GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Dnmt1 | decreases expression | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of DNMT1 mRNA | PMID:19770486 | Dnmt1 | increases degradation | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased degradation of DNMT1 protein | PMID:21150308 | Dnmt1 | increases expression | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of DNMT1 mRNA | PMID:32234424 | Dnmt1 | increases expression | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of DNMT1 mRNA; Benzo(a)pyrene results in increased expression of DNMT1 protein | PMID:22228805 PMID:34979192 | Dnmt1 | increases methylation | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of DNMT1 promoter | PMID:27901495 | Dnmt1 | multiple interactions | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Benzo(a)pyrene results in increased degradation of DNMT1 protein] | PMID:21150308 | Dnmt1 | multiple interactions | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT1 mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT1 protein]; Benzo(a)pyrene inhibits the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter] | PMID:17682057 PMID:34979192 | |
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