Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SHTN1 mRNA | CTD | PMID:24763279 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SHTN1 mRNA | CTD | PMID:22079256 | (1->4)-beta-D-glucan | multiple interactions | ISO | Shtn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SHTN1 mRNA | CTD | PMID:36331819 | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of SHTN1 mRNA | CTD | PMID:30723492 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of SHTN1 mRNA | CTD | PMID:26496021 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SHTN1 mRNA | CTD | PMID:22298810 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of SHTN1 protein | CTD | PMID:34915118 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SHTN1 mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of SHTN1 mRNA | CTD | PMID:28959563 | aristolochic acid A | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SHTN1 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to SHTN1 mRNA] | CTD | PMID:32406909 | arsenous acid | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of SHTN1 mRNA | CTD | PMID:20458559 and PMID:26705709 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of SHTN1 gene | CTD | PMID:35440735 | benzo[a]pyrene | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SHTN1 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | increases methylation | ISO | SHTN1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SHTN1 promoter | CTD | PMID:27901495 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of SHTN1 mRNA | CTD | PMID:26496021 | bisphenol A | increases expression | ISO | Shtn1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SHTN1 mRNA | CTD | PMID:35598803 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SHTN1 mRNA | CTD | PMID:30816183 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SHTN1 mRNA | CTD | PMID:25181051 | butanal | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of SHTN1 mRNA | CTD | PMID:26079696 | caffeine | affects phosphorylation | ISO | SHTN1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of SHTN1 protein | CTD | PMID:35688186 | copper(II) sulfate | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SHTN1 mRNA | CTD | PMID:19549813 | coumarin | affects phosphorylation | ISO | SHTN1 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of SHTN1 protein | CTD | PMID:35688186 | diarsenic trioxide | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of SHTN1 mRNA | CTD | PMID:20458559 and PMID:26705709 | dicrotophos | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of SHTN1 mRNA | CTD | PMID:28302478 | disodium selenite | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of SHTN1 mRNA | CTD | PMID:18175754 | dorsomorphin | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SHTN1 mRNA | CTD | PMID:29803840 | entinostat | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | entinostat results in increased expression of SHTN1 mRNA | CTD | PMID:27188386 | enzyme inhibitor | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SHTN1 protein | CTD | PMID:23301498 | FR900359 | increases phosphorylation | ISO | SHTN1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of SHTN1 protein | CTD | PMID:37730182 | ivermectin | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SHTN1 protein | CTD | PMID:32959892 | lead(0) | affects expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Lead affects the expression of SHTN1 mRNA | CTD | PMID:28903495 | malathion | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Malathion results in decreased expression of SHTN1 mRNA | CTD | PMID:37047231 | maneb | multiple interactions | ISO | Shtn1 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of SHTN1 mRNA | CTD | PMID:36117858 | mercury dibromide | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHTN1 mRNA | CTD | PMID:27188386 | mercury dibromide | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of SHTN1 mRNA | CTD | PMID:26272509 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of SHTN1 gene | CTD | PMID:35440735 | p-chloromercuribenzoic acid | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHTN1 mRNA | CTD | PMID:27188386 | p-chloromercuribenzoic acid | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in increased expression of SHTN1 mRNA | CTD | PMID:26272509 | paracetamol | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SHTN1 mRNA | CTD | PMID:21420995 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SHTN1 mRNA | CTD | PMID:33387578 | paraquat | multiple interactions | ISO | Shtn1 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of SHTN1 mRNA | CTD | PMID:36117858 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Shtn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SHTN1 mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of SHTN1 mRNA | CTD | PMID:36331819 | permethrin | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Permethrin results in decreased expression of SHTN1 mRNA | CTD | PMID:37047231 | phenylmercury acetate | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of SHTN1 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHTN1 mRNA | CTD | PMID:27188386 | potassium chromate | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SHTN1 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SHTN1 mRNA | CTD | PMID:22079256 | SB 431542 | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silver atom | increases expression | ISO | Shtn1 (Mus musculus) | 6480464 | Silver results in increased expression of SHTN1 mRNA | CTD | PMID:27131904 | silver(0) | increases expression | ISO | Shtn1 (Mus musculus) | 6480464 | Silver results in increased expression of SHTN1 mRNA | CTD | PMID:27131904 | sodium arsenite | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SHTN1 mRNA | CTD | PMID:29301061 | sodium dichromate | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | sodium bichromate results in decreased expression of SHTN1 mRNA | CTD | PMID:17685462 | sodium fluoride | decreases expression | ISO | Shtn1 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of SHTN1 mRNA | CTD | PMID:27862939 | sunitinib | decreases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of SHTN1 mRNA | CTD | PMID:31533062 | tetrachloromethane | increases expression | ISO | Shtn1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SHTN1 mRNA | CTD | PMID:27339419 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SHTN1 mRNA | CTD | PMID:31150632 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SHTN1 mRNA | CTD | PMID:23411599 | trichostatin A | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of SHTN1 mRNA | CTD | PMID:24935251 and PMID:26705709 | valproic acid | increases expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SHTN1 mRNA | CTD | PMID:19101580 more ... | valproic acid | affects expression | ISO | SHTN1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SHTN1 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | SHTN1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHTN1 mRNA | CTD | PMID:27188386 | vincaleukoblastine | affects response to substance | ISO | SHTN1 (Homo sapiens) | 6480464 | SHTN1 protein affects the susceptibility to Vinblastine | CTD | PMID:16217747 | |