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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | multiple interactions | EXP | | 6480464 | [cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to Pilocarpine | CTD | PMID:2533336 | (S)-nicotine | multiple interactions | EXP | | 6480464 | Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein] | CTD | PMID:21316381 | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of HTR1B mRNA | CTD | PMID:12008023 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10746 | 6480464 | Tetrachlorodibenzodioxin affects the expression of HTR1B mRNA | CTD | PMID:21570461 | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:731005 | 6480464 | HTR1B affects the reaction [almotriptan inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]] | CTD | PMID:11134654 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:10746 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of HTR1B mRNA | CTD | PMID:18648102 | 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate | affects binding | EXP | | 6480464 | CGS 12066B binds to HTR1B protein | CTD | PMID:11888550 | 5-carboxamidotryptamine | affects binding | EXP | | 6480464 | 5-carboxamidotryptamine binds to HTR1B protein | CTD | PMID:11888550 | almotriptan | multiple interactions | ISO | RGD:731005 | 6480464 | HTR1B affects the reaction [almotriptan inhibits the reaction [Forskolin results in increased abundance of Cyclic AMP]] | CTD | PMID:11134654 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of HTR1B mRNA | CTD | PMID:16483693 | amphetamine | increases response to substance | EXP | | 6480464 | HTR1B protein results in increased susceptibility to Amphetamine | CTD | PMID:19817843 | capsaicin | multiple interactions | ISO | RGD:10746 | 6480464 | HTR1B protein inhibits the reaction [Capsaicin results in increased expression of FOS protein] | CTD | PMID:12110114 | chlorpyrifos | affects expression | EXP | | 6480464 | Chlorpyrifos affects the expression of HTR1B mRNA | CTD | PMID:18835401 | choline | multiple interactions | ISO | RGD:10746 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR1B gene | CTD | PMID:20938992 | citalopram | decreases expression | EXP | | 6480464 | Citalopram results in decreased expression of HTR1B protein | CTD | PMID:18157704 | cocaine | increases response to substance | ISO | RGD:10746 | 6480464 | HTR1B mutant form results in increased susceptibility to Cocaine | CTD | PMID:9603521 | cocaine | affects activity | EXP | | 6480464 | Cocaine affects the activity of HTR1B protein | CTD | PMID:17074068 | cocaine | multiple interactions | EXP | | 6480464 | [3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine; more ... | CTD | PMID:9822762 | diazinon | increases expression | EXP | | 6480464 | Diazinon results in increased expression of HTR1B mRNA | CTD | PMID:17452286 | fluoxetine | decreases expression | EXP | | 6480464 | Fluoxetine results in decreased expression of HTR1B mRNA | CTD | PMID:10861803 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of HTR1B mRNA | CTD | PMID:10665824 | fluoxetine | decreases expression | EXP | | 6480464 | Fluoxetine results in decreased expression of HTR1B mRNA | CTD | PMID:10861803 PMID:8914125 | folic acid | multiple interactions | ISO | RGD:10746 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR1B gene | CTD | PMID:20938992 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of HTR1B mRNA | CTD | PMID:21782745 | GR 127935 | affects binding | EXP | | 6480464 | GR 127935 binds to HTR1B protein | CTD | PMID:11888550 | L-methionine | multiple interactions | ISO | RGD:10746 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR1B gene | CTD | PMID:20938992 | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of HTR1B mRNA | CTD | PMID:11578147 | metergoline | affects binding | EXP | | 6480464 | Metergoline binds to HTR1B protein | CTD | PMID:11888550 | methiothepin | affects binding | EXP | | 6480464 | Methiothepin binds to HTR1B protein | CTD | PMID:11888550 | methysergide | affects binding | EXP | | 6480464 | Methysergide binds to HTR1B protein | CTD | PMID:11888550 | naratriptan | affects binding | ISO | RGD:731005 | 6480464 | naratriptan binds to HTR1B protein | CTD | PMID:9170336 | paracetamol | decreases expression | ISO | RGD:731005 | 6480464 | Acetaminophen results in decreased expression of HTR1B mRNA | CTD | PMID:22230336 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of HTR1B mRNA | CTD | PMID:18198484 | paroxetine | decreases expression | EXP | | 6480464 | Paroxetine results in decreased expression of HTR1B mRNA | CTD | PMID:10861803 | pindolol | affects binding | EXP | | 6480464 | Pindolol binds to HTR1B protein | CTD | PMID:11888550 | propranolol | affects binding | EXP | | 6480464 | Propranolol binds to HTR1B protein | CTD | PMID:11888550 | serotonin | affects binding | EXP | | 6480464 | Serotonin binds to HTR1B protein | CTD | PMID:11888550 | sumatriptan | multiple interactions | EXP | | 6480464 | Sumatriptan binds to and results in increased activity of HTR1B protein | CTD | PMID:11301495 | sumatriptan | affects binding | EXP | | 6480464 | Sumatriptan binds to HTR1B protein | CTD | PMID:11888550 | valproic acid | affects expression | ISO | RGD:10746 | 6480464 | Valproic Acid affects the expression of HTR1B mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
| Serotonergic synapse | |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
| Serotonergic synapse | |
Phenotype AnnotationsReferences - curated| 1. |
Ahlander-Luttgen M, etal., Neuropsychopharmacology 2003 Sep;28(9):1642-55. |
| 2. |
Amato JL, etal., Neuropsychopharmacology. 2007 Apr;32(4):946-54. Epub 2006 Aug 2. |
| 3. |
Ansar S, etal., J Neurosurg. 2007 May;106(5):881-6. |
| 4. |
Banes AK and Watts SW, Hypertension. 2002 Feb;39(2 Pt 2):394-8. |
| 5. |
Barot SK, etal., Eur J Neurosci. 2007 May;25(10):3125-31. Epub 2007 May 17. |
| 6. |
Cambj-Sapunar L, etal., Stroke 2003 May;34(5):1269-75. Epub 2003 Apr 3. |
| 7. |
Carta M, etal., Brain. 2007 Jul;130(Pt 7):1819-33. Epub 2007 Apr 23. |
| 8. |
Chennaoui M, etal., Neurosci Lett 2003 Apr 10;340(2):131-4. |
| 9. |
Clark MS, etal., J Neurosci 2002 Jun 1;22(11):4550-62. |
| 10. |
GOA data from the GO Consortium |
| 11. |
Holden JE, etal., Neuroscience. 2005;135(4):1255-68. Epub 2005 Sep 13. |
| 12. |
Hoplight BJ, etal., Alcohol. 2006 Feb;38(2):73-9. |
| 13. |
Janiak P, etal., Cardiovasc Res. 2002 Nov;56(2):293-302. |
| 14. |
Keegan A, etal., Circ Res. 2001 Dec 7;89(12):1231-9. |
| 15. |
Lee JJ, etal., Neuropsychopharmacology. 2007 Mar 28;. |
| 16. |
Lee MD, etal., Psychopharmacology (Berl). 2002 Oct;164(1):49-60. Epub 2002 Jul 19. |
| 17. |
Lemos JC, etal., Eur J Neurosci. 2006 Dec;24(12):3415-30. |
| 18. |
Makarenko IG, etal., Neurosci Lett. 2005 Mar 11;376(2):71-5. Epub 2004 Dec 8. |
| 19. |
MGD data from the GO Consortium |
| 20. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 21. |
Park S, etal., Brain Res. 1999 Nov 13;847(1):90-7. |
| 22. |
Quist JF, etal., Mol Psychiatry 2003 Jan;8(1):98-102. |
| 23. |
RGD automated data pipeline |
| 24. |
RGD automated import pipeline for gene-chemical interactions |
| 25. |
Scott C, etal., Neuropharmacology. 2006 Jun;50(8):984-90. Epub 2006 Mar 20. |
| 26. |
Soyka M, etal., J Neural Transm 2004 Jan;111(1):101-9. Epub 2003 Dec 3. |
| 27. |
Verge D, etal., J Neurosci. 1986 Dec;6(12):3474-82. |
| 28. |
Yan QS, etal., Brain Res 2004 Sep 17;1021(1):82-91. |
| 29. |
Yan QS, etal., Brain Res. 2005 Oct 26;1060(1-2):126-37. Epub 2005 Oct 5. |
References - uncurated| PubMed | 12957218 |
| 16310183 | |
| 17074068 | |
| 17873013 | |
| 18207350 | |
| 1836757 | |
| 18502320 | |
| 18638459 | |
| 18793415 | |
| 19121358 | |
| 19556691 | |
| 19819310 | |
| 19963045 | |
| 20226766 | |
| 20385119 | |
| 20510890 | |
| 20833155 | |
| 20843634 | |
| 21047499 | |
| 21107539 | |
| 21653728 | |
| 21681557 | |
| 21718722 | |
| 21801291 | |
| 21982809 | |
| 22585122 | |
| 22659115 | |
| 22848635 |
RGD Disease Portals| Htr1b has been annotated in the following RGD Disease Portals. |
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Candidate Gene StatusComparative Map Data| Htr1b (Rattus norvegicus) |
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| HTR1B (Homo sapiens) |
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| Htr1b (Mus musculus) |
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Position Markers| PMC166422P1 |
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| GDB:580614 |
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| UniSTS:491331 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Related Rat StrainsNucleotide Sequences| Nucleotide RefSeqs | NM_022225 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06056045 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01055882 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473954 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M89954 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X62944 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022225 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_071561 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_071561 | (Get FASTA) |
| GenBank Protein | AAA40613 | (Get FASTA) |
| CAA44716 | (Get FASTA) | |
| EDL77686 | (Get FASTA) | |
| P28564 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000013042 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000017411 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000017411 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25075 | ENTREZGENE |
| Germonline | ENSRNOG00000013042 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 669 | ENTREZGENE |
| InterPro | 5HT1B_rcpt | UniProtKB/Swiss-Prot |
| 5HT_rcpt | UniProtKB/Swiss-Prot | |
| 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot | |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:25075 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR24247 | UniProtKB/Swiss-Prot |
| PTHR24247:SF16 | UniProtKB/Swiss-Prot | |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PharmGKB | HTR1B | RGD |
| PRINTS | 5HT1BRECEPTR | UniProtKB/Swiss-Prot |
| 5HTRECEPTOR | UniProtKB/Swiss-Prot | |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.138109 | ENTREZGENE |
| UniProt | 5HT1B_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2012-07-17 | Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2001-07-23 | Htr1b | 5-hydroxytryptamine (serotonin ) receptor 1B | Name updated to reflect Human and Mouse nomenclature | 461 | APPROVED | ||
| 2001-07-23 | Htr1b | Serotonin (5-hydroxytryptamine (5HT)) receptor, type 1B | Name withdrawn | 461 | WITHDRAWN | ||
| 2001-07-23 | Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B | Name updated to reflect Human and Mouse nomenclature | 461 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | associated with stress, depression and anxiety behaviors | 625756 |
| gene_drugs | antidepressants downregulate the receptor activity and normalize serotonergic neurotransmission; fluoxetine or paroxetine acts on a time-dependent and reversible manner resulting in decrease of receptor expression in striatum | 625756 |
| gene_expression | expressed in the midbrain raphe nuclei and dorsal raphe nucleus (DRN) and serotonergic neurons of brain | 625756 |
| gene_mutations_overexpression | receptor overexpression in dorsal raphe nucleus mediates pathological response to behavioural disorders such as anxiety and stress | 625756 |
| gene_mutations_overexpression | overexpression in dorsal raphe nucleus causes an increase in anxiety behavior | 625756 |
| gene_process | involved in the negative feedback system regulating extracellular serotonin [ 5-HT ] neurotransmission | 625756 |
| gene_regulation | upregulated in animals during behavior related learning periods and downregulated by antidepressants | 625756 |
| gene_regulation | activated by subarachnoid hemorrhage | 737621 |
| More on Htr1b | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2846 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-06-04 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.