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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionEXP 6480464CTDAzacitidine results in decreased expression of DNMT1 proteinPMID:19723570 PMID:21224363
Dnmt1multiple interactionsEXP 6480464CTD[Azacitidine co-treated with entinostat] results in decreased expression of DNMT1 protein; [Cisplatin co-treated with Azacitidine] results in decreased expression of DNMT1 proteinPMID:19723570 PMID:21224363
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDAzacitidine results in decreased expression of DNMT1 proteinPMID:28901456
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTD[SLC28A1 protein results in increased uptake of Azacitidine] which results in decreased expression of DNMT1 protein; Arsenic Trioxide promotes the reaction [Azacitidine results in decreased expression of DNMT1 protein]; Azacitidine inhibits the reaction [DNMT1 protein binds to MIR497 promoter]PMID:19139132 PMID:28901456 PMID:35066776
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