Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases activityEXP 6480464CTDDecitabine results in decreased activity of DNMT1 proteinPMID:21449042
Dnmt1decreases expressionEXP 6480464CTDDecitabine results in decreased expression of DNMT1 proteinPMID:23423710
Dnmt1multiple interactionsEXP 6480464CTDDecitabine inhibits the reaction [Dust results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [Dust results in increased expression of DNMT1 protein]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of DNMT1 protein]PMID:24211420 PMID:30815999
Dnmt1affects response to substanceISODNMT1 (Homo sapiens)6480464CTDDNMT1 protein affects the susceptibility to DecitabinePMID:17991895
Dnmt1affects response to substanceISODnmt1 (Mus musculus)6480464CTDDNMT1 affects the susceptibility to DecitabinePMID:14581508
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDDecitabine results in decreased expression of DNMT1 mRNA; Decitabine results in decreased expression of DNMT1 proteinPMID:16613325 PMID:17571247 PMID:17616700 PMID:17621267 PMID:17653094 PMID:17991895 PMID:18676679 PMID:19117987 PMID:19221000 PMID:19470736 PMID:19732952 PMID:19840838 PMID:21078381 PMID:21771726 PMID:21801466 PMID:22749965
Dnmt1decreases expressionISODnmt1 (Mus musculus)6480464CTDDecitabine results in decreased expression of DNMT1 proteinPMID:19222872 PMID:19679824
Dnmt1increases degradationISODNMT1 (Homo sapiens)6480464CTDDecitabine results in increased degradation of DNMT1 proteinPMID:19417133
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDDecitabine results in increased expression of DNMT1 mRNAPMID:19117987
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTDDecitabine affects the reaction [PARP1 protein affects the expression of DNMT1 mRNA]; Decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT1 protein]; Decitabine inhibits the reaction [sodium arsenite results in increased expression of DNMT1 protein]; Decitabine promotes the reaction [sodium arsenite results in decreased expression of DNMT1 protein]; DNMT1 protein affects the reaction [Decitabine results in increased expression of H2AX protein]; IL6 protein inhibits the reaction [Decitabine results in decreased expression of DNMT1 mRNA]PMID:17621267 PMID:17991895 PMID:22112500 PMID:26409248 PMID:32006662 PMID:32905139
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTDDecitabine inhibits the reaction [Particulate Matter promotes the reaction [[ovalbumin-alum co-treated with Ovalbumin] results in increased expression of DNMT1 protein]]; Decitabine inhibits the reaction [Particulate Matter results in increased expression of DNMT1 protein]PMID:30481581
Go Back to source page   Continue to Ontology report