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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1affects expressionISODNMT1 (Homo sapiens)6480464CTDhydroquinone affects the expression of DNMT1 mRNAPMID:31899212
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDhydroquinone results in decreased expression of DNMT1 mRNA; hydroquinone results in decreased expression of DNMT1 proteinPMID:22245671 PMID:27979589 PMID:34612549
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDhydroquinone results in increased expression of DNMT1 mRNAPMID:35135009
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