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Gene Ontology AnnotationsGene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | activation of meiosis involved in egg activation | | ISO | RGD:10285 | 1624291 | MGI:MGI:1327475|PMID:9882483 | RGD | MGI:MGI:1327475 PMID:9882483 | activation of meiosis involved in egg activation | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | calcium ion transport | | ISO | RGD:10285 | 1624291 | MGI:MGI:2667242|PMID:12660151 | RGD | MGI:MGI:2667242 PMID:12660151 | calcium ion transport | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | G1/S transition of mitotic cell cycle | | ISO | RGD:10285 | 1624291 | MGI:MGI:2667242|PMID:12660151 | RGD | MGI:MGI:2667242 PMID:12660151 | G1/S transition of mitotic cell cycle | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | inhibitory G-protein coupled receptor phosphorylation | | ISO | RGD:10285 | 1624291 | MGI:MGI:4352609|PMID:19332541 | RGD | MGI:MGI:4352609 PMID:19332541 | inhibitory G-protein coupled receptor phosphorylation | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | long-term synaptic potentiation | | IMP | | | PMID:2549638 | MGI | PMID:2549638 | neuromuscular process controlling balance | | ISO | RGD:10285 | 1624291 | MGI:MGI:4359775 | RGD | MGI:MGI:4359140 PMID:19503086 | neuromuscular process controlling balance | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | peptidyl-serine phosphorylation | | ISO | RGD:10285 | 1624291 | MGI:MGI:4352609|PMID:19332541 | RGD | MGI:MGI:4352609 PMID:19332541 | peptidyl-serine phosphorylation | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of apoptotic signaling pathway | | ISO | RGD:10285 | 1624291 | MGI:MGI:3710042|PMID:17367784 | RGD | MGI:MGI:3710042 PMID:17367784 | positive regulation of apoptotic signaling pathway | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of dendritic spine morphogenesis | | IMP | | | PMID:12873385 | UniProtKB | PMID:12873385 | positive regulation of neuron projection development | | IMP | | | PMID:12873385 | UniProtKB | PMID:12873385 | positive regulation of synapse maturation | | IMP | | | PMID:12873385 | UniProtKB | PMID:12873385 | protein autophosphorylation | | ISO | RGD:10285 | 1624291 | MGI:MGI:2667242|PMID:12660151 | RGD | MGI:MGI:2667242 PMID:12660151 | protein autophosphorylation | | ISS | UniProtKB:Q13554 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | protein autophosphorylation | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | protein autophosphorylation | | IEA | Ensembl:ENSP00000379098 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | protein autophosphorylation | | ISO | RGD:735326 | 1624291 | PMID:18817731 | RGD | PMID:18817731 | regulation of long-term neuronal synaptic plasticity | | ISO | RGD:10285 | 1624291 | MGI:MGI:4359775 | RGD | MGI:MGI:4359140 PMID:19503086 | regulation of long-term neuronal synaptic plasticity | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | regulation of synaptic transmission, cholinergic | | ISO | RGD:10285 | 1624291 | MGI:MGI:4352609|PMID:19332541 | RGD | MGI:MGI:4352609 PMID:19332541 | regulation of synaptic transmission, cholinergic | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | response to cadmium ion | | ISO | RGD:10285 | 1624291 | MGI:MGI:3710042|PMID:17367784 | RGD | MGI:MGI:3710042 PMID:17367784 | response to cadmium ion | | IEA | Ensembl:ENSMUSP00000087925 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Amphetamine addiction |
| Calcium signaling pathway | |
| Cholinergic synapse | |
| Circadian entrainment | |
| Dopaminergic synapse | |
| ErbB signaling pathway | |
| Gastric acid secretion | |
| Glioma | |
| GnRH signaling pathway | |
| HIF-1 signaling pathway | |
| Insulin secretion | |
| Long-term potentiation | |
| Melanogenesis | |
| Neurotrophin signaling pathway | |
| Olfactory transduction | |
| Oocyte meiosis | |
| Tuberculosis | |
| Wnt signaling pathway | |
| Pathway Interaction Database | IFN-gamma pathway (PID:200129) |
| p38 MAPK signaling pathway (PID:200018) | |
| Regulation of Ras family activation (PID:200212) | |
References - curated| 1. |
Bennett MK and Kennedy MB, Proc Natl Acad Sci U S A 1987 Apr;84(7):1794-8. |
| 2. |
Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192. |
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MGD data from the GO Consortium |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
Xue J, etal., Brain Res Dev Brain Res 2002 Sep 20;138(1):61-70. |
| 12. |
Yamamoto H Tanpakushitsu Kakusan Koso 2002 Mar;47(3):241-7. |
References - uncurated| PubMed | 11264466 |
| 11597763 | |
| 12873385 | |
| 15312654 | |
| 15576376 | |
| 16436603 | |
| 16928958 | |
| 18562151 | |
| 18840684 | |
| 19047462 | |
| 21610080 | |
| 21718540 | |
| 21952434 | |
| 22114270 | |
| 22579289 | |
| 2549638 | |
| 7821422 | |
| 9755160 |
RGD Disease Portals| Camk2b has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Camk2b (Rattus norvegicus) |
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| CAMK2B (Homo sapiens) |
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| Camk2b (Mus musculus) |
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Position Markers| D14Rat93 |
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| PMC145549P1 |
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| BF405463 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001042354 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001042356 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_021739 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06080317 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06080318 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06080319 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01080911 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01080912 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01080913 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01080914 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01080915 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB054054 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF069731 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB616255 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB692429 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB728582 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473963 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CO395982 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CO406099 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M16112 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X83375 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_021739 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_068507 | ||||||||||||||||||||
| Peptide Label: | isoform 2 | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001042356 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001035815 | ||||||||||||||||||||
| Peptide Label: | isoform 3 | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001042354 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001035813 | ||||||||||||||||||||
| Peptide Label: | isoform 1 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001035813 | (Get FASTA) |
| NP_001035815 | (Get FASTA) | |
| NP_068507 | (Get FASTA) | |
| GenBank Protein | AAA41866 | (Get FASTA) |
| AAC83644 | (Get FASTA) | |
| BAB62715 | (Get FASTA) | |
| CAA58289 | (Get FASTA) | |
| EDM00329 | (Get FASTA) | |
| EDM00330 | (Get FASTA) | |
| EDM00331 | (Get FASTA) | |
| EDM00332 | (Get FASTA) | |
| EDM00333 | (Get FASTA) | |
| P08413 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000004005 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000005441 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000046543 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000005441 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000045935 | ENTREZGENE, UniProtKB/TrEMBL | |
| Entrez Gene | 24245 | ENTREZGENE |
| Germonline | ENSRNOG00000004005 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 128755 | ENTREZGENE |
| InterPro | Ca/CaM-dep_Ca-dep_prot_Kinase | UniProtKB/Swiss-Prot |
| Ca/CaM-dep_prot_kinase-assoc | UniProtKB/Swiss-Prot | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00209824 | UniProtKB/TrEMBL |
| IPI00211185 | UniProtKB/Swiss-Prot | |
| IPI00326171 | UniProtKB/TrEMBL | |
| KEGG Report | rno:24245 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR24347 | UniProtKB/Swiss-Prot |
| Pfam | CaMKII_AD | UniProtKB/Swiss-Prot |
| Pkinase | UniProtKB/Swiss-Prot | |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| SMART | S_TKc | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.9743 | ENTREZGENE |
| UniProt | F1LNI8_RAT | UniProtKB/TrEMBL |
| G3V9G3_RAT | UniProtKB/TrEMBL | |
| KCC2B_RAT | UniProtKB/Swiss-Prot | |
| Q63094_RAT | UniProtKB/TrEMBL | |
| Q9Z2F1_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2009-02-25 | Camk2b | calcium/calmodulin-dependent protein kinase II beta | Camk2b | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-10-24 | Camk2b | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | Camk2b | calcium/calmodulin-dependent protein kinase II, beta | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Camk2b | calcium/calmodulin-dependent protein kinase II, beta | calcium/calmodulin-dependent protein kinase II beta subunit | Name updated | 10779 | APPROVED | |
| 2002-11-06 | Camk2b | calcium/calmodulin-dependent protein kinase II beta subunit | Ca++/calmodulin-dependent protein kinase II, beta subunit | Name updated | 2225 | APPROVED | |
| 2002-06-10 | Camk2b | Ca++/calmodulin-dependent protein kinase II, beta subunit | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_function | beta subunit of kinase | 634690 |
| gene_process | may play a role in the development of the retina | 634688 |
| gene_protein | 542 amino acid protein | 634690 |
| More on Camk2b | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2262 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.