Dnmt1 (DNA methyltransferase 1) - Rat Genome Database

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Gene: Dnmt1 (DNA methyltransferase 1) Rattus norvegicus
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Symbol: Dnmt1
Name: DNA methyltransferase 1
RGD ID: 620979
Description: Enables several functions, including DNA (cytosine-5-)-methyltransferase activity; histone deacetylase binding activity; and nuclear estrogen receptor binding activity. Involved in several processes, including cellular response to lead ion; cellular response to platelet-derived growth factor stimulus; and negative regulation of gene expression via chromosomal CpG island methylation. Located in nucleus. Part of protein-containing complex. Used to study choline deficiency disease and lung carcinoma. Biomarker of several diseases, including choline deficiency disease; congestive heart failure; fetal alcohol spectrum disorder; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1); PARTICIPATES IN DNA modification pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase I; DNA MTase RnoIP; m.RnoIP; MCMT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Dnmt1tm1(Myh6-cre)Cqin  
Genetic Models: SD-Dnmt1tm1(Myh6-cre)Cqin
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,716,797 - 27,763,405 (-)NCBIGRCr8
mRatBN7.2819,440,611 - 19,486,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,440,611 - 19,486,659 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,459,969 - 23,505,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,757,816 - 21,803,779 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,670,294 - 19,716,334 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,922,515 - 21,968,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,922,515 - 21,968,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,978,830 - 22,024,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,926,995 - 19,973,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1819,927,666 - 19,973,220 (-)NCBI
Celera820,835,612 - 20,881,380 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Alcoholic Fatty Liver  (ISO)
alopecia areata  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
Ataxia  (ISO)
autism spectrum disorder  (ISO)
autoimmune disease  (ISO)
autosomal dominant cerebellar ataxia, deafness and narcolepsy  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
Binge Drinking  (ISO)
Brain Injuries  (IEP)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Carcinogenesis  (IDA)
carcinoma  (ISO)
cardiomyopathy  (ISO)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
choline deficiency disease  (IDA,IEP)
choreatic disease  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
Colonic Neoplasms  (IDA,ISO)
Colorectal Neoplasms  (IEP)
congenital heart disease  (IEP)
congestive heart failure  (IEP)
dementia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
Experimental Arthritis  (ISO)
fetal alcohol spectrum disorder  (IEP)
Fetal Growth Retardation  (IEP)
genetic disease  (ISO)
Graves' disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (IEP)
hereditary sensory neuropathy  (ISO)
hereditary sensory neuropathy type 1E  (ISO)
hypertrophic cardiomyopathy  (ISO)
liver cirrhosis  (IEP)
lung cancer  (ISO)
lung carcinoma  (IDA)
lung non-small cell carcinoma  (ISO)
medulloblastoma  (ISO)
meningioma  (ISO)
middle cerebral artery infarction  (ISO)
mucoepidermoid carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Invasiveness  (ISO)
Oral Lichen Planus  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Intraepithelial Neoplasia  (ISO)
Peritoneal Fibrosis  (IEP)
Pituitary Stalk Interruption Syndrome  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sleep disorder  (ISO)
spastic ataxia  (ISO)
Spastic Paraparesis  (ISO)
Stomach Neoplasms  (ISO)
systemic lupus erythematosus  (ISO)
type 2 diabetes mellitus  (IEP)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP,ISO)
6-prenylnaringenin  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitriptyline  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzophenanthridine  (ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
Brodifacoum  (ISO)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP)
cladribine  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
daidzein  (EXP)
daidzein 7-O-beta-D-glucoside  (EXP)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
Difenacoum  (ISO)
dihydro-beta-erythroidine  (EXP)
dimethyl sulfate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
disodium cromoglycate  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (EXP)
enzyme inhibitor  (ISO)
escitalopram  (EXP)
ethanol  (ISO)
etoposide  (EXP,ISO)
fenthion  (ISO)
fenvalerate  (EXP)
fisetin  (ISO)
Flocoumafen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
glucaric acid  (ISO)
glucose  (ISO)
glycine betaine  (ISO)
glycitein  (EXP)
glycitin  (EXP)
glyphosate  (ISO)
guggulsterone  (ISO)
hexadecanoic acid  (ISO)
hexane  (EXP)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leptomycin B  (ISO)
linsidomine  (EXP)
magnesium atom  (ISO)
malathion  (EXP)
mancozeb  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (ISO)
myricetin  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
nicotine  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
procyanidin B2  (ISO)
pterostilbene  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (EXP)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sinefungin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tangeretin  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
uranium atom  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
withaferin A  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to bisphenol A  (IEA,ISO)
cellular response to lead ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IMP)
chromosomal DNA methylation maintenance following DNA replication  (ISO)
DNA methylation-dependent heterochromatin formation  (IEA,ISO)
DNA-templated transcription  (IEA,ISO)
epigenetic programming of gene expression  (IEA,ISO)
methylation  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gene expression via chromosomal CpG island methylation  (IBA,IDA,IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (IEA,ISO)
neuron differentiation  (IEP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (ISO)
response to activity  (IEP)
response to alcohol  (IEP)
response to bisphenol A  (IEP)
response to caffeine  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to ionizing radiation  (IEP)
response to lead ion  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient levels  (IEP)
response to testosterone  (IEP)
response to toxic substance  (IEP)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (IDA,IEP,IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease. Arakawa Y, etal., Clin Exp Immunol. 2012 Nov;170(2):194-201. doi: 10.1111/j.1365-2249.2012.04646.x.
2. Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus. Balada E, etal., Immunology. 2008 Jul;124(3):339-47. doi: 10.1111/j.1365-2567.2007.02771.x. Epub 2008 Jan 11.
3. Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats. Bian EB, etal., Toxicol Lett. 2014 Jan 13;224(2):175-85. doi: 10.1016/j.toxlet.2013.10.038. Epub 2013 Nov 6.
4. Lipopolysaccharide induces epididymal and testicular antimicrobial gene expression in vitro: insights into the epigenetic regulation of sperm-associated antigen 11e gene. Biswas B and Yenugu S, Immunogenetics. 2013 Apr;65(4):239-53. doi: 10.1007/s00251-012-0674-5. Epub 2012 Dec 28.
5. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cavuoto P and Fenech MF, Cancer Treat Rev. 2012 Oct;38(6):726-36. doi: 10.1016/j.ctrv.2012.01.004. Epub 2012 Feb 17.
6. Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Cowin PA, etal., Endocrinology. 2010 Feb;151(2):783-92. doi: 10.1210/en.2009-0982. Epub 2010 Jan 7.
7. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
8. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
9. Downregulation of DNA (cytosine-5-)methyltransferase is a late event in NGF-induced PC12 cell differentiation. Deng J and Szyf M, Brain Res Mol Brain Res. 1999 Jul 23;71(1):23-31.
10. Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study. Elsner VR, etal., Exp Gerontol. 2013 Feb;48(2):136-9. doi: 10.1016/j.exger.2012.11.011. Epub 2012 Nov 30.
11. Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons. Endres M, etal., Neuroreport. 2001 Dec 4;12(17):3763-6.
12. Ethylation of poly(dC-dG).poly(dC-dG) by ethyl methanesulfonate stimulates the activity of mammalian DNA methyltransferase in vitro. Farrance IK and Ivarie R, Proc Natl Acad Sci U S A. 1985 Feb;82(4):1045-9.
13. Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. Feng Y, etal., J Nutr Biochem. 2013 Jul;24(7):1373-80. doi: 10.1016/j.jnutbio.2012.11.005. Epub 2013 Jan 17.
14. [Expression and significance of DNA methyltransferase in sera of patients with lung cancer]. Feng YJ, etal., Zhonghua Yi Xue Za Zhi. 2013 Dec 24;93(48):3822-5.
15. DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus. Fonseca-Silva T, etal., Pathobiology. 2012;79(1):18-23. doi: 10.1159/000330171. Epub 2012 Jan 12.
16. Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms. Gangisetty O, etal., PLoS One. 2015 Oct 28;10(10):e0140699. doi: 10.1371/journal.pone.0140699. eCollection 2015.
17. Promoter methylation of glutathione S-transferase pi1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression. Gao P, etal., Cancer. 2009 Jul 15;115(14):3222-32.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. Ghoshal K, etal., J Nutr. 2006 Jun;136(6):1522-7.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers. Hu Y, etal., PLoS One. 2013 May 23;8(5):e64362. doi: 10.1371/journal.pone.0064362. Print 2013.
22. Heart failure and angiotensin II modulate atrial Pitx2c promotor methylation. Kao YH, etal., Clin Exp Pharmacol Physiol. 2013 Jun;40(6):379-84. doi: 10.1111/1440-1681.12089.
23. Heat shock prevents insulin resistance-induced vascular complications by augmenting angiotensin-(1-7) signaling. Karpe PA and Tikoo K, Diabetes. 2014 Mar;63(3):1124-39. doi: 10.2337/db13-1267. Epub 2013 Nov 22.
24. Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Ke X, etal., Physiol Genomics. 2006 Mar 13;25(1):16-28. Epub 2005 Dec 27.
25. Effect of DNA Demethylation in Experimental Encapsulating Peritoneal Sclerosis. Kim KH, etal., Ther Apher Dial. 2014 Sep 26. doi: 10.1111/1744-9987.12186.
26. Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. Kimura H and Shiota K, J Biol Chem 2003 Feb 14;278(7):4806-12. Epub 2002 Dec 6.
27. Expression of rat DNA (cytosine-5) methyltransferase (DNA MTase) in rodent trophoblast giant cells: molecular cloning and characterization of rat DNA MTase. Kimura H, etal., Biochem Biophys Res Commun 1998 Dec 18;253(2):495-501.
28. Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer. Kinney SR, etal., Mol Cell Biol. 2010 Sep;30(17):4159-74. doi: 10.1128/MCB.00235-10. Epub 2010 Jun 28.
29. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Klein CJ, etal., Nat Genet. 2011 Jun;43(6):595-600. doi: 10.1038/ng.830. Epub 2011 May 1.
30. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. Kovacheva VP, etal., J Biol Chem. 2007 Oct 26;282(43):31777-88. Epub 2007 Aug 27.
31. Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet. Kutay H, etal., PLoS One. 2012;7(8):e41949. doi: 10.1371/journal.pone.0041949. Epub 2012 Aug 8.
32. Lead exposure in pheochromocytoma cells induces persistent changes in amyloid precursor protein gene methylation patterns. Li YY, etal., Environ Toxicol. 2012 Aug;27(8):495-502. doi: 10.1002/tox.20666. Epub 2010 Nov 29.
33. Global DNA methylation, DNMT1, and MBD2 in patients with rheumatoid arthritis. Liu CC, etal., Immunol Lett. 2011 Mar 30;135(1-2):96-9. doi: 10.1016/j.imlet.2010.10.003. Epub 2010 Oct 16.
34. Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a. Liu WB, etal., Toxicol Appl Pharmacol. 2011 Feb 15;251(1):70-8. doi: 10.1016/j.taap.2010.12.002. Epub 2010 Dec 14.
35. Aberrant immunoreactivity of deoxyribonucleic acid methyltransferases in adenomyosis. Liu X and Guo SW, Gynecol Obstet Invest. 2012;74(2):100-8. Epub 2012 May 4.
36. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Loree J, etal., Int J Radiat Biol. 2006 Nov;82(11):805-15.
37. Traumatic brain injury induces relocalization of DNA-methyltransferase 1. Lundberg J, etal., Neurosci Lett. 2009 Jun 19;457(1):8-11. doi: 10.1016/j.neulet.2009.03.105. Epub 2009 Apr 5.
38. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. Majumder S, etal., J Biol Chem. 2002 May 3;277(18):16048-58. Epub 2002 Feb 13.
39. Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice. Matrisciano F, etal., Neuropharmacology. 2013 May;68:184-94. doi: 10.1016/j.neuropharm.2012.04.013. Epub 2012 Apr 28.
40. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Melas PA, etal., Int J Neuropsychopharmacol. 2012 Jun;15(5):669-79. doi: 10.1017/S1461145711000940. Epub 2011 Jun 20.
41. Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1. Meunier L, etal., Endocrinology. 2012 Apr;153(4):1936-47. doi: 10.1210/en.2011-1109. Epub 2012 Feb 14.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Mizuno S, etal., Blood. 2001 Mar 1;97(5):1172-9.
44. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Morey SR, etal., Cancer Res. 2006 Dec 15;66(24):11659-67.
45. DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population. Mostowska A, etal., Mol Biol Rep. 2013 Aug;40(8):4893-9. doi: 10.1007/s11033-013-2589-0. Epub 2013 May 12.
46. Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder. Nakagawa T, etal., J Urol. 2003 Dec;170(6 Pt 1):2463-6.
47. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
48. 5-Aza-2'-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching. Ning Y, etal., Arch Toxicol. 2013 May;87(5):871-81. doi: 10.1007/s00204-012-1008-y. Epub 2013 Feb 20.
49. Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure. Ohsawa K, etal., J Neurochem 1996 Jul;67(1):89-97.
50. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
51. Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Pathak S, etal., Mol Cell Endocrinol. 2010 Jan 15;314(1):110-7. doi: 10.1016/j.mce.2009.08.005. Epub 2009 Aug 14.
52. Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Pham TD, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R962-70. Epub 2003 Jul 17.
53. Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Ping J, etal., Toxicology. 2014 Jul 3;321:53-61. doi: 10.1016/j.tox.2014.03.011. Epub 2014 Apr 6.
54. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
55. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
56. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
57. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
58. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Ruzicka WB, etal., Mol Psychiatry. 2007 Apr;12(4):385-97. Epub 2007 Jan 30.
59. Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats. Sakharkar AJ, etal., Int J Neuropsychopharmacol. 2014 Dec;17(12):2057-67. doi: 10.1017/S1461145714001047. Epub 2014 Jun 26.
60. Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion. Sawada M, etal., Cancer Lett. 2007 Jun 28;251(2):211-9. Epub 2006 Dec 29.
61. Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus. Schneider JS, etal., Toxicol Lett. 2013 Feb 13;217(1):75-81. doi: 10.1016/j.toxlet.2012.12.004. Epub 2012 Dec 15.
62. DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma. Shieh YS, etal., Cancer. 2005 Sep 1;104(5):1013-21.
63. DNA methylation markers in the postnatal developing rat brain. Simmons RK, etal., Brain Res. 2013 Oct 2;1533:26-36. doi: 10.1016/j.brainres.2013.08.005. Epub 2013 Aug 14.
64. Cellular epigenetic modifications of neural stem cell differentiation. Singh RP, etal., Cell Transplant. 2009;18(10):1197-211. doi: 10.3727/096368909X12483162197204. Epub 2009 Aug 5.
65. 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats. Tikoo K, etal., Toxicol Lett. 2009 Dec 15;191(2-3):158-66. doi: 10.1016/j.toxlet.2009.08.018. Epub 2009 Aug 31.
66. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Tryndyak VP, etal., Carcinogenesis. 2006 Aug;27(8):1713-20. Epub 2006 Apr 22.
67. The E2F1/DNMT1 axis is associated with the development of AR negative castration resistant prostate cancer. Valdez CD, etal., Prostate. 2013 Dec;73(16):1776-85. doi: 10.1002/pros.22715. Epub 2013 Sep 4.
68. Deoxyribonucleic acid methyltransferases and methyl-CpG-binding domain proteins in human endometrium and endometriosis. van Kaam KJ, etal., Fertil Steril. 2011 Mar 15;95(4):1421-7. doi: 10.1016/j.fertnstert.2011.01.031. Epub 2011 Feb 12.
69. Epigenetic regulation of DNMT1 gene in mouse model of asthma disease. Verma M, etal., Mol Biol Rep. 2013 Mar;40(3):2357-68. doi: 10.1007/s11033-012-2317-1. Epub 2012 Nov 30.
70. Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity. Wang L, etal., Blood. 2013 May 2;121(18):3631-9. doi: 10.1182/blood-2012-08-451765. Epub 2013 Feb 26.
71. Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer. Wang W, etal., Oncol Rep. 2009 Jun;21(6):1439-47.
72. Chromatin remodeling--a novel strategy to control excessive alcohol drinking. Warnault V, etal., Transl Psychiatry. 2013 Feb 19;3:e231. doi: 10.1038/tp.2013.4.
73. Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat. Williams KT and Schalinske KL, Diabetes Metab Res Rev. 2012 Feb;28(2):123-31. doi: 10.1002/dmrr.1281.
74. Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin. Wu TT, etal., Lab Invest. 2020 Jul;100(7):974-985. doi: 10.1038/s41374-020-0402-y. Epub 2020 Feb 12.
75. DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer. Wu XY, etal., J Biochem. 2020 Aug 1;168(2):151-157. doi: 10.1093/jb/mvaa034.
76. Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Xiong Y, etal., Gynecol Oncol. 2005 Mar;96(3):601-9.
77. Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers. Xu HT, etal., Hum Pathol. 2011 Oct;42(10):1491-8. doi: 10.1016/j.humpath.2011.01.004. Epub 2011 Apr 14.
78. [Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats]. Zhang Q, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Feb;31(2):92-5.
79. Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. Zhao M, etal., Br J Dermatol. 2012 Feb;166(2):226-73. doi: 10.1111/j.1365-2133.2011.10646.x. Epub 2012 Jan 9.
80. Persistent overexpression of DNA methyltransferase 1 attenuating GABAergic inhibition in basolateral amygdala accounts for anxiety in rat offspring exposed perinatally to low-dose bisphenol A. Zhou R, etal., J Psychiatr Res. 2013 Oct;47(10):1535-44. doi: 10.1016/j.jpsychires.2013.05.013. Epub 2013 Jun 20.
81. Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosus. Zhu X, etal., Int J Dermatol. 2011 Jun;50(6):697-704. doi: 10.1111/j.1365-4632.2010.04804.x.
82. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Zimmermann N, etal., Biochem J. 2012 Nov 15;448(1):93-102. doi: 10.1042/BJ20120674.
Additional References at PubMed
PMID:1606615   PMID:8702988   PMID:8889548   PMID:9722504   PMID:10615135   PMID:10888872   PMID:10919675   PMID:11399088   PMID:11942627   PMID:14519686   PMID:15063176   PMID:15326124  
PMID:16424344   PMID:16491076   PMID:16791210   PMID:16887828   PMID:17245608   PMID:17254711   PMID:17576694   PMID:17931718   PMID:18413740   PMID:18754681   PMID:20548288   PMID:20573698  
PMID:21745816   PMID:22295098   PMID:22784989   PMID:22841775   PMID:23028046   PMID:24105743   PMID:24276224   PMID:24527678   PMID:24623306   PMID:25194984   PMID:25449846   PMID:25532521  
PMID:26093272   PMID:27021683   PMID:27697222   PMID:29117290   PMID:29155363   PMID:29555308   PMID:30229399   PMID:32008164   PMID:32313015   PMID:32800775   PMID:32989761   PMID:33284093  
PMID:33932446   PMID:34424481   PMID:34830365   PMID:35149775   PMID:36183073   PMID:36257574   PMID:36675153   PMID:36690210   PMID:36852448   PMID:37001844   PMID:37199639   PMID:37702447  


Genomics

Comparative Map Data
Dnmt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,716,797 - 27,763,405 (-)NCBIGRCr8
mRatBN7.2819,440,611 - 19,486,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,440,611 - 19,486,659 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,459,969 - 23,505,932 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,757,816 - 21,803,779 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,670,294 - 19,716,334 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,922,515 - 21,968,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,922,515 - 21,968,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,978,830 - 22,024,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,926,995 - 19,973,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1819,927,666 - 19,973,220 (-)NCBI
Celera820,835,612 - 20,881,380 (-)NCBICelera
Cytogenetic Map8q13NCBI
DNMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,133,346 - 10,194,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,133,342 - 10,231,286 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,244,022 - 10,305,629 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,105,022 - 10,166,811 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,105,022 - 10,166,811NCBI
Celera1910,139,454 - 10,201,147 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,824,670 - 9,886,268 (-)NCBIHuRef
CHM1_11910,244,307 - 10,306,021 (-)NCBICHM1_1
T2T-CHM13v2.01910,259,569 - 10,321,116 (-)NCBIT2T-CHM13v2.0
Dnmt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,818,501 - 20,871,084 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,818,505 - 20,871,184 (-)EnsemblGRCm39 Ensembl
GRCm38920,907,206 - 20,959,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,907,209 - 20,959,888 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,711,653 - 20,757,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,657,611 - 20,703,267 (-)NCBIMGSCv36mm8
Celera918,175,907 - 18,221,569 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
Dnmt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,465,480 - 1,505,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,465,529 - 1,505,379 (-)NCBIChiLan1.0ChiLan1.0
DNMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,048,374 - 15,112,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,048,694 - 14,110,457 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,681,847 - 9,745,334 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,342,478 - 10,390,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,342,478 - 10,406,972 (-)Ensemblpanpan1.1panPan2
DNMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,872,213 - 50,928,352 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,879,527 - 50,928,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,741,748 - 50,797,884 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,393,895 - 51,450,128 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,401,720 - 51,450,127 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,599,735 - 50,657,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,028,945 - 51,085,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,269,676 - 51,325,956 (+)NCBIUU_Cfam_GSD_1.0
Dnmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,789,213 - 209,834,531 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659520,493 - 565,416 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659520,181 - 565,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,981,566 - 69,029,844 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,981,564 - 69,040,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,309,511 - 69,357,838 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,199,006 - 9,263,890 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,199,003 - 9,263,607 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,795,260 - 10,857,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnmt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,315,251 - 2,358,711 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,316,042 - 2,358,866 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnmt1
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2536
Count of miRNA genes:286
Interacting mature miRNAs:352
Transcripts:ENSRNOT00000064304, ENSRNOT00000064932, ENSRNOT00000064978, ENSRNOT00000067325
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat

Markers in Region
RH128464  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,441,331 - 19,441,531 (+)MAPPERmRatBN7.2
Rnor_6.0821,923,236 - 21,923,435NCBIRnor6.0
Rnor_5.0821,979,551 - 21,979,750UniSTSRnor5.0
RGSC_v3.4819,927,716 - 19,927,915UniSTSRGSC3.4
Celera820,836,333 - 20,836,532UniSTS
RH 3.4 Map8181.0UniSTS
Cytogenetic Map8q13UniSTS


Genetic Models
This gene Dnmt1 is modified in the following models/strains:
SD-Dnmt1tm1(Myh6-cre)Cqin    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 40 24 19 24 1 1 72 25 34 11 1
Low 15 17 17 17 7 10 2 10 7 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB056446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF116344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF116345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF555651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA504141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA511167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA513509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB712236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB732375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB738113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV075240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D64060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV214494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY313807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV768908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV775426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000064932   ⟹   ENSRNOP00000063831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,440,611 - 19,486,659 (-)Ensembl
Rnor_6.0 Ensembl821,922,515 - 21,968,495 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000067325   ⟹   ENSRNOP00000063029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl821,923,489 - 21,968,415 (-)Ensembl
RefSeq Acc Id: NM_053354   ⟹   NP_445806
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,716,797 - 27,762,841 (-)NCBI
mRatBN7.2819,440,611 - 19,486,659 (-)NCBI
Rnor_6.0821,922,515 - 21,968,495 (-)NCBI
Rnor_5.0821,978,830 - 22,024,656 (-)NCBI
RGSC_v3.4819,926,995 - 19,973,256 (-)RGD
Celera820,835,612 - 20,881,380 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266223   ⟹   XP_063122293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,717,468 - 27,763,405 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_445806   ⟸   NM_053354
- UniProtKB: Q9Z330 (UniProtKB/Swiss-Prot),   Q9WU57 (UniProtKB/Swiss-Prot),   Q9WTX3 (UniProtKB/Swiss-Prot),   Q9R252 (UniProtKB/Swiss-Prot),   P70487 (UniProtKB/Swiss-Prot),   F1LQT9 (UniProtKB/TrEMBL),   A6JNM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063029   ⟸   ENSRNOT00000067325
RefSeq Acc Id: ENSRNOP00000063831   ⟸   ENSRNOT00000064932
RefSeq Acc Id: XP_063122293   ⟸   XM_063266223
- Peptide Label: isoform X1
Protein Domains
BAH   CXXC-type   DMAP1-binding   SAM-dependent MTase C5-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z330-F1-model_v2 AlphaFold Q9Z330 1-1622 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695780
Promoter ID:EPDNEW_R6293
Type:initiation region
Name:Dnmt1_1
Description:DNA methyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0821,968,445 - 21,968,505EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620979 AgrOrtholog
BioCyc Gene G2FUF-31449 BioCyc
Ensembl Genes ENSRNOG00000039859 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064932 ENTREZGENE
  ENSRNOT00000064932.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA Methylase, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BAH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C5_DNA_meth_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C5_MeTfrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C5_meth_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytosine_MeTrfase1_RFD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DMAP1-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNMT1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84350 UniProtKB/TrEMBL
NCBI Gene 84350 ENTREZGENE
PANTHER CYTOSINE-SPECIFIC METHYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DMAP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_methylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNMT1-RFD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CXXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnmt1 PhenoGen
PIRSF DNMT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS C5METTRFRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C5_MTASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C5_MTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DMAP1_BIND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_MT_C5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039859 RatGTEx
SMART BAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DMAP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JNM5 ENTREZGENE, UniProtKB/TrEMBL
  A6JNM6_RAT UniProtKB/TrEMBL
  A6JNM7_RAT UniProtKB/TrEMBL
  DNMT1_RAT UniProtKB/Swiss-Prot
  F1LQT9 ENTREZGENE, UniProtKB/TrEMBL
  P70487 ENTREZGENE
  Q9R252 ENTREZGENE
  Q9WTX3 ENTREZGENE
  Q9WU57 ENTREZGENE
  Q9Z330 ENTREZGENE
UniProt Secondary P70487 UniProtKB/Swiss-Prot
  Q9R252 UniProtKB/Swiss-Prot
  Q9WTX3 UniProtKB/Swiss-Prot
  Q9WU57 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Dnmt1  DNA methyltransferase 1  Dnmt1  DNA (cytosine-5-)-methyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Dnmt1  DNA (cytosine-5-)-methyltransferase 1  Dnmt1  DNA methyltransferase (cytosine-5) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Dnmt1  DNA methyltransferase (cytosine-5) 1  Dnmt1  DNA (cytosine-5-)-methyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dnmt1  DNA (cytosine-5-)-methyltransferase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dnmt1  DNA (cytosine-5-)-methyltransferase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction may bind to annexin V 631943
gene_regulation activity is regulated posttranslationally 632518