Gene: Il18 (interleukin 18)  Rattus norvegicus Symbol: Il18 Name: interleukin 18 Description: ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN cellular response to cAMP; cellular response to hydrogen peroxide; cellular response to interferon-gamma; PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH Arthritis, Experimental; Brain Injuries; Brain Ischemia; FOUND IN apical plasma membrane; cytoplasm; extracellular space; INTERACTS WITH (R)-mevalonic acid; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine Type: protein-coding RefSeq Status: PROVISIONAL Also known as: IFN-gamma-inducing factor; IL-1 gamma; IL-18; interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin 18; interleukin-1 gamma; interleukin-18 Orthologs: Homo sapiens : IL18 (interleukin 18 (interferon-gamma-inducing factor))  HGNC Mus musculus : Il18 (interleukin 18)  MGI Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 8 q23   NCBI RGSC Genome Assembly v5.0 8 53,606,988 - 53,613,608 + NCBI RGSC Genome Assembly v3.4 8 53,936,584 - 53,943,228 + NCBI Rat Celera Assembly 8 50,474,845 - 50,479,055 + NCBI Genome Assembly 3.1 8 53,955,637 - 53,962,282 + NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acute Kidney Injury   ISS RGD:730895 6893450   RGD   Anti-Glomerular Basement Membrane Disease   ISS RGD:730895 6893447   RGD   Arthritis, Experimental   IPM   4889503   RGD   Arthritis, Experimental Disease_progression IEP   4889415   RGD   Asthma Susceptibility ISS RGD:730894 4889910 DNA:polymorphism: :c. -105A>C (human) RGD   Asthma Severity ISS RGD:730894 4889900 DNA:SNP:promoter: c.-380C>G (rs5744247)(human) RGD   Asthma Susceptibility ISS RGD:730894 4889923 DNA:SNP:promoter:c.and -137G>C (rs187238)(human) RGD   Asthma   ISS RGD:730895 4889908   RGD   Asthma Severity ISS RGD:730894 4889585 DNA:SNPs:Promoter:c. -607C>A (rs1946518), -137G/C (rs187238) (human) RGD   Asthma   ISS RGD:730895 RGD:730894 4889898   RGD   Asthma Disease_progression ISS RGD:730894 4889863 protein:increased expression:serum RGD   Behcet Syndrome   ISS RGD:730894 4889844   RGD   Brain Injuries   IPM   2315917 mRNA, protein:increased expression:brain RGD   Brain Ischemia   IEP   4889510 mRNA:increased expression:brain RGD   Bronchial Hyperreactivity   ISS RGD:730895 4889856   RGD   Burns   ISS RGD:730895 4889576 protein:decreased expression:liver RGD   Carcinoma, Non-Small-Cell Lung   ISS RGD:730894 4889836 protein:increased expression:serum RGD   Carotid Artery Injuries   IPM   4889500   RGD   Carotid Artery Injuries   IEP   4889159 protein:increased expression:carotid artery RGD   Cystic Fibrosis   ISS RGD:730894 4889551 protein:increased expression:serum RGD   Cystitis   IEP   2317284 protein:increased expression:urine, bladder RGD   Dermatomyositis   ISS RGD:730894 4889547 protein:increased expression:serum RGD   Diabetic Retinopathy   ISS RGD:730895 4889417   RGD   Edema   IPM   4889403   RGD   Encephalomyelitis, Autoimmune, Experimental   IEP   4889542 mRNA:increased expression:spinal cord RGD   Encephalomyelitis, Autoimmune, Experimental   IPM   4889543   RGD   Enterocolitis, Necrotizing   ISS RGD:730895 4889475   RGD   Enterocolitis, Necrotizing   IEP   5490305 protein:increased expression:ileum RGD   Enterocolitis, Necrotizing   IEP   4889473 protein:increased expression:liver RGD   Enterocolitis, Necrotizing   IEP   729222 protein:increased expression:ileum RGD   Fatty Liver   IED   4889416   RGD   Glomerulonephritis, IGA   ISS RGD:730894 6893446   RGD   Heart Arrest   IEP   4889454   RGD   Heart Diseases   IPM   4889158   RGD   Hyperoxia   IED   4889402   RGD   Hypertension, Pulmonary   ISS RGD:730895 4889590   RGD   Influenza, Human   ISS RGD:730895 4889964   RGD   Ischemia   IEP   6893448   RGD   Legionnaires' Disease   ISS RGD:730895 4889865   RGD   Lung Diseases   ISS RGD:730895 4889576 acute lung injury; more ... RGD   Lung Diseases   ISS RGD:730894 4889548 acute lung injury; more ... RGD   Lung Diseases   ISS RGD:730894 4889574 lung injury; more ... RGD   Lung Diseases   ISS RGD:730895 4889574 lung injury RGD   Lung Diseases, Interstitial   IEP   4889883 associated with Pseudomonas Infection; more ... RGD   Lung Diseases, Interstitial   ISS RGD:730894 4889547 associated with dermatomyositis; more ... RGD   Lung Diseases, Interstitial   ISS RGD:730895 5144220   RGD   Lupus Nephritis   ISS RGD:730895 6893449   RGD   Metabolic Syndrome X   IEP   4889401 protein:increased expression:serum RGD   Mycobacterium Infections, Nontuberculous   ISS RGD:730894 4889546   RGD   Myocardial Reperfusion Injury   ISS RGD:730895 4889578   RGD   Myocardial Reperfusion Injury   IED   4889400   RGD   Neoplasm Metastasis   ISS RGD:730894 4889862 protein:increased expression:serum RGD   Pain   IED   2315887   RGD   Pancreatitis   IEP   4889404 protein:increased expression:serum RGD   Pneumonia   ISS RGD:730895 4889825 associated with reperfusion injury RGD   Pneumonia   IEP   729357 mRNA, protein:increased expression:lung,bronchoalveolar fluid RGD   Pneumonia   ISS RGD:730894 4889836 protein:increased expression:serum RGD   Pneumonia   ISS RGD:730895 4889590   RGD   Pneumonia, Bacterial   ISS RGD:730895 4889913   RGD   Pneumonia, Pneumococcal   ISS RGD:730895 4889960   RGD   Polymyositis   ISS RGD:730894 4889547 protein:increased expression:serum RGD   Pulmonary Disease, Chronic Obstructive   ISS RGD:730894 4889551 protein:increased expression:serum RGD   Pulmonary Disease, Chronic Obstructive   ISS RGD:730894 4889575 protein:increased expression:sputum, macrophage RGD   Pulmonary Edema   ISS RGD:730895 4889555   RGD   Pulmonary Emphysema   ISS RGD:730895 4889590   RGD   Pulmonary Fibrosis   ISS RGD:730894 4889841 idiopathic pulmonary fibrosis; more ... RGD   Pulmonary Fibrosis   ISS RGD:730895 4889581 protein:increased expression:lung RGD   Reperfusion Injury   ISS RGD:730895 4889555   RGD   Reperfusion Injury   ISS RGD:730895 4889825 protein:increased expression:serum RGD   Respiratory Insufficiency   ISS RGD:730894 4889556 associated with pancreatitis; more ... RGD   Respiratory Syncytial Virus Infections   ISS RGD:730894 4889584 DNA:polymorphism:intron:rs360721 (human) RGD   Respiratory Syncytial Virus Infections   ISS RGD:730895 4889550   RGD   Rhinitis Disease_progression ISS RGD:730894 4889927 rhinitis allergic, seasonal; more ... RGD   Rhinitis   ISS RGD:730895 4889917 protein:increased expression:nasal lavage fluid, bronchoalveolar lavage fluid RGD   Rhinitis   ISS RGD:730894 4889916 protein:increased expression:serum RGD   Rhinitis, Allergic, Perennial Susceptibility ISS RGD:730894 4889924 DNA:SNP:promoter:c. -607A>C (rs1946518) (human) RGD   Sarcoidosis Disease_progression ISS RGD:730894 4889815 protein:increased expression:plasma RGD   Sarcoidosis, Pulmonary   ISS RGD:730894 4889863 protein:increased expression:serum RGD   Sarcoidosis, Pulmonary   ISS RGD:730894 4889823 protein:increased expression:bronchoalveolar lavage fluid RGD   Sleep Apnea Syndromes Severity ISS RGD:730894 4889903   RGD   Spinal Cord Injuries   IED   2315889   RGD   Status Epilepticus   IED   4889491   RGD   Stroke   IEP   4891154 mRNA:increased expression:brain RGD   Tibial Fractures   IEP   2315887 protein:increased expression:skin RGD   Tuberculosis, Pulmonary   ISS RGD:730894 4889836 protein:increased expression:serum RGD   Urinary Tract Infections   IEP   2311084 protein:increased expression:urine RGD   Vasculitis   IED   4889401   RGD   Wallerian Degeneration   IEP   4889526 mRNA, protein:increased expression:macrophage, microglia: RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (R)-mevalonic acid multiple interactions EXP   6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]] CTD PMID:18660453 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:730894 6480464 CASP1 protein promotes the reaction [Picryl Chloride results in increased cleavage of IL18 protein] CTD PMID:17429439 1-chloro-2,4,6-trinitrobenzene increases secretion ISO RGD:730895 6480464 Picryl Chloride results in increased secretion of IL18 protein CTD PMID:20381601 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:730895 6480464 Picryl Chloride results in increased expression of IL18 mRNA CTD PMID:20381601 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:730895 6480464 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Picryl Chloride results in increased secretion of IL18 protein]; more ... CTD PMID:20381601 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:730895 6480464 Picryl Chloride results in increased expression of IL18 protein CTD PMID:15734285 PMID:16442096 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:730895 6480464 Picryl Chloride results in increased expression of IL18 protein CTD PMID:16442096 PMID:15734285 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:730895 6480464 Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]; more ... CTD PMID:16442096 1-chloro-2,4,6-trinitrobenzene increases cleavage ISO RGD:730894 6480464 Picryl Chloride results in increased cleavage of IL18 protein CTD PMID:17429439 1-chloro-2,4-dinitrobenzene increases activity ISO RGD:730895 6480464 Dinitrochlorobenzene results in increased activity of IL18 protein CTD PMID:15840424 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:730895 6480464 Dinitrochlorobenzene results in increased expression of IL18 mRNA CTD PMID:11708898 17alpha-ethynylestradiol decreases expression EXP   6480464 Ethinyl Estradiol results in decreased expression of IL18 mRNA CTD PMID:12075121 17alpha-ethynylestradiol increases expression EXP   6480464 Ethinyl Estradiol results in increased expression of IL18 mRNA CTD PMID:15576828 PMID:17351261 17alpha-ethynylestradiol increases expression EXP   6480464 Ethinyl Estradiol results in increased expression of IL18 mRNA CTD PMID:17351261 PMID:15576828 17beta-estradiol affects expression ISO RGD:730894 6480464 Estradiol affects the expression of IL18 mRNA CTD PMID:22574217 17beta-estradiol increases expression ISO RGD:730894 6480464 Estradiol results in increased expression of IL18 mRNA CTD PMID:23373633 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:730894 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL18 mRNA CTD PMID:16039398 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of IL18 mRNA CTD PMID:20959002 PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:730895 6480464 Tetrachlorodibenzodioxin affects the expression of IL18 mRNA CTD PMID:12167310 PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of IL18 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of IL18 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:730894 6480464 Tetrachlorodibenzodioxin affects the expression of IL18 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:730895 6480464 Tetrachlorodibenzodioxin affects the expression of IL18 mRNA CTD PMID:12167310 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:730895 6480464 Trinitrobenzenesulfonic Acid results in increased expression of IL18 mRNA CTD PMID:15973123 2-amino-2-deoxy-D-galactopyranose increases expression ISO RGD:730895 6480464 Galactosamine results in increased expression of IL18 mRNA; more ... CTD PMID:20102673 2-amino-2-deoxy-D-galactopyranose increases expression EXP   6480464 Galactosamine results in increased expression of IL18 mRNA CTD PMID:22310181 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP   6480464 mangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA] CTD PMID:22310181 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:730895 6480464 [LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 mRNA; more ... CTD PMID:19913045 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:730895 6480464 Plant Preparations inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA]; more ... CTD PMID:20102673 3,3',4,4',5-pentachlorobiphenyl affects expression ISO RGD:730894 6480464 3,4,5,3',4'-pentachlorobiphenyl affects the expression of IL18 mRNA CTD PMID:21703328 3-methylcholanthrene increases expression ISO RGD:730894 6480464 Methylcholanthrene results in increased expression of IL18 mRNA CTD PMID:14993811 3H-1,2-dithiole-3-thione decreases expression EXP   6480464 1,2-dithiol-3-thione results in decreased expression of IL18 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane decreases expression ISO RGD:730895 6480464 4,4'-diaminodiphenylmethane results in decreased expression of IL18 mRNA CTD PMID:18648102 4-hydroxynon-2-enal decreases expression ISO RGD:730895 6480464 4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA CTD PMID:19191707 4-hydroxynon-2-enal decreases expression ISO RGD:730894 6480464 4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA CTD PMID:12419474 5-fluorouracil multiple interactions ISO RGD:730894 6480464 [Fluorouracil co-treated with irinotecan] results in decreased expression of IL18 mRNA CTD PMID:16391804 5-fluorouracil affects expression ISO RGD:730895 6480464 Fluorouracil affects the expression of IL18 mRNA CTD PMID:20421339 5-fluorouracil multiple interactions ISO RGD:730894 6480464 Fluorouracil promotes the reaction [IL18 protein modified form results in increased expression of IFNG protein]; more ... CTD PMID:15162350 8-bromo-3',5'-cyclic AMP increases expression ISO RGD:730894 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL18 mRNA CTD PMID:22079614 acetylsalicylic acid multiple interactions ISO RGD:730895 6480464 Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA] CTD PMID:19164858 acetylsalicylic acid affects response to substance ISO RGD:730894 6480464 IL18 polymorphism affects the susceptibility to Aspirin CTD PMID:21692767 aflatoxin B1 affects expression ISO RGD:730894 6480464 Aflatoxin B1 affects the expression of IL18 protein CTD PMID:20106945 aldosterone increases expression EXP   6480464 Aldosterone results in increased expression of IL18 protein; more ... CTD PMID:18660453 aldosterone multiple interactions EXP   6480464 Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]; more ... CTD PMID:18660453 all-trans-retinoic acid affects expression ISO RGD:730895 6480464 Tretinoin affects the expression of IL18 mRNA CTD PMID:20421339 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of IL18 mRNA CTD PMID:16483693 anthranilic acid multiple interactions ISO RGD:730894 6480464 anthranilic acid analog inhibits the reaction [IL18 protein results in increased secretion of IFNG protein] CTD PMID:15799959 Aroclor 1254 decreases expression ISO RGD:730894 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of IL18 mRNA CTD PMID:17851650 arsenite(3-) decreases expression ISO RGD:730894 6480464 arsenite results in decreased expression of IL18 mRNA CTD PMID:16085347 arsenite(3-) multiple interactions ISO RGD:730894 6480464 caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL18 mRNA] CTD PMID:16085347 ATP multiple interactions ISO RGD:730894 6480464 [Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein CTD PMID:17404311 benzo[a]pyrene increases expression ISO RGD:730894 6480464 Benzo(a)pyrene results in increased expression of IL18 mRNA CTD PMID:21632981 benzo[a]pyrene multiple interactions ISO RGD:730895 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of IL18 mRNA] CTD PMID:22228805 benzocaine increases activity ISO RGD:730895 6480464 Benzocaine results in increased activity of IL18 protein CTD PMID:15840424 beryllium sulfate increases expression ISO RGD:730894 6480464 beryllium sulfate results in increased expression of IL18 mRNA; more ... CTD PMID:16100009 bezafibrate multiple interactions EXP   6480464 Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 bilirubin multiple interactions ISO RGD:730894 6480464 Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; more ... CTD PMID:18215737 bilirubin decreases response to substance ISO RGD:730894 6480464 Bilirubin results in decreased susceptibility to IL18 protein CTD PMID:18215737 biliverdin multiple interactions ISO RGD:730894 6480464 Biliverdine inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; more ... CTD PMID:18215737 biliverdin decreases response to substance ISO RGD:730894 6480464 Biliverdine results in decreased susceptibility to IL18 protein CTD PMID:18215737 bis(2-chloroethyl) sulfide decreases expression ISO RGD:730895 6480464 Mustard Gas results in decreased expression of IL18 mRNA CTD PMID:18955075 bisphenol A decreases expression EXP   6480464 bisphenol A results in decreased expression of IL18 mRNA CTD PMID:12075121 butyric acid increases expression ISO RGD:730894 6480464 Butyric Acid results in increased expression of IL18 mRNA CTD PMID:17928716 carbon monoxide decreases response to substance ISO RGD:730894 6480464 Carbon Monoxide results in decreased susceptibility to IL18 protein CTD PMID:18215737 carbon monoxide multiple interactions ISO RGD:730894 6480464 Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; more ... CTD PMID:18215737 cefaloridine increases expression EXP   6480464 Cephaloridine results in increased expression of IL18 mRNA CTD PMID:18500788 cimetidine multiple interactions ISO RGD:730894 6480464 CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]; more ... CTD PMID:16723495 cimetidine multiple interactions ISO RGD:730895 6480464 HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein] CTD PMID:16723495 cimetidine increases expression ISO RGD:730895 6480464 Cimetidine results in increased expression of IL18 protein CTD PMID:16723495 cimetidine increases expression ISO RGD:730894 6480464 Cimetidine results in increased expression of IL18 protein CTD PMID:16723495 cisplatin decreases expression ISO RGD:730894 6480464 Cisplatin results in decreased expression of IL18 CTD PMID:17021654 cisplatin increases expression ISO RGD:730895 6480464 Cisplatin results in increased expression of IL18 mRNA CTD PMID:21151649 clenbuterol increases expression ISO RGD:730895 6480464 Clenbuterol results in increased expression of IL18 mRNA; more ... CTD PMID:15178407 clofibrate decreases expression ISO RGD:730895 6480464 Clofibrate results in decreased expression of IL18 mRNA CTD PMID:17585979 cobalt atom multiple interactions ISO RGD:730895 6480464 [Cobalt co-treated with Organometallic Compounds] results in increased expression of IL18 mRNA CTD PMID:22147119 cobalt atom increases expression ISO RGD:730895 6480464 Cobalt results in increased expression of IL18 mRNA CTD PMID:22147119 cobalt atom multiple interactions EXP   6480464 [Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA CTD PMID:22198552 cobalt dichloride increases expression ISO RGD:730894 6480464 cobaltous chloride results in increased expression of IL18 mRNA CTD PMID:19376846 copper(2+) sulfate increases expression ISO RGD:730894 6480464 Copper Sulfate results in increased expression of IL18 mRNA CTD PMID:19549813 curcumin multiple interactions ISO RGD:730894 6480464 Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; more ... CTD PMID:16368150 curcumin decreases expression ISO RGD:730895 6480464 Curcumin results in decreased expression of IL18 mRNA CTD PMID:16751071 curcumin decreases expression ISO RGD:730894 6480464 Curcumin results in decreased expression of IL18 mRNA; more ... CTD PMID:17399992 curcumin multiple interactions ISO RGD:730894 6480464 Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; more ... CTD PMID:17399992 cycloheximide multiple interactions EXP   6480464 Cycloheximide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 cyclophosphamide increases expression EXP   6480464 Cyclophosphamide results in increased expression of IL18 protein CTD PMID:18848347 cyclosporin A increases expression ISO RGD:730894 6480464 Cyclosporine results in increased expression of IL18 mRNA CTD PMID:20106945 cyclosporin A multiple interactions ISO RGD:730895 6480464 Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 dexamethasone multiple interactions ISO RGD:730894 6480464 Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]; more ... CTD PMID:18951874 dexamethasone increases expression ISO RGD:730895 6480464 Dexamethasone results in increased expression of IL18 mRNA CTD PMID:21041162 dextran sulfate affects response to substance ISO RGD:730895 6480464 IL18 protein affects the susceptibility to Dextran Sulfate CTD PMID:12940437 diarsenic trioxide decreases expression ISO RGD:730895 6480464 arsenic trioxide results in decreased expression of IL18 CTD PMID:20693187 diazoxide multiple interactions ISO RGD:730895 6480464 ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]; more ... CTD PMID:15178407 diazoxide decreases expression ISO RGD:730895 6480464 Isoproterenol results in decreased expression of IL18 mRNA CTD PMID:21335049 dichlorine multiple interactions EXP   6480464 [Ozone co-treated with Chlorine] results in decreased expression of IL18 mRNA CTD PMID:18636392 famotidine multiple interactions ISO RGD:730894 6480464 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; more ... CTD PMID:11752121 famotidine multiple interactions ISO RGD:730894 6480464 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; more ... CTD PMID:11752121 PMID:12364868 famotidine multiple interactions ISO RGD:730894 6480464 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; more ... CTD PMID:12364868 PMID:11752121 famotidine multiple interactions ISO RGD:730894 6480464 Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein] CTD PMID:16723495 felodipine multiple interactions EXP   6480464 Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; more ... CTD PMID:18504504 formaldehyde increases expression ISO RGD:730895 6480464 Formaldehyde results in increased expression of IL18 mRNA CTD PMID:12161283 fructose multiple interactions EXP   6480464 Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; more ... CTD PMID:18504504 fructose increases expression EXP   6480464 Fructose results in increased expression of IL18 mRNA; more ... CTD PMID:18504504 fulvestrant multiple interactions ISO RGD:730895 6480464 [fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]] CTD PMID:17850464 furan decreases expression ISO RGD:730895 6480464 furan results in decreased expression of IL18 mRNA CTD PMID:20194422 genistein decreases expression EXP   6480464 Genistein results in decreased expression of IL18 mRNA CTD PMID:12075121 hemin multiple interactions ISO RGD:730894 6480464 Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein]; more ... CTD PMID:18215737 hemin decreases response to substance ISO RGD:730894 6480464 Hemin results in decreased susceptibility to IL18 protein CTD PMID:18215737 hexachlorobenzene increases expression EXP   6480464 Hexachlorobenzene results in increased expression of IL18 mRNA CTD PMID:15159207 histamine multiple interactions ISO RGD:730894 6480464 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; more ... CTD PMID:12364868 PMID:11752121 histamine increases expression ISO RGD:730895 6480464 Histamine results in increased expression of IL18 protein CTD PMID:16723495 histamine multiple interactions ISO RGD:730895 6480464 HRH2 protein affects the reaction [Histamine results in increased expression of IL18 protein] CTD PMID:16723495 histamine multiple interactions ISO RGD:730894 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of IL18 protein] CTD PMID:16723495 histamine increases expression ISO RGD:730894 6480464 Histamine results in increased expression of IL18 protein CTD PMID:16723495 histamine multiple interactions ISO RGD:730894 6480464 Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; more ... CTD PMID:11752121 PMID:12364868 histamine multiple interactions ISO RGD:730894 6480464 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; more ... CTD PMID:11752121 hydrogen peroxide decreases expression ISO RGD:730894 6480464 Hydrogen Peroxide results in decreased expression of IL18 mRNA CTD PMID:12419474 hydrogen peroxide affects expression ISO RGD:730894 6480464 Hydrogen Peroxide affects the expression of IL18 mRNA CTD PMID:21179406 hydrogen peroxide multiple interactions ISO RGD:730894 6480464 Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]; more ... CTD PMID:18951874 indomethacin increases expression EXP   6480464 Indomethacin results in increased expression of IL18 mRNA; more ... CTD PMID:18996434 iron atom multiple interactions ISO RGD:730894 6480464 Iron affects the reaction [IL18 protein results in increased secretion of IFNG protein] CTD PMID:15799959 isoprenaline multiple interactions ISO RGD:730895 6480464 ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]; more ... CTD PMID:15178407 isoprenaline decreases expression ISO RGD:730895 6480464 Isoproterenol results in decreased expression of IL18 mRNA CTD PMID:21335049 lead diacetate affects expression ISO RGD:730895 6480464 lead acetate affects the expression of IL18 protein CTD PMID:21322097 lucanthone decreases expression ISO RGD:730894 6480464 Lucanthone results in decreased expression of IL18 mRNA CTD PMID:21148553 m-xylene decreases expression EXP   6480464 3-xylene results in decreased expression of IL18 mRNA CTD PMID:12815608 mangiferin multiple interactions EXP   6480464 mangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA] CTD PMID:22310181 methotrexate increases expression ISO RGD:730894 6480464 Methotrexate results in increased expression of IL18 mRNA CTD PMID:17400583 mevalonic acid multiple interactions EXP   6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]] CTD PMID:18660453 mifepristone multiple interactions ISO RGD:730895 6480464 [fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]] CTD PMID:17850464 mitomycin C decreases expression ISO RGD:730894 6480464 Mitomycin results in decreased expression of IL18 CTD PMID:17021654 mitomycin C decreases expression ISO RGD:730894 6480464 Mitomycin results in decreased expression of IL18 protein CTD PMID:16019139 monocrotaline multiple interactions ISO RGD:730895 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 mycophenolic acid decreases expression ISO RGD:730895 6480464 Mycophenolic Acid results in decreased expression of IL18 mRNA CTD PMID:19818335 N-nitrosodimethylamine multiple interactions ISO RGD:730895 6480464 CSF3 protein affects the reaction [Dimethylnitrosamine affects the expression of IL18 mRNA] CTD PMID:17869372 N-nitrosodimethylamine affects expression ISO RGD:730895 6480464 Dimethylnitrosamine affects the expression of IL18 mRNA CTD PMID:17869372 nickel atom multiple interactions EXP   6480464 [Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA CTD PMID:22198552 nickel sulfate decreases expression ISO RGD:730894 6480464 nickel sulfate results in decreased expression of IL18 mRNA CTD PMID:18651567 ozone multiple interactions EXP   6480464 [Ozone co-treated with Chlorine] results in decreased expression of IL18 mRNA CTD PMID:18636392 ozone multiple interactions ISO RGD:730895 6480464 CASP1 gene mutant form inhibits the reaction [Ozone results in increased secretion of IL18 protein]; more ... CTD PMID:23010656 ozone increases expression ISO RGD:730895 6480464 Ozone results in increased expression of IL18 mRNA CTD PMID:23010656 ozone increases secretion ISO RGD:730895 6480464 Ozone results in increased secretion of IL18 protein CTD PMID:23010656 paracetamol increases expression ISO RGD:730895 6480464 Acetaminophen results in increased expression of IL18 mRNA CTD PMID:20102673 more ... paracetamol increases expression ISO RGD:730895 6480464 Acetaminophen results in increased expression of IL18 mRNA CTD PMID:17585979 more ... paracetamol increases expression ISO RGD:730895 6480464 Acetaminophen results in increased expression of IL18 mRNA CTD PMID:19164858 more ... paracetamol increases expression ISO RGD:730895 6480464 Acetaminophen results in increased expression of IL18 mRNA CTD PMID:19164858 PMID:20102673 paracetamol multiple interactions ISO RGD:730895 6480464 Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA] CTD PMID:19164858 paracetamol multiple interactions ISO RGD:730895 6480464 Plant Preparations inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA]; more ... CTD PMID:20102673 paracetamol affects expression ISO RGD:730895 6480464 Acetaminophen affects the expression of IL18 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:730895 6480464 Acetaminophen results in increased expression of IL18 mRNA CTD PMID:20102673 PMID:19164858 paracetamol increases expression ISO RGD:730895 6480464 Acetaminophen results in increased expression of IL18 protein CTD PMID:20102673 paracetamol increases expression ISO RGD:730895 6480464 Acetaminophen results in increased expression of IL18 mRNA CTD PMID:20102673 more ... paraquat increases expression ISO RGD:730894 6480464 Paraquat results in increased expression of IL18 mRNA CTD PMID:20883675 phenytoin multiple interactions ISO RGD:730895 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 phthalic anhydride increases activity ISO RGD:730895 6480464 phthalic anhydride results in increased activity of IL18 protein CTD PMID:15840424 pioglitazone multiple interactions EXP   6480464 pioglitazone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 pirinixic acid multiple interactions ISO RGD:730895 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of IL18 mRNA CTD PMID:20813756 pirinixic acid decreases expression ISO RGD:730895 6480464 pirinixic acid results in decreased expression of IL18 mRNA CTD PMID:17321000 more ... pirinixic acid decreases expression ISO RGD:730895 6480464 pirinixic acid results in decreased expression of IL18 mRNA CTD PMID:20813756 more ... pirinixic acid decreases expression ISO RGD:730895 6480464 pirinixic acid results in decreased expression of IL18 mRNA CTD PMID:17321000 more ... pirinixic acid multiple interactions ISO RGD:730895 6480464 PPARA protein affects the reaction [pirinixic acid results in decreased expression of IL18 mRNA] CTD PMID:17321000 pirinixic acid decreases expression ISO RGD:730895 6480464 pirinixic acid results in decreased expression of IL18 mRNA CTD PMID:20813756 more ... prednisolone multiple interactions ISO RGD:730895 6480464 Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 progesterone multiple interactions ISO RGD:730895 6480464 [fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]]; more ... CTD PMID:17850464 ranitidine multiple interactions ISO RGD:730894 6480464 Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein] CTD PMID:16723495 ranitidine multiple interactions ISO RGD:730894 6480464 Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; more ... CTD PMID:11752121 reserpine increases expression EXP   6480464 Reserpine results in increased expression of IL18 mRNA CTD PMID:8999896 resveratrol multiple interactions ISO RGD:730894 6480464 resveratrol inhibits the reaction [BSG protein results in increased expression of IL18 mRNA]; more ... CTD PMID:19561311 rifampicin multiple interactions ISO RGD:730895 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 rolipram multiple interactions ISO RGD:730895 6480464 Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 rosiglitazone decreases expression ISO RGD:730894 6480464 rosiglitazone results in decreased expression of IL18 protein CTD PMID:16644639 rosiglitazone decreases expression ISO RGD:730895 6480464 rosiglitazone results in decreased expression of IL18 mRNA CTD PMID:18541527 simvastatin multiple interactions EXP   6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]] CTD PMID:18660453 sodium dichromate increases expression EXP   6480464 sodium bichromate results in increased expression of IL18 mRNA CTD PMID:22561333 spironolactone multiple interactions EXP   6480464 Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 sterigmatocystin increases expression ISO RGD:730895 6480464 Sterigmatocystin results in increased expression of IL18 mRNA CTD PMID:19818335 thalidomide increases expression ISO RGD:730895 6480464 Thalidomide results in increased expression of IL18 CTD PMID:17089043 theophylline multiple interactions ISO RGD:730894 6480464 Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]; more ... CTD PMID:18951874 trans-resveratrol multiple interactions ISO RGD:730894 6480464 resveratrol inhibits the reaction [BSG protein results in increased expression of IL18 mRNA]; more ... CTD PMID:19561311 tungsten atom multiple interactions EXP   6480464 [Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA CTD PMID:22198552 valproic acid affects expression ISO RGD:730895 6480464 Valproic Acid affects the expression of IL18 mRNA CTD PMID:20421339 wortmannin multiple interactions ISO RGD:730895 6480464 wortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein] CTD PMID:15178407 zinc protoporphyrin multiple interactions ISO RGD:730894 6480464 zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein] CTD PMID:18215737 zirconium atom increases expression ISO RGD:730894 6480464 Zirconium results in increased expression of IL18 protein CTD PMID:16100009 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) angiogenesis   ISO RGD:730894 1624291 PMID:11466388 RGD PMID:11466388 angiogenesis   ISS UniProtKB:Q14116   PMID:11466388 UniProtKB PMID:11466388 cellular response to cAMP   IEP   4889506   RGD   cellular response to hydrogen peroxide   IEP   4889505   RGD   cellular response to interferon-gamma   IEP   4889457   RGD   cellular response to lipopolysaccharide   IEP   729357   RGD   cellular response to mechanical stimulus   IEP   4889461   RGD   cellular response to organic cyclic compound   ISO RGD:730894 1624291 PMID:21147091 RGD PMID:21147091 cellular response to parathyroid hormone stimulus   IEP   4889468   RGD   cellular response to peptide hormone stimulus   IMP   4889506   RGD   cellular response to tumor necrosis factor   IEP   4889457   RGD   detection of mechanical stimulus involved in sensory perception of pain   IDA   2315887   RGD   digestive tract morphogenesis   IEP   4889157   RGD   inflammatory response   ISO RGD:730894 1624291 PMID:21147091 RGD PMID:21147091 inflammatory response   IEA Ensembl:ENSP00000280357 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 interferon-gamma biosynthetic process   ISO RGD:730895 1624291 MGI:MGI:3687928|PMID:11907086 RGD MGI:MGI:3687928 PMID:11907086 interferon-gamma biosynthetic process   IEA Ensembl:ENSMUSP00000137193 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 learning or memory   TAS   727478   RGD   lipopolysaccharide-mediated signaling pathway   ISO RGD:730894 1624291 PMID:21147091 RGD PMID:21147091 lipopolysaccharide-mediated signaling pathway   IEA Ensembl:ENSP00000280357 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 lung development   IEP   2307417   RGD   MAPK cascade   ISO RGD:730894 1624291 PMID:21147091 RGD PMID:21147091 MAPK cascade   IEA Ensembl:ENSP00000280357 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 natural killer cell activation   ISO RGD:730895 1624291 MGI:MGI:2136797|PMID:10227969 RGD MGI:MGI:2136797 PMID:10227969 osteoblast differentiation   IEP   4889468   RGD   positive regulation of activated T cell proliferation   ISO RGD:730894 1624291 PMID:10000000 RGD PMID:10000000 positive regulation of activated T cell proliferation   ISS UniProtKB:Q14116   PMID:8766574 UniProtKB PMID:8766574 positive regulation of activated T cell proliferation   ISO RGD:730894 1624291 PMID:8766574 RGD PMID:8766574 positive regulation of blood vessel remodeling   IDA   4889401   RGD   positive regulation of chemokine production   IMP   4889403   RGD   positive regulation of collagen biosynthetic process   IDA   4889158   RGD   positive regulation of gene expression   ISO RGD:730895 1624291 MGI:MGI:4355633|PMID:19666510 RGD MGI:MGI:4355633 PMID:19666510 positive regulation of gene expression   IEA Ensembl:ENSMUSP00000137193 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of granulocyte macrophage colony-stimulating factor production   ISO RGD:730894 1624291 PMID:20027291 RGD PMID:20027291 positive regulation of granulocyte macrophage colony-stimulating factor production   IEA Ensembl:ENSP00000280357 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of interferon-gamma production   ISO RGD:730895 1624291 MGI:MGI:2176422|PMID:11894098 RGD MGI:MGI:2176422 PMID:11894098 positive regulation of interferon-gamma production   ISO RGD:730895 1624291 MGI:MGI:2136797|PMID:10227969 RGD MGI:MGI:2136797 PMID:10227969 positive regulation of interferon-gamma production   IEA Ensembl:ENSMUSP00000137193 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of interferon-gamma production   IEA Ensembl:ENSP00000280357 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of interferon-gamma production   ISO RGD:730894 1624291 PMID:20027291 RGD PMID:20027291 positive regulation of interferon-gamma production   ISO RGD:730894 1624291 PMID:19088061 RGD PMID:19088061 positive regulation of interferon-gamma production   ISO RGD:730895 1624291 MGI:MGI:2176424|PMID:11894097 RGD MGI:MGI:2176424 PMID:11894097 positive regulation of interleukin-1 beta production   IEP   4889480   RGD   positive regulation of interleukin-17 production   ISO RGD:730894 1624291 PMID:16482511 RGD PMID:16482511 positive regulation of interleukin-17 production   IEA Ensembl:ENSP00000280357 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of interleukin-8 production   IDA   4889457   RGD   positive regulation of male germ cell proliferation   IDA   4889501   RGD   positive regulation of natural killer cell proliferation   ISO RGD:730894 1624291 PMID:19088061 RGD PMID:19088061 positive regulation of natural killer cell proliferation   IEA Ensembl:ENSP00000280357 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of neuron apoptotic process   IMP   2315917   RGD   positive regulation of NF-kappaB import into nucleus   ISO RGD:730895 1624291 MGI:MGI:2136797|PMID:10227969 RGD MGI:MGI:2136797 PMID:10227969 positive regulation of NK T cell proliferation   ISO RGD:730894 1624291 PMID:19088061 RGD PMID:19088061 positive regulation of NK T cell proliferation   IEA Ensembl:ENSP00000280357 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of superoxide anion generation   IMP   4889403   RGD   positive regulation of tumor necrosis factor production   IMP   4889480   RGD   positive regulation of vascular permeability   IMP   729357   RGD   regulation of cell adhesion   ISO RGD:730894 1624291 PMID:11477102 RGD PMID:11477102 regulation of cell adhesion   ISS UniProtKB:Q14116   PMID:11477102 UniProtKB PMID:11477102 regulation of circadian sleep/wake cycle, non-REM sleep   TAS     PMID:11506998 UniProtKB PMID:11506998 response to cold   IEP   69858   RGD   response to hyperoxia   IEP   4889402   RGD   response to hypoxia   IMP   628353   RGD   response to peptide hormone stimulus   IEP   4889540   RGD   response to radiation   IEP   4889159   RGD   sleep   TAS   727478   RGD   sleep   IDA     PMID:11506998 UniProtKB PMID:11506998 T-helper 1 type immune response   ISO RGD:730894 1624291 PMID:8766574 RGD PMID:8766574 T-helper 1 type immune response   ISS UniProtKB:Q14116   PMID:8766574 UniProtKB PMID:8766574 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) apical plasma membrane   IDA   729222   RGD   cytoplasm   IDA   729222   RGD   extracellular space   IDA   4889401   RGD   extracellular space   IDA   4889501   RGD   extracellular space   ISO RGD:730895 1624291 MGI:MGI:3686795|PMID:16949315 RGD MGI:MGI:3686795 PMID:16949315 extracellular space   ISO RGD:730895 1624291 MGI:MGI:3050756|PMID:15220916 RGD MGI:MGI:3050756 PMID:15220916 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytokine activity   ISO RGD:730895 1624291 MGI:MGI:2176422|PMID:11894098 RGD MGI:MGI:2176422 PMID:11894098 cytokine activity   IEA Ensembl:ENSMUSP00000137193 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 interleukin-18 receptor binding   TAS   628353   RGD   protein binding   IPI RGD:620042 633082   RGD   Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytokine mediated signaling pathway   IEA RGD:2889 6907045   KEGG rno:04060 influenza A virus infection pathway   IEA RGD:2889 6907045   KEGG rno:05164 interleukin-12 signaling pathway   ISO RGD:730894 6484113   PID PID:200045 interleukin-23 signaling pathway   ISO RGD:730894 6484113   PID PID:200154 interleukin-27 signaling pathway   ISO RGD:730894 6484113   PID PID:200028 Mycobacterium tuberculosis infection pathway   IEA RGD:2889 6907045   KEGG rno:05152 NOD-like receptor signaling pathway   IEA RGD:2889 6907045   KEGG rno:04621 Plasmodium infection pathway   IEA RGD:2889 6907045   KEGG rno:05144 rheumatoid arthritis pathway   IEA RGD:2889 6907045   KEGG rno:05323 Trypanosoma brucei infection pathway   IEA RGD:2889 6907045   KEGG rno:05143 External Database Links KEGG Pathway African trypanosomiasis Cytokine-cytokine receptor interaction Cytosolic DNA-sensing pathway Influenza A Legionellosis Malaria NOD-like receptor signaling pathway Rheumatoid arthritis Salmonella infection Tuberculosis Pathway Interaction Database Cellular roles of Anthrax toxin (PID:200210) IL12 signaling mediated by STAT4 (PID:200229) IL12-mediated signaling events (PID:200045) IL23-mediated signaling events (PID:200154) IL27-mediated signaling events (PID:200028) Disease Annotations Acute Kidney Injury  (ISS) Anti-Glomerular Basement Membrane Disease  (ISS) Arthritis, Experimental  (IEP,IPM) Asthma  (ISS) Behcet Syndrome  (ISS) Brain Injuries  (IPM) Brain Ischemia  (IEP) Bronchial Hyperreactivity  (ISS) Burns  (ISS) Carcinoma, Non-Small-Cell Lung  (ISS) Carotid Artery Injuries  (IEP,IPM) Cystic Fibrosis  (ISS) Cystitis  (IEP) Dermatomyositis  (ISS) Diabetic Retinopathy  (ISS) Edema  (IPM) Encephalomyelitis, Autoimmune, Experimental  (IEP,IPM) Enterocolitis, Necrotizing  (IEP,ISS) Fatty Liver  (IED) Glomerulonephritis, IGA  (ISS) Heart Arrest  (IEP) Heart Diseases  (IPM) Hyperoxia  (IED) Hypertension, Pulmonary  (ISS) Influenza, Human  (ISS) Ischemia  (IEP) Legionnaires' Disease  (ISS) Lung Diseases  (ISS) Lung Diseases, Interstitial  (IEP,ISS) Lupus Nephritis  (ISS) Metabolic Syndrome X  (IEP) Mycobacterium Infections, Nontuberculous  (ISS) Myocardial Reperfusion Injury  (IED,ISS) Neoplasm Metastasis  (ISS) Pain  (IED) Pancreatitis  (IEP) Pneumonia  (IEP,ISS) Pneumonia, Bacterial  (ISS) Pneumonia, Pneumococcal  (ISS) Polymyositis  (ISS) Pulmonary Disease, Chronic Obstructive  (ISS) Pulmonary Edema  (ISS) Pulmonary Emphysema  (ISS) Pulmonary Fibrosis  (ISS) Reperfusion Injury  (ISS) Respiratory Insufficiency  (ISS) Respiratory Syncytial Virus Infections  (ISS) Rhinitis  (ISS) Rhinitis, Allergic, Perennial  (ISS) Sarcoidosis  (ISS) Sarcoidosis, Pulmonary  (ISS) Sleep Apnea Syndromes  (ISS) Spinal Cord Injuries  (IED) Status Epilepticus  (IED) Stroke  (IEP) Tibial Fractures  (IEP) Tuberculosis, Pulmonary  (ISS) Urinary Tract Infections  (IEP) Vasculitis  (IED) Wallerian Degeneration  (IEP) Gene-Chemical Interaction Annotations (R)-mevalonic acid  (EXP) 1-chloro-2,4,6-trinitrobenzene  (ISO) 1-chloro-2,4-dinitrobenzene  (ISO) 17alpha-ethynylestradiol  (EXP) 17beta-estradiol  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,4,6-trinitrobenzenesulfonic acid  (ISO) 2-amino-2-deoxy-D-galactopyranose  (EXP,ISO) 3,3',4,4',5-pentachlorobiphenyl  (ISO) 3-methylcholanthrene  (ISO) 3H-1,2-dithiole-3-thione  (EXP) 4,4'-diaminodiphenylmethane  (ISO) 4-hydroxynon-2-enal  (ISO) 5-fluorouracil  (ISO) 8-bromo-3',5'-cyclic AMP  (ISO) acetylsalicylic acid  (ISO) aflatoxin B1  (ISO) aldosterone  (EXP) all-trans-retinoic acid  (ISO) ammonium chloride  (EXP) anthranilic acid  (ISO) Aroclor 1254  (ISO) arsenite(3-)  (ISO) ATP  (ISO) benzo[a]pyrene  (ISO) benzocaine  (ISO) beryllium sulfate  (ISO) bezafibrate  (EXP) bilirubin  (ISO) biliverdin  (ISO) bis(2-chloroethyl) sulfide  (ISO) bisphenol A  (EXP) butyric acid  (ISO) carbon monoxide  (ISO) cefaloridine  (EXP) cimetidine  (ISO) cisplatin  (ISO) clenbuterol  (ISO) clofibrate  (ISO) cobalt atom  (EXP,ISO) cobalt dichloride  (ISO) copper(2+) sulfate  (ISO) curcumin  (ISO) cycloheximide  (EXP) cyclophosphamide  (EXP) cyclosporin A  (ISO) dexamethasone  (ISO) dextran sulfate  (ISO) diarsenic trioxide  (ISO) diazoxide  (ISO) dichlorine  (EXP) famotidine  (ISO) felodipine  (EXP) formaldehyde  (ISO) fructose  (EXP) fulvestrant  (ISO) furan  (ISO) genistein  (EXP) hemin  (ISO) hexachlorobenzene  (EXP) histamine  (ISO) hydrogen peroxide  (ISO) indomethacin  (EXP) iron atom  (ISO) isoprenaline  (ISO) lead diacetate  (ISO) lucanthone  (ISO) m-xylene  (EXP) mangiferin  (EXP) methotrexate  (ISO) mevalonic acid  (EXP) mifepristone  (ISO) mitomycin C  (ISO) monocrotaline  (ISO) mycophenolic acid  (ISO) N-nitrosodimethylamine  (ISO) nickel atom  (EXP) nickel sulfate  (ISO) ozone  (EXP,ISO) paracetamol  (ISO) paraquat  (ISO) phenytoin  (ISO) phthalic anhydride  (ISO) pioglitazone  (EXP) pirinixic acid  (ISO) prednisolone  (ISO) progesterone  (ISO) ranitidine  (ISO) reserpine  (EXP) resveratrol  (ISO) rifampicin  (ISO) rolipram  (ISO) rosiglitazone  (ISO) simvastatin  (EXP) sodium dichromate  (EXP) spironolactone  (EXP) sterigmatocystin  (ISO) thalidomide  (ISO) theophylline  (ISO) trans-resveratrol  (ISO) tungsten atom  (EXP) valproic acid  (ISO) wortmannin  (ISO) zinc protoporphyrin  (ISO) zirconium atom  (ISO) Gene Ontology Annotations Biological Process angiogenesis  (ISO,ISS) cellular response to cAMP  (IEP) cellular response to hydrogen peroxide  (IEP) cellular response to interferon-gamma  (IEP) cellular response to lipopolysaccharide  (IEP) cellular response to mechanical stimulus  (IEP) cellular response to organic cyclic compound  (ISO) cellular response to parathyroid hormone stimulus  (IEP) cellular response to peptide hormone stimulus  (IMP) cellular response to tumor necrosis factor  (IEP) detection of mechanical stimulus involved in sensory perception of pain  (IDA) digestive tract morphogenesis  (IEP) inflammatory response  (IEA,ISO) interferon-gamma biosynthetic process  (IEA,ISO) learning or memory  (TAS) lipopolysaccharide-mediated signaling pathway  (IEA,ISO) lung development  (IEP) MAPK cascade  (IEA,ISO) natural killer cell activation  (ISO) osteoblast differentiation  (IEP) positive regulation of activated T cell proliferation  (ISO,ISS) positive regulation of blood vessel remodeling  (IDA) positive regulation of chemokine production  (IMP) positive regulation of collagen biosynthetic process  (IDA) positive regulation of gene expression  (IEA,ISO) positive regulation of granulocyte macrophage colony-stimulating factor production  (IEA,ISO) positive regulation of interferon-gamma production  (IEA,ISO) positive regulation of interleukin-1 beta production  (IEP) positive regulation of interleukin-17 production  (IEA,ISO) positive regulation of interleukin-8 production  (IDA) positive regulation of male germ cell proliferation  (IDA) positive regulation of natural killer cell proliferation  (IEA,ISO) positive regulation of neuron apoptotic process  (IMP) positive regulation of NF-kappaB import into nucleus  (ISO) positive regulation of NK T cell proliferation  (IEA,ISO) positive regulation of superoxide anion generation  (IMP) positive regulation of tumor necrosis factor production  (IMP) positive regulation of vascular permeability  (IMP) regulation of cell adhesion  (ISO,ISS) regulation of circadian sleep/wake cycle, non-REM sleep  (TAS) response to cold  (IEP) response to hyperoxia  (IEP) response to hypoxia  (IMP) response to peptide hormone stimulus  (IEP) response to radiation  (IEP) sleep  (IDA,TAS) T-helper 1 type immune response  (ISO,ISS) Cellular Component apical plasma membrane  (IDA) cytoplasm  (IDA) extracellular space  (IDA,ISO) Molecular Function cytokine activity  (IEA,ISO) interleukin-18 receptor binding  (TAS) protein binding  (IPI) Molecular Pathway Annotations cytokine mediated signaling pathway  (IEA) influenza A virus infection pathway  (IEA) interleukin-12 signaling pathway  (ISO) interleukin-23 signaling pathway  (ISO) interleukin-27 signaling pathway  (ISO) Mycobacterium tuberculosis infection pathway  (IEA) NOD-like receptor signaling pathway  (IEA) Plasmodium infection pathway  (IEA) rheumatoid arthritis pathway  (IEA) Trypanosoma brucei infection pathway  (IEA) External Database Links KEGG Pathway African trypanosomiasis Cytokine-cytokine receptor interaction Cytosolic DNA-sensing pathway Influenza A Legionellosis Malaria NOD-like receptor signaling pathway Rheumatoid arthritis Salmonella infection Tuberculosis Pathway Interaction Database Cellular roles of Anthrax toxin (PID:200210) IL12 signaling mediated by STAT4 (PID:200229) IL12-mediated signaling events (PID:200045) IL23-mediated signaling events (PID:200154) IL27-mediated signaling events (PID:200028) References - curated 1. 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References - uncurated PubMed 10227975   11466388   11477102   11506998   11714750   12787406   15890643   16707557   17010950   17220368   17352829   18504504   18662782   19036970   20844839   21273803   21442623   21591858   21882482   21920610   22001439   22318348   22636674   23000553   8766574   9702748 RGD Disease Portals Il18 has been annotated in the following RGD Disease Portals. Biological Process Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Biological Process Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data Il18   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 8 q23   NCBI RGSC Genome Assembly v5.0 8 53,606,988 - 53,613,608 + NCBI RGSC Genome Assembly v3.4 8 53,936,584 - 53,943,228 + NCBI Rat Celera Assembly 8 50,474,845 - 50,479,055 + NCBI Genome Assembly 3.1 8 53,955,637 - 53,962,282 + NCBI IL18   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 111,877,529 - 111,898,396 - NCBI Human Genome Assembly HuRef 11 107,938,095 - 107,959,011 - NCBI Human Genome Assembly GRCh37 11 112,013,974 - 112,034,840 - NCBI Human Genome Assembly Build 36 11 111,519,186 - 111,540,050 - NCBI Human Cytogenetic Map 11 q22.2-q22.3   NCBI Human Genome Assembly 11 111,519,185 - 111,540,050   NCBI Il18   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 9 50,565,368 - 50,581,837 + NCBI Mouse cM Map 9 27.75   NCBI Mouse Celera Assembly 9 47,860,314 - 47,877,082 + NCBI Mouse Genome Assembly Build 37 9 50,373,473 - 50,389,942 + NCBI Mouse Genome Assembly Build 36.1 9 50,373,473 - 50,389,942 + NCBI Mouse Cytogenetic Map 9 A5.3   NCBI QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 71120 Niddm21 Non-insulin dependent diabetes mellitus QTL 21 3.73 Glucose level postprandial 8 3039822 61462321 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 Brain/spinal cord inflammation demyelination 8 8294860 115338082 Rat 1354595 Despr4 Despair related QTL 4 .0036 Activity level immobility level 8 9008612 54008612 Rat 1354627 Despr14 Despair related QTL 14 .0056 Activity level swimming level 8 9008612 54008612 Rat 1598824 Memor4 Memory QTL 4 2.5 Memory navigation-spatial 8 9581132 56397678 Rat 61353 Bp35 Blood pressure QTL 35 Blood pressure 8 9581132 103685771 Rat 2317030 Wbc5 White blood cell count QTL 5 3.21 .005 White blood cell count 8 10116155 55116155 Rat 2317051 Aia18 Adjuvant induced arthritis QTL 18 2.42 Joint/bone inflammation adjuvant induced 8 10116155 55116155 Rat 1558646 Swd5 Spike wave discharge measurement QTL 5 3.45 .00036 Spike wave discharge measurement frequency 8 16442230 61442230 Rat 631271 Cati1 Cataract Ihara QTL 1 .001 Cataract susceptibility 8 16468237 61468237 Rat 731182 Uae24 Urinary albumin excretion QTL 24 6.4 Renal function urine albumin level 8 19815642 98451660 Rat 631842 Inf1 Infertility severity QTL 1 4.1 .001 Seminal vesicle mass 8 26358063 71358063 Rat 631648 Stl5 Serum triglyceride level QTL 5 4 .0003 Lipid level triglyceride 8 28414004 58991068 Rat 1358892 Kidm26 Kidney mass QTL 26 3.69 Kidney mass 8 28414004 103684785 Rat 1358896 Bp262 Blood pressure QTL 262 2.89 Blood pressure post sympathetic nervous system block 8 28414004 103684785 Rat 1358907 Cm40 Cardiac mass QTL 40 1.89 Cardiac mass 8 28414004 103684785 Rat 2303572 Insul13 Insulin level QTL 13 2 Insulin level 8 29077622 74077622 Rat 2303564 Gluco43 Glucose level QTL 43 3 Glucose level fasting 8 29077622 74077622 Rat 1300146 Rf17 Renal function QTL 17 2.9 Renal function salt-loaded renal blood flow 8 29559446 74559446 Rat 1331804 Cm30 Cardiac mass QTL 30 3.77443 Cardiac mass 8 29559446 103672447 Rat 724514 Uae15 Urinary albumin excretion QTL 15 2.9 Renal function urine albumin level 8 30878636 74178909 Rat 1549908 Neudeg1 Neurodegradation QTL 1 5 0 Neurodegradation motoneuron cell number 8 31508524 98947320 Rat 1331744 Bp217 Blood pressure QTL 217 3.398 Blood pressure systolic 8 32203394 61853629 Rat 1359033 Bp273 Blood pressure QTL 273 Blood pressure response to intrathecal cytisine 8 32203394 64762616 Rat 2313046 Bss78 Bone structure and strength QTL 78 3.5 .0001 Bone strength 8 32203394 86628010 Rat 2313057 Bss76 Bone structure and strength QTL 76 3 .0001 Bone structure 8 32203394 86628010 Rat 2313067 Bss77 Bone structure and strength QTL 77 3.1 .0001 Bone structure 8 32203394 86628010 Rat 2313088 Bss75 Bone structure and strength QTL 75 3.1 .0001 Bone structure 8 32203394 86628010 Rat 724540 Uae8 Urinary albumin excretion QTL 8 5 Renal function urine abumin level 8 32203394 98986263 Rat 1578755 Pur5 Proteinuria QTL 5 3.3 .0001 Renal function urine protein level 8 32203394 98986263 Rat 1578765 Klgr1 Kidney lesion grade QTL 1 3.3 .0001 Renal histology kidney lesion grade 8 32203499 98986085 Rat 1578769 Uae31 Urinary albumin excretion QTL 31 3.3 .001 Renal function urine albumin level 8 32203499 98986085 Rat 2316950 Scl66 Serum cholesterol level QTL 66 4.1 Lipid level serum cholesterol 8 32203499 110106272 Rat 1298065 Scl16 Serum cholesterol level QTL 16 3.8 Lipid level cholesterol 8 33897608 78897608 Rat 1582222 Epfw2 Epididymal fat weight QTL 2 3.2 .0005 Epididymal fat weight 8 34808657 79808657 Rat 1331838 Niddm61 Non-insulin dependent diabetes mellitus QTL 61 3.53 .0004 Insulin level fasting 8 38003289 103665018 Rat 61358 Bp39 Blood pressure QTL 39 2 Blood pressure 8 38902937 83902937 Rat 737824 Hcar10 Hepatocarcinoma resistance QTL 10 2.9 Liver tumor resistance nodule number 8 43313902 87122960 Rat 1358906 Bp253 Blood pressure QTL 253 4 .0004 Blood pressure post sympathetic nervous system block 8 43313902 98451660 Rat 1554321 Bmd3 Bone mineral density QTL 3 7.9 .0001 Bone mineral density distal femur volumetric BMD by pQCT 8 43561064 129041809 Rat 1331769 Rf39 Renal function QTL 39 3.871 Renal function urine volume 8 44484215 103672447 Rat 1298079 Activ2 Activity QTL 2 9.5 .000001 Activity level novel environment 8 44484215 129041809 Rat 631216 Stl9 Serum triglyceride level QTL 9 4.71 .0001 Lipid level triglyceride 8 44484347 74178405 Rat 70161 Bp62 Blood pressure QTL 62 2.9 .001 Blood pressure salt-loaded systolic 8 45291674 94514282 Rat 2313086 Bss60 Bone structure and strength QTL 60 4.1 .0001 Bone structure 8 53049279 86628010 Rat 4889938 Bss89 Bone structure and strength QTL 89 3.8 Bone structure 8 53049279 86628010 Rat 5684973 Bss100 Bone structure and strength QTL 100 4.7 Bone structure tibial area 8 53049279 86628010 Rat 2303570 Gluco48 Glucose level QTL 48 2 Glucose level post-restraint 8 53621297 98621297 Rat Sequence Nucleotide Sequences Nucleotide RefSeqs NM_019165 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06054732 (Get FASTA) Search GEO for Microarray Profiles   AAHX01054600 (Get FASTA) Search GEO for Microarray Profiles   AAHX01054601 (Get FASTA) Search GEO for Microarray Profiles   AJ222813 (Get FASTA) Search GEO for Microarray Profiles   AY077842 (Get FASTA) Search GEO for Microarray Profiles   AY258448 (Get FASTA) Search GEO for Microarray Profiles   CH473975 (Get FASTA) Search GEO for Microarray Profiles   U77776 (Get FASTA) Search GEO for Microarray Profiles   U77777 (Get FASTA) Search GEO for Microarray Profiles   Y13337 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_019165 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_062038 Peptide Label: precursor Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 8 53,606,988 - 53,613,608 + NCBI RGSC Genome Assembly v3.4 8 53,936,584 - 53,943,228 + RGD Rat Celera Assembly 8 50,474,845 - 50,479,055 + RGD Protein Sequences Protein RefSeqs NP_062038 (Get FASTA) GenBank Protein AAC53009 (Get FASTA)   AAC53010 (Get FASTA)   AAL77211 (Get FASTA)   AAP14669 (Get FASTA)   CAA11001 (Get FASTA)   CAA73781 (Get FASTA)   EDL95461 (Get FASTA)   P97636 (Get FASTA) Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000009848 ENTREZGENE Ensembl Protein ENSRNOP00000013093 ENTREZGENE Ensembl Transcript ENSRNOT00000013093 ENTREZGENE Entrez Gene 29197 ENTREZGENE Germonline ENSRNOG00000009848 UniProtKB/Swiss-Prot HomoloGene Group ID 1200 ENTREZGENE InterPro Cytokine_IL1-like UniProtKB/Swiss-Prot   Interleukin_1 UniProtKB/Swiss-Prot   Interleukin_18 UniProtKB/Swiss-Prot IPI IPI00206468 UniProtKB/Swiss-Prot   IPI00231939 UniProtKB/Swiss-Prot KEGG Report rno:29197 ENTREZGENE, UniProtKB/Swiss-Prot PANTHER Interleukin_18 UniProtKB/Swiss-Prot Pfam IL1 UniProtKB/Swiss-Prot PIRSF Interleukin_18 UniProtKB/Swiss-Prot PRINTS INTRLEUKIN18 UniProtKB/Swiss-Prot SMART IL1 UniProtKB/Swiss-Prot Superfamily-SCOP Cytok_IL1_like UniProtKB/Swiss-Prot UniGene Rn.11118 ENTREZGENE UniProt IL18_RAT UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2002-06-10 Il18  interleukin 18      Name updated 1488 APPROVED RGD Curation Notes Note Type Note Reference gene_disease plays a role in the injurious processes in the brain after hypoxic-ischemic (HI) 628353 gene_expression expressed in neurons of the superior part of the medial habenula (MHbS) 727478 gene_expression expressed in brain 628353 gene_homology closely related to IL-1b and similar in terms of structure, processing, receptor complex, signal transduction pathway, and proinflammatory properties 628353 gene_other synthesized as inactive precursors that require cleavage by caspase-1 to become fully bioactive 628353 gene_process in nervous system acts to induce sleep and to influence long-term potentiation 727478 gene_regulation expression increased after ischemia/reperfusion in the kidney and heart 628353 gene_regulation expression is greatly increased in microglia after hypoxic-ischemic (HI) 628353

More on Il18 Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 2889 Created: 2000-05-25 Species: Rattus norvegicus Last Modified: 2013-04-16 Status: ACTIVE