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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | ISO | RGD:1347719 | 6480464 | Estradiol results in decreased expression of MLL mRNA | CTD | PMID:19167446 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10900 | 6480464 | Tetrachlorodibenzodioxin affects the expression of MLL1 mRNA | CTD | PMID:18691609 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of MLL mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of MLL mRNA | CTD | PMID:21346803 | aflatoxin B1 | increases expression | ISO | RGD:10900 | 6480464 | Aflatoxin B1 results in increased expression of MLL1 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | decreases expression | ISO | RGD:1347719 | 6480464 | Benzo(a)pyrene results in decreased expression of MLL mRNA | CTD | PMID:22316170 | bisphenol A | decreases expression | ISO | RGD:1347719 | 6480464 | bisphenol A results in decreased expression of MLL mRNA | CTD | PMID:22576693 | bisphenol A | increases methylation | ISO | RGD:1347719 | 6480464 | bisphenol A results in increased methylation of MLL gene | CTD | PMID:22576693 | cisplatin | affects response to substance | ISO | RGD:1347719 | 6480464 | MLL protein affects the susceptibility to Cisplatin | CTD | PMID:16217747 | cladribine | increases response to substance | ISO | RGD:1347719 | 6480464 | MLL gene mutant form results in increased susceptibility to Cladribine | CTD | PMID:14712291 | clozapine | increases expression | ISO | RGD:1347719 | 6480464 | Clozapine results in increased expression of MLL mRNA | CTD | PMID:17942719 | clozapine | decreases expression | ISO | RGD:10900 | 6480464 | Clozapine results in decreased expression of MLL1 mRNA | CTD | PMID:14647396 | clozapine | increases expression | ISO | RGD:10900 | 6480464 | Clozapine results in increased expression of MLL1 mRNA | CTD | PMID:17942719 | clozapine | multiple interactions | ISO | RGD:10900 | 6480464 | Clozapine promotes the reaction [MLL1 protein binds to GAD1 promoter] | CTD | PMID:17942719 | copper(2+) sulfate | decreases expression | ISO | RGD:1347719 | 6480464 | Copper Sulfate results in decreased expression of MLL mRNA | CTD | PMID:19549813 | cytarabine | increases response to substance | ISO | RGD:1347719 | 6480464 | MLL gene mutant form results in increased susceptibility to Cytarabine | CTD | PMID:14712291 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of MLL1 mRNA | CTD | PMID:21266533 | doxorubicin | decreases response to substance | ISO | RGD:1347719 | 6480464 | MLL mRNA results in decreased susceptibility to Doxorubicin | CTD | PMID:16322897 | doxorubicin | decreases response to substance | ISO | RGD:1347719 | 6480464 | MLL gene mutant form results in decreased susceptibility to Doxorubicin | CTD | PMID:14712291 | etoposide | increases response to substance | ISO | RGD:1347719 | 6480464 | MLL gene mutant form results in increased susceptibility to Etoposide | CTD | PMID:14712291 | genistein | increases mutagenesis | ISO | RGD:1347719 | 6480464 | Genistein results in increased mutagenesis of MLL gene | CTD | PMID:17468513 | haloperidol | decreases expression | ISO | RGD:10900 | 6480464 | Haloperidol results in decreased expression of MLL1 mRNA | CTD | PMID:14647396 | kaempferol | increases mutagenesis | ISO | RGD:1347719 | 6480464 | kaempferol results in increased mutagenesis of MLL gene | CTD | PMID:17468513 | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of MLL1 mRNA | CTD | PMID:22110744 | permethrin | increases mutagenesis | ISO | RGD:1347719 | 6480464 | Permethrin results in increased mutagenesis of MLL gene | CTD | PMID:12937054 | pirinixic acid | decreases expression | ISO | RGD:10900 | 6480464 | pirinixic acid results in decreased expression of MLL1 mRNA | CTD | PMID:17426115 | prednisolone | decreases response to substance | ISO | RGD:1347719 | 6480464 | MLL gene mutant form results in decreased susceptibility to Prednisolone | CTD | PMID:14712291 | quercetin | decreases expression | ISO | RGD:1347719 | 6480464 | Quercetin results in decreased expression of MLL mRNA | CTD | PMID:15309432 | quercetin | increases mutagenesis | ISO | RGD:1347719 | 6480464 | Quercetin results in increased mutagenesis of MLL gene | CTD | PMID:17468513 | testosterone enanthate | affects expression | ISO | RGD:1347719 | 6480464 | testosterone enanthate affects the expression of MLL mRNA | CTD | PMID:17440010 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Lysine degradation |
| Transcriptional misregulation in cancer | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Lysine degradation |
| Transcriptional misregulation in cancer | |
References - curated| 1. |
RGD automated data pipeline |
| 2. |
RGD automated import pipeline for gene-chemical interactions |
| 3. |
RGD comprehensive gene curation |
| 4. |
Thirman MJ, etal., N Engl J Med. 1993 Sep 23;329(13):909-14. |
RGD Disease Portals| Kmt2a has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Kmt2a (Rattus norvegicus) |
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| KMT2A (Homo sapiens) |
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| Mll1 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | XM_003750506 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_003754423 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06054545 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01054367 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01054368 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01054369 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01054370 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473975 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225552 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230296 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230992 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232224 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233101 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234118 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001108139 | |||||||||||||||
| RefSeq Status: | ||||||||||||||||
| Type: | CODING | |||||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003750506 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_003750554 | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003754423 |
| RefSeq Status: | |
| Type: | CODING |
| Protein Acc Id: | XP_003754471 |
| Position: | No map positions available. |
Protein Sequences| Protein RefSeqs | XP_003750554 | (Get FASTA) |
| XP_003754471 | (Get FASTA) | |
| GenBank Protein | EDL95339 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015133 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000020573 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000020573 | UniProtKB/TrEMBL |
| Entrez Gene | 315606 | ENTREZGENE |
| Gene3D-CATH | Znf_RING/FYVE/PHD | UniProtKB/TrEMBL |
| HomoloGene Group ID | 4338 | ENTREZGENE |
| InterPro | AT_hook_DNA-bd_motif | UniProtKB/TrEMBL |
| Bromodomain | UniProtKB/TrEMBL | |
| FYrich_C | UniProtKB/TrEMBL | |
| FYrich_N | UniProtKB/TrEMBL | |
| MeTrfase_trithorax | UniProtKB/TrEMBL | |
| Post-SET_dom | UniProtKB/TrEMBL | |
| SET_dom | UniProtKB/TrEMBL | |
| Znf_CXXC | UniProtKB/TrEMBL | |
| Znf_FYVE_PHD | UniProtKB/TrEMBL | |
| Znf_PHD | UniProtKB/TrEMBL | |
| Znf_PHD-finger | UniProtKB/TrEMBL | |
| Znf_RING/FYVE/PHD | UniProtKB/TrEMBL | |
| IPI | IPI00870656 | UniProtKB/TrEMBL |
| KEGG Report | rno:315606 | ENTREZGENE |
| Pfam | FYRC | UniProtKB/TrEMBL |
| FYRN | UniProtKB/TrEMBL | |
| PHD | UniProtKB/TrEMBL | |
| SET | UniProtKB/TrEMBL | |
| zf-CXXC | UniProtKB/TrEMBL | |
| PharmGKB | MLL | RGD |
| PIRSF | Methyltransferase_trithorax | UniProtKB/TrEMBL |
| PROSITE | BROMODOMAIN_2 | UniProtKB/TrEMBL |
| FYRC | UniProtKB/TrEMBL | |
| FYRN | UniProtKB/TrEMBL | |
| POST_SET | UniProtKB/TrEMBL | |
| SET | UniProtKB/TrEMBL | |
| ZF_CXXC | UniProtKB/TrEMBL | |
| ZF_PHD_2 | UniProtKB/TrEMBL | |
| SMART | AT_hook | UniProtKB/TrEMBL |
| BROMO | UniProtKB/TrEMBL | |
| FYRC | UniProtKB/TrEMBL | |
| FYRN | UniProtKB/TrEMBL | |
| PHD | UniProtKB/TrEMBL | |
| PostSET | UniProtKB/TrEMBL | |
| SET | UniProtKB/TrEMBL | |
| Superfamily-SCOP | Bromodomain | UniProtKB/TrEMBL |
| FYVE_PHD_ZnF | UniProtKB/TrEMBL | |
| UniGene | Rn.226018 | ENTREZGENE |
| UniProt | F1M0L3_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2013-05-15 | Kmt2a | lysine (K)-specific methyltransferase 2A | Mll | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2013-02-27 | Mll | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | Mll1 | myeloid/lymphoid or mixed-lineage leukemia 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-03-06 | Mll1 | myeloid/lymphoid or mixed-lineage leukemia 1 | Mll | myeloid/lymphoid or mixed-lineage leukemia | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2007-04-13 | myeloid/lymphoid or mixed-lineage leukemia | Mll | myeloid/lymphoid or mixed-lineage leukemia (mapped) | Name updated | 9333 | APPROVED | |
| 2007-04-11 | Mll | myeloid/lymphoid or mixed-lineage leukemia (mapped) | Mll_mapped | myeloid/lymphoid or mixed-lineage leukemia (mapped) | Data Merged | 9333 | APPROVED |
| 2006-11-19 | Mll | myeloid/lymphoid or mixed-lineage leukemia (mapped) | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2005-11-17 | Mll_mapped | myeloid/lymphoid or mixed-lineage leukemia (mapped) | Symbol and Name updated | 14094 | APPROVED | ||
| 2002-06-10 | Mll | Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene) | Symbol and Name status set to approved | 1490 | APPROVED |
| More on Kmt2a | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1586165 |
| Created: | 2006-11-19 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




