Cbr2 (carbonyl reductase 2) - Rat Genome Database

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Gene: Cbr2 (carbonyl reductase 2) Rattus norvegicus
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Symbol: Cbr2
Name: carbonyl reductase 2
RGD ID: 1590051
Description: Predicted to enable identical protein binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and protein self-association. Predicted to be involved in glucose metabolic process and xylulose metabolic process; INTERACTS WITH 1,2-dimethylhydrazine (ortholog); 17beta-estradiol (ortholog); 2-amino-2-deoxy-D-glucopyranose (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: carbonyl reductase [NADPH] 2; LOC688320; similar to Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27)
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,508,964 - 106,511,614 (-)NCBIGRCr8
mRatBN7.210106,008,535 - 106,012,838 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,991,589 - 106,013,001 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.010109,911,918 - 109,944,190 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,911,922 - 109,913,879 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,503,550 - 109,505,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10104,554,800 - 104,571,770 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Cbr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,508,964 - 106,511,614 (-)NCBIGRCr8
mRatBN7.210106,008,535 - 106,012,838 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,991,589 - 106,013,001 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.010109,911,918 - 109,944,190 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,911,922 - 109,913,879 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,503,550 - 109,505,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10104,554,800 - 104,571,770 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Cbr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,620,311 - 120,622,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,620,315 - 120,622,940 (-)EnsemblGRCm39 Ensembl
GRCm3811120,729,485 - 120,732,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,729,489 - 120,732,114 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,590,799 - 120,593,335 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,545,599 - 120,548,085 (-)NCBIMGSCv36mm8
Celera11132,465,181 - 132,467,717 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.47NCBI

Variants

.
Variants in Cbr2
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:71
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000072947
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat

Markers in Region
Cbr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210106,011,680 - 106,012,071 (+)MAPPERmRatBN7.2
Rnor_6.010109,912,722 - 109,913,112NCBIRnor6.0
Rnor_5.010109,504,354 - 109,504,744UniSTSRnor5.0
Celera10104,555,623 - 104,556,013UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 5 5 1
Below cutoff 2 8 4 1 3 1 2 2 8 19 17 4 2

Sequence


RefSeq Acc Id: ENSRNOT00000072947   ⟹   ENSRNOP00000066045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10109,911,922 - 109,913,879 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111882   ⟹   ENSRNOP00000087729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,991,589 - 106,013,001 (-)Ensembl
RefSeq Acc Id: XM_003750987   ⟹   XP_003751035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,508,964 - 106,511,614 (-)NCBI
mRatBN7.210106,008,535 - 106,012,838 (-)NCBI
Rnor_6.010109,911,918 - 109,913,914 (-)NCBI
Rnor_5.010109,503,550 - 109,505,511 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003751035 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06895 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087729
  ENSRNOP00000087729.1
RefSeq Acc Id: XP_003751035   ⟸   XM_003750987
- UniProtKB: M0R983 (UniProtKB/TrEMBL),   A6HLJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066045   ⟸   ENSRNOT00000072947
RefSeq Acc Id: ENSRNOP00000087729   ⟸   ENSRNOT00000111882

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R983-F1-model_v2 AlphaFold M0R983 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590051 AgrOrtholog
BioCyc Gene G2FUF-22389 BioCyc
Ensembl Genes ENSRNOG00000046260 Ensembl
  ENSRNOG00000069492 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000111882.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Glc/ribitol_DH UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
KEGG Report rno:688320 UniProtKB/TrEMBL
NCBI Gene 688320 ENTREZGENE
PANTHER CARBONYL REDUCTASE [NADPH] 2 UniProtKB/TrEMBL
  D-ERYTHRULOSE REDUCTASE UniProtKB/TrEMBL
Pfam adh_short_C2 UniProtKB/TrEMBL
PhenoGen Cbr2 PhenoGen
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046260 RatGTEx
  ENSRNOG00000069492 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A6HLJ0 ENTREZGENE, UniProtKB/TrEMBL
  M0R983 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-07 Cbr2  carbonyl reductase 2  LOC688320  similar to Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27)  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC688320  similar to Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27)      Symbol and Name status set to provisional 70820 PROVISIONAL