Gene: Plp1 (proteolipid protein 1) Rattus norvegicus
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Symbol: Plp1
Name: proteolipid protein 1
Description: ENCODES a protein that exhibits structural constituent of myelin sheath; structural molecule activity; identical protein binding (ortholog); INVOLVED IN axon ensheathment; glial cell differentiation; integrin-mediated signaling pathway; ASSOCIATED WITH premature death; tremors; ASSOCIATED WITH demyelinating disease; Demyelinating Diseases; Seizures; FOUND IN myelin sheath; plasma membrane (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: lipophilin; myelin proteolipid protein; Plp; proteolipid protein; proteolipid protein (myelin); proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)
Orthologs:
Homo sapiens (human) : PLP1 (proteolipid protein 1)  HGNC  AGR
Mus musculus (house mouse) : Plp1 (proteolipid protein (myelin) 1)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Plp1 (proteolipid protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLP1 (proteolipid protein 1)
Canis lupus familiaris (dog) : PLP1 (proteolipid protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plp1 (proteolipid protein 1)
more info ...
Allele / Splice: Plp1md  
Genetic Models: W-Plp1md/Nya
Is Marker For: Strains:   W-Plp1md/Nya  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X107,494,326 - 107,511,355 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X107,379,831 - 107,394,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X124,488,627 - 124,503,639 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X124,562,059 - 124,577,072 (+)NCBI
CeleraX101,020,110 - 101,035,276 (+)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Plp1
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3354
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE