Gene: Ctsd (cathepsin D)  Rattus norvegicus Symbol: Ctsd Name: cathepsin D Description: ENCODES a protein that exhibits endopeptidase activity; peptide binding; aspartic-type endopeptidase activity (ortholog); INVOLVED IN autophagy; proteolysis; autophagic vacuole assembly (ortholog); PARTICIPATES IN autophagy pathway; ceramide signaling pathway; Mycobacterium tuberculosis infection pathway; ASSOCIATED WITH Alzheimer Disease (ortholog); Atherosclerosis (ortholog); Breast Neoplasms (ortholog); FOUND IN lysosome; extracellular matrix (ortholog); extracellular space (ortholog); INTERACTS WITH (+)-alpha-tocopherol; (+)-pilocarpine; (-)-epigallocatechin 3-gallate Type: protein-coding RefSeq Status: PROVISIONAL Also known as: cathepsin D Orthologs: Homo sapiens : CTSD (cathepsin D)  HGNC Mus musculus : Ctsd (cathepsin D)  MGI Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   NCBI RGSC Genome Assembly v5.0 1 222,436,922 - 222,448,798 - NCBI RGSC Genome Assembly v3.4 1 202,619,669 - 202,631,545 - NCBI Rat Celera Assembly 1 195,146,345 - 195,158,236 - NCBI Genome Assembly 3.1 1 202,779,384 - 202,791,261 - NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Alzheimer Disease   ISS   1358532   RGD   Atherosclerosis   ISS RGD:732637 5687152   RGD   Breast Neoplasms   ISS   1547890   RGD   Ceroid Lipofuscinosis, Neuronal, 10   ISS RGD:1351014 7240710   OMIM   Neoplasm Metastasis   ISS   1547892   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-alpha-tocopherol increases expression EXP   6480464 alpha-Tocopherol results in increased expression of CTSD protein CTD PMID:18942769 (+)-pilocarpine increases expression EXP   6480464 Pilocarpine results in increased expression of CTSD mRNA CTD PMID:17971868 (-)-epigallocatechin 3-gallate multiple interactions EXP   6480464 epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:18294627 (R)-lipoic acid multiple interactions EXP   6480464 Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 (S)-amphetamine decreases expression ISO RGD:732637 6480464 Dextroamphetamine results in decreased expression of CTSD mRNA CTD PMID:12558987 1,2,4-trimethylbenzene decreases expression EXP   6480464 pseudocumene results in decreased expression of CTSD protein CTD PMID:17337753 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD protein CTD PMID:22235307 PMID:8524236 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD protein CTD PMID:22235307 more ... 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased secretion of CTSD protein CTD PMID:7909315 17beta-estradiol increases secretion ISO RGD:1351014 6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:2278856 more ... 17beta-estradiol increases secretion ISO RGD:1351014 6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:2278856 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 [Estradiol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:22403704 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 more ... 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD protein CTD PMID:22235307 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]; more ... CTD PMID:22235307 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:19365803 PMID:19654927 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:19654927 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11179685 PMID:11165043 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:15090535 more ... 17beta-estradiol increases secretion ISO RGD:1351014 6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:8384872 PMID:2278856 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:11179685 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Estradiol promotes the reaction [[ESR1 protein binds to CTSD promoter] which results in increased expression of CTSD mRNA] CTD PMID:11165043 PMID:11165043 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:19654927 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:19619570 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:2278856 PMID:8384872 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:11165043 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein modified form] CTD PMID:2278856 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:8384872 PMID:2278856 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 PMID:11179685 17beta-estradiol increases secretion ISO RGD:1351014 6480464 Estradiol results in increased secretion of CTSD protein modified form CTD PMID:2278856 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:19619570 more ... 17beta-estradiol increases secretion ISO RGD:1351014 6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:2278856 PMID:8384872 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CTSD mRNA CTD PMID:19619570 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter] CTD PMID:19698761 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]; more ... CTD PMID:11165043 17beta-estradiol increases expression ISO RGD:1351014 6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:2278856 more ... 17beta-estradiol multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD protein] CTD PMID:22235307 PMID:8524236 17beta-estradiol increases secretion ISO RGD:1351014 6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:2278856 more ... 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases expression ISO RGD:1351014 6480464 Metribolone results in decreased expression of CTSD protein CTD PMID:17152098 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:8384872 PMID:2278856 2,3,7,8-tetrachlorodibenzodioxine increases secretion ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin results in increased secretion of CTSD protein CTD PMID:7909315 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased secretion of CTSD protein CTD PMID:7909315 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD protein] CTD PMID:22235307 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732637 6480464 Tetrachlorodibenzodioxin affects the expression of CTSD mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD protein] CTD PMID:22235307 PMID:8524236 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:2278856 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:2278856 PMID:8384872 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 PMID:11179685 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11179685 PMID:11165043 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CTSD mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]; more ... CTD PMID:11165043 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732637 6480464 Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA CTD PMID:11879969 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin results in decreased expression of CTSD mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351014 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein modified form] CTD PMID:2278856 2-amino-2-deoxy-D-glucopyranose affects localization ISO RGD:1351014 6480464 Glucosamine affects the localization of CTSD protein CTD PMID:15972124 2-amino-2-deoxy-D-glucopyranose decreases expression ISO RGD:1351014 6480464 Glucosamine results in decreased expression of CTSD protein alternative form CTD PMID:16850161 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO RGD:1351014 6480464 pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form] CTD PMID:16850161 2-amino-2-deoxy-D-glucopyranose increases activity ISO RGD:1351014 6480464 Glucosamine results in increased activity of CTSD protein CTD PMID:16850161 2-butoxyethanol increases expression ISO RGD:732637 6480464 n-butoxyethanol results in increased expression of CTSD mRNA CTD PMID:19812364 2-nitrofluorene increases expression EXP   6480464 2-nitrofluorene results in increased expression of CTSD mRNA CTD PMID:15890375 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases activity EXP   6480464 Puromycin Aminonucleoside results in increased activity of CTSD protein CTD PMID:6497855 3,4-methylenedioxymethamphetamine increases expression ISO RGD:732637 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CTSD mRNA CTD PMID:20188158 3-methylcholanthrene increases expression ISO RGD:1351014 6480464 Methylcholanthrene results in increased expression of CTSD mRNA CTD PMID:16257430 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP   6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTSD mRNA CTD PMID:15890375 6alpha-methylprednisolone multiple interactions EXP   6480464 Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 7,12-dimethyltetraphene increases expression EXP   6480464 9,10-Dimethyl-1,2-benzanthracene results in increased expression of CTSD mRNA CTD PMID:12097258 aflatoxin B1 increases expression EXP   6480464 Aflatoxin B1 results in increased expression of CTSD mRNA CTD PMID:15890375 aldehydo-D-glucosamine affects localization ISO RGD:1351014 6480464 Glucosamine affects the localization of CTSD protein CTD PMID:15972124 aldehydo-D-glucosamine increases activity ISO RGD:1351014 6480464 Glucosamine results in increased activity of CTSD protein CTD PMID:16850161 aldehydo-D-glucosamine decreases expression ISO RGD:1351014 6480464 Glucosamine results in decreased expression of CTSD protein alternative form CTD PMID:16850161 aldehydo-D-glucosamine multiple interactions ISO RGD:1351014 6480464 pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form] CTD PMID:16850161 all-trans-retinoic acid increases expression ISO RGD:1351014 6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:17218384 PMID:16054129 all-trans-retinoic acid increases expression ISO RGD:1351014 6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:15498508 more ... all-trans-retinoic acid increases expression ISO RGD:1351014 6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:15498508 more ... all-trans-retinoic acid increases expression ISO RGD:1351014 6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:17218384 more ... all-trans-retinoic acid increases expression ISO RGD:1351014 6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:16054129 more ... amlodipine multiple interactions EXP   6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 amlodipine multiple interactions EXP   6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:14499179 PMID:11829124 amlodipine multiple interactions EXP   6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:14499179 ammonium chloride increases expression EXP   6480464 Ammonium Chloride results in increased expression of CTSD protein CTD PMID:16483693 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of CTSD mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression ISO RGD:1351014 6480464 Benzo(a)pyrene results in decreased expression of CTSD mRNA CTD PMID:17879257 benzo[a]pyrene multiple interactions ISO RGD:1351014 6480464 fulvestrant inhibits the reaction [Benzo(a)pyrene results in increased expression of CTSD mRNA]; more ... CTD PMID:19365803 benzo[a]pyrene increases expression ISO RGD:1351014 6480464 Benzo(a)pyrene analog results in increased expression of CTSD mRNA; more ... CTD PMID:19365803 benzo[a]pyrene increases expression ISO RGD:732637 6480464 Benzo(a)pyrene results in increased expression of CTSD mRNA CTD PMID:21715664 PMID:22228805 benzo[a]pyrene increases expression ISO RGD:732637 6480464 Benzo(a)pyrene results in increased expression of CTSD mRNA CTD PMID:21715664 beta-D-glucosamine affects localization ISO RGD:1351014 6480464 Glucosamine affects the localization of CTSD protein CTD PMID:15972124 beta-D-glucosamine decreases expression ISO RGD:1351014 6480464 Glucosamine results in decreased expression of CTSD protein alternative form CTD PMID:16850161 beta-D-glucosamine multiple interactions ISO RGD:1351014 6480464 pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form] CTD PMID:16850161 beta-D-glucosamine increases activity ISO RGD:1351014 6480464 Glucosamine results in increased activity of CTSD protein CTD PMID:16850161 bisphenol A multiple interactions ISO RGD:1351014 6480464 [bisphenol A results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:14754635 bisphenol A multiple interactions ISO RGD:1351014 6480464 [bisphenol A results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:14754635 PMID:22403704 cadmium dichloride increases expression ISO RGD:1351014 6480464 Cadmium Chloride results in increased expression of CTSD CTD PMID:22041583 cadmium dichloride decreases expression EXP   6480464 Cadmium Chloride results in decreased expression of CTSD mRNA CTD PMID:21297351 cadmium dichloride multiple interactions ISO RGD:1351014 6480464 Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD] CTD PMID:22041583 chloroquine affects localization EXP   6480464 Chloroquine affects the localization of CTSD protein CTD PMID:7715800 chloroquine increases expression EXP   6480464 Chloroquine results in increased expression of CTSD protein CTD PMID:2759144 choline multiple interactions ISO RGD:732637 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTSD mRNA CTD PMID:20938992 cimetidine decreases activity EXP   6480464 Cimetidine results in decreased activity of CTSD protein CTD PMID:12903910 cis-caffeic acid multiple interactions EXP   6480464 caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:20391626 cisplatin increases expression ISO RGD:732637 6480464 Cisplatin results in increased expression of CTSD mRNA CTD PMID:21151649 clofibrate decreases expression ISO RGD:732637 6480464 Clofibrate results in decreased expression of CTSD mRNA CTD PMID:17585979 cobalt dichloride increases expression ISO RGD:1351014 6480464 cobaltous chloride results in increased expression of CTSD mRNA CTD PMID:19320972 PMID:19376846 cocaine affects expression ISO RGD:732637 6480464 Cocaine affects the expression of CTSD mRNA CTD PMID:15681117 copper atom multiple interactions ISO RGD:1351014 6480464 [NSC 689534 binds to Copper] which results in increased expression of CTSD mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1351014 6480464 [NSC 689534 binds to Copper] which results in increased expression of CTSD mRNA CTD PMID:20971185 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; more ... CTD PMID:8534267 cyclophosphamide multiple interactions ISO RGD:732637 6480464 [Cyclophosphamide co-treated with Mecamylamine] results in increased expression of CTSD mRNA CTD PMID:18433785 cyclosporin A increases expression ISO RGD:1351014 6480464 Cyclosporine results in increased expression of CTSD mRNA CTD PMID:20106945 cysteamine increases expression EXP   6480464 Cysteamine results in increased expression of CTSD protein CTD PMID:20165931 cysteamine multiple interactions EXP   6480464 thamira parpam inhibits the reaction [Cysteamine results in increased expression of CTSD protein]; more ... CTD PMID:20165931 DDT multiple interactions ISO RGD:1351014 6480464 [DDT results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:22403704 Delta(9)-tetrahydrocannabinol increases expression ISO RGD:1351014 6480464 Tetrahydrocannabinol results in increased expression of CTSD protein; more ... CTD PMID:18163980 dexamethasone increases expression ISO RGD:732637 6480464 Dexamethasone results in increased expression of CTSD mRNA CTD PMID:21041162 diazoxide multiple interactions EXP   6480464 alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:17623887 diazoxide affects activity EXP   6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 more ... diazoxide multiple interactions EXP   6480464 epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:18294627 diazoxide affects activity EXP   6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 PMID:20391626 diazoxide multiple interactions EXP   6480464 caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:20391626 diazoxide increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:11829124 more ... diazoxide increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:17188415 more ... diazoxide decreases activity EXP   6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:14499179 more ... diazoxide increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:14499179 more ... diazoxide increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:17188415 more ... diazoxide decreases activity EXP   6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:14499179 more ... diazoxide increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:21762681 more ... diazoxide decreases activity EXP   6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:19172585 more ... diazoxide multiple interactions EXP   6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 diazoxide increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:19641666 more ... diazoxide increases expression EXP   6480464 Isoproterenol results in increased expression of CTSD mRNA CTD PMID:17182065 PMID:894732 diazoxide decreases activity EXP   6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:8534267 more ... diazoxide multiple interactions EXP   6480464 Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:21762681 diazoxide multiple interactions EXP   6480464 S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:17182065 diazoxide multiple interactions EXP   6480464 Plant Extracts inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:19641666 diazoxide multiple interactions EXP   6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:14499179 PMID:11829124 diazoxide multiple interactions EXP   6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:14499179 diazoxide multiple interactions EXP   6480464 naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17188415 diazoxide multiple interactions EXP   6480464 Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 diazoxide multiple interactions EXP   6480464 mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:19172585 diazoxide increases expression EXP   6480464 Isoproterenol results in increased expression of CTSD protein CTD PMID:18424012 diazoxide increases expression EXP   6480464 Isoproterenol results in increased expression of CTSD mRNA CTD PMID:894732 PMID:17182065 diazoxide increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:8534267 more ... diazoxide decreases activity EXP   6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:8534267 more ... diazoxide affects activity EXP   6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 diazoxide multiple interactions EXP   6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17045618 diazoxide multiple interactions EXP   6480464 Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; more ... CTD PMID:8534267 dibutyl phthalate decreases expression EXP   6480464 Dibutyl Phthalate results in decreased expression of CTSD mRNA CTD PMID:17379624 diethylstilbestrol increases expression EXP   6480464 Diethylstilbestrol results in increased expression of CTSD mRNA CTD PMID:15890375 disodium cromoglycate multiple interactions ISO RGD:732637 6480464 [pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein CTD PMID:8812242 diuron decreases expression EXP   6480464 Diuron results in decreased expression of CTSD mRNA CTD PMID:21551480 doxorubicin decreases response to substance ISO RGD:1351014 6480464 CTSD protein results in decreased susceptibility to Doxorubicin CTD PMID:18566016 doxorubicin decreases activity EXP   6480464 Doxorubicin results in decreased activity of CTSD protein CTD PMID:12841641 doxorubicin multiple interactions EXP   6480464 Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 doxorubicin decreases expression EXP   6480464 Doxorubicin results in decreased expression of CTSD mRNA CTD PMID:19915844 doxorubicin increases expression ISO RGD:1351014 6480464 Doxorubicin results in increased expression of CTSD protein CTD PMID:18566016 ellagic acid multiple interactions EXP   6480464 Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:21762681 emodin decreases expression ISO RGD:1351014 6480464 Emodin results in decreased expression of CTSD mRNA CTD PMID:16045814 ethambutol multiple interactions EXP   6480464 Ethambutol results in increased expression of and affects the localization of CTSD protein; more ... CTD PMID:19063910 ferulic acid multiple interactions EXP   6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17045618 folic acid multiple interactions ISO RGD:732637 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTSD mRNA CTD PMID:20938992 fulvestrant increases expression ISO RGD:1351014 6480464 fulvestrant results in increased expression of CTSD mRNA CTD PMID:15072547 fulvestrant multiple interactions ISO RGD:1351014 6480464 fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CTSD mRNA] CTD PMID:23219593 fulvestrant decreases expression ISO RGD:1351014 6480464 fulvestrant results in decreased expression of CTSD mRNA CTD PMID:14750165 fulvestrant multiple interactions ISO RGD:1351014 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:19365803 PMID:19654927 fulvestrant multiple interactions ISO RGD:1351014 6480464 fulvestrant inhibits the reaction [Benzo(a)pyrene analog results in increased expression of CTSD mRNA]; more ... CTD PMID:19365803 fulvestrant multiple interactions ISO RGD:1351014 6480464 fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of CTSD mRNA]; more ... CTD PMID:19654927 fumonisin B1 increases expression ISO RGD:732637 6480464 fumonisin B1 results in increased expression of CTSD mRNA CTD PMID:16221962 genistein increases expression ISO RGD:1351014 6480464 Genistein results in increased expression of CTSD mRNA CTD PMID:15090535 genistein decreases expression ISO RGD:732637 6480464 Genistein results in decreased expression of CTSD mRNA CTD PMID:21048042 hydrogen peroxide affects expression ISO RGD:1351014 6480464 Hydrogen Peroxide affects the expression of CTSD protein CTD PMID:21179406 indole-3-methanol decreases expression ISO RGD:1351014 6480464 indole-3-carbinol results in decreased expression of CTSD protein CTD PMID:11110848 isoprenaline multiple interactions EXP   6480464 alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:17623887 isoprenaline affects activity EXP   6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 more ... isoprenaline multiple interactions EXP   6480464 epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:18294627 isoprenaline affects activity EXP   6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 PMID:20391626 isoprenaline multiple interactions EXP   6480464 caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:20391626 isoprenaline increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:11829124 more ... isoprenaline increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:17188415 more ... isoprenaline decreases activity EXP   6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:14499179 more ... isoprenaline increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:14499179 more ... isoprenaline multiple interactions EXP   6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 isoprenaline increases expression EXP   6480464 Isoproterenol results in increased expression of CTSD mRNA CTD PMID:17182065 PMID:894732 isoprenaline increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:17188415 more ... isoprenaline decreases activity EXP   6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:14499179 more ... isoprenaline multiple interactions EXP   6480464 S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:17182065 isoprenaline multiple interactions EXP   6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:14499179 PMID:11829124 isoprenaline multiple interactions EXP   6480464 Plant Extracts inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:19641666 isoprenaline multiple interactions EXP   6480464 naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17188415 isoprenaline multiple interactions EXP   6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:14499179 isoprenaline multiple interactions EXP   6480464 Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 isoprenaline increases expression EXP   6480464 Isoproterenol results in increased expression of CTSD protein CTD PMID:18424012 isoprenaline multiple interactions EXP   6480464 mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:19172585 isoprenaline increases expression EXP   6480464 Isoproterenol results in increased expression of CTSD mRNA CTD PMID:894732 PMID:17182065 isoprenaline increases activity EXP   6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:21762681 more ... isoprenaline decreases activity EXP   6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:19172585 more ... isoprenaline affects activity EXP   6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 isoprenaline multiple interactions EXP   6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17045618 isoprenaline multiple interactions EXP   6480464 Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:21762681 isoprenaline multiple interactions EXP   6480464 Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; more ... CTD PMID:8534267 L-ascorbic acid multiple interactions EXP   6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17045618 L-methionine multiple interactions ISO RGD:732637 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTSD mRNA CTD PMID:20938992 linalool increases expression ISO RGD:1351014 6480464 linalool results in increased expression of CTSD mRNA CTD PMID:19922762 lipoic acid multiple interactions EXP   6480464 Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 lithium atom increases expression EXP   6480464 Lithium results in increased expression of CTSD protein CTD PMID:18296634 lucanthone increases expression ISO RGD:1351014 6480464 Lucanthone results in increased expression of CTSD protein; more ... CTD PMID:21148553 malathion increases expression ISO RGD:732637 6480464 Malathion results in increased expression of CTSD protein CTD PMID:8812242 mangiferin multiple interactions EXP   6480464 mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:19172585 melatonin multiple interactions ISO RGD:1351014 6480464 Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD] CTD PMID:22041583 methamphetamine affects localization EXP   6480464 Methamphetamine affects the localization of CTSD protein CTD PMID:17105920 methapyrilene increases expression EXP   6480464 Methapyrilene results in increased expression of CTSD mRNA CTD PMID:15890375 N-nitrosodimethylamine increases expression EXP   6480464 Dimethylnitrosamine results in increased expression of CTSD mRNA CTD PMID:15890375 N-tosyl-L-phenylalanyl chloromethyl ketone increases expression ISO RGD:1351014 6480464 Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CTSD protein CTD PMID:10772776 naringin multiple interactions EXP   6480464 naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17188415 nitric oxide increases secretion EXP   6480464 Nitric Oxide results in increased secretion of CTSD protein CTD PMID:15040013 nitroglycerin decreases expression EXP   6480464 Nitroglycerin results in decreased expression of CTSD mRNA CTD PMID:12102619 omeprazole multiple interactions EXP   6480464 Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein] CTD PMID:20165931 paracetamol increases expression ISO RGD:732637 6480464 Acetaminophen results in increased expression of CTSD protein CTD PMID:8794998 paracetamol affects expression ISO RGD:732637 6480464 Acetaminophen affects the expression of CTSD mRNA CTD PMID:17562736 paraquat decreases expression ISO RGD:732637 6480464 Paraquat results in decreased expression of CTSD mRNA CTD PMID:16797015 phenacetin increases expression EXP   6480464 Phenacetin results in increased expression of CTSD mRNA CTD PMID:17698508 phenobarbital increases expression EXP   6480464 Phenobarbital results in increased expression of CTSD mRNA CTD PMID:19162173 phenylhydrazine increases expression EXP   6480464 phenylhydrazine results in increased expression of CTSD mRNA CTD PMID:17698508 piperonyl butoxide increases expression EXP   6480464 Piperonyl Butoxide results in increased expression of CTSD mRNA CTD PMID:15890375 piperonyl butoxide increases expression EXP   6480464 Piperonyl Butoxide results in increased expression of CTSD mRNA CTD PMID:15890375 PMID:22484513 pirimiphos-methyl decreases activity EXP   6480464 pirimiphos methyl results in decreased activity of CTSD protein CTD PMID:9204212 pirimiphos-methyl increases activity EXP   6480464 pirimiphos methyl results in increased activity of CTSD protein CTD PMID:9204212 pirinixic acid increases expression ISO RGD:732637 6480464 pirinixic acid results in increased expression of CTSD mRNA CTD PMID:18301758 PMID:20813756 pirinixic acid increases expression ISO RGD:732637 6480464 pirinixic acid results in increased expression of CTSD mRNA CTD PMID:20813756 PMID:18301758 pirinixic acid increases expression EXP   6480464 pirinixic acid results in increased expression of CTSD mRNA CTD PMID:19162173 PMID:15890375 pirinixic acid increases expression EXP   6480464 pirinixic acid results in increased expression of CTSD mRNA CTD PMID:15890375 PMID:19162173 pregnenolone 16alpha-carbonitrile increases expression EXP   6480464 Pregnenolone Carbonitrile results in increased expression of CTSD mRNA CTD PMID:19162173 pristane increases expression ISO RGD:732637 6480464 pristane results in increased expression of CTSD protein CTD PMID:8812242 pristane multiple interactions ISO RGD:732637 6480464 [pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein CTD PMID:8812242 propiconazole increases expression ISO RGD:732637 6480464 propiconazole results in increased expression of CTSD mRNA CTD PMID:22334560 quercetin increases expression ISO RGD:1351014 6480464 Quercetin results in increased expression of CTSD mRNA CTD PMID:15090535 quercetin increases expression ISO RGD:1351014 6480464 Quercetin results in increased expression of CTSD mRNA CTD PMID:15090535 PMID:21632981 resveratrol increases expression ISO RGD:1351014 6480464 resveratrol metabolite results in increased expression of CTSD mRNA CTD PMID:19496085 resveratrol increases expression ISO RGD:1351014 6480464 resveratrol results in increased expression of CTSD mRNA CTD PMID:20878097 resveratrol increases expression ISO RGD:1351014 6480464 resveratrol results in increased expression of CTSD protein CTD PMID:18089832 resveratrol increases expression ISO RGD:1351014 6480464 resveratrol results in increased expression of CTSD CTD PMID:10402233 resveratrol decreases expression ISO RGD:1351014 6480464 resveratrol results in decreased expression of CTSD mRNA CTD PMID:14750165 resveratrol increases expression ISO RGD:732637 6480464 resveratrol results in increased expression of CTSD mRNA CTD PMID:16081268 resveratrol increases secretion ISO RGD:1351014 6480464 resveratrol results in increased secretion of CTSD protein CTD PMID:16393696 resveratrol affects expression ISO RGD:1351014 6480464 resveratrol affects the expression of CTSD mRNA CTD PMID:16393696 resveratrol affects response to substance ISO RGD:1351014 6480464 CTSD protein affects the susceptibility to resveratrol CTD PMID:17116725 resveratrol multiple interactions ISO RGD:1351014 6480464 ESR1 protein affects the reaction [resveratrol affects the secretion of CTSD protein]; more ... CTD PMID:16393696 resveratrol multiple interactions ISO RGD:1351014 6480464 CTSD protein affects the reaction [resveratrol affects the localization of CYCS protein]; more ... CTD PMID:17116725 retinyl acetate increases expression ISO RGD:732637 6480464 retinol acetate results in increased expression of CTSD mRNA CTD PMID:16772331 stilben-4-ol increases expression ISO RGD:1351014 6480464 4-hydroxystilbene results in increased expression of CTSD mRNA CTD PMID:19496085 stilbene-4,4'-diol increases expression ISO RGD:1351014 6480464 4,4'-dihydroxystilbene results in increased expression of CTSD mRNA CTD PMID:19496085 tamibarotene increases expression ISO RGD:1351014 6480464 Am 80 results in increased expression of CTSD mRNA; more ... CTD PMID:15498508 trans-resveratrol increases expression ISO RGD:1351014 6480464 resveratrol metabolite results in increased expression of CTSD mRNA CTD PMID:19496085 trans-resveratrol increases expression ISO RGD:1351014 6480464 resveratrol results in increased expression of CTSD mRNA CTD PMID:20878097 trans-resveratrol increases expression ISO RGD:1351014 6480464 resveratrol results in increased expression of CTSD protein CTD PMID:18089832 trans-resveratrol increases expression ISO RGD:1351014 6480464 resveratrol results in increased expression of CTSD CTD PMID:10402233 trans-resveratrol decreases expression ISO RGD:1351014 6480464 resveratrol results in decreased expression of CTSD mRNA CTD PMID:14750165 trans-resveratrol multiple interactions ISO RGD:1351014 6480464 CTSD protein affects the reaction [resveratrol affects the localization of CYCS protein]; more ... CTD PMID:17116725 trans-resveratrol multiple interactions ISO RGD:1351014 6480464 ESR1 protein affects the reaction [resveratrol affects the secretion of CTSD protein]; more ... CTD PMID:16393696 trans-resveratrol affects response to substance ISO RGD:1351014 6480464 CTSD protein affects the susceptibility to resveratrol CTD PMID:17116725 trans-resveratrol affects expression ISO RGD:1351014 6480464 resveratrol affects the expression of CTSD mRNA CTD PMID:16393696 trans-resveratrol increases secretion ISO RGD:1351014 6480464 resveratrol results in increased secretion of CTSD protein CTD PMID:16393696 trans-resveratrol increases expression ISO RGD:732637 6480464 resveratrol results in increased expression of CTSD mRNA CTD PMID:16081268 vancomycin decreases expression ISO RGD:732637 6480464 Vancomycin results in decreased expression of CTSD mRNA CTD PMID:18930951 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) autophagic vacuole assembly   ISO RGD:732637 1624291 MGI:MGI:3057045|PMID:15452145 RGD MGI:MGI:3057045 PMID:15452145 autophagic vacuole assembly   IEA Ensembl:ENSMUSP00000121203 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 autophagy   IEP   1643198   RGD   epithelial tube branching involved in lung morphogenesis NOT ISO RGD:732637 1624291 MGI:MGI:3722010|PMID:17500053 RGD MGI:MGI:3722010 PMID:17500053 metabolic process   ISO RGD:732637 1624291 MGI:MGI:3848759|PMID:19293336 RGD MGI:MGI:3848759 PMID:19293336 metabolic process   ISO RGD:732637 1624291 MGI:MGI:3527911|PMID:15588329 RGD MGI:MGI:3527911 PMID:15588329 metabolic process   ISO RGD:732637 1624291 MGI:MGI:3653585|PMID:16423528 RGD MGI:MGI:3653585 PMID:16423528 proteolysis   IDA   1299317   RGD   proteolysis   IEA UniProtKB-KW:KW-0645 1600115 GO_REF:0000038 UniProtKB GO_REF:0000038 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) extracellular matrix colocalizes_with ISO RGD:1351014 1624291 PMID:20551380 RGD PMID:20551380 extracellular matrix   IEA Ensembl:ENSP00000236671 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 extracellular space   ISO RGD:1351014 1624291 PMID:20551380 RGD PMID:20551380 extracellular space   IEA Ensembl:ENSP00000236671 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 extracellular space   IEA UniProtKB-SubCell:SL-0112 1600115 GO_REF:0000039 UniProtKB GO_REF:0000039 lysosome   IDA   1299317   RGD   lysosome   IEA Ensembl:ENSMUSP00000121203 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 lysosome   ISO RGD:1351014 1624291 PMID:19723497 RGD PMID:19723497 lysosome   ISO RGD:1351014 1624291 PMID:1837142 RGD PMID:1837142 lysosome   IDA   1600623   RGD   lysosome   IDA   1625498   RGD   lysosome   ISO RGD:732637 1624291 MGI:MGI:3057045|PMID:15452145 RGD MGI:MGI:3057045 PMID:15452145 lysosome   ISO RGD:732637 1624291 MGI:MGI:86330|PMID:9034150 RGD MGI:MGI:86330 PMID:9034150 lysosome   ISO RGD:732637 1624291 MGI:MGI:3608104|PMID:16242638 RGD MGI:MGI:3608104 PMID:16242638 lysosome   ISO RGD:732637 1624291 MGI:MGI:1352198|PMID:10591619 RGD MGI:MGI:1352198 PMID:10591619 lysosome   ISO RGD:732637 1624291 MGI:MGI:1271008|PMID:9645704 RGD MGI:MGI:1271008 PMID:9645704 lysosome   ISO RGD:732637 1624291 MGI:MGI:2673081|PMID:12775715 RGD MGI:MGI:2673081 PMID:12775715 melanosome   IEA UniProtKB-SubCell:SL-0161 1600115 GO_REF:0000039 UniProtKB GO_REF:0000039 mitochondrion   ISO RGD:732637 1624291 MGI:MGI:2682130|PMID:14651853 RGD MGI:MGI:2682130 PMID:14651853 mitochondrion   IEA Ensembl:ENSMUSP00000121203 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) aspartic-type endopeptidase activity   ISO RGD:732637 1624291 MGI:MGI:3848759|PMID:19293336 RGD MGI:MGI:3848759 PMID:19293336 aspartic-type endopeptidase activity   IEA Ensembl:ENSMUSP00000121203 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 aspartic-type endopeptidase activity   IEA UniProtKB-KW:KW-0064 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 endopeptidase activity   IMP   1625507   RGD   endopeptidase activity   IDA   1600623   RGD   endopeptidase activity   IDA   1625498   RGD   endopeptidase activity   IDA   1299317   RGD   peptidase activity   ISO RGD:732637 1624291 MGI:MGI:3653585|PMID:16423528 RGD MGI:MGI:3653585 PMID:16423528 peptidase activity   ISO RGD:732637 1624291 MGI:MGI:3527911|PMID:15588329 RGD MGI:MGI:3527911 PMID:15588329 peptide binding   IDA   1625498   RGD   Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) autophagy pathway   IEP   1643198   RGD   ceramide signaling pathway   ISO RGD:1351014 6484113   PID PID:200119 Mycobacterium tuberculosis infection pathway   IEA RGD:621511 6907045   KEGG rno:05152 External Database Links KEGG Pathway Lysosome Tuberculosis Pathway Interaction Database Ceramide signaling pathway (PID:200119) Direct p53 effectors (PID:200120) LKB1 signaling events (PID:200074) Validated nuclear estrogen receptor alpha network (PID:200158) Disease Annotations Alzheimer Disease  (ISS) Atherosclerosis  (ISS) Breast Neoplasms  (ISS) Ceroid Lipofuscinosis, Neuronal, 10  (ISS) Neoplasm Metastasis  (ISS) Gene-Chemical Interaction Annotations (+)-alpha-tocopherol  (EXP) (+)-pilocarpine  (EXP) (-)-epigallocatechin 3-gallate  (EXP) (R)-lipoic acid  (EXP) (S)-amphetamine  (ISO) 1,2,4-trimethylbenzene  (EXP) 17beta-estradiol  (ISO) 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 2-amino-2-deoxy-D-glucopyranose  (ISO) 2-butoxyethanol  (ISO) 2-nitrofluorene  (EXP) 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP) 3,4-methylenedioxymethamphetamine  (ISO) 3-methylcholanthrene  (ISO) 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP) 6alpha-methylprednisolone  (EXP) 7,12-dimethyltetraphene  (EXP) aflatoxin B1  (EXP) aldehydo-D-glucosamine  (ISO) all-trans-retinoic acid  (ISO) amlodipine  (EXP) ammonium chloride  (EXP) benzo[a]pyrene  (ISO) beta-D-glucosamine  (ISO) bisphenol A  (ISO) cadmium dichloride  (EXP,ISO) chloroquine  (EXP) choline  (ISO) cimetidine  (EXP) cis-caffeic acid  (EXP) cisplatin  (ISO) clofibrate  (ISO) cobalt dichloride  (ISO) cocaine  (ISO) copper atom  (ISO) copper(0)  (ISO) curcumin  (EXP) cyclophosphamide  (ISO) cyclosporin A  (ISO) cysteamine  (EXP) DDT  (ISO) Delta(9)-tetrahydrocannabinol  (ISO) dexamethasone  (ISO) diazoxide  (EXP) dibutyl phthalate  (EXP) diethylstilbestrol  (EXP) disodium cromoglycate  (ISO) diuron  (EXP) doxorubicin  (EXP,ISO) ellagic acid  (EXP) emodin  (ISO) ethambutol  (EXP) ferulic acid  (EXP) folic acid  (ISO) fulvestrant  (ISO) fumonisin B1  (ISO) genistein  (ISO) hydrogen peroxide  (ISO) indole-3-methanol  (ISO) isoprenaline  (EXP) L-ascorbic acid  (EXP) L-methionine  (ISO) linalool  (ISO) lipoic acid  (EXP) lithium atom  (EXP) lucanthone  (ISO) malathion  (ISO) mangiferin  (EXP) melatonin  (ISO) methamphetamine  (EXP) methapyrilene  (EXP) N-nitrosodimethylamine  (EXP) N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO) naringin  (EXP) nitric oxide  (EXP) nitroglycerin  (EXP) omeprazole  (EXP) paracetamol  (ISO) paraquat  (ISO) phenacetin  (EXP) phenobarbital  (EXP) phenylhydrazine  (EXP) piperonyl butoxide  (EXP) pirimiphos-methyl  (EXP) pirinixic acid  (EXP,ISO) pregnenolone 16alpha-carbonitrile  (EXP) pristane  (ISO) propiconazole  (ISO) quercetin  (ISO) resveratrol  (ISO) retinyl acetate  (ISO) stilben-4-ol  (ISO) stilbene-4,4'-diol  (ISO) tamibarotene  (ISO) trans-resveratrol  (ISO) vancomycin  (ISO) Gene Ontology Annotations Biological Process autophagic vacuole assembly  (IEA,ISO) autophagy  (IEP) epithelial tube branching involved in lung morphogenesis  (ISO) metabolic process  (ISO) proteolysis  (IDA,IEA) Cellular Component extracellular matrix  (IEA,ISO) extracellular space  (IEA,ISO) lysosome  (IDA,IEA,ISO) melanosome  (IEA) mitochondrion  (IEA,ISO) Molecular Function aspartic-type endopeptidase activity  (IEA,ISO) endopeptidase activity  (IDA,IMP) peptidase activity  (ISO) peptide binding  (IDA) Molecular Pathway Annotations autophagy pathway  (IEP) ceramide signaling pathway  (ISO) Mycobacterium tuberculosis infection pathway  (IEA) External Database Links KEGG Pathway Lysosome Tuberculosis Pathway Interaction Database Ceramide signaling pathway (PID:200119) Direct p53 effectors (PID:200120) LKB1 signaling events (PID:200074) Validated nuclear estrogen receptor alpha network (PID:200158) References - curated 1. Benes P, etal., Comp Biochem Physiol B Biochem Mol Biol 2002 Sep;133(1):113-8. 2. Birch NP and Loh YP, Nucleic Acids Res 1990 Nov 11;18(21):6445-6. 3. Burdan F, etal., Acta Physiol Hung 2003;90(1):47-56. 4. Gandour-Edwards R, etal., Head Neck 1999 Dec;21(8):718-22. 5. Glondu M, etal., Oncogene 2002 Aug 1;21(33):5127-34. 6. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45. 7. Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7. 8. Menzer G, etal., Am J Med Genet 2001 Mar 8;105(2):179-82. 9. MGD data from the GO Consortium 10. NCBI rat LocusLink and RefSeq merged data July 26, 2002 11. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 12. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 13. Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1996 Jan 26;154(2):165-70. 14. RGD automated data pipeline 15. RGD automated import pipeline for gene-chemical interactions 16. RGD Automated Pipelines 17. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8. 18. Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. 19. Wohlgemuth SE, etal., Rejuvenation Res. 2007 Sep;10(3):281-92. References - uncurated PubMed 14631510   14977632   15456852   16914181   17105920   17285857   18419753   18420735   1883350   18840968   19819948   21374014   23295649   3182800 RGD Disease Portals Ctsd has been annotated in the following RGD Disease Portals. Cancer Diseases Cancer Pathways Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Obesity Diseases Obesity Pathways Respiratory Pathways Genomics Comparative Map Data Ctsd   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   NCBI RGSC Genome Assembly v5.0 1 222,436,922 - 222,448,798 - NCBI RGSC Genome Assembly v3.4 1 202,619,669 - 202,631,545 - NCBI Rat Celera Assembly 1 195,146,345 - 195,158,236 - NCBI Genome Assembly 3.1 1 202,779,384 - 202,791,261 - NCBI CTSD   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 1,708,731 - 1,719,969 - NCBI Human Genome Assembly HuRef 11 1,564,872 - 1,576,226 - NCBI Human Genome Assembly GRCh37 11 1,773,982 - 1,785,222 - NCBI Human Genome Assembly Build 36 11 1,730,561 - 1,741,798 - NCBI Human Cytogenetic Map 11 p15.5   NCBI Human Genome Assembly 11 1,730,560 - 1,741,798   NCBI Ctsd   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 142,375,916 - 142,387,870 - NCBI Mouse cM Map 7   - NCBI Mouse Celera Assembly 7 142,131,673 - 142,143,627 - NCBI Mouse Genome Assembly Build 37 7 149,561,821 - 149,573,775 - NCBI Mouse Genome Assembly Build 36.1 7 149,561,821 - 149,573,775 - NCBI Mouse Cytogenetic Map 7 F5   NCBI Position Markers D1Bda43   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 222,437,169 - 222,437,481   UniSTS RGSC Genome Assembly v3.4 1 202,619,916 - 202,620,228   UniSTS Rat Celera Assembly 1 195,146,592 - 195,146,904   UniSTS UniSTS:498756   Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   UniSTS RGSC Genome Assembly v5.0 1 222,437,203 - 222,438,510   UniSTS RGSC Genome Assembly v3.4 1 202,619,950 - 202,621,257   UniSTS Rat Celera Assembly 1 195,146,626 - 195,147,948   UniSTS QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 Glucose level 1 43872827 204280278 Rat 1578780 Cm52 Cardiac mass QTL 52 3.3 .0001 Cardiac mass 1 81342810 225814178 Rat 1331749 Hrtrt11 Heart rate QTL 11 2.973 Heart rate 1 94473940 203303100 Rat 70209 Niddm23 Non-insulin dependent diabetes mellitus QTL 23 2.82 Glucose level fasting 1 94473940 203416143 Rat 731168 Bp154 Blood pressure QTL 154 3.4 Blood pressure systolic 1 94624828 220639653 Rat 1354591 Cm36 Cardiac mass QTL 36 4.1 Cardiac mass left ventricle adjusted for tibia length 1 103149923 206567907 Rat 1354615 Cm32 Cardiac mass QTL 32 5.2 Cardiac mass left ventricle 1 103149923 206567907 Rat 1354606 Bp246 Blood pressure QTL 246 3.6 Blood pressure pulse pressure 1 103149923 224426393 Rat 1600363 Hc6 Hypercalciuria QTL 6 2.7 Renal function calcium excretion 1 112148733 250430505 Rat 631205 Bp196 Blood pressure QTL 196 4 .0001 Blood pressure mean arterial 1 119780561 204280278 Rat 631549 Bp89 Blood pressure QTL 89 5.7 Blood pressure 1 124614852 206574205 Rat 1598853 Memor3 Memory QTL 3 4.5 Memory navigation-spatial 1 146189650 218467340 Rat 61341 Bp26 Blood pressure QTL 26 Blood pressure 1 146971846 202915231 Rat 724562 Rends1 Renal damage susceptibility QTL 1 .05 Renal histology renal lesion severity 1 146971846 202915231 Rat 737828 Hcas3 Hepatocarcinoma susceptibility QTL 3 4.9 Liver tumor susceptibility nodule number 1 146971846 228781113 Rat 2302378 Insul11 Insulin level QTL 11 3.25 Insulin level 1 146971846 247322277 Rat 61348 Bp30 Blood pressure QTL 30 2.4 Blood pressure salt-loaded systolic 1 153220905 202915231 Rat 724531 Uae5 Urinary albumin excretion QTL 5 4 Renal function urine albumin level 1 153578442 259173490 Rat 1354602 Bw35 Body weight QTL 35 12.2 Body weight 1 154074905 206567907 Rat 1354620 Kidm19 Kidney mass QTL 19 4 Kidney mass left kidney mass adjusted for tibia length 1 154074905 206567907 Rat 1354634 Kidm12 Kidney mass QTL 12 3.9 Kidney mass right kidney mass 1 154074905 206567907 Rat 1354636 Lmblg1 Limb length QTL 1 6.4 Limb morphology tibia length 1 154074905 206567907 Rat 1354610 Bw34 Body weight QTL 34 4.1 Body weight 1 154074905 263699089 Rat 1354646 Kidm18 Kidney mass QTL 18 5.7 Kidney mass right kidney mass adjusted for body weight 1 154074905 263699089 Rat 1354661 Bw33 Body weight QTL 33 5.2 Body weight 1 154074905 263699089 Rat 1358886 Bp260 Blood pressure QTL 260 3.67 Blood pressure post nitric oxide system block 1 154075310 231726050 Rat 1549837 Hcar15 Hepatocarcinoma resistance QTL 15 .05 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced 1 156124624 247322277 Rat 2303622 Vencon6 Ventilatory control QTL 6 .001 Ventilatory control re-oxygenation after hypoxia 1 158856292 203856292 Rat 1354618 Kidm15 Kidney mass QTL 15 5 Kidney mass left kidney mass 1 159782445 206567907 Rat 2312420 Pur17 Proteinuria QTL 17 7.1 .0001 Renal function urine protein level 1 159782445 224426393 Rat 1354580 Scort1 Serum corticosterone level QTL 1 3.4 Hormone level corticosterone 1 159782445 263699089 Rat 61347 Bp197 Blood pressure QTL 197 4.2 Blood pressure systolic blood pressure 1 163190108 208190108 Rat 2292222 Bp307 Blood pressure QTL 307 3.06 .0014 Blood pressure systolic 1 167931220 219629888 Rat 2292220 Bp306 Blood pressure QTL 306 3.47 .00087 Blood pressure systolic 1 167931220 250119874 Rat 1354653 Despr9 Despair related QTL 9 .00019 Activity level climbing level 1 172723568 217723568 Rat 1358294 Bw37 Body weight QTL 37 5 .000011 Body weight 1 176292515 221292515 Rat 2293654 Bss30 Bone structure and strength QTL 30 32.65 .0001 Bone structure 1 176612333 221612333 Rat 2293673 Bss27 Bone structure and strength QTL 27 18.63 .0001 Bone structure 1 176612333 221612333 Rat 2293677 Bss41 Bone structure and strength QTL 41 9.38 .0001 Bone structure 1 176612333 221612333 Rat 2293689 Bss47 Bone structure and strength QTL 47 7.25 .0001 Bone structure 1 176612333 221612333 Rat 2293693 Bss22 Bone structure and strength QTL 22 33.52 .0001 Bone structure 1 176612333 221612333 Rat 2300161 Bmd43 Bone mineral density QTL 43 8.4 .0001 Bone mineral density 1 176612333 221612333 Rat 2300174 Bmd42 Bone mineral density QTL 42 8.4 .0001 Bone mineral density 1 176612333 221612333 Rat 2300187 Bmd41 Bone mineral density QTL 41 8.9 .0001 Bone mineral density 1 176612333 221612333 Rat 1549830 Bss1 Bone structure and strength QTL 1 4.8 Bone strength Femoral ultimate force 1 177666790 222666790 Rat 70163 Bw20 Body weight QTL 20 5.1 Body weight 1 178054386 247322277 Rat 738032 Hcas5 Hepatocarcinoma susceptibility QTL 5 3.12 Liver tumor susceptibility nodule number 1 180678929 265343617 Rat 1354624 Cm35 Cardiac mass QTL35 5.7 Cardiac mass left ventricle adjusted for body weight 1 181524849 263699089 Rat 1354652 Kidm20 Kidney mass QTL 20 4.3 Kidney mass left kidney mass adjusted for body weight 1 181524849 263699089 Rat 1600380 Niddm70 Non-insulin dependent diabetes mellitus QTL 70 3.1 .0008 Insulin level 1 181780342 226780342 Rat 634321 Hc1 Hypercalciuria QTL 1 2.91 Renal function calcium excretion 1 183163129 248833756 Rat 1578759 Uae30 Urinary albumin excretion QTL 30 3.3 .003 Renal function urine albumin level 1 183946692 267910886 Rat 1578763 Kidm29 Kidney mass QTL 29 3.3 .0001 Kidney mass 1 183946692 267910886 Rat 1558658 Bw59 Body weight QTL 59 3.5 .0003 Body weight 1 184074275 229074275 Rat 1302787 Stl25 Serum triglyceride level QTL 25 2.7 .0073 Lipid level triglyceride level 1 184857716 216663271 Rat 6903303 Scl34 Serum cholesterol QTL 34 2.5 .0033 Lipid level cholesterol level 1 184857716 223729371 Rat 724559 Pancm1 Pancreatic morphology QTL 1 7.1 Pancreatic morphology 1 186391887 220639539 Rat 2293083 Iddm25 Insulin dependent diabetes mellitus QTL 25 3.03 Glucose level insulin-dependent 1 186471692 230411453 Rat 1300145 Rf7 Renal function QTL 7 2.96 Renal function salt-loaded urine creatinine concentration 1 189900686 227005733 Rat 1359018 Hrtrt20 Heart rate QTL 20 3.08 Heart rate stress-induced tachycardia 1 190114247 208110419 Rat 2312564 Glom18 Glomerulus QTL 18 2.4 .003 Renal pathology 1 190114247 238037551 Rat 631837 Niddm35 Non-insulin dependent diabetes mellitus QTL 35 .01 Insulin level 1 190677683 235677683 Rat 1582206 Kidm33 Kidney mass QTL 33 6.9 Kidney mass 1 193069836 229876997 Rat 1358898 Bp255 Blood pressure QTL 255 3.6 Blood pressure post nitric oxide system block 1 195927908 252497797 Rat 631260 Tcas2 Tongue tumor susceptibility QTL 2 4.5 Tongue tumor susceptibility 1 197423292 204280406 Rat 1358191 Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 3.8 Gland mass pituitary 1 197770157 250119666 Rat 61455 Niddm7 Non-insulin dependent diabetes mellitus QTL 7 5.5 Glucose level 1 198139596 243139596 Rat 634338 Hcar4 Hepatocarcinoma resistance QTL 4 4.6 Liver tumor resistance 3-methyl-4-dimethylaminoazobenzene induced 1 198396580 220639653 Rat 6480780 Insul18 Insulin level QTL 18 4.11 Insulin level fasting 1 198853034 205897680 Rat 6480783 Insul19 Insulin level QTL 19 4.33 Insulin level sensitivity 1 198853034 205897680 Rat 634312 Bp143 Blood pressure QTL 143 3 .0002 Blood pressure systolic 1 198853034 225625256 Rat 1600388 Niddm67 Non-insulin dependent diabetes mellitus QTL 67 5.84 .000004 Glucose level 1 200882874 264367394 Rat 1600395 Niddm69 Non-insulin dependent diabetes mellitus QTL 69 4.14 .0002 Insulin level 1 200882874 264367394 Rat 1600396 Niddm68 Non-insulin dependent diabetes mellitus QTL 68 4.97 .0003 Glucose level 1 200882874 264367394 Rat 631658 Cm7 Cardiac mass QTL 7 5.32 .0001 Cardiac mass aorta 1 201920676 246920676 Rat 1358292 Cm37 Cardiac mass QTL 37 6.2 .00000081 Cardiac mass cardiac mass index 1 201920676 246920676 Rat 61345 Rf1 Renal disease susceptibility QTL 1 8.9 Renal function urine protein excretion rate 1 202322277 247322277 Rat 6480777 Insul17 Insulin level QTL 17 3.86 Insulin level 1 202350579 203303100 Rat Sequence Nucleotide Sequences Nucleotide RefSeqs NM_134334 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06009392 (Get FASTA) Search GEO for Microarray Profiles   AAHX01009092 (Get FASTA) Search GEO for Microarray Profiles   AAHX01009093 (Get FASTA) Search GEO for Microarray Profiles   BC062032 (Get FASTA) Search GEO for Microarray Profiles   CH473953 (Get FASTA) Search GEO for Microarray Profiles   FQ213891 (Get FASTA) Search GEO for Microarray Profiles   FQ228180 (Get FASTA) Search GEO for Microarray Profiles   FQ232703 (Get FASTA) Search GEO for Microarray Profiles   X54467 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_134334 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_599161 Peptide Label: precursor Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 1 222,436,922 - 222,448,798 - NCBI RGSC Genome Assembly v3.4 1 202,619,669 - 202,631,545 - RGD Rat Celera Assembly 1 195,146,345 - 195,158,236 - RGD Protein Sequences Protein RefSeqs NP_599161 (Get FASTA) GenBank Protein AAH62032 (Get FASTA)   CAA38349 (Get FASTA)   EDM12124 (Get FASTA)   EDM12125 (Get FASTA)   EDM12126 (Get FASTA)   P24268 (Get FASTA) Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000020206 ENTREZGENE, UniProtKB/TrEMBL Ensembl Protein ENSRNOP00000027407 ENTREZGENE, UniProtKB/TrEMBL Ensembl Transcript ENSRNOT00000027407 ENTREZGENE, UniProtKB/TrEMBL Entrez Gene 171293 ENTREZGENE Gene3D-CATH Pept_Aspartc_cat UniProtKB/Swiss-Prot Germonline ENSRNOG00000020206 UniProtKB/Swiss-Prot HomoloGene Group ID 55616 ENTREZGENE IMAGE_CLONE IMAGE:5623627 IMAGE-MGC_LOAD InterPro Peptidase_A1 UniProtKB/Swiss-Prot   Peptidase_aspartic UniProtKB/Swiss-Prot   Peptidase_aspartic_AS UniProtKB/Swiss-Prot   Propep_A1 UniProtKB/Swiss-Prot IPI IPI00212731 UniProtKB/Swiss-Prot   IPI00421525 UniProtKB/TrEMBL KEGG Report rno:171293 ENTREZGENE, UniProtKB/TrEMBL MGC_CLONE MGC:72315 IMAGE-MGC_LOAD PANTHER Peptidase_A1 UniProtKB/Swiss-Prot Pfam A1_Propeptide UniProtKB/Swiss-Prot   Asp UniProtKB/Swiss-Prot PRINTS PEPSIN UniProtKB/Swiss-Prot PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot Superfamily-SCOP Pept_Aspartic UniProtKB/Swiss-Prot UniGene Rn.11085 ENTREZGENE UniProt CATD_RAT UniProtKB/Swiss-Prot   Q6P6T6_RAT UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2005-01-20 Ctsd  cathepsin D      Symbol and Name status set to approved 10779 APPROVED 2002-08-07 Ctsd        Symbol and Name status set to provisional 1724 PROVISIONAL RGD Curation Notes Note Type Note Reference gene_cellular_localization found secreted in mammal breast milk 1299318

More on Ctsd Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 621511 Created: 2002-08-06 Species: Rattus norvegicus Last Modified: 2013-04-23 Status: ACTIVE