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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:9986
Term: vinclozolin
Definition: A racemate comprising equimolar amounts of (R)- and (S)-vinclozolin. A fungicide used mainly on oilseed rape, vines, fruit and vegetables to control Botrytis, Sclerotinia and Monilia spp.
Chemical ID: MESH:C025643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionEXP 6480464CTDvinclozolin results in decreased expression of DNMT1 mRNA; vinclozolin results in decreased expression of DNMT1 proteinPMID:18042343 PMID:20056826
Dnmt1increases expressionEXP 6480464CTDvinclozolin results in increased expression of DNMT1 mRNAPMID:23034163
Dnmt1multiple interactionsEXP 6480464CTD[Testosterone co-treated with vinclozolin] results in increased expression of DNMT1 mRNA; Testosterone inhibits the reaction [vinclozolin results in decreased expression of DNMT1 mRNA]PMID:20056826
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