
EXP
Malathion affects the expression of L1TD1 mRNA [Malathion results in increased methylation of L1TD1 promoter] which affects the expression of L1TD1 mRNA
CTD
PMID:36370973
NCBI chr 5:113,373,193...113,386,088
Ensembl chr 5:113,379,870...113,385,730
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Lat
linker for activation of T cells
increases expression
EXP
Malathion results in increased expression of LAT mRNA
CTD
PMID:19784758
NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578
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Lcorl
ligand dependent nuclear receptor corepressor-like
increases expression
ISO
Malathion results in increased expression of LCORL mRNA
CTD
PMID:37047231
NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174
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Lemd1
LEM domain containing 1
increases expression
ISO
Malathion results in increased expression of LEMD1 mRNA
CTD
PMID:37047231
NCBI chr13:43,631,705...43,697,765
Ensembl chr13:43,665,926...43,697,948
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Lgals1
galectin 1
decreases expression
ISO
Malathion results in decreased expression of LGALS1 mRNA
CTD
PMID:32069766
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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Lif
LIF, interleukin 6 family cytokine
increases expression
ISO
Malathion results in increased expression of LIF mRNA
CTD
PMID:37047231
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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Lin28b
lin-28 homolog B
increases expression
ISO
Malathion results in increased expression of LIN28B mRNA
CTD
PMID:37047231
NCBI chr20:48,865,329...48,964,769
Ensembl chr20:48,869,485...48,955,077
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Lingo1
leucine rich repeat and Ig domain containing 1
decreases expression
ISO
Malathion results in decreased expression of LINGO1 mRNA
CTD
PMID:37047231
NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:57,010,007...57,196,544
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Lmbr1
limb development membrane protein 1
increases expression
ISO
Malathion results in increased expression of LMBR1 mRNA
CTD
PMID:37047231
NCBI chr 4:5,974,687...6,146,348
Ensembl chr 4:5,974,750...6,146,368
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LOC120095955
mucin-12-like
decreases expression
ISO
Malathion results in decreased expression of MUC12 mRNA
CTD
PMID:37047231
NCBI chr12:19,486,041...19,493,995
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Lpcat4
lysophosphatidylcholine acyltransferase 4
increases expression
ISO
Malathion results in increased expression of LPCAT4 mRNA
CTD
PMID:32069766
NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875
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Lrguk
leucine-rich repeats and guanylate kinase domain containing
decreases expression
ISO
Malathion results in decreased expression of LRGUK mRNA
CTD
PMID:37047231
NCBI chr 4:62,647,222...62,770,268
Ensembl chr 4:62,647,264...62,770,319
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Lrp3
LDL receptor related protein 3
decreases expression
ISO
Malathion results in decreased expression of LRP3 mRNA
CTD
PMID:37047231
NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:87,844,868...87,859,110
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Lypd1
Ly6/Plaur domain containing 1
decreases expression
ISO
Malathion results in decreased expression of LYPD1 mRNA
CTD
PMID:37047231
NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493
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Lzts1
leucine zipper tumor suppressor 1
increases expression
ISO
Malathion results in increased expression of LZTS1 mRNA
CTD
PMID:37047231
NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
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Lzts2
leucine zipper tumor suppressor 2
decreases expression
ISO
Malathion results in decreased expression of LZTS2 mRNA
CTD
PMID:32069766
NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:243,880,022...243,888,423
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Macrod2
mono-ADP ribosylhydrolase 2
decreases expression
ISO
Malathion results in decreased expression of MACROD2 mRNA
CTD
PMID:37047231
NCBI chr 3:127,720,066...129,737,511
Ensembl chr 3:127,720,181...129,734,492
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Map2k3
mitogen activated protein kinase kinase 3
decreases expression
ISO
Malathion results in decreased expression of MAP2K3 mRNA
CTD
PMID:32069766
NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
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Marchf3
membrane associated ring-CH-type finger 3
increases expression
ISO
Malathion results in increased expression of MARCHF3 mRNA
CTD
PMID:37047231
NCBI chr18:50,237,218...50,389,343
Ensembl chr18:50,237,230...50,389,150
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Mbp
myelin basic protein
decreases expression
ISO
Malathion results in decreased expression of MBP mRNA
CTD
PMID:37047231
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Mcm2
minichromosome maintenance complex component 2
multiple interactions increases expression
ISO
[Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNA Malathion results in increased expression of MCM2 mRNA
CTD
PMID:18204794
NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
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Meis1
Meis homeobox 1
decreases expression
ISO
Malathion results in decreased expression of MEIS1 mRNA
CTD
PMID:37047231
NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265
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Met
MET proto-oncogene, receptor tyrosine kinase
increases expression
ISO
Malathion results in increased expression of MET mRNA
CTD
PMID:37047231
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
increases expression
ISO
Malathion results in increased expression of MFSD2A mRNA
CTD
PMID:37047231
NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
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Mill1
MHC I like leukocyte 1
increases expression
ISO
Malathion results in increased expression of MICA mRNA
CTD
PMID:32069766
NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930
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Mmp1
matrix metallopeptidase 1
increases expression
ISO
Malathion results in increased expression of MMP1 mRNA
CTD
PMID:37047231
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp10
matrix metallopeptidase 10
increases expression
ISO
Malathion results in increased expression of MMP10 mRNA
CTD
PMID:37047231
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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Mmp12
matrix metallopeptidase 12
increases expression
ISO
Malathion results in increased expression of MMP12 mRNA
CTD
PMID:37047231
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
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Mmp3
matrix metallopeptidase 3
increases expression
ISO
Malathion results in increased expression of MMP3 mRNA
CTD
PMID:37047231
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mpo
myeloperoxidase
multiple interactions increases activity
EXP
Acetylcysteine inhibits the reaction [Malathion results in increased activity of MPO protein]
CTD
PMID:24810974 PMID:25180440
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mt-co1
mitochondrially encoded cytochrome c oxidase I
decreases expression
ISO
Malathion results in decreased expression of COX1 mRNA
CTD
PMID:18214912
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt-co3
mitochondrially encoded cytochrome c oxidase III
decreases expression
ISO
Malathion results in decreased expression of COX3 mRNA
CTD
PMID:18214912
NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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Mt1-ps3
metallothionein 1, pseudogene 3
increases expression
ISO
Malathion results in increased expression of MT1E mRNA
CTD
PMID:37047231
NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
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Mt2A
metallothionein 2A
increases expression
ISO
Malathion results in increased expression of MT2A mRNA
CTD
PMID:37047231
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mybphl
myosin binding protein H-like
increases expression
ISO
Malathion results in increased expression of MYBPHL mRNA
CTD
PMID:37047231
NCBI chr 2:196,005,297...196,018,826
Ensembl chr 2:196,005,325...196,018,824
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Myo1b
myosin Ib
increases expression
ISO
Malathion results in increased expression of MYO1B mRNA
CTD
PMID:37047231
NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
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Myzap
myocardial zonula adherens protein
increases expression
ISO
Malathion results in increased expression of MYZAP mRNA
CTD
PMID:37047231
NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:72,131,530...72,243,036
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Ndufs7
NADH:ubiquinone oxidoreductase core subunit S7
decreases expression
ISO
Malathion results in decreased expression of NDUFS7 mRNA
CTD
PMID:37047231
NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
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Nefh
neurofilament heavy chain
affects expression increases expression
EXP
Malathion affects the expression of NEFH mRNA Malathion results in increased expression of NEFH mRNA
CTD
PMID:22954530 PMID:28385489
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nek10
NIMA-related kinase 10
decreases expression
ISO
Malathion results in decreased expression of NEK10 mRNA
CTD
PMID:37047231
NCBI chr15:10,387,063...10,564,177
Ensembl chr15:10,381,140...10,559,722
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Neu4
neuraminidase 4
increases expression
ISO
Malathion results in increased expression of NEU4 mRNA
CTD
PMID:37047231
NCBI chr 9:94,396,920...94,402,576
Ensembl chr 9:94,396,920...94,402,576
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Neurl3
neuralized E3 ubiquitin protein ligase 3
increases expression
ISO
Malathion results in increased expression of NEURL3 mRNA
CTD
PMID:37047231
NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
Malathion results in increased activity of NFE2L2 protein
CTD
PMID:30114225 PMID:30203046
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfib
nuclear factor I/B
decreases expression
ISO
Malathion results in decreased expression of NFIB mRNA
CTD
PMID:37047231
NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479
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Ngf
nerve growth factor
multiple interactions
EXP
Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA]
CTD
PMID:28385489
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Ninj1
ninjurin 1
decreases expression
ISO
Malathion results in decreased expression of NINJ1 mRNA
CTD
PMID:32069766
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nnt
nicotinamide nucleotide transhydrogenase
decreases expression
ISO
Malathion results in decreased expression of NNT mRNA
CTD
PMID:37047231
NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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Nos2
nitric oxide synthase 2
increases expression
EXP
Malathion results in increased expression of NOS2 mRNA
CTD
PMID:20233601
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
Malathion results in increased expression of NQO1 mRNA
CTD
PMID:17311802
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression increases activity
ISO
Malathion results in increased expression of NR1I3 mRNA Malathion results in increased activity of NR1I3 protein
CTD
PMID:22310298 PMID:28927721 PMID:30203046
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
ISO
Malathion results in increased expression of NR4A1 mRNA
CTD
PMID:37047231
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nr4a3
nuclear receptor subfamily 4, group A, member 3
decreases methylation increases expression
ISO
Malathion results in decreased methylation of NR4A3 promoter Malathion results in increased expression of NR4A3 mRNA
CTD
PMID:37047231
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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Ntn1
netrin 1
increases expression
ISO
Malathion results in increased expression of NTN1 mRNA
CTD
PMID:37047231
NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326
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Ntrk2
neurotrophic receptor tyrosine kinase 2
increases expression
ISO
Malathion results in increased expression of NTRK2 mRNA
CTD
PMID:32069766
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Ocln
occludin
multiple interactions decreases expression
EXP
[Malathion co-treated with Lead] results in decreased expression of OCLN protein Malathion results in decreased expression of OCLN protein
CTD
PMID:20970449
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Ocstamp
osteoclast stimulatory transmembrane protein
increases expression
ISO
Malathion results in increased expression of OCSTAMP mRNA
CTD
PMID:37047231
NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991
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Odam
odontogenic, ameloblast associated
decreases expression
ISO
Malathion results in decreased expression of ODAM mRNA
CTD
PMID:37047231
NCBI chr14:20,193,286...20,202,517
Ensembl chr14:20,193,302...20,202,517
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Odf2l
outer dense fiber of sperm tails 2-like
decreases expression
ISO
Malathion results in decreased expression of ODF2L mRNA
CTD
PMID:37047231
NCBI chr 2:234,036,049...234,072,751
Ensembl chr 2:234,033,652...234,072,747
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Olr1433
olfactory receptor 1433
increases expression
ISO
Malathion results in increased expression of OR2W3 mRNA
CTD
PMID:37047231
NCBI chr10:43,042,427...43,046,293
Ensembl chr10:43,037,857...43,046,701
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Olr1523
olfactory receptor 1523
decreases expression
ISO
Malathion results in decreased expression of OR4D1 mRNA
CTD
PMID:37047231
NCBI chr10:72,708,272...72,709,213
Ensembl chr10:72,707,063...72,715,311
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Olr35
olfactory receptor 35
decreases expression
ISO
Malathion results in decreased expression of OR2AT4 mRNA
CTD
PMID:37047231
NCBI chr 1:153,994,678...154,043,281
Ensembl chr 1:154,041,306...154,043,257
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Omg
oligodendrocyte-myelin glycoprotein
affects expression
ISO
Malathion affects the expression of OMG mRNA
CTD
PMID:37047231
NCBI chr10:64,461,350...64,464,084
Ensembl chr10:64,461,350...64,464,084
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Opn5
opsin 5
decreases expression
ISO
Malathion results in decreased expression of OPN5 mRNA
CTD
PMID:37047231
NCBI chr 9:18,368,393...18,416,098
Ensembl chr 9:18,368,416...18,415,476
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Or4f7
olfactory receptor family 4 subfamily F member 7
decreases expression
ISO
Malathion results in decreased expression of OR4F29 mRNA
CTD
PMID:37047231
NCBI chr 3:98,482,895...98,483,833
Ensembl chr 3:98,481,730...98,489,462
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Or4f7c
olfactory receptor family 4 subfamily F member 7C
decreases expression
ISO
Malathion results in decreased expression of OR4F21 mRNA
CTD
PMID:37047231
NCBI chr 3:98,458,889...98,459,827
Ensembl chr 3:98,457,871...98,464,794
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Or6c2
olfactory receptor family 6 subfamily C member 2
decreases expression
ISO
Malathion results in decreased expression of OR6C2 mRNA
CTD
PMID:37047231
NCBI chr 7:2,188,601...2,189,539
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Or9g4
olfactory receptor family 9 subfamily G member 4
decreases expression
ISO
Malathion results in decreased expression of OR9G4 mRNA
CTD
PMID:37047231
NCBI chr 3:70,727,963...70,728,901
Ensembl chr 3:70,726,935...70,732,439
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P2rx1
purinergic receptor P2X 1
increases expression
EXP
Malathion results in increased expression of P2RX1 mRNA
CTD
PMID:19784758
NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
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Palmd
palmdelphin
decreases expression
ISO
Malathion results in decreased expression of PALMD mRNA
CTD
PMID:37047231
NCBI chr 2:204,889,526...204,941,355
Ensembl chr 2:204,889,533...204,941,519
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage multiple interactions
ISO
Malathion results in increased cleavage of PARP1 protein Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]
CTD
PMID:29027213
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pax1
paired box 1
increases expression
ISO
Malathion results in increased expression of PAX1 mRNA
CTD
PMID:32069766
NCBI chr 3:134,792,330...134,801,637
Ensembl chr 3:134,789,182...134,801,636
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Pcdh15
protocadherin related 15
decreases expression
ISO
Malathion results in decreased expression of PCDH15 mRNA
CTD
PMID:37047231
NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719
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Pcdhb19
protocadherin beta 19
decreases expression
ISO
Malathion results in decreased expression of PCDHB12 mRNA
CTD
PMID:37047231
NCBI chr18:29,204,838...29,207,646
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Pcdhgb1
protocadherin gamma subfamily B, 1
increases expression
ISO
Malathion results in increased expression of PCDHGB1 mRNA
CTD
PMID:37047231
NCBI chr18:29,501,739...29,508,024
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Pck1
phosphoenolpyruvate carboxykinase 1
multiple interactions increases expression
EXP
Acetylcysteine inhibits the reaction [Malathion results in increased expression of PCK1 mRNA]
CTD
PMID:25449180
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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Pcna
proliferating cell nuclear antigen
multiple interactions increases expression
ISO
Atropine inhibits the reaction [Malathion results in increased expression of PCNA]
CTD
PMID:12762645
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pde6c
phosphodiesterase 6C
decreases expression
ISO
Malathion results in decreased expression of PDE6C mRNA
CTD
PMID:37047231
NCBI chr 1:235,909,583...235,965,435
Ensembl chr 1:235,909,775...235,965,315
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Pdia2
protein disulfide isomerase family A, member 2
decreases expression
ISO
Malathion results in decreased expression of PDIA2 mRNA
CTD
PMID:37047231
NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
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Pebp1
phosphatidylethanolamine binding protein 1
decreases expression
ISO
Malathion results in decreased expression of PEBP1 mRNA
CTD
PMID:32069766
NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
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Peg10
paternally expressed 10
increases expression
ISO
Malathion results in increased expression of PEG10 mRNA
CTD
PMID:37047231
NCBI chr 4:32,842,441...32,855,639
Ensembl chr 4:32,848,493...32,852,621
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Pfn1
profilin 1
decreases expression
ISO
Malathion results in decreased expression of PFN1 mRNA
CTD
PMID:32069766
NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
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Phb1
prohibitin 1
decreases expression
ISO
Malathion results in decreased expression of PHB1 mRNA
CTD
PMID:32069766
NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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Pitx1
paired-like homeodomain 1
decreases expression
ISO
Malathion results in decreased expression of PITX1 mRNA
CTD
PMID:37047231
NCBI chr17:8,794,134...8,800,292
Ensembl chr17:8,794,134...8,800,291
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Plat
plasminogen activator, tissue type
decreases expression
ISO
Malathion results in decreased expression of PLAT mRNA
CTD
PMID:16079077
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plau
plasminogen activator, urokinase
increases expression
ISO
Malathion results in increased expression of PLAU mRNA
CTD
PMID:32069766
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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Plaur
plasminogen activator, urokinase receptor
increases expression
ISO
Malathion results in increased expression of PLAUR mRNA
CTD
PMID:37047231
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Plcb4
phospholipase C, beta 4
increases expression
ISO
Malathion results in increased expression of PLCB4 mRNA
CTD
PMID:37047231
NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
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Plekhd1
pleckstrin homology and coiled-coil domain containing D1
decreases expression
ISO
Malathion results in decreased expression of PLEKHD1 mRNA
CTD
PMID:37047231
NCBI chr 6:100,340,655...100,371,942
Ensembl chr 6:100,340,655...100,371,941
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Plin1
perilipin 1
increases expression
ISO
Malathion results in increased expression of PLIN1 mRNA
CTD
PMID:37047231
NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
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Plin2
perilipin 2
increases expression
ISO
Malathion results in increased expression of PLIN2 mRNA
CTD
PMID:37047231
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Plp1
proteolipid protein 1
decreases expression
ISO
Malathion results in decreased expression of PLP1 mRNA
CTD
PMID:37047231
NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032
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Pls3
plastin 3
increases expression
ISO
Malathion results in increased expression of PLS3 mRNA
CTD
PMID:37047231
NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891
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Plvap
plasmalemma vesicle associated protein
decreases expression
ISO
Malathion results in decreased expression of PLVAP mRNA
CTD
PMID:37047231
NCBI chr16:18,184,985...18,197,301
Ensembl chr16:18,184,975...18,197,301
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Pml
PML nuclear body scaffold
decreases expression
ISO
Malathion results in decreased expression of PML mRNA
CTD
PMID:32069766
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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Ppara
peroxisome proliferator activated receptor alpha
decreases expression
ISO
Malathion results in decreased expression of PPARA mRNA
CTD
PMID:25689681
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Prkd1
protein kinase D1
increases expression
ISO
Malathion results in increased expression of PRKD1 mRNA
CTD
PMID:32069766
NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042
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Prox2
prospero homeobox 2
decreases expression
ISO
Malathion results in decreased expression of PROX2 mRNA
CTD
PMID:37047231
NCBI chr 6:104,731,385...104,758,619
Ensembl chr 6:104,733,002...104,742,093
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Proz
protein Z, vitamin K-dependent plasma glycoprotein
decreases expression
ISO
Malathion results in decreased expression of PROZ mRNA
CTD
PMID:37047231
NCBI chr16:76,450,013...76,463,558
Ensembl chr16:76,450,013...76,463,480
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Ptcra
pre T-cell antigen receptor alpha
decreases expression
ISO
Malathion results in decreased expression of PTCRA mRNA
CTD
PMID:37047231
NCBI chr 9:14,218,907...14,229,141
Ensembl chr 9:14,218,802...14,229,235
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
Malathion results in increased expression of PTGS2 mRNA; Malathion results in increased expression of PTGS2 protein
CTD
PMID:30673264
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pygl
glycogen phosphorylase L
multiple interactions increases expression
EXP
Acetylcysteine inhibits the reaction [Malathion results in increased expression of PYGL mRNA]
CTD
PMID:25449180
NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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Rab11fip3
RAB11 family interacting protein 3
increases expression
ISO
Malathion results in increased expression of RAB11FIP3 mRNA
CTD
PMID:32069766
NCBI chr10:15,002,650...15,086,382
Ensembl chr10:15,002,926...15,118,479
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Rab3c
RAB3C, member RAS oncogene family
decreases expression
ISO
Malathion results in decreased expression of RAB3C mRNA
CTD
PMID:37047231
NCBI chr 2:41,627,720...41,843,541
Ensembl chr 2:41,627,720...41,843,749
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Rapgef5
Rap guanine nucleotide exchange factor 5
increases expression
ISO
Malathion results in increased expression of RAPGEF5 mRNA
CTD
PMID:37047231
NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:138,437,991...138,679,936
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Rbp3
retinol binding protein 3
decreases expression
ISO
Malathion results in decreased expression of RBP3 mRNA
CTD
PMID:37047231
NCBI chr16:9,267,538...9,276,006
Ensembl chr16:9,267,538...9,276,006
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Rbp7
retinol binding protein 7
decreases expression
ISO
Malathion results in decreased expression of RBP7 mRNA
CTD
PMID:37047231
NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339
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Redic1
regulator of DNA class I crossover intermediates 1
decreases expression
ISO
Malathion results in decreased expression of REDIC1 mRNA
CTD
PMID:37047231
NCBI chr 7:122,318,495...122,386,002
Ensembl chr 7:122,318,499...122,385,983
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression multiple interactions
EXP ISO
Malathion results in increased expression of RELA mRNA Taurine inhibits the reaction [Malathion results in increased expression of RELA mRNA]
CTD
PMID:28987951 PMID:30673264
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Reln
reelin
increases expression
ISO
Malathion results in increased expression of RELN mRNA
CTD
PMID:37047231
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Rfc3
replication factor C subunit 3
decreases expression
ISO
Malathion results in decreased expression of RFC3 mRNA
CTD
PMID:16079077
NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
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Rft1
RFT1 homolog
decreases expression
ISO
Malathion results in decreased expression of RFT1 mRNA
CTD
PMID:37047231
NCBI chr16:5,827,063...5,861,120
Ensembl chr16:5,827,088...5,861,120
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Rhoa
ras homolog family member A
decreases activity
ISO
Malathion results in decreased activity of RHOA protein
CTD
PMID:37270087
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Rhox13
Rhox homeobox family member 13
increases expression
ISO
Malathion results in increased expression of RHOXF1 mRNA
CTD
PMID:37047231
NCBI chr X:116,911,226...116,917,758
Ensembl chr X:116,911,329...116,917,644
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Rimbp2
RIMS binding protein 2
decreases expression
ISO
Malathion results in decreased expression of RIMBP2 mRNA
CTD
PMID:37047231
NCBI chr12:27,747,615...27,946,256
Ensembl chr12:27,747,980...27,956,763
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Rnase6
ribonuclease A family member k6
increases expression
EXP
Malathion results in increased expression of RNASE6 mRNA
CTD
PMID:19784758
NCBI chr15:24,354,305...24,357,289
Ensembl chr15:24,354,303...24,357,328
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Rnf170
ring finger protein 170
increases expression
ISO
Malathion results in increased expression of RNF170 mRNA
CTD
PMID:37047231
NCBI chr16:65,928,886...65,954,092
Ensembl chr16:65,928,895...65,954,083
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Rnf183
ring finger protein 183
increases expression
ISO
Malathion results in increased expression of RNF183 mRNA
CTD
PMID:37047231
NCBI chr 5:75,877,111...75,886,253
Ensembl chr 5:75,876,003...75,886,191
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Robo4
roundabout guidance receptor 4
decreases expression
ISO
Malathion results in decreased expression of ROBO4 mRNA
CTD
PMID:37047231
NCBI chr 8:37,119,953...37,133,887
Ensembl chr 8:37,119,988...37,132,519
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Rph3a
rabphilin 3A
decreases expression
ISO
Malathion results in decreased expression of RPH3A mRNA
CTD
PMID:37047231
NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592
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Rrad
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
increases expression
ISO
Malathion results in increased expression of RRAD mRNA
CTD
PMID:37047231
NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
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Rs1
retinoschisin 1
increases expression
ISO
Malathion results in increased expression of RS1 mRNA
CTD
PMID:37047231
NCBI chr X:33,962,440...33,992,203
Ensembl chr X:33,963,657...33,992,115
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Rsad2
radical S-adenosyl methionine domain containing 2
increases expression
ISO
Malathion results in increased expression of RSAD2 mRNA
CTD
PMID:37047231
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
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Rspo2
R-spondin 2
decreases expression
ISO
Malathion results in decreased expression of RSPO2 mRNA
CTD
PMID:37047231
NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:74,103,090...74,238,933
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RT1-A2
RT1 class Ia, locus A2
decreases expression
ISO
Malathion results in decreased expression of HLA-E mRNA
CTD
PMID:32069766
NCBI chr20:4,870,939...4,910,183
G
RT1-CE16
RT1 class I, locus CE16
decreases expression
ISO
Malathion results in decreased expression of HLA-A mRNA
CTD
PMID:32069766
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
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Runx1
RUNX family transcription factor 1
increases expression
ISO
Malathion results in increased expression of RUNX1 mRNA mutant form
CTD
PMID:28624474
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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S100a1
S100 calcium binding protein A1
decreases expression
ISO
Malathion results in decreased expression of S100A1 mRNA
CTD
PMID:37047231
NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544
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Scg5
secretogranin V
increases expression
ISO
Malathion results in increased expression of SCG5 mRNA
CTD
PMID:37047231
NCBI chr 3:100,544,101...100,588,558
Ensembl chr 3:100,544,099...100,588,463
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Scn9a
sodium voltage-gated channel alpha subunit 9
decreases expression
ISO
Malathion results in decreased expression of SCN9A mRNA
CTD
PMID:37047231
NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
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Serpinb2
serpin family B member 2
increases expression
ISO
Malathion results in increased expression of SERPINB2 mRNA
CTD
PMID:37047231
NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
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Sftpb
surfactant protein B
decreases expression
ISO
Malathion results in decreased expression of SFTPB mRNA
CTD
PMID:37047231
NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
G
Sgpp2
sphingosine-1-phosphate phosphatase 2
increases expression
ISO
Malathion results in increased expression of SGPP2 mRNA
CTD
PMID:37047231
NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457
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Shc1
SHC adaptor protein 1
increases expression
ISO
Malathion results in increased expression of SHC1 mRNA
CTD
PMID:32069766
NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
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Shisa3
shisa family member 3
increases expression
ISO
Malathion results in increased expression of SHISA3 mRNA
CTD
PMID:37047231
NCBI chr14:40,563,672...40,568,244
Ensembl chr14:40,563,673...40,568,244
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Shisa9
shisa family member 9
increases expression
ISO
Malathion results in increased expression of SHISA9 mRNA
CTD
PMID:37047231
NCBI chr10:3,335,616...3,629,334
Ensembl chr10:3,337,979...3,627,773
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Shtn1
shootin 1
decreases expression
ISO
Malathion results in decreased expression of SHTN1 mRNA
CTD
PMID:37047231
NCBI chr 1:258,121,966...258,225,861
Ensembl chr 1:258,121,968...258,228,265
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Slc14a1
solute carrier family 14 member 1 (Kidd blood group)
decreases expression
ISO
Malathion results in decreased expression of SLC14A1 mRNA
CTD
PMID:37047231
NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Malathion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:23770354
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
Malathion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:21561794
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc4a5
solute carrier family 4 member 5
decreases expression
ISO
Malathion results in decreased expression of SLC4A5 mRNA
CTD
PMID:37047231
NCBI chr 4:115,710,101...115,810,330
Ensembl chr 4:115,725,592...115,810,323
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Slco4a1
solute carrier organic anion transporter family, member 4a1
increases expression
ISO
Malathion results in increased expression of SLCO4A1 mRNA
CTD
PMID:37047231
NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
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Smim32
small integral membrane protein 32
decreases expression
ISO
Malathion results in decreased expression of SMIM32 mRNA
CTD
PMID:37047231
NCBI chr17:7,853,492...7,857,235
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Snca
synuclein alpha
increases expression multiple interactions
EXP
Malathion results in increased expression of SNCA mRNA; Malathion results in increased expression of SNCA protein crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA protein]
CTD
PMID:35274200
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Sntg1
syntrophin, gamma 1
decreases expression
ISO
Malathion results in decreased expression of SNTG1 mRNA
CTD
PMID:37047231
NCBI chr 5:9,980,550...10,794,666
Ensembl chr 5:9,981,115...10,791,181
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Socs3
suppressor of cytokine signaling 3
decreases expression
ISO
Malathion results in decreased expression of SOCS3 mRNA
CTD
PMID:32069766
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Sod1
superoxide dismutase 1
increases activity decreases expression multiple interactions
EXP ISO
Malathion results in increased activity of SOD1 protein Malathion results in decreased expression of SOD1 protein lavender oil inhibits the reaction [Malathion results in decreased expression of SOD1 protein] alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein]
CTD
PMID:20194575 PMID:30409133
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
multiple interactions decreases expression
EXP ISO
alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; Malathion results in increased expression of and results in increased activity of SOD2 protein lavender oil inhibits the reaction [Malathion results in decreased expression of SOD2 protein]
CTD
PMID:20194575 PMID:30409133
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Spata17
spermatogenesis associated 17
decreases expression
ISO
Malathion results in decreased expression of SPATA17 mRNA
CTD
PMID:37047231
NCBI chr13:98,605,986...98,784,855
Ensembl chr13:98,605,986...98,784,929
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Spdya
speedy/RINGO cell cycle regulator family member A
increases expression
ISO
Malathion results in increased expression of SPDYA mRNA
CTD
PMID:37047231
NCBI chr 6:23,905,574...23,954,926
Ensembl chr 6:23,910,223...23,954,850
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Spink13
serine peptidase inhibitor Kazal type 13
decreases expression
ISO
Malathion results in decreased expression of SPINK13 mRNA
CTD
PMID:37047231
NCBI chr18:56,064,839...56,206,257
Ensembl chr18:56,064,839...56,206,257
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Spink4
serine peptidase inhibitor, Kazal type 4
decreases expression
ISO
Malathion results in decreased expression of SPINK4 mRNA
CTD
PMID:37047231
NCBI chr 5:56,043,936...56,064,841
Ensembl chr 5:55,981,624...56,064,795
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Srsf5
serine and arginine rich splicing factor 5
decreases expression
EXP
Malathion results in decreased expression of SRSF5 mRNA
CTD
PMID:19784758
NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
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Sspo
SCO-spondin
decreases expression
ISO
Malathion results in decreased expression of SSPOP mRNA
CTD
PMID:37047231
NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412
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Sst
somatostatin
decreases expression
ISO
Malathion results in decreased expression of SST mRNA
CTD
PMID:37047231
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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Sstr2
somatostatin receptor 2
increases expression
ISO
Malathion results in increased expression of SSTR2 mRNA
CTD
PMID:37047231
NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
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St6gal2
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
increases expression
ISO
Malathion results in increased expression of ST6GAL2 mRNA
CTD
PMID:37047231
NCBI chr 9:9,181,744...9,274,161
Ensembl chr 9:9,182,399...9,269,697
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St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
increases expression
EXP
Malathion results in increased expression of ST8SIA1 mRNA
CTD
PMID:19784758
NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
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St8sia4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
increases expression
ISO
Malathion results in increased expression of ST8SIA4 mRNA
CTD
PMID:37047231
NCBI chr 9:95,990,131...96,084,661
Ensembl chr 9:95,993,503...96,084,653
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Star
steroidogenic acute regulatory protein
decreases expression multiple interactions
ISO
Malathion results in decreased expression of STAR mRNA lavender oil inhibits the reaction [Malathion results in decreased expression of STAR mRNA]
CTD
PMID:30409133
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stat3
signal transducer and activator of transcription 3
decreases phosphorylation
EXP
Malathion results in decreased phosphorylation of STAT3 protein
CTD
PMID:34778934
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stat5b
signal transducer and activator of transcription 5B
decreases activity
ISO
Malathion results in decreased activity of STAT5B protein
CTD
PMID:30114225
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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Stk36
serine/threonine kinase 36
decreases expression
ISO
Malathion results in decreased expression of STK36 mRNA
CTD
PMID:37047231
NCBI chr 9:76,176,922...76,204,423
Ensembl chr 9:76,176,920...76,204,422
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Stra6
signaling receptor and transporter of retinol STRA6
decreases expression
ISO
Malathion results in decreased expression of STRA6 mRNA
CTD
PMID:37047231
NCBI chr 8:58,548,899...58,568,861
Ensembl chr 8:58,549,736...58,568,860
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Tcf7l1
transcription factor 7 like 1
increases expression
ISO
Malathion results in increased expression of TCF7L1 mRNA
CTD
PMID:37047231
NCBI chr 4:104,680,734...104,846,086
Ensembl chr 4:104,680,739...104,845,287
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Tchhl1
trichohyalin-like 1
decreases expression
ISO
Malathion results in decreased expression of TCHHL1 mRNA
CTD
PMID:37047231
NCBI chr 2:179,134,941...179,138,467
Ensembl chr 2:179,135,796...179,138,202
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Tdrd1
tudor domain containing 1
increases expression
ISO
Malathion results in increased expression of TDRD1 mRNA
CTD
PMID:37047231
NCBI chr 1:255,871,939...255,919,222
Ensembl chr 1:255,875,887...255,915,871
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Tdrd6
tudor domain containing 6
increases expression
ISO
Malathion results in increased expression of TDRD6 mRNA
CTD
PMID:37047231
NCBI chr 9:17,344,033...17,359,348
Ensembl chr 9:17,344,026...17,359,344
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Tdrp
testis development related protein
decreases expression
ISO
Malathion results in decreased expression of TDRP mRNA
CTD
PMID:37047231
NCBI chr16:75,624,047...75,652,635
Ensembl chr16:75,624,907...75,652,420
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Tek
TEK receptor tyrosine kinase
increases expression
ISO
Malathion results in increased expression of TEK mRNA
CTD
PMID:32069766
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
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Tet1
tet methylcytosine dioxygenase 1
affects expression
EXP
Malathion affects the expression of TET1 mRNA
CTD
PMID:36370973
NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
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Tet2
tet methylcytosine dioxygenase 2
decreases expression
EXP
Malathion results in decreased expression of TET2 mRNA
CTD
PMID:36370973
NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
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Tet3
tet methylcytosine dioxygenase 3
affects expression
EXP
Malathion affects the expression of TET3 mRNA
CTD
PMID:36370973
NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193
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Tfpi2
tissue factor pathway inhibitor 2
increases expression
ISO
Malathion results in increased expression of TFPI2 mRNA
CTD
PMID:37047231
NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
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Tfrc
transferrin receptor
increases expression
ISO
Malathion results in increased expression of TFRC mRNA
CTD
PMID:32069766
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tg
thyroglobulin
decreases expression
EXP
Malathion results in decreased expression of TG mRNA; Malathion results in decreased expression of TG protein
CTD
PMID:29143548
NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
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Tifab
TIFA inhibitor
decreases expression
ISO
Malathion results in decreased expression of TIFAB mRNA
CTD
PMID:37047231
NCBI chr17:8,433,406...8,436,541
Ensembl chr17:8,431,635...8,436,592
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Timp3
TIMP metallopeptidase inhibitor 3
decreases expression
EXP
Malathion results in decreased expression of TIMP3 mRNA
CTD
PMID:19784758
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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Tjp1
tight junction protein 1
multiple interactions decreases expression
EXP
[Malathion co-treated with Lead] results in decreased expression of TJP1 protein Malathion results in decreased expression of TJP1 protein
CTD
PMID:20970449
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tjp2
tight junction protein 2
multiple interactions decreases expression
EXP
[Malathion co-treated with Lead] results in decreased expression of TJP2 protein Malathion results in decreased expression of TJP2 protein
CTD
PMID:20970449
NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295
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Tlr4
toll-like receptor 4
multiple interactions increases expression
ISO
Plant Extracts inhibits the reaction [Malathion results in increased expression of TLR4 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TLR4 protein]
CTD
PMID:32120800
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr8
toll-like receptor 8
increases expression
ISO
Malathion results in increased expression of TLR8 mRNA
CTD
PMID:32069766
NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549
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Tmem114
transmembrane protein 114
decreases expression
ISO
Malathion results in decreased expression of TMEM114 mRNA
CTD
PMID:37047231
NCBI chr10:7,168,998...7,185,251
Ensembl chr10:7,169,746...7,185,251
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Tmem158
transmembrane protein 158
increases expression
ISO
Malathion results in increased expression of TMEM158 mRNA
CTD
PMID:37047231
NCBI chr 8:122,913,675...122,914,673
Ensembl chr 8:122,913,675...122,914,673
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Tmem241
transmembrane protein 241
decreases expression
ISO
Malathion results in decreased expression of TMEM241 mRNA
CTD
PMID:37047231
NCBI chr18:3,168,072...3,318,340
Ensembl chr18:3,168,067...3,318,293
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Tmem65
transmembrane protein 65
increases expression
ISO
Malathion results in increased expression of TMEM65 mRNA
CTD
PMID:37047231
NCBI chr 7:90,336,997...90,378,930
Ensembl chr 7:90,274,142...90,379,474
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Tnf
tumor necrosis factor
increases expression multiple interactions
EXP ISO
Malathion results in increased expression of TNF mRNA Taurine inhibits the reaction [Malathion results in increased expression of TNF mRNA]
CTD
PMID:28987951 PMID:37047231
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip6
TNF alpha induced protein 6
increases expression
ISO
Malathion results in increased expression of TNFAIP6 mRNA
CTD
PMID:37047231
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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Tnfaip8l3
TNF alpha induced protein 8 like 3
decreases expression
ISO
Malathion results in decreased expression of TNFAIP8L3 mRNA
CTD
PMID:37047231
NCBI chr 8:54,413,503...54,455,512
Ensembl chr 8:54,414,457...54,500,079
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Tnfsf15
TNF superfamily member 15
affects expression
ISO
Malathion affects the expression of TNFSF15 mRNA
CTD
PMID:37047231
NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228
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Tnip3
TNFAIP3 interacting protein 3
increases expression
ISO
Malathion results in increased expression of TNIP3 mRNA
CTD
PMID:37047231
NCBI chr 4:94,867,258...94,908,780
Ensembl chr 4:94,811,097...94,907,605
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Tp53
tumor protein p53
multiple interactions increases expression
ISO EXP
Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein] Plant Extracts inhibits the reaction [Malathion results in increased expression of TRP53 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TRP53 protein] [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of TP53 mRNA] Malathion results in increased expression of TP53 mRNA; Malathion results in increased expression of TP53 protein
CTD
PMID:12505448 PMID:12762645 PMID:18204794 PMID:19787260 PMID:21628957 PMID:32120800 More...
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53i3
tumor protein p53 inducible protein 3
increases expression multiple interactions
ISO
Malathion results in increased expression of TP53I3 mRNA [Malathion co-treated with Estrogens] results in increased expression of TP53I3 mRNA
CTD
PMID:18204794
NCBI chr 6:27,818,327...27,825,753
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Tpd52l3
TPD52 like 3
decreases expression
ISO
Malathion results in decreased expression of TPD52L3 mRNA
CTD
PMID:37047231
NCBI chr 1:227,781,173...227,785,040
Ensembl chr 1:227,773,724...227,784,467
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Tpr
translocated promoter region, nuclear basket protein
increases expression
ISO
Malathion results in increased expression of TPR mRNA
CTD
PMID:32069766
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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Tram1l1
translocation associated membrane protein 1-like 1
increases expression
ISO
Malathion results in increased expression of TRAM1L1 mRNA
CTD
PMID:37047231
NCBI chr 2:212,511,130...212,513,311
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Trim35
tripartite motif-containing 35
decreases expression
ISO
Malathion results in decreased expression of TRIM35 mRNA
CTD
PMID:32069766
NCBI chr15:40,493,697...40,510,246
Ensembl chr15:40,493,755...40,510,240
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Trpc1
transient receptor potential cation channel, subfamily C, member 1
increases expression
EXP
Malathion results in increased expression of TRPC1 mRNA; Malathion results in increased expression of TRPC1 protein
CTD
PMID:22674931
NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
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Trpc4
transient receptor potential cation channel, subfamily C, member 4
increases expression decreases expression
EXP ISO
Malathion results in increased expression of TRPC4 mRNA; Malathion results in increased expression of TRPC4 protein Malathion results in decreased expression of TRPC4 mRNA
CTD
PMID:22674931 PMID:37047231
NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768
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Trpc5os
TRPC5 opposite strand
increases expression
ISO
Malathion results in increased expression of TRPC5OS mRNA
CTD
PMID:37047231
NCBI chr X:108,025,172...108,044,201
Ensembl chr X:108,024,924...108,046,581
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Tshr
thyroid stimulating hormone receptor
decreases expression
EXP
Malathion results in decreased expression of TSHR protein
CTD
PMID:29143548
NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
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Ttc9
tetratricopeptide repeat domain 9
decreases expression
ISO
Malathion results in decreased expression of TTC9 mRNA
CTD
PMID:37047231
NCBI chr 6:101,333,274...101,368,110
Ensembl chr 6:101,333,141...101,368,110
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Tusc2
tumor suppressor 2, mitochondrial calcium regulator
decreases expression
ISO
Malathion results in decreased expression of TUSC2 mRNA
CTD
PMID:32069766
NCBI chr 8:108,236,838...108,240,056
Ensembl chr 8:108,236,838...108,240,056
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Twist1
twist family bHLH transcription factor 1
increases expression
ISO
Malathion results in increased expression of TWIST1 mRNA
CTD
PMID:32069766
NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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Txnrd3
thioredoxin reductase 3
decreases expression
ISO
Malathion results in decreased expression of TXNRD3 mRNA
CTD
PMID:37047231
NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491
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Tyms
thymidylate synthetase
decreases expression
ISO
Malathion results in decreased expression of TYMS mRNA
CTD
PMID:16079077
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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Ubd
ubiquitin D
increases expression
ISO
Malathion results in increased expression of UBD mRNA
CTD
PMID:37047231
NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639 Ensembl chr20:1,385,864...1,408,639
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Umodl1
uromodulin-like 1
increases expression
ISO
Malathion results in increased expression of UMODL1 mRNA
CTD
PMID:37047231
NCBI chr20:9,027,751...9,087,133
Ensembl chr20:9,025,724...9,087,146
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Usp2
ubiquitin specific peptidase 2
increases expression
ISO
Malathion results in increased expression of USP2 mRNA
CTD
PMID:37047231
NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
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Usp27x
ubiquitin specific peptidase 27, X-linked
increases expression
ISO
Malathion results in increased expression of USP27X mRNA
CTD
PMID:37047231
NCBI chr X:15,123,620...15,126,855
Ensembl chr X:15,124,596...15,125,912
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Vhl
von Hippel-Lindau tumor suppressor
decreases expression
ISO
Malathion results in decreased expression of VHL mRNA
CTD
PMID:32069766
NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
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Vpreb3
V-set pre-B cell surrogate light chain 3
increases expression
ISO
Malathion results in increased expression of VPREB3 mRNA
CTD
PMID:32069766
NCBI chr20:12,717,421...12,718,785
Ensembl chr20:12,716,779...12,719,520
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Wbp2nl
WBP2 N-terminal like
decreases expression
ISO
Malathion results in decreased expression of WBP2NL mRNA
CTD
PMID:37047231
NCBI chr 7:113,814,793...113,831,974
Ensembl chr 7:113,814,992...113,831,333
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Wfdc6a
WAP four-disulfide core domain 6A
decreases expression
ISO
Malathion results in decreased expression of WFDC6 mRNA
CTD
PMID:37047231
NCBI chr 3:153,305,336...153,309,144
Ensembl chr 3:153,305,336...153,309,144
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Wipf3
WAS/WASL interacting protein family, member 3
decreases expression
ISO
Malathion results in decreased expression of WIPF3 mRNA
CTD
PMID:37047231
NCBI chr 4:83,550,075...83,629,929
Ensembl chr 4:83,550,468...83,629,386
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Wt1
WT1 transcription factor
increases expression
ISO
Malathion results in increased expression of WT1 mRNA
CTD
PMID:32069766
NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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Xkr4
XK related 4
decreases expression
ISO
Malathion results in decreased expression of XKR4 mRNA
CTD
PMID:37047231
NCBI chr 5:15,896,818...16,297,733
Ensembl chr 5:15,895,863...16,282,962
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Zfp42
zinc finger protein 42
decreases expression
ISO
Malathion results in decreased expression of ZFP42 mRNA
CTD
PMID:37047231
NCBI chr16:48,836,463...48,845,443
Ensembl chr16:48,836,648...48,845,401
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Zfpm2
zinc finger protein, multitype 2
increases expression
ISO
Malathion results in increased expression of ZFPM2 mRNA
CTD
PMID:37047231
NCBI chr 7:71,678,658...72,116,209
Ensembl chr 7:71,678,880...72,116,205
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Zscan5b
zinc finger and SCAN domain containing 5B
decreases expression
ISO
Malathion results in decreased expression of ZSCAN5B mRNA
CTD
PMID:37047231
NCBI chr 1:67,666,684...67,674,238
Ensembl chr 1:67,666,691...67,674,238
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Casp3
caspase 3
multiple interactions
ISO
[Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [Glutamic Acid co-treated with malic acid] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]
CTD
PMID:24732427
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions decreases abundance
ISO
Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid]
CTD
PMID:27469509
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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Mdh1
malate dehydrogenase 1
increases expression
ISO
malic acid deficiency results in increased expression of MDH1 mRNA
CTD
PMID:26811028
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
[[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of malic acid
CTD
PMID:28223344
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
G
Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO
malic acid results in increased expression of PPARGC1A mRNA
CTD
PMID:23056435
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
G
Ces2h
carboxylesterase 2H
multiple interactions increases hydrolysis
EXP
Dexamethasone promotes the reaction [CES2 protein results in increased hydrolysis of Methylprednisolone Hemisuccinate]
CTD
PMID:15794950
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Slc2a4
solute carrier family 2 member 4
multiple interactions
ISO
[alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA]
CTD
PMID:21802492
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Tp53
tumor protein p53
multiple interactions
ISO
monomethyl succinate inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]
CTD
PMID:21548882
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Egfr
epidermal growth factor receptor
decreases phosphorylation
ISO
2-acetamidoethanethiol analog results in decreased phosphorylation of EGFR protein
CTD
PMID:20058253
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Erbb2
erb-b2 receptor tyrosine kinase 2
multiple interactions
ISO
2-acetamidoethanethiol analog results in decreased activity of and results in decreased phosphorylation of ERBB2 protein
CTD
PMID:20058253
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Erbb3
erb-b2 receptor tyrosine kinase 3
decreases phosphorylation
ISO
2-acetamidoethanethiol analog results in decreased phosphorylation of ERBB3 protein
CTD
PMID:20058253
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
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Got1
glutamic-oxaloacetic transaminase 1
increases expression
ISO
Oxaloacetic Acid results in increased expression of GOT1 mRNA
CTD
PMID:26811028
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Mdh1
malate dehydrogenase 1
increases expression
ISO
Oxaloacetic Acid results in increased expression of MDH1 protein
CTD
PMID:26811028
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
increases expression
ISO
Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein
CTD
PMID:26811028
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO
Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein
CTD
PMID:23056435 PMID:26811028
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Ppargc1b
PPARG coactivator 1 beta
increases expression
ISO
Oxaloacetic Acid results in increased expression of PPARGC1B protein
CTD
PMID:26811028
NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
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Pprc1
PPARG related coactivator 1
increases expression
ISO
Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein
CTD
PMID:26811028
NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
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Sirt1
sirtuin 1
multiple interactions
ISO
Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein
CTD
PMID:26811028
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Tfam
transcription factor A, mitochondrial
increases expression
ISO
Oxaloacetic Acid results in increased expression of TFAM mRNA
CTD
PMID:26811028
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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Pkm
pyruvate kinase M1/2
multiple interactions
ISO
Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein]
CTD
PMID:23086999
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Acat1
acetyl-CoA acetyltransferase 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]
CTD
PMID:16157345
NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
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Adipoq
adiponectin, C1Q and collagen domain containing
increases expression
ISO
sarpogrelate results in increased expression of ADIPOQ protein
CTD
PMID:18235151
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Adra1a
adrenoceptor alpha 1A
multiple interactions
ISO
sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]
CTD
PMID:11937776
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
G
Adra1b
adrenoceptor alpha 1B
multiple interactions
ISO
sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein]
CTD
PMID:11937776
NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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Adra1d
adrenoceptor alpha 1D
multiple interactions
ISO
sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein]
CTD
PMID:11937776
NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]
CTD
PMID:22975078
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
affects expression
EXP
sarpogrelate affects the expression of ATP2A2 mRNA; sarpogrelate affects the expression of ATP2A2 protein
CTD
PMID:18088389
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]] Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccl2
C-C motif chemokine ligand 2
multiple interactions decreases expression
ISO
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein] sarpogrelate results in decreased expression of CCL2 protein
CTD
PMID:18235151 PMID:26824242
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity multiple interactions
ISO
sarpogrelate metabolite results in decreased activity of CYP2D6 protein; sarpogrelate results in decreased activity of CYP2D6 protein sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]
CTD
PMID:24167220
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Ddc
dopa decarboxylase
multiple interactions
ISO
sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein]
CTD
PMID:34560070 PMID:35202708
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Dnm1l
dynamin 1-like
multiple interactions
ISO
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]] Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]
CTD
PMID:35202708
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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Fabp1
fatty acid binding protein 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of FABP1 protein]
CTD
PMID:24107419
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fis1
fission, mitochondrial 1
multiple interactions
ISO
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]] Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]
CTD
PMID:35202708
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]
CTD
PMID:35202708
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Htr1b
5-hydroxytryptamine receptor 1B
multiple interactions
EXP
sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]; sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]
CTD
PMID:8937629
NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549
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Htr2a
5-hydroxytryptamine receptor 2A
multiple interactions affects binding
ISO EXP
sarpogrelate binds to and results in decreased activity of HTR2A protein; sarpogrelate binds to and results in decreased activity of HTR2A protein mutant form; sarpogrelate metabolite binds to and results in decreased activity of HTR2A protein sarpogrelate binds to HTR2A protein; sarpogrelate metabolite binds to HTR2A protein
CTD
PMID:8937629 PMID:16974069 PMID:17031071 PMID:19672037
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Htr2c
5-hydroxytryptamine receptor 2C
affects binding
ISO
sarpogrelate binds to HTR2C protein
CTD
PMID:16880620
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Glucose results in increased expression of ICAM1 protein]
CTD
PMID:23111892
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il18
interleukin 18
decreases expression
ISO
sarpogrelate results in decreased expression of IL18 protein
CTD
PMID:15080020
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of IL1B protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD
PMID:34560070
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]
CTD
PMID:11076827
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Irs1
insulin receptor substrate 1
multiple interactions
ISO
[sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]
CTD
PMID:22975078
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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Kdr
kinase insert domain receptor
multiple interactions
ISO
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]
CTD
PMID:27097221
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Maoa
monoamine oxidase A
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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Mfn1
mitofusin 1
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein] Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]
CTD
PMID:35202708
NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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Mmp13
matrix metallopeptidase 13
multiple interactions
EXP
sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA]
CTD
PMID:25931318
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Mt-atp6
mitochondrially encoded ATP synthase membrane subunit 6
multiple interactions
ISO
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]] Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]
CTD
PMID:35202708
NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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Mt-cyb
mitochondrially encoded cytochrome b
multiple interactions
ISO
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]] Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]
CTD
PMID:35202708
NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
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Mt-nd1
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein] Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]
CTD
PMID:35202708
NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
sarpogrelate inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]; sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein]
CTD
PMID:27133527
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Nos3
nitric oxide synthase 3
multiple interactions
EXP
sarpogrelate promotes the reaction [Oxygen deficiency results in increased expression of NOS3 protein]
CTD
PMID:25931318
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Pecam1
platelet and endothelial cell adhesion molecule 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein]
CTD
PMID:27097221
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Pln
phospholamban
affects expression
EXP
sarpogrelate affects the expression of PLN mRNA; sarpogrelate affects the expression of PLN protein
CTD
PMID:18088389
NCBI chr20:32,629,537...32,639,559
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein]
CTD
PMID:21262218
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
CTD
PMID:34560070
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Serpine2
serpin family E member 2
decreases expression multiple interactions
ISO
sarpogrelate results in decreased expression of SERPINE2 mRNA sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
CTD
PMID:24107419 PMID:27097221
NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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Slc2a1
solute carrier family 2 member 1
affects expression
EXP
sarpogrelate affects the expression of SLC2A1 protein
CTD
PMID:21183729
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc2a4
solute carrier family 2 member 4
affects expression
EXP
sarpogrelate affects the expression of SLC2A4 protein
CTD
PMID:21183729
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Sorl1
sortilin related receptor 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA]
CTD
PMID:24650663
NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]
CTD
PMID:34560070
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
CTD
PMID:24107419 PMID:27097221
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of TNF protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD
PMID:34560070
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tph1
tryptophan hydroxylase 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein]
CTD
PMID:34560070 PMID:35202708
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
increases glucuronidation
ISO
UGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite
CTD
PMID:23704698
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of sarpogrelate metabolite
CTD
PMID:23704698
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein]
CTD
PMID:22785018
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX protein
CTD
PMID:31401087
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 protein
CTD
PMID:31401087
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Col2a1
collagen type II alpha 1 chain
multiple interactions
EXP
[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]
CTD
PMID:24709313
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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Dek
DEK proto-oncogene
multiple interactions
ISO
DEK protein affects the chemical synthesis of and affects the secretion of Succinic Acid
CTD
PMID:28558019
NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
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Ercc6
ERCC excision repair 6, chromatin remodeling factor
increases abundance
ISO
ERCC6 gene mutant form results in increased abundance of Succinic Acid
CTD
PMID:25440059
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
EXP
Succinic Acid inhibits the reaction [Rotenone affects the expression of HIF1A protein]
CTD
PMID:16034640
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Lepr
leptin receptor
affects abundance
ISO
LEPR affects the abundance of Succinic Acid
CTD
PMID:20567778
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC protein
CTD
PMID:31401087
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of NFKB1 mRNA
CTD
PMID:31401087
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
multiple interactions
ISO
[Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA
CTD
PMID:20505214
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 protein
CTD
PMID:31401087
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of RELA mRNA
CTD
PMID:31401087
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Slc13a3
solute carrier family 13 member 3
affects binding
ISO EXP
Succinic Acid binds to SLC13A3 protein
CTD
PMID:12397032
NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606
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Slc22a25
solute carrier family 22, member 25
multiple interactions
EXP
Succinic Acid affects the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]
CTD
PMID:16079298 PMID:18441515
NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
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Slc22a6
solute carrier family 22 member 6
multiple interactions increases activity
ISO
[Succinic Acid results in increased activity of SLC22A6 protein] which results in increased uptake of p-Aminohippuric Acid
CTD
PMID:36958672
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
multiple interactions increases activity
ISO
[Succinic Acid results in increased activity of SLC22A8 protein] which results in increased uptake of p-Aminohippuric Acid
CTD
PMID:36958672
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Slco1a4
solute carrier organic anion transporter family, member 1a4
affects abundance
ISO
SLCO1A4 protein affects the abundance of Succinic Acid
CTD
PMID:21561886
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of STAT3 mRNA
CTD
PMID:31401087
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Bche
butyrylcholinesterase
increases response to substance increases metabolic processing increases hydrolysis affects hydrolysis multiple interactions decreases abundance decreases hydrolysis affects response to substance
ISO
BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine BCHE protein results in increased metabolism of Succinylcholine BCHE protein results in increased hydrolysis of Succinylcholine BCHE protein mutant form affects the hydrolysis of Succinylcholine [Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine] BCHE protein results in decreased abundance of Succinylcholine BCHE protein mutant form results in decreased hydrolysis of Succinylcholine BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine
CTD
PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 PMID:1218148 PMID:1218179 PMID:1734774 PMID:1781528 PMID:2249680 PMID:2432808 PMID:4319258 PMID:4698763 PMID:4728581 PMID:4746059 PMID:4850696 PMID:4985882 PMID:4998912 PMID:5365519 PMID:5412891 PMID:5488351 PMID:5673118 PMID:6465587 PMID:6859614 PMID:6928942 PMID:7069741 PMID:7294376 PMID:7378868 PMID:7793179 PMID:8179139 PMID:9110359 PMID:12190811 PMID:12881446 PMID:15688329 PMID:15826794 PMID:16788378 PMID:16884476 PMID:18075469 PMID:18399847 PMID:18555211 PMID:21029050 PMID:21228368 PMID:25054547 More...
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:14645658
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:14645658
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Mb
myoglobin
increases secretion
ISO
Succinylcholine results in increased secretion of MB protein
CTD
PMID:8217179
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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Pklr
pyruvate kinase L/R
decreases activity
EXP
suxibuzone results in decreased activity of PKLR protein
CTD
PMID:3107799
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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Ahr
aryl hydrocarbon receptor
multiple interactions
EXP
theaflavin inhibits the reaction [Tetrachlorodibenzodioxin binds to and affects the activity of AHR protein]
CTD
PMID:15914905
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Apc
APC regulator of WNT signaling pathway
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC protein]
CTD
PMID:27058323
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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Apoe
apolipoprotein E
multiple interactions
ISO
theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein]
CTD
PMID:20093625
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 mRNA]
CTD
PMID:18656336
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Ccnd1
cyclin D1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]
CTD
PMID:27058323
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cd44
CD44 molecule
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CD44 protein]
CTD
PMID:27058323
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cdh1
cadherin 1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of CDH1 mRNA]
CTD
PMID:27058323
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]
CTD
PMID:23717041
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Ctnnb1
catenin beta 1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 protein]
CTD
PMID:27058323
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Egf
epidermal growth factor
multiple interactions
ISO
theaflavin inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin inhibits the reaction [EGF protein results in increased expression of FAS protein]
CTD
PMID:12931129
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Egfr
epidermal growth factor receptor
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of EGFR mRNA]
CTD
PMID:27058323
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Ercc1
ERCC excision repair 1, endonuclease non-catalytic subunit
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ERCC1 mRNA]
CTD
PMID:23717041
NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
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Fas
Fas cell surface death receptor
multiple interactions
ISO
theaflavin inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin inhibits the reaction [EGF protein results in increased expression of FAS protein]
CTD
PMID:12931129
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of GADD45A mRNA]
CTD
PMID:23717041
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gli1
GLI family zinc finger 1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein]
CTD
PMID:27058323
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]; theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein]
CTD
PMID:18656336
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Ins1
insulin 1
multiple interactions
ISO
theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; theaflavin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
CTD
PMID:18591783
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Mdm2
MDM2 proto-oncogene
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]
CTD
PMID:23717041
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
ISO
theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of MYC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of MYC mRNA]
CTD
PMID:18656336 PMID:27058323
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Myh6
myosin heavy chain 6
increases expression
ISO
theaflavin results in increased expression of MYHC mRNA
CTD
PMID:32830510
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
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Myod1
myogenic differentiation 1
increases expression
ISO
theaflavin results in increased expression of MYOD1 mRNA
CTD
PMID:32830510
NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
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Myog
myogenin
increases expression
ISO
theaflavin results in increased expression of MYOG mRNA
CTD
PMID:32830510
NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
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Nos3
nitric oxide synthase 3
multiple interactions
ISO
theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein]
CTD
PMID:20093625
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Ptgr1
prostaglandin reductase 1
multiple interactions
ISO
theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]
CTD
PMID:20093625
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]
CTD
PMID:23717041
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Selp
selectin P
multiple interactions
ISO
theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein]
CTD
PMID:20093625
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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Sfrp1
secreted frizzled-related protein 1
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein]
CTD
PMID:27058323
NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286
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Slc2a4
solute carrier family 2 member 4
multiple interactions
ISO
theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]
CTD
PMID:18591783
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Smo
smoothened, frizzled class receptor
multiple interactions
ISO
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein]
CTD
PMID:27058323
NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
G
Tp53
tumor protein p53
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA]
CTD
PMID:18656336 PMID:23717041
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Xrcc1
X-ray repair cross complementing 1
multiple interactions
ISO
[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA]
CTD
PMID:23717041
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
G
Xrcc3
X-ray repair cross complementing 3
multiple interactions
ISO
[theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]
CTD
PMID:23717041
NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
G
Endog
endonuclease G
multiple interactions
EXP
[Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein
CTD
PMID:16407272
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
G
Gpx1
glutathione peroxidase 1
decreases activity
ISO
2-thiomalic acid results in decreased activity of GPX1 protein
CTD
PMID:21892612
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Tnf
tumor necrosis factor
multiple interactions
ISO
2-thiomalic acid promotes the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein]
CTD
PMID:10486238
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Slc6a4
solute carrier family 6 member 4
increases activity
EXP
sodium vanadate increases activity of Slc6a4 protein in synaptosomes trisodium vanadate increases activity of Slc6a4 protein in cultured neurons
RGD
PMID:12590935 PMID:11859926
RGD:38549585 , RGD:38549589
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
G
Cat
catalase
increases expression
ISO
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of CAT protein
CTD
PMID:17388698
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl5
C-C motif chemokine ligand 5
increases expression
ISO
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of CCL5 mRNA
CTD
PMID:12007958
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
G
Gstp1
glutathione S-transferase pi 1
decreases expression
ISO
N-(2-mercaptoethyl)-1,3-diaminopropane results in decreased expression of GSTP1 mRNA
CTD
PMID:12007958
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Il2ra
interleukin 2 receptor subunit alpha
increases expression
ISO
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of IL2RA mRNA
CTD
PMID:12007958
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
G
Myb
MYB proto-oncogene, transcription factor
increases expression
ISO
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of MYB mRNA
CTD
PMID:12007958
NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
G
Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
N-(2-mercaptoethyl)-1,3-diaminopropane results in decreased expression of MYC mRNA
CTD
PMID:12007958
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [NFKB1 protein binds to RELA protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [RELA protein binds to NFKB1 protein]
CTD
PMID:11390188 PMID:11917294 PMID:12007958
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [NFKB1 protein binds to RELA protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of [RELA protein binds to NFKB1 protein]
CTD
PMID:11390188 PMID:11917294 PMID:12007958
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Sod2
superoxide dismutase 2
increases expression increases activity multiple interactions
ISO
N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 mRNA; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2 [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2] helenalin inhibits the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of SOD2 protein]; N-(2-mercaptoethyl)-1,3-diaminopropane results in increased expression of and results in increased activity of SOD2 protein
CTD
PMID:11390188 PMID:11917294 PMID:12007958 PMID:16540396 PMID:17388698 PMID:21945096 More...
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Tnfrsf1a
TNF receptor superfamily member 1A
multiple interactions
ISO
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]
CTD
PMID:21945096
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
G
Tnfrsf1b
TNF receptor superfamily member 1B
multiple interactions
ISO
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [N-(2-mercaptoethyl)-1,3-diaminopropane results in increased activity of SOD2]
CTD
PMID:21945096
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
G
Ache
acetylcholinesterase
multiple interactions affects activity
EXP
zingerone affects the reaction [Vancomycin affects the activity of ACHE protein] zingerone affects the activity of ACHE protein
CTD
PMID:31454121
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
zingerone results in decreased expression of and results in decreased phosphorylation of AKT1 protein
CTD
PMID:32905641
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Akt2
AKT serine/threonine kinase 2
multiple interactions increases expression
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of AKT2 mRNA] zingerone results in increased expression of AKT2 mRNA
CTD
PMID:36822304
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
G
Ar
androgen receptor
multiple interactions
ISO
zingerone binds to and results in decreased activity of AR protein
CTD
PMID:20226658
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases expression
EXP ISO
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX protein]; zingerone inhibits the reaction [Ethanol results in increased expression of BAX protein] zingerone results in increased expression of BAX protein
CTD
PMID:28442378 PMID:31476248 PMID:36822304
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bche
butyrylcholinesterase
affects activity multiple interactions
EXP
zingerone affects the activity of BCHE protein zingerone affects the reaction [Vancomycin affects the activity of BCHE protein]
CTD
PMID:31454121
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
G
Bcl2
BCL2, apoptosis regulator
multiple interactions increases expression decreases expression
EXP ISO
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 protein]; zingerone inhibits the reaction [Ethanol results in decreased expression of BCL2 protein] zingerone results in increased expression of BCL2 mRNA zingerone results in decreased expression of BCL2 protein
CTD
PMID:28442378 PMID:31476248 PMID:36822304
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Becn1
beclin 1
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BECN1 mRNA]
CTD
PMID:36822304
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
G
Bid
BH3 interacting domain death agonist
increases expression
ISO
zingerone results in increased expression of BID protein
CTD
PMID:31476248
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
G
Casp3
caspase 3
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP3 mRNA]; zingerone inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
CTD
PMID:28442378 PMID:36822304
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased expression of CASP9 protein]
CTD
PMID:28442378
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cat
catalase
multiple interactions
EXP
zingerone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]
CTD
PMID:31476248 PMID:36822304
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccnd1
cyclin D1
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1]
CTD
PMID:30720227
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Cyb5a
cytochrome b5 type A
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased activity of CYB5A protein]
CTD
PMID:28442378
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
G
Cyb5r3
cytochrome b5 reductase 3
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased activity of CYB5R3 protein]
CTD
PMID:28442378
NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CYP2E1 protein]; zingerone inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]
CTD
PMID:28442378 PMID:30720227
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Foxo1
forkhead box O1
multiple interactions increases expression
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of FOXO1 mRNA] zingerone results in increased expression of FOXO1 mRNA
CTD
PMID:36822304
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
G
Gsr
glutathione-disulfide reductase
multiple interactions
EXP
zingerone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein]
CTD
PMID:31476248
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased activity of HMGCR protein]
CTD
PMID:28442378
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Ifng
interferon gamma
multiple interactions
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNG protein]
CTD
PMID:29289488
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il1b
interleukin 1 beta
multiple interactions decreases expression
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IL1B mRNA] zingerone results in decreased expression of IL1B mRNA; zingerone results in decreased expression of IL1B protein
CTD
PMID:36822304
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO EXP
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL6 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IL6 mRNA]
CTD
PMID:29289488 PMID:30720227 PMID:36822304
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Irf3
interferon regulatory factor 3
multiple interactions
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRF3 protein]
CTD
PMID:29289488
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
G
Lcat
lecithin cholesterol acyltransferase
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in decreased activity of LCAT protein]
CTD
PMID:28442378
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
G
Lpl
lipoprotein lipase
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in decreased activity of LPL protein]
CTD
PMID:28442378
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
EXP
zingerone results in decreased phosphorylation of MAPK1 protein
CTD
PMID:20211236
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk14
mitogen activated protein kinase 14
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK14 mRNA]
CTD
PMID:36822304
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
G
Mapk15
mitogen-activated protein kinase 15
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK15 mRNA]
CTD
PMID:36822304
NCBI chr 7:107,694,907...107,714,640
Ensembl chr 7:107,694,964...107,714,645
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
EXP
zingerone results in decreased phosphorylation of MAPK3 protein
CTD
PMID:20211236
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions increases expression
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK8 mRNA] zingerone results in increased expression of MAPK8 mRNA
CTD
PMID:36822304
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mki67
marker of proliferation Ki-67
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]
CTD
PMID:30720227
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
G
Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
zingerone results in decreased expression of and results in decreased phosphorylation of MTOR protein
CTD
PMID:32905641
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NFE2L2 protein]
CTD
PMID:30720227
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkb1
nuclear factor kappa B subunit 1
affects localization multiple interactions decreases expression
EXP
zingerone affects the localization of NFKB1 protein zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFKB1 mRNA] zingerone results in decreased expression of NFKB1 mRNA
CTD
PMID:20211236 PMID:36822304
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFKBIA protein]
CTD
PMID:29289488
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nos2
nitric oxide synthase 2
decreases expression multiple interactions
EXP
zingerone results in decreased expression of NOS2 protein zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NOS2 mRNA]
CTD
PMID:20211236 PMID:30720227 PMID:36822304
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nphs1
NPHS1 adhesion molecule, nephrin
multiple interactions
EXP
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NPHS1 protein]
CTD
PMID:36822304
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in decreased activity of NQO1 protein]
CTD
PMID:28442378
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Or5d18
olfactory receptor family 5 subfamily D member 18
multiple interactions
ISO
zingerone binds to and results in increased activity of OR5D18 protein
CTD
PMID:21142015
NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858 Ensembl chr 3:73,516,364...73,519,858
G
Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]
CTD
PMID:30720227
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Pon1
paraoxonase 1
multiple interactions affects activity
EXP
zingerone affects the reaction [Vancomycin results in decreased activity of PON1 protein] zingerone affects the activity of PON1 protein
CTD
PMID:31454121
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
G
Por
cytochrome p450 oxidoreductase
multiple interactions
EXP
zingerone inhibits the reaction [Ethanol results in increased activity of POR protein]
CTD
PMID:28442378
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Psgb1
pregnancy-specific beta 1-glycoprotein
multiple interactions
EXP
zingerone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CEACAM5 protein]
CTD
PMID:31476248
NCBI chr 1:77,923,170...77,932,605
Ensembl chr 1:77,923,170...77,932,053
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression multiple interactions
EXP
zingerone results in decreased expression of PTGS2 protein zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTGS2 mRNA]
CTD
PMID:20211236 PMID:30720227 PMID:36822304
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
zingerone affects the localization of and results in increased phosphorylation of RELA protein; zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]
CTD
PMID:20211236 PMID:30720227
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
zingerone inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
CTD
PMID:28904557
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tlr4
toll-like receptor 4
multiple interactions
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein]
CTD
PMID:29289488
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tnf
tumor necrosis factor
multiple interactions decreases expression
ISO EXP
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] zingerone results in decreased expression of TNF mRNA zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF mRNA]
CTD
PMID:29289488 PMID:30720227 PMID:36822304
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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