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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of DNMT1 mRNAPMID:25181051 PMID:30816183 PMID:32145629
Dnmt1increases expressionEXP 6480464CTDbisphenol A results in increased expression of DNMT1 mRNA; bisphenol A results in increased expression of DNMT1 proteinPMID:23791455 PMID:32450286
Dnmt1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of DNMT1 genePMID:28505145
Dnmt1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of DNMT1 mRNAPMID:36041667
Dnmt1affects expressionISODnmt1 (Mus musculus)6480464CTDbisphenol A affects the expression of DNMT1 mRNAPMID:23716699 PMID:31201698
Dnmt1affects methylationISODnmt1 (Mus musculus)6480464CTDbisphenol A affects the methylation of DNMT1 exonPMID:23716699
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of DNMT1 mRNA; bisphenol A results in decreased expression of DNMT1 proteinPMID:28597690 PMID:29275510 PMID:34537452 PMID:37567409
Dnmt1decreases expressionISODnmt1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of DNMT1 mRNA; bisphenol A results in decreased expression of DNMT1 proteinPMID:21980460 PMID:22131059 PMID:23535407 PMID:27502578 PMID:30015891 PMID:31463084
Dnmt1decreases methylationISODNMT1 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of DNMT1 genePMID:31601247
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of DNMT1 mRNA; bisphenol A results in increased expression of DNMT1 proteinPMID:28765096 PMID:30303745 PMID:31601247 PMID:32030086 PMID:32105160 PMID:37834465
Dnmt1increases expressionISODnmt1 (Mus musculus)6480464CTDbisphenol A results in increased expression of DNMT1 mRNA; bisphenol A results in increased expression of DNMT1 proteinPMID:25385582 PMID:28496034 PMID:30303745 PMID:30892605 PMID:31649729 PMID:32488702
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTD[bisphenol A co-treated with decabromobiphenyl ether] results in decreased expression of DNMT1 mRNA; [naringenin co-treated with bisphenol A] results in increased expression of DNMT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of DNMT1 mRNA; bisphenol A promotes the reaction [ESR1 protein binds to DNMT1 promoter]; DNMT1 protein promotes the reaction [bisphenol A results in decreased abundance of 5-hydroxymethylcytosine]; DNMT1 protein promotes the reaction [bisphenol A results in decreased expression of TET2 protein]; DNMT1 protein promotes the reaction [bisphenol A results in increased methylation of TET2 promoter]; ESR1 protein promotes the reaction [bisphenol A results in increased expression of DNMT1 mRNA]; ESR1 protein promotes the reaction [bisphenol A results in increased expression of DNMT1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of DNMT1 mRNA]PMID:28597690 PMID:31601247 PMID:32105160 PMID:34537452 PMID:36235125
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTDDrugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of DNMT1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of DNMT1 mRNA]PMID:22131059 PMID:30892605 PMID:32488702
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