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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of DNMT1 mRNAPMID:26455773
Dnmt1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of DNMT1 mRNAPMID:34747641
Dnmt1multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]PMID:24136580
Dnmt1affects expressionISODnmt1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of DNMT1 mRNAPMID:21570461
Dnmt1decreases expressionISODnmt1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of DNMT1 mRNAPMID:16611356
Dnmt1increases expressionISODnmt1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of DNMT1 mRNAPMID:15667827
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]; Resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Tetrachlorodibenzodioxin inhibits the reaction [DNMT1 protein binds to BRCA1 promoter]; Tetrachlorodibenzodioxin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]PMID:20631324 PMID:22197621 PMID:32986415
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNMT1 mRNAPMID:17942748
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