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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of DNMT1 mRNAPMID:22952798
Dnmt1decreases phosphorylationISODNMT1 (Homo sapiens)6480464CTDEstradiol results in decreased phosphorylation of DNMT1 proteinPMID:27026707
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDEstradiol results in increased expression of DNMT1 mRNAPMID:30684530 PMID:32030086
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTD6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]; [sodium arsenite co-treated with Estradiol] results in decreased expression of DNMT1 mRNA; Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]; Plant Extracts inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; Resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; sulforaphane inhibits the reaction [Estradiol results in increased expression of DNMT1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]PMID:20631324 PMID:22952798 PMID:30684530 PMID:32986415
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