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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323180
Species: Mus musculus
RGD Object: Gene
Symbol: Tet2
Name: tet methylcytosine dioxygenase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tet2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TET2 mRNAPMID:32156529 PMID:33221593 PMID:38074096
Tet2increases expressionEXP 6480464CTDbisphenol A results in increased expression of TET2 mRNAPMID:31649729 PMID:35598803
Tet2affects expressionISOTet2 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of TET2 mRNAPMID:25181051
Tet2decreases expressionISOTet2 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of TET2 mRNAPMID:32145629
Tet2decreases expressionISOTET2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of TET2 mRNA; bisphenol A results in decreased expression of TET2 proteinPMID:32105160 PMID:37315367
Tet2increases expressionISOTET2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of TET2 mRNAPMID:31601247
Tet2increases methylationISOTET2 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of TET2 promoterPMID:32105160
Tet2multiple interactionsISOTET2 (Homo sapiens)6480464CTD[bisphenol A promotes the reaction [WDR5 protein binds to TET2 protein]] which binds to ESR2 exon; [bisphenol A promotes the reaction [WDR5 protein binds to TET2 protein]] which binds to ESR2 promoter; [KDM2A protein co-treated with bisphenol A] results in decreased expression of and results in decreased activity of TET2 protein; [KDM2A protein co-treated with bisphenol A] results in decreased expression of TET2 mRNA; bisphenol A promotes the reaction [KDM2A protein binds to TET2 promoter]; bisphenol A promotes the reaction [TET2 protein results in increased abundance of 5-hydroxymethylcytosine]; bisphenol A promotes the reaction [WDR5 protein binds to TET2 protein]; bisphenol A results in decreased expression of and results in decreased activity of TET2 protein; DNMT1 protein promotes the reaction [bisphenol A results in decreased expression of TET2 protein]; DNMT1 protein promotes the reaction [bisphenol A results in increased methylation of TET2 promoter]; DNMT3A protein promotes the reaction [bisphenol A results in decreased expression of TET2 protein]; ESR1 protein promotes the reaction [bisphenol A results in increased methylation of TET2 promoter]; TET2 protein inhibits the reaction [[bisphenol A promotes the reaction [WDR5 protein binds to TET2 protein]] which binds to ESR2 exon]; TET2 protein inhibits the reaction [[bisphenol A promotes the reaction [WDR5 protein binds to TET2 protein]] which binds to ESR2 promoter]; TET2 protein inhibits the reaction [bisphenol A promotes the reaction [WDR5 protein binds to TET2 protein]]; TET2 protein inhibits the reaction [bisphenol A results in decreased abundance of 5-hydroxymethylcytosine]; TET2 protein inhibits the reaction [bisphenol A results in increased expression of ESR2 protein]PMID:32105160 PMID:33022573 PMID:37315367
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