Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of DNMT1 proteinPMID:19723570
Dnmt1decreases response to substanceEXP 6480464CTDDNMT1 protein results in decreased susceptibility to CisplatinPMID:18314485
Dnmt1multiple interactionsEXP 6480464CTD[Cisplatin co-treated with Azacitidine] results in decreased expression of DNMT1 proteinPMID:19723570
Dnmt1decreases response to substanceISODNMT1 (Homo sapiens)6480464CTDDNMT1 protein results in decreased susceptibility to CisplatinPMID:18314485 PMID:21458988
Go Back to source page   Continue to Ontology report