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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionEXP 6480464CTDArsenic results in decreased expression of DNMT1 proteinPMID:9380733
Dnmt1increases expressionEXP 6480464CTDArsenic results in increased expression of DNMT1 mRNAPMID:9380733
Dnmt1affects methylationISODNMT1 (Homo sapiens)6480464CTDArsenic affects the methylation of DNMT1 genePMID:25304211
Dnmt1affects response to substanceISODNMT1 (Homo sapiens)6480464CTDDNMT1 gene SNP affects the susceptibility to ArsenicPMID:27292127 PMID:31864032
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDArsenic results in decreased expression of DNMT1 mRNAPMID:35490796
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDArsenic results in increased expression of DNMT1 mRNAPMID:27838757
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTDFolic Acid inhibits the reaction [Arsenic results in decreased expression of DNMT1 mRNA]PMID:35490796
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DNMT1 proteinPMID:34952004
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