GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Dnmt1 | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of DNMT1 mRNA | PMID:25181051 PMID:30816183 PMID:32145629 | Dnmt1 | increases expression | EXP | | 6480464 | CTD | bisphenol A results in increased expression of DNMT1 mRNA; bisphenol A results in increased expression of DNMT1 protein | PMID:23791455 PMID:32450286 | Dnmt1 | increases methylation | EXP | | 6480464 | CTD | bisphenol A results in increased methylation of DNMT1 gene | PMID:28505145 | Dnmt1 | multiple interactions | EXP | | 6480464 | CTD | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of DNMT1 mRNA | PMID:36041667 | Dnmt1 | affects expression | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | bisphenol A affects the expression of DNMT1 mRNA | PMID:23716699 PMID:31201698 | Dnmt1 | affects methylation | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | bisphenol A affects the methylation of DNMT1 exon | PMID:23716699 | Dnmt1 | decreases expression | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of DNMT1 mRNA; bisphenol A results in decreased expression of DNMT1 protein | PMID:28597690 PMID:29275510 PMID:34537452 PMID:37567409 | Dnmt1 | decreases expression | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | bisphenol A results in decreased expression of DNMT1 mRNA; bisphenol A results in decreased expression of DNMT1 protein | PMID:21980460 PMID:22131059 PMID:23535407 PMID:27502578 PMID:30015891 PMID:31463084 | Dnmt1 | decreases methylation | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased methylation of DNMT1 gene | PMID:31601247 | Dnmt1 | increases expression | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased expression of DNMT1 mRNA; bisphenol A results in increased expression of DNMT1 protein | PMID:28765096 PMID:30303745 PMID:31601247 PMID:32030086 PMID:32105160 PMID:37834465 | Dnmt1 | increases expression | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | bisphenol A results in increased expression of DNMT1 mRNA; bisphenol A results in increased expression of DNMT1 protein | PMID:25385582 PMID:28496034 PMID:30303745 PMID:30892605 PMID:31649729 PMID:32488702 | Dnmt1 | multiple interactions | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | [bisphenol A co-treated with decabromobiphenyl ether] results in decreased expression of DNMT1 mRNA; [naringenin co-treated with bisphenol A] results in increased expression of DNMT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of DNMT1 mRNA; bisphenol A promotes the reaction [ESR1 protein binds to DNMT1 promoter]; DNMT1 protein promotes the reaction [bisphenol A results in decreased abundance of 5-hydroxymethylcytosine]; DNMT1 protein promotes the reaction [bisphenol A results in decreased expression of TET2 protein]; DNMT1 protein promotes the reaction [bisphenol A results in increased methylation of TET2 promoter]; ESR1 protein promotes the reaction [bisphenol A results in increased expression of DNMT1 mRNA]; ESR1 protein promotes the reaction [bisphenol A results in increased expression of DNMT1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of DNMT1 mRNA] | PMID:28597690 PMID:31601247 PMID:32105160 PMID:34537452 PMID:36235125 | Dnmt1 | multiple interactions | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of DNMT1 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of DNMT1 mRNA] | PMID:22131059 PMID:30892605 PMID:32488702 | |
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