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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1affects activityISODnmt1 (Mus musculus)6480464CTDCholine affects the activity of DNMT1 proteinPMID:16855792
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency co-treated with sodium arsenite] results in decreased expression of DNMT1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DNMT1 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of DNMT1 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of DNMT1 proteinPMID:20978746 PMID:25690533
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