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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1affects activityISODnmt1 (Mus musculus)6480464CTDFolic Acid affects the activity of DNMT1 proteinPMID:16855792
Dnmt1affects expressionISODNMT1 (Homo sapiens)6480464CTDFolic Acid affects the expression of DNMT1 mRNAPMID:17311948 PMID:26492244
Dnmt1affects expressionISODnmt1 (Mus musculus)6480464CTDFolic Acid affects the expression of DNMT1 mRNAPMID:29986310
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDFolic Acid results in increased expression of DNMT1 mRNAPMID:23219837
Dnmt1increases expressionISODnmt1 (Mus musculus)6480464CTDFolic Acid results in increased expression of DNMT1 mRNA; Folic Acid results in increased expression of DNMT1 proteinPMID:30920123
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTDAPP protein affects the reaction [Folic Acid affects the expression of DNMT1 mRNA]; Folic Acid inhibits the reaction [Arsenic results in decreased expression of DNMT1 mRNA]PMID:26492244 PMID:35490796
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency co-treated with sodium arsenite] results in decreased expression of DNMT1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DNMT1 mRNA; Folic Acid affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of DNMT1 mRNA]; Folic Acid deficiency promotes the reaction [Streptozocin results in decreased expression of DNMT1 mRNA]; Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of DNMT1 mRNA]; Folic Acid inhibits the reaction [Streptozocin results in decreased expression of DNMT1 mRNA]PMID:20978746 PMID:22206623 PMID:28422052 PMID:28475147
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