Tmem114 (transmembrane protein 114) - Rat Genome Database

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Gene: Tmem114 (transmembrane protein 114) Rattus norvegicus
Analyze
Symbol: Tmem114
Name: transmembrane protein 114
RGD ID: 1560593
Description: Predicted to be located in apicolateral plasma membrane. Predicted to be active in apical plasma membrane. Orthologous to human TMEM114 (transmembrane protein 114); INTERACTS WITH furan; trichloroethene; 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC501675; RGD1560593; similar to RIKEN cDNA 4930511J11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8107,676,380 - 7,691,883 (+)NCBIGRCr8
mRatBN7.2107,168,998 - 7,185,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl107,169,746 - 7,185,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1011,876,450 - 11,892,151 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01011,373,320 - 11,389,035 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0107,022,285 - 7,037,959 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0107,279,920 - 7,295,452 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl107,279,920 - 7,295,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0106,082,816 - 6,098,029 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4107,216,358 - 7,232,102 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera106,164,918 - 6,180,424 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21276448   PMID:21689651  


Genomics

Comparative Map Data
Tmem114
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8107,676,380 - 7,691,883 (+)NCBIGRCr8
mRatBN7.2107,168,998 - 7,185,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl107,169,746 - 7,185,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1011,876,450 - 11,892,151 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01011,373,320 - 11,389,035 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0107,022,285 - 7,037,959 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0107,279,920 - 7,295,452 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl107,279,920 - 7,295,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0106,082,816 - 6,098,029 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4107,216,358 - 7,232,102 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera106,164,918 - 6,180,424 (+)NCBICelera
Cytogenetic Map10q12NCBI
TMEM114
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38168,526,552 - 8,590,511 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl168,537,605 - 8,590,511 (-)EnsemblGRCh38hg38GRCh38
GRCh37168,576,554 - 8,622,226 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36168,559,501 - 8,562,305 (-)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map16p13.2NCBI
HuRef168,587,245 - 8,607,568 (-)NCBIHuRef
CHM1_1168,620,041 - 8,622,765 (-)NCBICHM1_1
T2T-CHM13v2.0168,559,018 - 8,623,032 (-)NCBIT2T-CHM13v2.0
Tmem114
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39168,227,140 - 8,243,000 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl168,227,139 - 8,243,000 (-)EnsemblGRCm39 Ensembl
GRCm38168,409,276 - 8,425,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl168,409,275 - 8,425,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv37168,409,369 - 8,425,229 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36168,324,597 - 8,340,457 (-)NCBIMGSCv36mm8
Celera169,054,056 - 9,069,916 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map163.84NCBI
Tmem114
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554429,603,698 - 9,630,012 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554429,604,175 - 9,626,096 (+)NCBIChiLan1.0ChiLan1.0
TMEM114
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,110,163 - 9,131,305 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11612,894,810 - 12,915,944 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0167,504,370 - 7,525,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,717,666 - 8,765,926 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,745,202 - 8,765,632 (-)Ensemblpanpan1.1panPan2
TMEM114
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1633,549,377 - 33,552,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha634,928,706 - 34,942,684 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0633,736,866 - 33,750,875 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl633,736,772 - 33,750,571 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1633,539,587 - 33,553,592 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0633,409,076 - 33,423,057 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0633,831,010 - 33,845,032 (+)NCBIUU_Cfam_GSD_1.0
Tmem114
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344109,626,179 - 109,647,439 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365307,471,877 - 7,486,245 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365307,471,877 - 7,486,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM114
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl334,083,830 - 34,096,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1334,083,997 - 34,099,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2334,967,801 - 34,980,770 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM114
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.158,177,907 - 8,198,891 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl58,178,228 - 8,197,800 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606822,020,590 - 22,082,632 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem114
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248245,999,855 - 6,023,849 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248245,952,430 - 6,023,900 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem114
137 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:126
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000003749
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 18 7
Below cutoff 1 1 24 4 21 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003749   ⟹   ENSRNOP00000003749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl107,169,746 - 7,185,251 (+)Ensembl
Rnor_6.0 Ensembl107,279,920 - 7,295,452 (+)Ensembl
RefSeq Acc Id: NM_001134638   ⟹   NP_001128110
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,676,380 - 7,691,883 (+)NCBI
mRatBN7.2107,169,746 - 7,185,251 (+)NCBI
Rnor_6.0107,279,920 - 7,295,452 (+)NCBI
Rnor_5.0106,082,816 - 6,098,029 (+)NCBI
RGSC_v3.4107,216,358 - 7,232,102 (+)RGD
Celera106,164,918 - 6,180,424 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086654   ⟹   XP_038942582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,677,560 - 7,691,878 (+)NCBI
mRatBN7.2107,170,932 - 7,185,251 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001128110 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942582 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96247 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003749
  ENSRNOP00000003749.3
Reference Protein Sequences
RefSeq Acc Id: NP_001128110   ⟸   NM_001134638
- UniProtKB: D3Z9M6 (UniProtKB/TrEMBL),   A6K4M5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003749   ⟸   ENSRNOT00000003749
RefSeq Acc Id: XP_038942582   ⟸   XM_039086654
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9M6-F1-model_v2 AlphaFold D3Z9M6 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560593 AgrOrtholog
BioCyc Gene G2FUF-26086 BioCyc
Ensembl Genes ENSRNOG00000002768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003749 ENTREZGENE
  ENSRNOT00000003749.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
InterPro PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
  TMEM114/TMEM235 UniProtKB/TrEMBL
KEGG Report rno:501675 UniProtKB/TrEMBL
NCBI Gene 501675 ENTREZGENE
PANTHER PTHR20516 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 114 UniProtKB/TrEMBL
Pfam Claudin_2 UniProtKB/TrEMBL
PhenoGen Tmem114 PhenoGen
RatGTEx ENSRNOG00000002768 RatGTEx
UniProt A6K4M5 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9M6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Tmem114  transmembrane protein 114  RGD1560593  similar to RIKEN cDNA 4930511J11   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560593  similar to RIKEN cDNA 4930511J11   RGD1560593_predicted  similar to RIKEN cDNA 4930511J11 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560593_predicted  similar to RIKEN cDNA 4930511J11 (predicted)  LOC501675  similar to RIKEN cDNA 4930511J11  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501675  similar to RIKEN cDNA 4930511J11      Symbol and Name status set to provisional 70820 PROVISIONAL