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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases response to substanceEXP 6480464CTDDNMT1 protein results in decreased susceptibility to Hydrogen PeroxidePMID:18314485
Dnmt1decreases response to substanceISODNMT1 (Homo sapiens)6480464CTDDNMT1 protein results in decreased susceptibility to Hydrogen PeroxidePMID:18314485
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of DNMT1 mRNA; Hydrogen Peroxide results in increased expression of DNMT1 proteinPMID:18314485 PMID:27655674
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTD[Acetylcysteine co-treated with Hydrogen Peroxide] results in increased expression of DNMT1 mRNA; [Acetylcysteine co-treated with Hydrogen Peroxide] results in increased methylation of DNMT1 promoterPMID:29854080
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