Tet2 (tet methylcytosine dioxygenase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Tet2 (tet methylcytosine dioxygenase 2) Mus musculus
Analyze
Symbol: Tet2
Name: tet methylcytosine dioxygenase 2
RGD ID: 1323180
MGI Page MGI
Description: Enables 5-methylcytosine dioxygenase activity. Involved in myeloid cell differentiation; positive regulation of transcription by RNA polymerase II; and protein O-linked glycosylation. Acts upstream of or within several processes, including DNA demethylation; hematopoietic stem cell homeostasis; and myeloid progenitor cell differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; immune system; lower urogenital tract; and reproductive system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ayu17-44; Ayu17-449; E130014J05Rik; methylcytosine dioxygenase TET2; MGC37385; mKIAA1546; probable methylcytosine dioxygenase TET2; tet oncogene 2; tet oncogene family member 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393133,169,438 - 133,250,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3133,169,440 - 133,250,900 (-)EnsemblGRCm39 Ensembl
GRCm383133,463,677 - 133,545,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3133,463,679 - 133,545,139 (-)EnsemblGRCm38mm10GRCm38
MGSCv373133,126,641 - 133,207,354 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363133,400,983 - 133,426,624 (-)NCBIMGSCv36mm8
Celera3139,886,715 - 139,967,658 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map361.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-(hydroxymethyl)cytosine  (EXP,ISO)
5-methylcytosine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
chloroquine  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
curcumin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
hydrogen peroxide  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
p-chloromercuribenzoic acid  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
SB 431542  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
succimer  (EXP)
sulfadimethoxine  (ISO)
tetrachloro-1,4-benzoquinone  (EXP)
tetrachlorohydroquinone  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (EXP)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
nucleoplasm  (TAS)
nucleus  (IBA,IC)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal erythroid progenitor cell morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal liver sinusoid morphology  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal monocyte differentiation  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal tumor pathology  (IAGP)
anemia  (IAGP)
decreased B cell number  (IAGP)
decreased effector memory T-helper cell number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
hypochromic macrocytic anemia  (IAGP)
increased B cell number  (IAGP)
increased bone marrow cell number  (IAGP)
increased chronic myelocytic leukemia incidence  (IAGP)
increased DN1 thymic pro-T cell number  (IAGP)
increased double-negative T cell number  (IAGP)
increased erythroblast number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased granulocyte number  (IAGP)
increased hematopoietic cell number  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hemoglobin content  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased mean corpuscular volume  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased spleen weight  (IAGP)
increased splenocyte number  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
macrocytosis  (IAGP)
myeloid hyperplasia  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
thrombocytopenia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression Patterns for TETs, LGR5 and BMI1 in Cancer Stem-like Cells Isolated from Human Colon Cancer. Atlasy N, etal., Avicenna J Med Biotechnol. 2019 Apr-Jun;11(2):156-161.
2. Demethylation of the RB1 promoter concomitant with reactivation of TET2 and TET3 impairs gastric carcinogenesis in K19-Wnt1/C2mE transgenic mice. Cao D, etal., Life Sci. 2020 Dec 15;263:118580. doi: 10.1016/j.lfs.2020.118580. Epub 2020 Oct 12.
3. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
4. FISH analysis for TET2 deletion in a cohort of 362 Brazilian myeloid malignancies: correlation with karyotype abnormalities. de Oliveira FM, etal., Med Oncol. 2013 Mar;30(1):483. doi: 10.1007/s12032-013-0483-1. Epub 2013 Feb 7.
5. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
6. LncRNA-ANRIL promotes gastric cancer progression by enhancing NF-kB signaling. Deng W, etal., Exp Biol Med (Maywood). 2019 Sep;244(12):953-959. doi: 10.1177/1535370219860207. Epub 2019 Jun 26.
7. TET2 regulates LncRNA-ANRIL expression and inhibits the growth of human gastric cancer cells. Deng W, etal., IUBMB Life. 2016 May;68(5):355-64. doi: 10.1002/iub.1490. Epub 2016 Mar 29.
8. Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions-benign adenomas and inflammatory bowel disease. Dziaman T, etal., Clin Epigenetics. 2018 May 30;10:72. doi: 10.1186/s13148-018-0505-0. eCollection 2018.
9. DNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients. Elashi AA, etal., Oncoimmunology. 2018 Nov 10;8(2):e1542918. doi: 10.1080/2162402X.2018.1542918. eCollection 2019.
10. Loss of nuclear localization of TET2 in colorectal cancer. Huang Y, etal., Clin Epigenetics. 2016 Jan 26;8:9. doi: 10.1186/s13148-016-0176-7. eCollection 2016.
11. Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver. Jiang Y, etal., PLoS One. 2014 Dec 30;9(12):e116179. doi: 10.1371/journal.pone.0116179. eCollection 2014.
12. FGFR3â–³7-9 promotes tumor progression via the phosphorylation and destabilization of ten-eleven translocation-2 in human hepatocellular carcinoma. Jin Z, etal., Cell Death Dis. 2020 Oct 23;11(10):903. doi: 10.1038/s41419-020-03089-2.
13. Loss of 5-hydroxymethylcytosine and TET2 in oral squamous cell carcinoma. Jäwert F, etal., Anticancer Res. 2013 Oct;33(10):4325-8.
14. Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma. Liu J, etal., Hepatology. 2019 Jan;69(1):196-208. doi: 10.1002/hep.30146. Epub 2018 Dec 17.
15. STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer. Ma H, etal., J Immunol Res. 2018 Jun 14;2018:6985031. doi: 10.1155/2018/6985031. eCollection 2018.
16. TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma. Murata A, etal., Oncotarget. 2015 Sep 15;6(27):23372-82.
17. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. Muto T, etal., J Exp Med. 2013 Nov 18;210(12):2627-39. doi: 10.1084/jem.20131144. Epub 2013 Nov 11.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms. Saint-Martin C, etal., Blood. 2009 Aug 20;114(8):1628-32. doi: 10.1182/blood-2009-01-197525. Epub 2009 Jun 29.
23. Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. Sawada G, etal., Gastroenterology. 2016 May;150(5):1171-1182. doi: 10.1053/j.gastro.2016.01.035. Epub 2016 Feb 10.
24. Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes. Scopim-Ribeiro R, etal., Eur J Haematol. 2015 May;94(5):413-8. doi: 10.1111/ejh.12445. Epub 2014 Oct 1.
25. Loss of 5-Hydroxymethylcytosine Is an Independent Unfavorable Prognostic Factor for Esophageal Squamous Cell Carcinoma. Shi X, etal., PLoS One. 2016 Apr 6;11(4):e0153100. doi: 10.1371/journal.pone.0153100. eCollection 2016.
26. Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. Smith AE, etal., Blood. 2010 Nov 11;116(19):3923-32. doi: 10.1182/blood-2010-03-274704. Epub 2010 Aug 6.
27. TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes. Wang J, etal., Leuk Res. 2013 Mar;37(3):305-11. doi: 10.1016/j.leukres.2012.10.004. Epub 2012 Oct 23.
28. The TET2/E-cadherin/β-catenin regulatory loop confers growth and invasion in hepatocellular carcinoma cells. Yang G, etal., Exp Cell Res. 2018 Feb 15;363(2):218-226. doi: 10.1016/j.yexcr.2018.01.011. Epub 2018 Jan 10.
29. TET2 suppresses nasopharyngeal carcinoma progression by inhibiting glycolysis metabolism. Zhang X, etal., Cancer Cell Int. 2020 Aug 3;20:363. doi: 10.1186/s12935-020-01456-9. eCollection 2020.
30. Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors. Zhao D, etal., Lung Cancer. 2020 Aug;146:174-181. doi: 10.1016/j.lungcan.2020.05.025. Epub 2020 May 24.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12646957   PMID:12904583  
PMID:14610273   PMID:14621295   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16520305   PMID:16722336   PMID:17967808   PMID:18288583   PMID:18799693   PMID:19372391   PMID:20639862  
PMID:20887958   PMID:21057493   PMID:21267068   PMID:21295276   PMID:21321204   PMID:21490601   PMID:21677750   PMID:21723200   PMID:21723201   PMID:21778364   PMID:21803851   PMID:21816367  
PMID:21817016   PMID:21863549   PMID:21873190   PMID:21873635   PMID:22355785   PMID:22445327   PMID:22467095   PMID:22469782   PMID:22569366   PMID:22569552   PMID:22902501   PMID:22981865  
PMID:23028748   PMID:23074272   PMID:23151479   PMID:23222540   PMID:23254757   PMID:23352454   PMID:23352810   PMID:23353889   PMID:23359070   PMID:23395962   PMID:23415914   PMID:23453809  
PMID:23548903   PMID:23563267   PMID:23643243   PMID:23920106   PMID:23926181   PMID:23992847   PMID:24077167   PMID:24194590   PMID:24214992   PMID:24218140   PMID:24335252   PMID:24357321  
PMID:24474761   PMID:24529596   PMID:24645644   PMID:24672749   PMID:24735881   PMID:24786459   PMID:24788138   PMID:24838012   PMID:24844363   PMID:24984151   PMID:25224413   PMID:25263596  
PMID:25281607   PMID:25395421   PMID:25501021   PMID:25557551   PMID:25601757   PMID:25608811   PMID:25862091   PMID:25873173   PMID:25886910   PMID:25915124   PMID:26095772   PMID:26231219  
PMID:26275994   PMID:26287468   PMID:26325469   PMID:26328763   PMID:26378518   PMID:26493943   PMID:26576615   PMID:26586431   PMID:26598602   PMID:26607761   PMID:26620559   PMID:26773568  
PMID:26876596   PMID:26902115   PMID:26903244   PMID:26989192   PMID:27003514   PMID:27091986   PMID:27160912   PMID:27184841   PMID:27288448   PMID:27289557   PMID:27345836   PMID:27362828  
PMID:27384303   PMID:27424808   PMID:27428748   PMID:27622333   PMID:27694924   PMID:27760115   PMID:27778125   PMID:27821816   PMID:27863519   PMID:27869616   PMID:27869820   PMID:27895551  
PMID:27930333   PMID:27941786   PMID:28077417   PMID:28100914   PMID:28104796   PMID:28167288   PMID:28192139   PMID:28193779   PMID:28272491   PMID:28378742   PMID:28440315   PMID:28504700  
PMID:28538185   PMID:28614801   PMID:28636844   PMID:28660881   PMID:28697999   PMID:28783731   PMID:28813659   PMID:28823558   PMID:28825709   PMID:28826859   PMID:29048538   PMID:29089070  
PMID:29108636   PMID:29150566   PMID:29195897   PMID:29275866   PMID:29290626   PMID:29351814   PMID:29364877   PMID:29398449   PMID:29466726   PMID:29467326   PMID:29471939   PMID:29530881  
PMID:29542811   PMID:29581109   PMID:29662175   PMID:29705354   PMID:29728415   PMID:29764867   PMID:29769727   PMID:29795194   PMID:29858571   PMID:29866713   PMID:29991556   PMID:30146412  
PMID:30193945   PMID:30220521   PMID:30228234   PMID:30274972   PMID:30343588   PMID:30526882   PMID:30538121   PMID:30540950   PMID:30554962   PMID:30651561   PMID:30726915   PMID:30778220  
PMID:30796038   PMID:30850438   PMID:30971697   PMID:31028100   PMID:31043609   PMID:31120187   PMID:31160465   PMID:31164154   PMID:31178255   PMID:31278362   PMID:31286885   PMID:31310587  
PMID:31361780   PMID:31371502   PMID:31433977   PMID:31467060   PMID:31467227   PMID:31484061   PMID:31530896   PMID:31541101   PMID:31563562   PMID:31578525   PMID:31582397   PMID:31611558  
PMID:31618637   PMID:31669647   PMID:31766102   PMID:31836704   PMID:31844322   PMID:31943063   PMID:32037456   PMID:32083332   PMID:32107212   PMID:32114381   PMID:32126143   PMID:32159369  
PMID:32160545   PMID:32169654   PMID:32192357   PMID:32203468   PMID:32220332   PMID:32234487   PMID:32325033   PMID:32341038   PMID:32393787   PMID:32572188   PMID:32572241   PMID:32579941  
PMID:32616016   PMID:32668244   PMID:32770325   PMID:32823238   PMID:32892421   PMID:32895473   PMID:32934200   PMID:33046509   PMID:33069358   PMID:33090974   PMID:33106431   PMID:33113366  
PMID:33134768   PMID:33165916   PMID:33207953   PMID:33216286   PMID:33230319   PMID:33268865   PMID:33352108   PMID:33402183   PMID:33452460   PMID:33535102   PMID:33589517   PMID:33636128  
PMID:33791790   PMID:33846634   PMID:33853366   PMID:33926529   PMID:33928261   PMID:34035232   PMID:34086379   PMID:34099715   PMID:34111946   PMID:34158086   PMID:34165552   PMID:34203454  
PMID:34218273   PMID:34226503   PMID:34417463   PMID:34644568   PMID:34657351   PMID:34661337   PMID:34698806   PMID:34709266   PMID:34848557   PMID:34855941   PMID:34919053   PMID:35011643  
PMID:35045331   PMID:35075236   PMID:35081358   PMID:35085104   PMID:35235365   PMID:35255774   PMID:35304452   PMID:35332328   PMID:35405484   PMID:35443168   PMID:35499082   PMID:35569195  
PMID:35658976   PMID:35697791   PMID:35714308   PMID:35820129   PMID:35908548   PMID:35921527   PMID:35955629   PMID:35990681   PMID:36030305   PMID:36073548   PMID:36076297   PMID:36202795  
PMID:36271153   PMID:36351399   PMID:36353202   PMID:36522157   PMID:36527131   PMID:36539616   PMID:36550214   PMID:36630508   PMID:36652477   PMID:36681742   PMID:36734233   PMID:36736318  
PMID:36880575   PMID:36947858   PMID:37225048   PMID:37267914   PMID:37402169   PMID:37414790   PMID:37541212   PMID:37639586   PMID:37781816   PMID:38012545   PMID:38043702   PMID:38177099  
PMID:38179947   PMID:38331641   PMID:38495876   PMID:38561362  


Genomics

Comparative Map Data
Tet2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393133,169,438 - 133,250,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3133,169,440 - 133,250,900 (-)EnsemblGRCm39 Ensembl
GRCm383133,463,677 - 133,545,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3133,463,679 - 133,545,139 (-)EnsemblGRCm38mm10GRCm38
MGSCv373133,126,641 - 133,207,354 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363133,400,983 - 133,426,624 (-)NCBIMGSCv36mm8
Celera3139,886,715 - 139,967,658 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map361.84NCBI
TET2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384105,145,875 - 105,279,803 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4105,145,875 - 105,279,816 (+)EnsemblGRCh38hg38GRCh38
GRCh374106,067,032 - 106,200,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364106,287,392 - 106,383,377 (+)NCBINCBI36Build 36hg18NCBI36
Celera4103,367,233 - 103,500,234 (+)NCBICelera
Cytogenetic Map4q24NCBI
HuRef4101,802,173 - 101,936,091 (+)NCBIHuRef
CHM1_14106,044,130 - 106,178,054 (+)NCBICHM1_1
T2T-CHM13v2.04108,456,807 - 108,590,746 (+)NCBIT2T-CHM13v2.0
Tet2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82224,662,654 - 224,746,819 (-)NCBIGRCr8
mRatBN7.22221,988,645 - 222,072,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2221,988,645 - 222,072,534 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02238,719,389 - 238,802,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2238,720,835 - 238,803,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02257,252,323 - 257,335,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42231,016,023 - 231,039,777 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12231,002,809 - 231,063,981 (-)NCBI
Celera2214,215,516 - 214,299,103 (-)NCBICelera
Cytogenetic Map2q43NCBI
Tet2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554963,885,035 - 3,926,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554963,885,684 - 3,963,056 (-)NCBIChiLan1.0ChiLan1.0
TET2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23103,232,771 - 103,365,873 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14103,525,110 - 103,658,251 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0497,612,439 - 97,745,544 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14108,225,209 - 108,358,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4108,269,082 - 108,358,400 (+)Ensemblpanpan1.1panPan2
TET2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13226,021,745 - 26,145,109 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3226,059,693 - 26,143,536 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3215,878,947 - 16,004,016 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03226,234,028 - 26,359,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3226,233,933 - 26,357,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13226,252,220 - 26,377,230 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03225,996,769 - 26,121,941 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03213,740,508 - 13,865,760 (-)NCBIUU_Cfam_GSD_1.0
Tet2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530115,030,779 - 15,167,846 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936752440,136 - 577,615 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936752440,137 - 577,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TET2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8116,415,267 - 116,545,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18116,413,253 - 116,546,976 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28125,007,902 - 125,139,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TET2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1753,193,824 - 53,326,813 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl753,193,941 - 53,326,942 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603731,808,498 - 31,945,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tet2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248303,446,141 - 3,519,084 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248303,446,331 - 3,543,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tet2
2925 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:858
Count of miRNA genes:516
Interacting mature miRNAs:614
Transcripts:ENSMUST00000098603
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3109834882143835005Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110084357135715812Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110084357135715812Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110084357135715812Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
26884415Bzwq11_mbi-zygomatic width QTL 11, 16 week (mouse)3124993649137205761Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3130736935159745316Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3130849375159745316Mouse
1300753Eae10_msusceptibility to experimental allergic encephalomyelitis 10 (mouse)Not determined3131736617148451178Mouse
10412120Ccs3_mcolon cancer susceptibility 3 (mouse)Not determined3131754536146017669Mouse

Markers in Region
45.MMHAP66FLG6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383133,529,715 - 133,529,872UniSTSGRCm38
MGSCv373133,192,679 - 133,192,836UniSTSGRCm37
Celera3139,952,940 - 139,953,097UniSTS
Cytogenetic Map3G3UniSTS
Whitehead_YAC18 UniSTS
UniSTS:234827  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383133,463,988 - 133,464,301UniSTSGRCm38
MGSCv373133,126,952 - 133,127,265UniSTSGRCm37
Celera3139,887,026 - 139,887,339UniSTS
Cytogenetic Map3G3UniSTS
Tet2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383133,476,526 - 133,476,628UniSTSGRCm38
Celera3139,899,576 - 139,899,678UniSTS
Cytogenetic Map3G3UniSTS
cM Map361.84UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001040400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001346736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE137977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF463367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ079067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU079949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000098603   ⟹   ENSMUSP00000096203
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,169,440 - 133,250,151 (-)Ensembl
GRCm38.p6 Ensembl3133,463,679 - 133,544,390 (-)Ensembl
RefSeq Acc Id: ENSMUST00000195913
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,244,523 - 133,250,047 (-)Ensembl
GRCm38.p6 Ensembl3133,538,762 - 133,544,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196292
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,219,218 - 133,250,063 (-)Ensembl
GRCm38.p6 Ensembl3133,513,457 - 133,544,302 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196398   ⟹   ENSMUSP00000143029
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,169,600 - 133,250,129 (-)Ensembl
GRCm38.p6 Ensembl3133,463,839 - 133,544,368 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197118   ⟹   ENSMUSP00000143619
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,194,296 - 133,250,900 (-)Ensembl
GRCm38.p6 Ensembl3133,488,535 - 133,545,139 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197211
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,171,608 - 133,177,578 (-)Ensembl
GRCm38.p6 Ensembl3133,465,847 - 133,471,817 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198974   ⟹   ENSMUSP00000143468
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,173,288 - 133,182,331 (-)Ensembl
GRCm38.p6 Ensembl3133,467,527 - 133,476,570 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199176
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,180,836 - 133,184,687 (-)Ensembl
GRCm38.p6 Ensembl3133,475,075 - 133,478,926 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199381
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,169,444 - 133,180,580 (-)Ensembl
GRCm38.p6 Ensembl3133,463,683 - 133,474,819 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200203
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,184,817 - 133,186,443 (-)Ensembl
GRCm38.p6 Ensembl3133,479,056 - 133,480,682 (-)Ensembl
RefSeq Acc Id: NM_001040400   ⟹   NP_001035490
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,438 - 133,250,151 (-)NCBI
GRCm383133,463,677 - 133,544,390 (-)NCBI
MGSCv373133,126,641 - 133,207,354 (-)RGD
Celera3139,886,715 - 139,967,658 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001346736   ⟹   NP_001333665
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,438 - 133,250,151 (-)NCBI
GRCm383133,463,677 - 133,544,390 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006501283   ⟹   XP_006501346
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,882 (-)NCBI
GRCm383133,463,677 - 133,545,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006501286   ⟹   XP_006501349
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,356 (-)NCBI
GRCm383133,463,677 - 133,544,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006501287   ⟹   XP_006501350
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,356 (-)NCBI
GRCm383133,463,677 - 133,544,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011240068   ⟹   XP_011238370
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,245 (-)NCBI
GRCm383133,463,677 - 133,544,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163012   ⟹   XP_036018905
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,155 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001035490   ⟸   NM_001040400
- Peptide Label: isoform 1
- UniProtKB: Q6ZPN2 (UniProtKB/Swiss-Prot),   Q3UAI0 (UniProtKB/Swiss-Prot),   Q3U633 (UniProtKB/Swiss-Prot),   Q3U5R5 (UniProtKB/Swiss-Prot),   Q8K2K3 (UniProtKB/Swiss-Prot),   Q4JK59 (UniProtKB/Swiss-Prot),   D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501346   ⟸   XM_006501283
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JF55 (UniProtKB/TrEMBL),   D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501350   ⟸   XM_006501287
- Peptide Label: isoform X3
- UniProtKB: D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501349   ⟸   XM_006501286
- Peptide Label: isoform X2
- UniProtKB: D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238370   ⟸   XM_011240068
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JF55 (UniProtKB/TrEMBL),   D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001333665   ⟸   NM_001346736
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JF55 (UniProtKB/TrEMBL),   D0VLQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000143468   ⟸   ENSMUST00000198974
RefSeq Acc Id: ENSMUSP00000143619   ⟸   ENSMUST00000197118
RefSeq Acc Id: ENSMUSP00000096203   ⟸   ENSMUST00000098603
RefSeq Acc Id: ENSMUSP00000143029   ⟸   ENSMUST00000196398
RefSeq Acc Id: XP_036018905   ⟸   XM_036163012
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JF55 (UniProtKB/TrEMBL),   D0VLQ5 (UniProtKB/TrEMBL)
Protein Domains
Methylcytosine dioxygenase TET1-3 oxygenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4JK59-F1-model_v2 AlphaFold Q4JK59 1-1912 view protein structure

Promoters
RGD ID:6833680
Promoter ID:MM_KWN:36143
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC008RKO.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363133,134,301 - 133,135,662 (-)MPROMDB
RGD ID:6833677
Promoter ID:MM_KWN:36144
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC008RKP.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363133,137,256 - 133,137,756 (-)MPROMDB
RGD ID:6834533
Promoter ID:MM_KWN:36145
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000041994,   NM_001040400
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363133,207,061 - 133,208,282 (-)MPROMDB
RGD ID:6882410
Promoter ID:EPDNEW_M4656
Type:multiple initiation site
Name:Tet2_2
Description:Mus musculus tet methylcytosine dioxygenase 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4657  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383133,506,672 - 133,506,732EPDNEW
RGD ID:6882412
Promoter ID:EPDNEW_M4657
Type:multiple initiation site
Name:Tet2_1
Description:Mus musculus tet methylcytosine dioxygenase 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4656  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383133,544,292 - 133,544,352EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443298 AgrOrtholog
Ensembl Genes ENSMUSG00000040943 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000098603 ENTREZGENE
  ENSMUST00000098603.8 UniProtKB/Swiss-Prot
  ENSMUST00000196398 ENTREZGENE
  ENSMUST00000196398.5 UniProtKB/TrEMBL
  ENSMUST00000197118.5 UniProtKB/TrEMBL
  ENSMUST00000198974.2 UniProtKB/TrEMBL
InterPro 2OGFeDO_noxygenase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TET1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TET_oxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:214133 UniProtKB/Swiss-Prot
MGD MGI:2443298 ENTREZGENE
NCBI Gene 214133 ENTREZGENE
PANTHER METHYLCYTOSINE DIOXYGENASE TET2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23358 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tet_JBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tet2 PhenoGen
SMART Tet_JBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JF55 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JG87_MOUSE UniProtKB/TrEMBL
  A0A0G2JGM1_MOUSE UniProtKB/TrEMBL
  D0VLQ5 ENTREZGENE, UniProtKB/TrEMBL
  Q3U1R1_MOUSE UniProtKB/TrEMBL
  Q3U5R5 ENTREZGENE
  Q3U633 ENTREZGENE
  Q3UAI0 ENTREZGENE
  Q4JK59 ENTREZGENE
  Q6ZPN2 ENTREZGENE
  Q8K2K3 ENTREZGENE
  TET2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3U5R5 UniProtKB/Swiss-Prot
  Q3U633 UniProtKB/Swiss-Prot
  Q3UAI0 UniProtKB/Swiss-Prot
  Q6ZPN2 UniProtKB/Swiss-Prot
  Q8K2K3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-14 Tet2  tet methylcytosine dioxygenase 2  Tet2  tet oncogene family member 2  Symbol and/or name change 5135510 APPROVED