Rasgrp3 (RAS guanyl releasing protein 3) - Rat Genome Database

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Gene: Rasgrp3 (RAS guanyl releasing protein 3) Rattus norvegicus
Analyze
Symbol: Rasgrp3
Name: RAS guanyl releasing protein 3
RGD ID: 1304612
Description: Predicted to enable GTPase regulator activity and enzyme binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3); PARTICIPATES IN B cell receptor signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313874; RAS guanyl releasing protein 3 (calcium and DAG-regulated); ras guanyl-releasing protein 3; RAS, guanyl releasing protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Rasgrp3em1Mcwi   Rasgrp3em3Mcwi  
Genetic Models: SS-Rasgrp3em1Mcwi SS-Rasgrp3em3Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8625,647,386 - 25,745,952 (-)NCBIGRCr8
mRatBN7.2619,895,361 - 19,993,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl619,895,390 - 19,958,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx620,225,551 - 20,288,760 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0620,541,387 - 20,604,597 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0620,021,820 - 20,085,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0621,072,634 - 21,171,619 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl621,072,634 - 21,135,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0630,966,364 - 31,065,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4619,808,453 - 19,871,923 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1619,815,248 - 19,848,714 (-)NCBI
Celera619,464,356 - 19,527,205 (-)NCBICelera
Cytogenetic Map6q12-q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cylindrospermopsin  (ISO)
delta-tocotrienol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP)
pentanal  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triticonazole  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. Yang HC, etal., PLoS One. 2009;4(5):e5459. Epub 2009 May 7.
Additional References at PubMed
PMID:10934204   PMID:15545601   PMID:15737652   PMID:15894621   PMID:18588530  


Genomics

Comparative Map Data
Rasgrp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8625,647,386 - 25,745,952 (-)NCBIGRCr8
mRatBN7.2619,895,361 - 19,993,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl619,895,390 - 19,958,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx620,225,551 - 20,288,760 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0620,541,387 - 20,604,597 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0620,021,820 - 20,085,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0621,072,634 - 21,171,619 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl621,072,634 - 21,135,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0630,966,364 - 31,065,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4619,808,453 - 19,871,923 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1619,815,248 - 19,848,714 (-)NCBI
Celera619,464,356 - 19,527,205 (-)NCBICelera
Cytogenetic Map6q12-q13NCBI
RASGRP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38233,436,348 - 33,564,731 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl233,436,324 - 33,564,750 (+)EnsemblGRCh38hg38GRCh38
GRCh37233,661,415 - 33,789,798 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36233,514,920 - 33,643,162 (+)NCBINCBI36Build 36hg18NCBI36
Celera233,500,106 - 33,628,502 (+)NCBICelera
Cytogenetic Map2p22.3NCBI
HuRef233,395,400 - 33,523,736 (+)NCBIHuRef
CHM1_1233,590,740 - 33,719,120 (+)NCBICHM1_1
T2T-CHM13v2.0233,482,495 - 33,610,876 (+)NCBIT2T-CHM13v2.0
Rasgrp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391775,742,849 - 75,836,049 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1775,742,891 - 75,836,049 (+)EnsemblGRCm39 Ensembl
GRCm381775,435,870 - 75,529,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1775,435,896 - 75,529,054 (+)EnsemblGRCm38mm10GRCm38
MGSCv371775,835,245 - 75,928,394 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361775,370,673 - 75,434,104 (+)NCBIMGSCv36mm8
Celera1779,726,720 - 79,821,715 (+)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1746.55NCBI
Rasgrp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554411,679,108 - 1,786,397 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554411,679,258 - 1,786,397 (+)NCBIChiLan1.0ChiLan1.0
RASGRP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21292,937,226 - 93,095,098 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A92,941,198 - 93,004,430 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A33,444,941 - 33,572,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A34,156,780 - 34,284,307 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A34,196,421 - 34,284,307 (+)Ensemblpanpan1.1panPan2
RASGRP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11726,560,832 - 26,657,276 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1726,569,488 - 26,655,361 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1726,350,794 - 26,449,397 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01727,127,589 - 27,226,234 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1727,127,678 - 27,226,226 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11726,423,287 - 26,521,834 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01726,496,776 - 26,595,712 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01726,653,466 - 26,752,215 (+)NCBIUU_Cfam_GSD_1.0
Rasgrp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629270,633,719 - 70,735,839 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936493109,275 - 143,640 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936493103,937 - 205,819 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASGRP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3106,099,821 - 106,213,728 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13106,098,541 - 106,213,787 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23112,971,430 - 113,002,767 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RASGRP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11473,871,343 - 73,950,119 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1473,895,534 - 73,946,358 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604537,985,721 - 38,114,455 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasgrp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473815,130,891 - 15,236,445 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473815,130,709 - 15,237,869 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rasgrp3
709 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:200
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000051239
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat

Markers in Region
D6Rat43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2619,955,899 - 19,956,076 (+)MAPPERmRatBN7.2
Rnor_6.0621,133,292 - 21,133,468NCBIRnor6.0
Rnor_5.0631,026,880 - 31,027,056UniSTSRnor5.0
RGSC_v3.4619,869,334 - 19,869,511RGDRGSC3.4
RGSC_v3.4619,869,335 - 19,869,511UniSTSRGSC3.4
RGSC_v3.1619,872,287 - 19,872,464RGD
Celera619,524,617 - 19,524,793UniSTS
RH 2.0 Map6177.6RGD
FHH x ACI Map621.5799RGD
Cytogenetic Map6q12UniSTS
RH133889  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2619,895,651 - 19,895,833 (+)MAPPERmRatBN7.2
Rnor_6.0621,072,896 - 21,073,077NCBIRnor6.0
Rnor_5.0630,966,626 - 30,966,807UniSTSRnor5.0
RGSC_v3.4619,808,715 - 19,808,896UniSTSRGSC3.4
Celera619,464,618 - 19,464,799UniSTS
Cytogenetic Map6q12UniSTS


Genetic Models
This gene Rasgrp3 is modified in the following models/strains:
SS-Rasgrp3em1Mcwi     SS-Rasgrp3em3Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 15 6 13 6 8 10 11 29 27 11 8
Low 1 42 35 6 35 1 63 6 14
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051239   ⟹   ENSRNOP00000051116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl619,895,390 - 19,958,488 (-)Ensembl
Rnor_6.0 Ensembl621,072,634 - 21,135,880 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079819   ⟹   ENSRNOP00000075529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl619,896,695 - 19,958,578 (-)Ensembl
Rnor_6.0 Ensembl621,074,604 - 21,112,734 (-)Ensembl
RefSeq Acc Id: NM_001399544   ⟹   NP_001386473
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,710,591 (-)NCBI
mRatBN7.2619,895,361 - 19,958,578 (-)NCBI
RefSeq Acc Id: XM_063261852   ⟹   XP_063117922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,952 (-)NCBI
RefSeq Acc Id: XM_063261853   ⟹   XP_063117923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,950 (-)NCBI
RefSeq Acc Id: XM_063261854   ⟹   XP_063117924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,710,595 (-)NCBI
RefSeq Acc Id: XM_063261855   ⟹   XP_063117925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,710,394 (-)NCBI
RefSeq Acc Id: XM_063261856   ⟹   XP_063117926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,509 (-)NCBI
RefSeq Acc Id: XM_063261857   ⟹   XP_063117927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,950 (-)NCBI
RefSeq Acc Id: XM_063261858   ⟹   XP_063117928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,950 (-)NCBI
RefSeq Acc Id: XM_063261859   ⟹   XP_063117929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,710,597 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000075529   ⟸   ENSRNOT00000079819
RefSeq Acc Id: ENSRNOP00000051116   ⟸   ENSRNOT00000051239
RefSeq Acc Id: NP_001386473   ⟸   NM_001399544
- UniProtKB: A0A0G2KAU4 (UniProtKB/TrEMBL),   A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117922   ⟸   XM_063261852
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117927   ⟸   XM_063261857
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117928   ⟸   XM_063261858
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117923   ⟸   XM_063261853
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117926   ⟸   XM_063261856
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117929   ⟸   XM_063261859
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117924   ⟸   XM_063261854
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117925   ⟸   XM_063261855
- Peptide Label: isoform X1
Protein Domains
EF-hand   N-terminal Ras-GEF   Phorbol-ester/DAG-type   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAU4-F1-model_v2 AlphaFold A0A0G2KAU4 1-691 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694406
Promoter ID:EPDNEW_R4931
Type:initiation region
Name:Rasgrp3_1
Description:RAS guanyl releasing protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0621,135,911 - 21,135,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304612 AgrOrtholog
BioCyc Gene G2FUF-38463 BioCyc
Ensembl Genes ENSRNOG00000032703 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051239.5 UniProtKB/TrEMBL
  ENSRNOT00000079819 ENTREZGENE
  ENSRNOT00000079819.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
KEGG Report rno:313874 UniProtKB/TrEMBL
NCBI Gene 313874 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  PTHR23113:SF178 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
PhenoGen Rasgrp3 PhenoGen
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032703 RatGTEx
SMART EFh UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A0G2KAU4 ENTREZGENE, UniProtKB/TrEMBL
  A6H9X0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZN2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Rasgrp3  RAS guanyl releasing protein 3 (calcium and DAG-regulated)  Rasgrp3  RAS, guanyl releasing protein 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rasgrp3  RAS, guanyl releasing protein 3   Rasgrp3_predicted  RAS, guanyl releasing protein 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rasgrp3_predicted  RAS, guanyl releasing protein 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED