Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,3-dinitrobenzene | increases expression | EXP | | 6480464 | 3-dinitrobenzene results in increased expression of TEK mRNA | CTD | PMID:21983209 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1552464 | 6480464 | Ethinyl Estradiol affects the expression of TEK mRNA | CTD | PMID:17555576 | 17beta-estradiol | affects expression | ISO | RGD:1552464 | 6480464 | Estradiol affects the expression of TEK mRNA | CTD | PMID:15598610 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TEK mRNA | CTD | PMID:16495355 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1552464 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TEK mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TEK mRNA | CTD | PMID:22298810 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | decreases expression | EXP | | 6480464 | Puromycin Aminonucleoside results in decreased expression of TEK mRNA | CTD | PMID:17667850 | 5-azacytidine | increases expression | EXP | | 6480464 | Azacitidine results in increased expression of TEK mRNA | CTD | PMID:18037191 | 5-fluorouracil | increases expression | ISO | RGD:1552464 | 6480464 | Fluorouracil results in increased expression of TEK mRNA | CTD | PMID:15817675 | benzo[a]pyrene | decreases expression | ISO | RGD:1552464 | 6480464 | Benzo(a)pyrene results in decreased expression of TEK mRNA | CTD | PMID:21569818 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of TEK protein | CTD | PMID:22150557 | capsaicin | multiple interactions | EXP | | 6480464 | [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; more ... | CTD | PMID:22150557 | capsaicin | increases expression | ISO | RGD:1342531 | 6480464 | Capsaicin results in increased expression of TEK mRNA | CTD | PMID:21310942 | cobalt dichloride | decreases expression | ISO | RGD:1342531 | 6480464 | cobaltous chloride results in decreased expression of TEK mRNA | CTD | PMID:19320972 | cytarabine | decreases expression | ISO | RGD:1342531 | 6480464 | Cytarabine results in decreased expression of TEK mRNA | CTD | PMID:21198554 | diarsenic trioxide | increases expression | ISO | RGD:1552464 | 6480464 | arsenic trioxide results in increased expression of TEK mRNA | CTD | PMID:15073043 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of TEK mRNA | CTD | PMID:21551480 | enalapril | multiple interactions | EXP | | 6480464 | Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] | CTD | PMID:19958114 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of TEK gene | CTD | PMID:22079235 | furosemide | increases expression | EXP | | 6480464 | Furosemide results in increased expression of TEK mRNA | CTD | PMID:16526316 | gefitinib | multiple interactions | ISO | RGD:1552464 | 6480464 | gefitinib inhibits the reaction [TGFA protein results in decreased expression of TEK mRNA] | CTD | PMID:18424623 | lenalidomide | decreases expression | ISO | RGD:1342531 | 6480464 | lenalidomide results in decreased expression of TEK mRNA | CTD | PMID:15618473 | manganese(II) chloride | increases expression | ISO | RGD:1552464 | 6480464 | manganese chloride results in increased expression of TEK mRNA | CTD | PMID:17467022 | methotrexate | affects expression | ISO | RGD:1552464 | 6480464 | Methotrexate affects the expression of TEK mRNA | CTD | PMID:18502557 | mifepristone | increases expression | ISO | RGD:1342531 | 6480464 | Mifepristone results in increased expression of TEK mRNA | CTD | PMID:17584828 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of TEK mRNA | CTD | PMID:17034775 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of TEK mRNA] | CTD | PMID:17034775 | naproxen | multiple interactions | EXP | | 6480464 | [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; more ... | CTD | PMID:22150557 | nicotinic acid | increases expression | EXP | | 6480464 | Niacin results in increased expression of TEK mRNA | CTD | PMID:17557352 | nicotinic acid | increases phosphorylation | EXP | | 6480464 | Niacin results in increased phosphorylation of TEK protein | CTD | PMID:17557352 | ozone | decreases expression | ISO | RGD:1552464 | 6480464 | Ozone results in decreased expression of TEK mRNA | CTD | PMID:12763052 | PD123319 | multiple interactions | EXP | | 6480464 | PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA] | CTD | PMID:14638905 | perfluorooctane-1-sulfonic acid | decreases activity | ISO | RGD:1342531 | 6480464 | perfluorooctane sulfonic acid results in decreased activity of TEK protein | CTD | PMID:21251949 | perfluorooctanoic acid | affects activity | ISO | RGD:1342531 | 6480464 | perfluorooctanoic acid affects the activity of TEK protein | CTD | PMID:21251949 | phenobarbital | multiple interactions | ISO | RGD:1552464 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TEK mRNA] | CTD | PMID:19482888 | phenobarbital | decreases expression | ISO | RGD:1552464 | 6480464 | Phenobarbital results in decreased expression of TEK mRNA | CTD | PMID:19482888 | phosgene | affects expression | ISO | RGD:1552464 | 6480464 | Phosgene affects the expression of TEK mRNA | CTD | PMID:16300373 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of TEK mRNA | CTD | PMID:19013527 | simvastatin | multiple interactions | EXP | | 6480464 | Simvastatin results in increased expression of and results in increased activity of TEK protein | CTD | PMID:18544044 | simvastatin | multiple interactions | EXP | | 6480464 | Simvastatin inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] | CTD | PMID:20821229 | simvastatin | increases expression | EXP | | 6480464 | Simvastatin results in increased expression of TEK mRNA | CTD | PMID:18544044 | streptozocin | increases expression | EXP | | 6480464 | Streptozocin results in increased expression of TEK mRNA; more ... | CTD | PMID:15643138 | streptozocin | increases expression | EXP | | 6480464 | Streptozocin results in increased expression of TEK mRNA | CTD | PMID:15643138 more ... | streptozocin | increases expression | EXP | | 6480464 | Streptozocin results in increased expression of TEK mRNA | CTD | PMID:19958114 more ... | streptozocin | increases expression | EXP | | 6480464 | Streptozocin results in increased expression of TEK mRNA | CTD | PMID:15643138 more ... | streptozocin | multiple interactions | EXP | | 6480464 | Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] | CTD | PMID:19958114 | streptozocin | multiple interactions | EXP | | 6480464 | Simvastatin inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] | CTD | PMID:20821229 | sulindac | multiple interactions | ISO | RGD:1552464 | 6480464 | Sulindac analog results in decreased phosphorylation of and results in decreased activity of TEK protein | CTD | PMID:16215210 | sumatriptan | multiple interactions | EXP | | 6480464 | [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; more ... | CTD | PMID:22150557 | tamoxifen | affects expression | ISO | RGD:1552464 | 6480464 | Tamoxifen affects the expression of TEK mRNA | CTD | PMID:17555576 | taurine | increases expression | ISO | RGD:1342531 | 6480464 | Taurine results in increased expression of TEK mRNA | CTD | PMID:16579726 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of TEK protein; more ... | CTD | PMID:15135347 | thalidomide | decreases expression | ISO | RGD:1342531 | 6480464 | Thalidomide results in decreased expression of TEK mRNA | CTD | PMID:15618473 | troglitazone | multiple interactions | ISO | RGD:1552464 | 6480464 | [Urethane co-treated with troglitazone] results in increased expression of TEK mRNA | CTD | PMID:18465119 | troglitazone | increases expression | ISO | RGD:1552464 | 6480464 | troglitazone results in increased expression of TEK mRNA | CTD | PMID:17569031 | urethane | increases expression | ISO | RGD:1552464 | 6480464 | Urethane results in increased expression of TEK mRNA | CTD | PMID:18465119 | urethane | multiple interactions | ISO | RGD:1552464 | 6480464 | [Urethane co-treated with troglitazone] results in increased expression of TEK mRNA | CTD | PMID:18465119 | valsartan | multiple interactions | EXP | | 6480464 | valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA] | CTD | PMID:14638905 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | HIF-1 signaling pathway |
| PI3K-Akt signaling pathway | |
| Rheumatoid arthritis | |
| Pathway Interaction Database | Angiopoietin receptor Tie2-mediated signaling (PID:200079) |
| SHP2 signaling (PID:200083) | |
Disease Annotations
|
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
| External Database Links | |
| KEGG Pathway | HIF-1 signaling pathway |
| PI3K-Akt signaling pathway | |
| Rheumatoid arthritis | |
| Pathway Interaction Database | Angiopoietin receptor Tie2-mediated signaling (PID:200079) |
| SHP2 signaling (PID:200083) | |
References - curated| 1. |
Abdulmalek K, etal., Am J Physiol Lung Cell Mol Physiol 2001 Sep;281(3):L582-90. |
| 2. |
Chung NA, etal., Eur J Clin Invest. 2003 Jul;33(7):529-35. |
| 3. |
DeBusk LM, etal., Arthritis Rheum. 2003 Sep;48(9):2461-71. |
| 4. |
Dedkov EI, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1686-93. Epub 2006 May 19. |
| 5. |
Dewachter L, etal., Am J Respir Crit Care Med. 2006 Nov 1;174(9):1025-33. Epub 2006 Aug 17. |
| 6. |
Hughes DP, etal., Circ Res. 2003 Apr 4;92(6):630-6. Epub 2003 Feb 27. |
| 7. |
Jones N, etal., J Biol Chem. 1999 Oct 22;274(43):30896-905. |
| 8. |
Jones N, etal., Mol Cell Biol. 2003 Apr;23(8):2658-68. |
| 9. |
Kosacka J, etal., Cell Tissue Res. 2005 Apr;320(1):11-9. Epub 2005 Feb 16. |
| 10. |
Lewinson D, etal., Histochem Cell Biol. 2001 Nov;116(5):381-8. Epub 2001 Oct 18. |
| 11. |
Li WZ, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Aug;31(4):523-7. |
| 12. |
Lin P, etal., J Clin Invest. 1997 Oct 15;100(8):2072-8. |
| 13. |
MGD data from the GO Consortium |
| 14. |
Miyabayashi K, etal., J Exp Zoolog A Comp Exp Biol. 2005 Jul 1;303(7):590-7. |
| 15. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 16. |
Peoch M, etal., Anticancer Res 2002 Jul-Aug;22(4):2147-51. |
| 17. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 18. |
Puri MC and Bernstein A, Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12753-8. Epub 2003 Oct 6. |
| 19. |
Ramsden JD, etal., J Clin Endocrinol Metab. 2001 Jun;86(6):2709-16. |
| 20. |
Reiss Y, etal., Brain Pathol. 2005 Oct;15(4):311-7. |
| 21. |
RGD automated data pipeline |
| 22. |
RGD automated import pipeline for gene-chemical interactions |
| 23. |
RGD Automated Pipelines |
| 24. |
RGD comprehensive gene curation |
| 25. |
Runting AS, etal., Growth Factors. 1993;9(2):99-105. |
| 26. |
Shyu KG, etal., Clin Sci (Lond). 2003 Sep;105(3):287-94. |
| 27. |
Sullivan CC, etal., Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12331-6. Epub 2003 Sep 25. |
| 28. |
Tachibana K, etal., Mol Cell Biol. 2005 Jun;25(11):4693-702. |
| 29. |
Vikkula M, etal., Cell. 1996 Dec 27;87(7):1181-90. |
| 30. |
Villanueva S, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R861-70. Epub 2005 Nov 10. |
| 31. |
Voskas D, etal., Am J Pathol. 2005 Mar;166(3):843-55. |
| 32. |
Wang X, etal., Am J Physiol Heart Circ Physiol. 2003 Feb;284(2):H613-8. Epub 2002 Oct 31. |
| 33. |
Wen CY, etal., J Gastroenterol. 2003;38(5):431-5. |
| 34. |
Willam C, etal., Circ Res 2000 Sep 1;87(5):370-7. |
| 35. |
Witzenbichler B, etal., J Biol Chem. 1998 Jul 17;273(29):18514-21. |
| 36. |
Ye F, etal., Steroids 2002 Mar;67(3-4):305-10. |
| 37. |
Zacharek A, etal., Neurosci Lett. 2006 Aug 14;404(1-2):28-32. Epub 2006 Jun 9. |
| 38. |
Zhang ZG, etal., J Cereb Blood Flow Metab 2002 Apr;22(4):379-92. |
References - uncurated| PubMed | 11822892 |
| 14966366 | |
| 15548727 | |
| 15845622 | |
| 18073453 | |
| 18285514 | |
| 18586890 | |
| 18751736 | |
| 18929864 | |
| 18947490 | |
| 19712575 | |
| 19786610 | |
| 20969813 | |
| 21701128 | |
| 22577112 | |
| 22869617 | |
| 23049737 |
RGD Disease Portals| Tek has been annotated in the following RGD Disease Portals. |
|||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
Comparative Map Data| Tek (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| TEK (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Tek (Mus musculus) |
|
Position Markers| D5Uwm29 |
|
||||||||||||||||||||||||||||||
| D5Lev12 |
|
||||||||||||||||||||||||||||||
| RH137123 |
|
||||||||||||||||||||||||||||||
| RH138516 |
|
||||||||||||||||||||||||||||||
| RH138553 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001105737 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06038741 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06038742 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06038743 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06038744 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038541 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038542 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038543 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038544 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038545 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01038546 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF030423 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473998 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001105737 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001099207 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_001099207 | (Get FASTA) |
| GenBank Protein | EDL97760 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000008587 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000036086 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000032248 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 89804 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/TrEMBL |
| HomoloGene Group ID | 397 | ENTREZGENE |
| InterPro | EGF-like_reg_CS | UniProtKB/TrEMBL |
| EGF_3 | UniProtKB/TrEMBL | |
| EGF_laminin | UniProtKB/TrEMBL | |
| FN_III | UniProtKB/TrEMBL | |
| Ig-like | UniProtKB/TrEMBL | |
| Ig-like_fold | UniProtKB/TrEMBL | |
| Kinase-like_dom | UniProtKB/TrEMBL | |
| Prot_kinase_cat_dom | UniProtKB/TrEMBL | |
| Protein_kinase_ATP_BS | UniProtKB/TrEMBL | |
| Ser-Thr/Tyr-Pkinase | UniProtKB/TrEMBL | |
| Tyr_kin_Tie2_Ig-like_dom-1_N | UniProtKB/TrEMBL | |
| Tyr_Pkinase_cat_dom | UniProtKB/TrEMBL | |
| Tyr_prot_kinase_AS | UniProtKB/TrEMBL | |
| IPI | IPI00389259 | UniProtKB/TrEMBL |
| KEGG Report | rno:89804 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | fn3 | UniProtKB/TrEMBL |
| Ig_Tie2_1 | UniProtKB/TrEMBL | |
| Pkinase_Tyr | UniProtKB/TrEMBL | |
| PRINTS | TYRKINASE | UniProtKB/TrEMBL |
| PROSITE | EGF_1 | UniProtKB/TrEMBL |
| EGF_3 | UniProtKB/TrEMBL | |
| FN3 | UniProtKB/TrEMBL | |
| IG_LIKE | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_ATP | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_DOM | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_TYR | UniProtKB/TrEMBL | |
| SMART | EGF | UniProtKB/TrEMBL |
| EGF_Lam | UniProtKB/TrEMBL | |
| FN3 | UniProtKB/TrEMBL | |
| TyrKc | UniProtKB/TrEMBL | |
| Superfamily-SCOP | FN_III-like | UniProtKB/TrEMBL |
| Kinase_like | UniProtKB/TrEMBL | |
| UniGene | Rn.9159 | ENTREZGENE |
| UniProt | D3ZCD0_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-10-23 | Tek | TEK tyrosine kinase, endothelial | Tek | endothelial-specific receptor tyrosine kinase | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Tek | endothelial-specific receptor tyrosine kinase | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | Tek | endothelial-specific receptor tyrosine kinase | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed by endothelial cells | 628494 |
| gene_function | receptor for Angiopoietin (Ang)-1 and Ang-2 | 628494 |
| gene_physical_interaction | binding of Ang-1 causes autophosphorylation and activation, but Ang-2 binding antagonizes this effect | 628494 |
| gene_process | mediates the maturation of blood vessels during embryonic development | 628494 |
| gene_process | plays a role in angiogenesis and stabilization of vascular integrity | 628494 |
| gene_regulation | induced by hypoxia and inflammatory cytokines | 724763 |
| gene_regulation | hypoxia reduces mRNA, protein, and phosphorylation levels in the lung, liver, cerebellum, and heart but not in the kidney and diaphragm | 628494 |
| gene_regulation | inhibitory effect of hypoxia on the gene expression acts through the reduction of angiopoietin-1 and upregulation of angiopoietin-2 and -3 | 628494 |
| More on Tek | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620980 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




