GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Dnmt1 | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of DNMT1 mRNA | PMID:26455773 | Dnmt1 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of DNMT1 mRNA | PMID:34747641 | Dnmt1 | multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter] | PMID:24136580 | Dnmt1 | affects expression | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of DNMT1 mRNA | PMID:21570461 | Dnmt1 | decreases expression | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of DNMT1 mRNA | PMID:16611356 | Dnmt1 | increases expression | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of DNMT1 mRNA | PMID:15667827 | Dnmt1 | multiple interactions | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]; Resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; Tetrachlorodibenzodioxin inhibits the reaction [DNMT1 protein binds to BRCA1 promoter]; Tetrachlorodibenzodioxin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter] | PMID:20631324 PMID:22197621 PMID:32986415 | Dnmt1 | multiple interactions | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNMT1 mRNA | PMID:17942748 | |
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