Gene: Rasgrp3 (RAS guanyl releasing protein 3 (calcium and DAG-regulated))
Rattus norvegicus
Symbol:
Rasgrp3
Name:
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Description:
ENCODES a protein that exhibits kinase binding (ortholog); Rap GTPase activator activity (ortholog); Ras GTPase binding (ortholog); INVOLVED IN positive regulation of Rap GTPase activity (ortholog); Ras protein signal transduction (ortholog); regulation of GTPase activity (ortholog); PARTICIPATES IN B cell receptor signaling pathway; mitogen activated protein kinase signaling pathway; ASSOCIATED WITH Hypertension (ortholog); FOUND IN cytoplasm (ortholog); guanyl-nucleotide exchange factor complex (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH dibutyl phthalate; quercetin; (-)-epigallocatechin 3-gallate (ortholog)
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC313874; RAS guanyl releasing protein 3; ras guanyl-releasing protein 3; RAS, guanyl releasing protein 3; RAS, guanyl releasing protein 3 ; RAS, guanyl releasing protein 3 (predicted); Rasgrp3_predicted
Orthologs:
Homo sapiens : RASGRP3
(RAS guanyl releasing protein 3 (calcium and DAG-regulated))
HGNC
Rasgrp3
(RAS, guanyl releasing protein 3)
MGI
Allele / Splice:
Rasgrp3em1Mcwi
Rasgrp3em3Mcwi
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 6 q12 NCBI RGSC Genome Assembly v5.0 6 30,966,364 - 31,029,468 - NCBI RGSC Genome Assembly v3.4 6 19,808,453 - 19,871,923 - NCBI Rat Celera Assembly 6 19,464,356 - 19,527,205 - NCBI Genome Assembly 3.1 6 19,815,248 - 19,848,714 - NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1312152 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RASGRP3 mRNA CTD PMID:22079256 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1312153 6480464 Tetrachlorodibenzodioxin results in decreased expression of RASGRP3 mRNA CTD PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1312153 6480464 Tetrachlorodibenzodioxin affects the expression of RASGRP3 mRNA CTD PMID:21570461 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1312153 6480464 4,4'-diaminodiphenylmethane results in decreased expression of RASGRP3 mRNA CTD PMID:18648102 4-hydroxynon-2-enal increases expression ISO RGD:1312153 6480464 4-hydroxy-2-nonenal results in increased expression of RASGRP3 mRNA CTD PMID:19191707 benzo[a]pyrene multiple interactions ISO RGD:1312153 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of RASGRP3 mRNA CTD PMID:21715664 benzo[a]pyrene increases expression ISO RGD:1312153 6480464 Benzo(a)pyrene results in increased expression of RASGRP3 mRNA CTD PMID:22228805 PMID:22610609 benzo[a]pyrene increases expression ISO RGD:1312153 6480464 Benzo(a)pyrene results in increased expression of RASGRP3 mRNA CTD PMID:22228805 chloroprene decreases expression ISO RGD:1312153 6480464 Chloroprene results in decreased expression of RASGRP3 mRNA CTD PMID:23125180 cobalt dichloride decreases expression ISO RGD:1312152 6480464 cobaltous chloride results in decreased expression of RASGRP3 mRNA CTD PMID:19320972 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of RASGRP3 mRNA CTD PMID:21266533 pirinixic acid multiple interactions ISO RGD:1312152 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RASGRP3 mRNA CTD PMID:19710929 quercetin affects expression EXP 6480464 Quercetin affects the expression of RASGRP3 mRNA CTD PMID:18178720 succimer multiple interactions ISO RGD:1312153 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RASGRP3 mRNA CTD PMID:21641980 tert-butyl hydroperoxide decreases expression ISO RGD:1312152 6480464 tert-Butylhydroperoxide results in decreased expression of RASGRP3 mRNA CTD PMID:15336504
Biological Process biological_process ND 1598407 11/2009: no relevant rat data RGD positive regulation of Rap GTPase activity ISO RGD:1312152 1624291 PMID:10934204 RGD PMID:10934204 Ras protein signal transduction ISO RGD:1312153 1624291 MGI:MGI:3512842|PMID:15545601 RGD MGI:MGI:3512842 PMID:15545601 Ras protein signal transduction IEA Ensembl:ENSMUSP00000129393 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of GTPase activity ISO RGD:1312153 1624291 MGI:MGI:3512842|PMID:15545601 RGD MGI:MGI:3512842 PMID:15545601 Cellular Component cellular_component ND 1598407 11/2009: no relevant rat data RGD cytoplasm ISO RGD:1312153 1624291 MGI:MGI:3512842|PMID:15545601 RGD MGI:MGI:3512842 PMID:15545601 cytoplasm ISO RGD:1312153 1624291 MGI:MGI:3583869|PMID:15894621 RGD MGI:MGI:3583869 PMID:15894621 guanyl-nucleotide exchange factor complex ISO RGD:1312153 1624291 MGI:MGI:3583869|PMID:15894621 RGD MGI:MGI:3583869 PMID:15894621 guanyl-nucleotide exchange factor complex IEA Ensembl:ENSMUSP00000129393 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 perinuclear region of cytoplasm ISO RGD:1312153 1624291 MGI:MGI:3583869|PMID:15894621 RGD MGI:MGI:3583869 PMID:15894621 perinuclear region of cytoplasm IEA Ensembl:ENSMUSP00000129393 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function kinase binding ISO RGD:1312153 1624291 RefSeq:NP_001074675 RGD MGI:MGI:3583869 PMID:15894621 kinase binding IEA Ensembl:ENSMUSP00000129393 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000038 UniProtKB GO_REF:0000038 molecular_function ND 1598407 11/2009: no relevant rat data RGD Rap GTPase activator activity IEA Ensembl:ENSP00000384192 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Rap GTPase activator activity ISO RGD:1312152 1624291 PMID:10934204 RGD PMID:10934204 Ras GTPase binding ISO RGD:1312153 1624291 UniProtKB:P62835 RGD MGI:MGI:3583869 PMID:15894621 Ras GTPase binding IEA Ensembl:ENSMUSP00000129393 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Ras GTPase binding ISO RGD:1312153 1624291 MGI:MGI:3512842|PMID:15545601 RGD MGI:MGI:3512842 PMID:15545601 Ras guanyl-nucleotide exchange factor activity ISO RGD:1312153 1624291 MGI:MGI:3512842|PMID:15545601 RGD MGI:MGI:3512842 PMID:15545601 Ras guanyl-nucleotide exchange factor activity IEA Ensembl:ENSMUSP00000129393 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019
1598843 Cm63 Cardiac mass QTL 63 2.6 Cardiac mass 6 1 23802078 Rat 1578758 Tcas9 Tongue tumor susceptibility QTL 9 3.29 Tongue tumor susceptibility tongue tumor number 6 1 25291384 Rat 1331743 Uae28 Urinary albumin excretion QTL 28 4.5 Renal function urine albumin level 6 1 28765971 Rat 738023 Alc17 Alcohol consumption QTL 17 3.1 .003 Consumption level alcohol preference 6 1 35786687 Rat 1549905 Stresp10 Stress response QTL 10 6.83 .0066 Stress response defensive burying - approach 6 1 35786687 Rat 1354616 Despr12 Despair related QTL 12 .0012 Activity level climbing level 6 1 35786687 Rat 2300176 Bmd51 Bone mineral density QTL 51 11.7 .0001 Bone mineral density 6 1 35786687 Rat 2300190 Bmd52 Bone mineral density QTL 52 11.2 .0001 Bone mineral density 6 1 35786687 Rat 2293709 Bss23 Bone structure and strength QTL 23 5.18 .0001 Bone structure 6 1 42401411 Rat 2293650 Bss31 Bone structure and strength QTL 31 5.05 .0001 Bone structure 6 1 42401411 Rat 2293656 Bss28 Bone structure and strength QTL 28 6.79 .0001 Bone structure 6 1 42401411 Rat 738024 Sach5 Saccharine consumption QTL 5 3.9 .00039 Consumption level saccharin preference 6 1 43326782 Rat 1359023 Bp272 Blood pressure QTL 272 2.5 Blood pressure mean arterial pressure, stress related changes 6 1301952 27253998 Rat 2292589 Emca10 Estrogen-induced mammary cancer QTL 10 .048 Mammary tumor resistance 6 1301952 46301952 Rat 1354664 Slep2 Serum leptin concentration QTL 2 4.49 Hormone level leptin 6 1301952 74436995 Rat 1576309 Emca7 Estrogen-induced mammary cancer QTL 7 4 Mammary tumor susceptibility estradiol-induced 6 2802670 111967837 Rat 70196 BpQTLcluster7 Blood pressure QTL cluster 7 6.82 Blood pressure intra-arterial 6 3158498 75049527 Rat 1578665 Bss16 Bone structure and strength QTL 16 4.4 Bone structure femoral neck trabecular area 6 6265856 75462111 Rat 1578668 Bmd14 Bone mineral density QTL 14 3.8 Bone mineral density femoral neck total vBMD 6 6265856 75462111 Rat 4145119 Mcs25 Mammary carcinoma susceptibility QTL 25 .0001 Mammary tumor susceptibility 6 7161389 115238799 Rat 2301972 Bp325 Blood pressure QTL 325 4.8 Blood pressure 6 7680593 75049644 Rat 2293706 Bmd20 Bone mineral density QTL 20 4.3 .0002 Bone mineral density 6 13286615 19901481 Rat 1300128 Rf16 Renal function QTL 16 3.89 Renal function salt-loaded renal blood flow 6 13286615 35233017 Rat 1300164 Rf15 Renal function QTL 15 Renal function salt-loaded renal blood flow 6 13286615 56714969 Rat
Gene-Chemical Interaction Annotations
