Gene: Mmp12 (matrix metallopeptidase 12) Rattus norvegicus
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Symbol: Mmp12
Name: matrix metallopeptidase 12
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); collagen binding (ortholog); core promoter binding (ortholog); INVOLVED IN positive regulation of epithelial cell proliferation; regulation of trophoblast cell migration; response to drug; ASSOCIATED WITH abnormal uterine spiral artery remodeling; ASSOCIATED WITH Anti-Glomerular Basement Membrane Disease; Cerebral Hemorrhage; crescentic glomerulonephritis; FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleus (ortholog); INTERACTS WITH (R)-lipoic acid; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: macrophage metalloelastase; matrix metalloproteinase 12; matrix metalloproteinase-12; Mme; MMP-12
Orthologs:
Homo sapiens (human) : MMP12 (matrix metallopeptidase 12)  HGNC
Mus musculus (house mouse) : Mmp12 (matrix metallopeptidase 12)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Mmp12 (matrix metallopeptidase 12)
Pan paniscus (bonobo/pygmy chimpanzee) : MMP12 (matrix metallopeptidase 12)
Canis lupus familiaris (dog) : MMP12 (matrix metallopeptidase 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp12 (matrix metallopeptidase 12)
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Allele / Splice: Mmp12em1Soar   Mmp12em2Soar  
Genetic Models: SD-Mmp12em2Soar SD-Mmp12em1Soar
Is Marker For: Strains:   SD-Mmp12em1Soar  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.085,594,717 - 5,616,494 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.085,610,392 - 5,620,294 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.484,249,938 - 4,259,675 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,249,937 - 4,259,675 (+)NCBI
Celera86,141,589 - 6,151,491 (+)NCBI
Cytogenetic Map8q11NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mmp12
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 620195
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-08-01
Status: ACTIVE