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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1affects response to substanceISODNMT1 (Homo sapiens)6480464CTDDNMT1 gene polymorphism affects the susceptibility to OzonePMID:27219456
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in decreased expression of and results in increased oxidation of DNMT1 mRNAPMID:32845096
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of DNMT1 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of DNMT1 mRNAPMID:34911549
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