RGD Reference Report - Playing TETris with DNA modifications. - Rat Genome Database

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Playing TETris with DNA modifications.

Authors: Delatte, B  Deplus, R  Fuks, F 
Citation: Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
RGD ID: 8695944
Pubmed: PMID:24825349   (View Abstract at PubMed)
PMCID: PMC4198024   (View Article at PubMed Central)
DOI: DOI:10.15252/embj.201488290   (Journal Full-text)

Methylation of the fifth carbon of cytosine was the first epigenetic modification to be discovered in DNA. Recently, three new DNA modifications have come to light: hydroxymethylcytosine, formylcytosine, and carboxylcytosine, all generated by oxidation of methylcytosine by Ten Eleven Translocation (TET) enzymes. These modifications can initiate full DNA demethylation, but they are also likely to participate, like methylcytosine, in epigenetic signalling per se. A scenario is emerging in which coordinated regulation at multiple levels governs the participation of TETs in a wide range of physiological functions, sometimes via a mechanism unrelated to their enzymatic activity. Although still under construction, a sophisticated picture is rapidly forming where, according to the function to be performed, TETs ensure epigenetic marking to create specific landscapes, and whose improper build-up can lead to diseases such as cancer and neurodegenerative disorders.

Objects Annotated

Genes (Rattus norvegicus)
Dnmt1  (DNA methyltransferase 1)
Dnmt3a  (DNA methyltransferase 3 alpha)
Dnmt3b  (DNA methyltransferase 3 beta)
Nanog  (Nanog homeobox)
Ogt  (O-linked N-acetylglucosamine (GlcNAc) transferase)
Pparg  (peroxisome proliferator-activated receptor gamma)
Sin3a  (SIN3 transcription regulator family member A)
Spi1  (Spi-1 proto-oncogene)
Tet1  (tet methylcytosine dioxygenase 1)
Tet2  (tet methylcytosine dioxygenase 2)
Tet3  (tet methylcytosine dioxygenase 3)

Genes (Mus musculus)
Dnmt1  (DNA methyltransferase 1)
Dnmt3a  (DNA methyltransferase 3A)
Dnmt3b  (DNA methyltransferase 3B)
Ebf1  (early B cell factor 1)
Nanog  (Nanog homeobox)
Ogt  (O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase))
Pparg  (peroxisome proliferator activated receptor gamma)
Prdm14  (PR domain containing 14)
Sin3a  (transcriptional regulator, SIN3A (yeast))
Spi1  (Spi-1 proto-oncogene)
Tet1  (tet methylcytosine dioxygenase 1)
Tet2  (tet methylcytosine dioxygenase 2)
Tet3  (tet methylcytosine dioxygenase 3)

Genes (Homo sapiens)
DNMT1  (DNA methyltransferase 1)
DNMT3A  (DNA methyltransferase 3 alpha)
DNMT3B  (DNA methyltransferase 3 beta)
EBF1  (EBF transcription factor 1)
NANOG  (Nanog homeobox)
OGT  (O-linked N-acetylglucosamine (GlcNAc) transferase)
PPARG  (peroxisome proliferator activated receptor gamma)
PRDM14  (PR/SET domain 14)
SIN3A  (SIN3 transcription regulator family member A)
SPI1  (Spi-1 proto-oncogene)
TET1  (tet methylcytosine dioxygenase 1)
TET2  (tet methylcytosine dioxygenase 2)
TET3  (tet methylcytosine dioxygenase 3)


Additional Information