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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:17362
Term: quinoline
Definition: The simplest member of the quinoline class of compounds, comprising a benzene ring ortho fused to C-2 and C-3 of a pyridine ring.
Chemical ID: MESH:C037219
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases activityISODnmt1 (Mus musculus)6480464CTDquinoline analog results in decreased activity of DNMT1 proteinPMID:19417133
Dnmt1increases degradationISODNMT1 (Homo sapiens)6480464CTDquinoline analog results in increased degradation of DNMT1 proteinPMID:19417133
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [quinoline analog results in increased degradation of DNMT1 protein]PMID:19417133
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