METHIONINE CYCLE/METABOLIC PATHWAY (PW:0000048)

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Description

Methionine is an essential amino acid derived from diet and necessary for normal mammalian growth and development. As an amino acid methionine is used for the synthesis of proteins while its metabolic cycle provides a number of metabolites important for a range of other metabolic pathways and processes. Methionine adenosyltransferases (Mat) catalyze the formation of S-adenosylmethionine (known as AdoMet or SAM) using ATP in two consecutive reactions of which the second is rate-limiting. Mammals

Pathway Diagram:

Ariadne Genomics Inc. S-adenosylmethioninamine ---> methylthioadenosine dimethylglycine ---| Bhmt Srm Sms polyamine metabolic pathway S-adenosylmethionine ---> S-adenosylhomocysteine AdoMet-dependent methyltransferases betaine 5-methyl-THF THF dimethylglycine homocysteine methylthioadenosine spermine metabolic pathway methyl group transfer  to carbon, nitrogen, oxygen or sulfur atoms on proteins, nucleic acids, carbohydrates, lipids, small molecules Cbl ATP ---> S-adenosylmethionine methylthioadenosine ---> 1-phosphomethylthioribose AdoMet radical reactions involved in co-factor and other natural products biosynthesis in anaerobic organisms S-adenosylmethionine ---> S-adenosylmethioninamine spermidine metabolic pathway Mtap S-adenosylmethioninamine 1-phosphomethylthioribose ATP methionine adenosine Mtrr ---> Mtr Mtrr Mat2b ---> Mat2a Mat2b folate cycle metabolic pathway Amd1 S-adenosylhomocysteine ---| AdoMet-dependent methyltransferases homocysteine metabolic pathway diet ---> methionine diet 5-methyl-THF ---> THF adenosine <--> S-adenosylhomocysteine Ahcy Mat2a Mat1a 1-phosphomethylthioribose ---> methionine methionine ---> protein biosynthesis protein biosynthesis methionine ---> S-adenosylmethionine S-adenosylmethionine ---> AdoMet radical reactions involved in co-factor and other natural products biosynthesis in anaerobic organisms Mtr homocysteine <--> S-adenosylhomocysteine folate mediated one-carbon metabolic pathway homocysteine ---> methionine Bhmt betaine ---> dimethylglycine S-adenosylhomocysteine S-adenosylmethionine
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Genes in Pathway:

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methionine cycle/metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahcy adenosylhomocysteinase JBrowse link 3 150,587,833 150,603,057 RGD:730275
RGD:7242425
RGD:7242932
RGD:10402751
G Amd1 adenosylmethionine decarboxylase 1 JBrowse link 20 45,384,000 45,399,694 RGD:7242425
RGD:7242932
RGD:10402751
G As3mt arsenite methyltransferase JBrowse link 1 266,482,787 266,514,570 RGD:625365
G Asmt acetylserotonin O-methyltransferase JBrowse link 12 18,521,383 18,527,036 RGD:1359073
G Bhmt betaine-homocysteine S-methyltransferase JBrowse link 2 23,236,573 23,256,158 RGD:1359026
RGD:7242425
RGD:10402751
G Carm1 coactivator-associated arginine methyltransferase 1 JBrowse link 8 22,577,723 22,622,555 RGD:1359044
RGD:7242552
G Cbs cystathionine beta synthase JBrowse link 20 10,361,987 10,386,663 RGD:10402751
G Chdh choline dehydrogenase JBrowse link 16 6,078,083 6,109,386 RGD:10402751
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:1359089
G Cth cystathionine gamma-lyase JBrowse link 2 264,266,959 264,293,040 RGD:10402751
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:1359078
RGD:7242551
RGD:10402751
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:7242551
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:7242551
G Dot1l DOT1 like histone lysine methyltransferase JBrowse link 7 11,786,105 11,824,742 RGD:1359080
RGD:7242554
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:7242554
G Gamt guanidinoacetate N-methyltransferase JBrowse link 7 12,314,848 12,317,998 RGD:1359081
G Gnmt glycine N-methyltransferase JBrowse link 9 16,565,274 16,568,626 RGD:1359070
RGD:7242425
RGD:7242551
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:1359041
G Icmt isoprenylcysteine carboxyl methyltransferase JBrowse link 5 169,475,270 169,482,031 RGD:1359083
G Il4i1 interleukin 4 induced 1 JBrowse link 1 100,811,727 100,836,901 RGD:10402751
G Kmt5a lysine methyltransferase 5A JBrowse link 12 37,558,150 37,581,183 RGD:7242554
G Mars methionyl-tRNA synthetase JBrowse link 7 70,585,011 70,602,425 RGD:10402751
G Mat1a methionine adenosyltransferase 1A JBrowse link 16 18,690,649 18,709,135 RGD:1359039
RGD:7242425
RGD:7242932
G Mat2a methionine adenosyltransferase 2A JBrowse link 4 100,297,478 100,303,047 RGD:1359040
RGD:7242425
RGD:10402751
G Mat2b methionine adenosyltransferase 2B JBrowse link 10 25,832,096 25,848,045 RGD:7242425
RGD:10402751
G Mrm2 mitochondrial rRNA methyltransferase 2 JBrowse link 12 16,398,749 16,403,656 RGD:1359074
G Msrb2 methionine sulfoxide reductase B2 JBrowse link 17 86,066,841 86,148,131 RGD:10402751
G Msrb3 methionine sulfoxide reductase B3 JBrowse link 7 62,850,506 62,972,487 RGD:10402751
G Mtap methylthioadenosine phosphorylase JBrowse link 5 107,711,077 107,777,530 RGD:7242425
RGD:7242932
RGD:10402751
G Mtfmt mitochondrial methionyl-tRNA formyltransferase JBrowse link 8 70,952,209 70,986,393 RGD:10402751
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:1535021
RGD:10402751
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:1359026
RGD:7242425
RGD:7242426
RGD:10402751
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase JBrowse link 1 37,743,089 37,774,485 RGD:1359037
RGD:7242426
G Nnmt nicotinamide N-methyltransferase JBrowse link 8 52,918,437 52,938,172 RGD:1359084
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 JBrowse link 1 1,734,863 1,767,759 RGD:729481
G Pemt phosphatidylethanolamine N-methyltransferase JBrowse link 10 46,339,821 46,404,640 RGD:729486
G Pnmt phenylethanolamine-N-methyltransferase JBrowse link 10 86,340,893 86,342,501 RGD:1359087
G Prmt1 protein arginine methyltransferase 1 JBrowse link 1 100,971,132 100,980,411 RGD:1359044
RGD:7242552
G Prmt2 protein arginine methyltransferase 2 JBrowse link 20 13,154,513 13,212,613 RGD:7242552
G Prmt3 protein arginine methyltransferase 3 JBrowse link 1 105,113,595 105,200,253 RGD:1359044
RGD:7242552
G Prmt5 protein arginine methyltransferase 5 JBrowse link 15 33,156,508 33,165,893 RGD:1359044
RGD:7242552
G Prmt6 protein arginine methyltransferase 6 JBrowse link 2 213,173,403 213,180,721 RGD:1359044
RGD:7242552
G Prmt7 protein arginine methyltransferase 7 JBrowse link 19 38,189,605 38,237,155 RGD:7242552
G Rnmt RNA (guanine-7-) methyltransferase JBrowse link 18 64,084,746 64,108,246 RGD:1359071
G Setd7 SET domain containing (lysine methyltransferase) 7 JBrowse link 2 140,576,188 140,618,405 RGD:7242554
G Setdb1 SET domain, bifurcated 1 JBrowse link 2 196,495,867 196,527,412 RGD:1359072
G Shmt1 serine hydroxymethyltransferase 1 JBrowse link 10 47,030,813 47,059,216 RGD:10402751
G Sms spermine synthase JBrowse link X 40,363,646 40,415,110 RGD:7242425
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:7242554
G Srm spermidine synthase JBrowse link 5 165,405,168 165,408,325 RGD:7242425
RGD:10402751
G Suv39h1l1 suppressor of variegation 3-9 homolog 1 (Drosophila)-like 1 JBrowse link X 15,171,280 15,185,191 RGD:7242554
G Suv39h2 suppressor of variegation 3-9 homolog 2 JBrowse link 17 78,762,897 78,782,016 RGD:1359810
RGD:7242554
G Trdmt1 tRNA aspartic acid methyltransferase 1 JBrowse link 17 80,824,652 80,859,585 RGD:1359088

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassAdoMet-dependent methyltransferases

Pathway Gene Annotations

Disease Annotations Associated with Genes in the methionine cycle/metabolic pathway
Disease TermsGene Symbols
AbetalipoproteinemiaDnmt1
Abnormalities, MultipleDnmt3a
Abortion, HabitualMthfr
Abruptio PlacentaeBhmt
Acute Kidney InjuryMthfr
AdenocarcinomaDnmt1
Adenocarcinoma of LungDnmt3a , Dnmt3b , Dot1l
Adenocarcinoma, Bronchiolo-AlveolarDnmt1
Adenocarcinoma, ColorectalDnmt3b
Adenocarcinoma, ProstaticDnmt1 , Dnmt3a , Dnmt3b
AdenomaMtrr
Adenoma, Liver CellCarm1
AdenomyosisDnmt1 , Dnmt3a , Dnmt3b
AlbuminuriaMthfr
AlcoholismComt
AlopeciaMthfr
Alopecia AreataDnmt1
Alzheimer DiseaseHnmt , Mthfr , Pcmt1 , Pnmt
Amino Acid Metabolism, Inborn ErrorsAhcy , Cth , Gamt , Mat1a
Amphetamine-Related DisordersComt
Amyotrophic Lateral SclerosisDnmt3a , Mthfr
AnemiaMthfr
Anemia, Sickle CellMthfr
AnencephalyMtrr
AnoxiaAhcy
Anxiety DisordersDnmt1 , Dnmt3b
Aortic Aneurysm, AbdominalMthfr
Aortic Aneurysm, ThoracicCbs
Aortic CoarctationMthfr
Aortic InjuriesPcmt1
Arakawa Syndrome 2Mtr
Arsenic PoisoningAs3mt , Mthfr
Arterial Occlusive DiseasesMthfr
Arthritis, ExperimentalAhcy , Dnmt1
Arthritis, RheumatoidDnmt1 , Dnmt3b , Mthfr , Sms
AsthmaCarm1 , Dnmt1 , Hnmt , Mthfr , Prmt1 , Prmt2 , Prmt3 , Prmt5
AstrocytomaPcmt1
AtaxiaDnmt1
AtherosclerosisMthfr
Attention Deficit Disorder with HyperactivityAs3mt , Comt , Mthfr
Autism Spectrum DisorderComt , Dnmt3a , Dnmt3b
Autistic DisorderAsmt , Comt , Mthfr , Mtr , Setdb1
Autoimmune DiseasesDnmt1
Biliary Tract NeoplasmsMtap
Binge DrinkingDnmt1
Bipolar DisorderComt , Mthfr
Birth WeightAs3mt
Blood Coagulation Disorders, InheritedMthfr
Bone Marrow DiseasesDnmt3a
Brain DiseasesMat1a
Brain InfarctionHnmt
Brain InjuriesComt , Dnmt1
Brain IschemiaMthfr
Breast NeoplasmsCarm1 , Comt , Dnmt1 , Dnmt3a , Dnmt3b , Ezh2 , Mthfr , Mtr , Shmt1
Bronchial HyperreactivityHnmt
Budd-Chiari SyndromeMthfr
CarcinogenesisDnmt1 , Dnmt3a
CarcinomaDnmt1 , Dnmt3b
Carcinoma, Ductal, BreastEzh2
Carcinoma, EndometrioidDnmt1 , Dnmt3b
Carcinoma, HepatocellularCarm1 , Comt , Dnmt1 , Dnmt3a , Dnmt3b , Ezh2 , Gnmt , Mat1a
Carcinoma, MucoepidermoidDnmt1
Carcinoma, Pancreatic DuctalDnmt1 , Dnmt3b
Carcinoma, Renal CellComt , Mthfr , Nnmt
Carcinoma, Squamous CellMthfr
Carcinoma, Squamous Cell of Head and NeckDnmt3b
Carcinoma, Transitional CellMthfr
Cardiomyopathy, DilatedComt
Cardiomyopathy, HypertrophicComt
Cardiomyopathy, Hypertrophic, FamilialComt
Cardiovascular DiseasesCbs , Mthfr
Carotid StenosisMthfr
CatalepsyComt
CataractCth , Mthfr
Cerebellar AtaxiaDnmt1
Cerebellar Ataxia, Deafness, and NarcolepsyDnmt1
Cerebral InfarctionMthfr
Cervical Intraepithelial NeoplasiaMthfr
Charcot-Marie-Tooth DiseaseMars
Charcot-Marie-Tooth Disease, Axonal, Type 2UMars
CholangiocarcinomaMthfr
Cholestasis, ExtrahepaticSetd7
Choline DeficiencyDnmt1
ChoreaDnmt1
Clear-Cell Metastatic Renal Cell CarcinomaMthfr
Cleft LipMthfr , Mtr
Cleft PalateMtr
ClubfootMthfr
Cocaine-Related DisordersComt
Cognition DisordersComt
Colonic NeoplasmsDnmt1 , Mthfr
Colorectal NeoplasmsDnmt1 , Dnmt3b , Mthfr , Mtrr
Combined Oxidative Phosphorylation Deficiency 15Mtfmt
Common Bile Duct NeoplasmsMtap
Conotruncal Cardiac DefectsMthfr
ContusionsPnmt
Coronary Artery DiseaseCbs , Mthfr
Coronary DiseaseMthfr
Coronary RestenosisMthfr
Craniofacial AbnormalitiesDnmt3a , Dnmt3b
CraniosynostosesEzh2
Crohn DiseaseDnmt3a
Deafness, Autosomal Recessive 74Msrb3
Deglutition DisordersDnmt1
DementiaDnmt1
Demyelinating DiseasesMat1a
Depressive DisorderDnmt3a , Mthfr
Dermatitis, AtopicHnmt
Developmental DisabilitiesAs3mt
Diabetes Mellitus, ExperimentalComt , Ezh2 , Mthfr , Mtr , Pemt , Pnmt
Diabetes Mellitus, Type 1Dnmt3b , Mthfr
Diabetes Mellitus, Type 2Bhmt , Cbs , Dnmt1 , Mat1a , Mthfr , Mtr
Diabetic AngiopathiesMthfr
Diabetic NephropathiesMthfr , Mtrr , Prmt1
Diabetic RetinopathyMthfr
Diaphyseal Medullary Stenosis with Malignant Fibrous HistiocytomaMtap
DiGeorge SyndromeComt
Down SyndromeHnmt , Mthfr , Mtrr
Drug EruptionsMthfr
Drug HypersensitivityHnmt
Drug-Induced Liver InjuryMthfr
Drug-Related Side Effects and Adverse ReactionsMthfr , Mtr , Mtrr , Shmt1
DysarthriaDnmt1
Dyskinesia, Drug-InducedComt
DysmenorrheaDnmt3b
Endometrial NeoplasmsComt , Dnmt1 , Dnmt3b , Ezh2 , Mthfr
EndometriosisDnmt1 , Dnmt3a , Dnmt3b
EpilepsyMtr
Esophageal Squamous Cell CarcinomaDnmt3b
Essential TremorHnmt
Eye DiseasesMthfr
FaciesDnmt3a
FatigueComt
Fatty LiverMat1a , Mthfr
Fatty Liver, AlcoholicDnmt1 , Pemt
Fetal Growth RetardationComt , Dnmt1 , Dnmt3b
Gamma-Cystathionase DeficiencyCth
Gastrointestinal DiseasesMthfr , Mtr
Gastrointestinal Stromal TumorsMthfr , Mtr , Mtrr , Shmt1
Genetic Diseases, InbornDnmt3a , Mtr , Mtrr , Sms
Glaucoma, Angle-ClosureMthfr
Glaucoma, Open-AngleMthfr
GliomaPcmt1 , Setdb1
GlomerulonephritisMthfr
Glomerulonephritis, IGAMtr
Graft vs Host DiseaseMthfr
Graves DiseaseDnmt1 , Mthfr
Growth DisordersDnmt3a
Guanidinoacetate Methyltransferase DeficiencyGamt
Hearing LossDnmt1 , Msrb3 , Mthfr , Mtr
Hearing Loss, Cisplatin-Induced, Susceptibility ToComt
Hearing Loss, SuddenMthfr , Mtr
Heart Defects, CongenitalDnmt1 , Dnmt3a , Dnmt3b , Mthfr
Heart DiseasesMtr , Mtrr
Heart FailureDnmt1 , Pcmt1
Heart Septal DefectsMtrr
Hematologic DiseasesMthfr , Mtr
Hematologic NeoplasmsMthfr
Hemophilia AMthfr
HepatitisGnmt
Hepatitis, ChronicGnmt
Hepatolenticular DegenerationAhcy , Asmt , Bhmt
Hereditary Sensory and Autonomic NeuropathiesDnmt1
HomocystinuriaCbs , Mthfr , Mtrr
Homocystinuria, Pyridoxine-ResponsiveCbs
Homocystinuria-Megaloblastic Anemia due to Defect in Cobalamin Metabolism, CblE Complementation TypeMtrr
Huntington DiseaseHnmt , Setdb1
HyperalgesiaComt , Dnmt1
HyperhomocysteinemiaAhcy , Cbs , Cth , Gnmt , Mthfr , Mtr , Mtrr
HypermethioninemiaAhcy , Gnmt , Mat1a
HyperplasiaMat1a
HypersensitivityMthfr
HypertensionAhcy , Cbs , Comt , Mtr , Pnmt
Hypertension, EssentialPnmt
HyperthyroidismMthfr
Hypertrophy, Left VentricularEzh2
HypoglycemiaPnmt
HypopituitarismMthfr
HypothyroidismMthfr
Hypoxia-Ischemia, BrainDnmt3a
Immunoblastic LymphadenopathyDnmt3a
Immunodeficiency Syndrome, VariableDnmt3b
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1Dnmt3b
Immunologic Deficiency SyndromesDnmt3b
Infantile Liver Failure Syndrome 2Mars
Infarction, Middle Cerebral ArteryDnmt1 , Dnmt3a
Infertility, FemaleMthfr
Infertility, MaleMthfr , Mtr , Mtrr
Inflammatory Bowel Disease 11Hnmt , Mtrr
Inflammatory Bowel DiseasesMthfr
Intellectual DisabilityDnmt3a , Gamt
IschemiaMthfr
Kidney DiseasesMthfr
Kidney Failure, ChronicMthfr
Leigh DiseaseGamt , Mtfmt
Leigh Syndrome Due To Mitochondrial Complex I DeficiencyMtfmt
LeiomyomaComt , Ezh2
Leukemia, Biphenotypic, AcuteDot1l
Leukemia, Lymphocytic, Chronic, B-CellDnmt3b , Mthfr
Leukemia, Megakaryoblastic, AcuteEzh2
Leukemia, Megakaryoblastic, of Down SyndromeEzh2
Leukemia, Monocytic, AcuteDnmt3a
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveDnmt1 , Dnmt3a , Dnmt3b , Mthfr
Leukemia, Myeloid, AcuteDnmt1 , Dnmt3a , Dnmt3b , Ezh2 , Mthfr , Mtrr
Leukemia, Myelomonocytic, ChronicEzh2
Leukemia, Myelomonocytic, JuvenileDnmt3a , Ezh2
Leukemia, Promyelocytic, AcuteDnmt3a
LeukoencephalopathiesMthfr , Mtr
LeukopeniaMthfr
Leydig Cell TumorPrmt5
Lichen Planus, OralDnmt1 , Dnmt3b
Liver CirrhosisDnmt1
Liver DiseasesMthfr
Liver NeoplasmsGnmt , Mthfr
Liver Neoplasms, ExperimentalPemt
Lung NeoplasmsDnmt1 , Dnmt3a , Dnmt3b , Mthfr , Setdb1
Lupus Erythematosus, SystemicDnmt1
Lymphatic MetastasisComt , Dnmt3b
LymphomaEzh2 , Mthfr , Mtr
Lymphoma, B-CellEzh2
Lymphoma, FollicularEzh2 , Mthfr , Mtr
Lymphoma, Large B-Cell, DiffuseEzh2 , Mthfr
Lymphoma, Non-HodgkinBhmt , Cbs , Ezh2 , Mthfr , Mtrr , Shmt1
Lymphoma, T-Cell, CutaneousDnmt3a
Lymphoma, T-Cell, PeripheralDnmt3a
MalnutritionCbs , Mthfr , Mtr
Mammary Neoplasms, AnimalComt
Mammary Neoplasms, ExperimentalDnmt3b
Maxillofacial AbnormalitiesMthfr
MedulloblastomaDnmt1
MelanomaCbs , Cth , Ezh2 , Mtap , Setdb1
Melanoma, Cutaneous MalignantDnmt3b
Meniere DiseaseMthfr
MeningiomaMtrr
MeningomyeloceleMthfr
Mental DisordersComt
Mental Retardation, Autosomal Recessive 51Hnmt
Mesothelioma, MalignantSetdb1
Metabolism, Inborn ErrorsMtr , Mtrr
Methylcobalamin Deficiency, CblG TypeMtr
Methylenetetrahydrofolate Reductase DeficiencyMthfr
Microsatellite InstabilityMthfr
Microvascular AnginaMthfr
Migraine DisordersMthfr
Migraine with AuraMthfr
Mitochondrial Complex I DeficiencyGamt
Mthfr Deficiency, Thermolabile TypeMthfr
MucositisMthfr
Multiple MyelomaMthfr , Mtr , Mtrr
Multiple SclerosisPnmt
Musculoskeletal PainComt
MycetomaComt
Myelodysplastic SyndromesDnmt3a , Ezh2 , Mtrr
Myelodysplastic-Myeloproliferative DiseasesEzh2
Myeloproliferative DisordersEzh2 , Mthfr
Myocardial InfarctionMthfr
NecrosisMthfr
Neoplasm MetastasisDnmt3b , Mthfr
Neoplasm Recurrence, LocalDnmt3a
Neoplasms, Glandular and EpithelialAs3mt
Neoplasms, Multiple PrimaryDnmt3b
NephrosclerosisMthfr
Nervous System DiseasesMthfr , Mtrr , Shmt1
Neural Tube Defect, Folate-SensitiveMthfr , Mtr , Mtrr
Neural Tube DefectsBhmt , Cbs , Mthfr
Neuropathy, Hereditary Sensory and Autonomic, Type IEDnmt1
NeutropeniaMthfr
NevusMtap
Non-alcoholic Fatty Liver DiseaseEzh2
Nonarteritic Anterior Ischemic Optic NeuropathyMthfr
Nonsyndromic DeafnessMsrb3
ObesityComt
Obsessive-Compulsive DisorderComt
Oral Squamous Cell CarcinomaDnmt3b , Mthfr
OsteonecrosisMthfr
OsteosarcomaEzh2 , Mthfr
Ovarian NeoplasmsComt , Dnmt1 , Shmt1
PainComt
Pancreatic Intraepithelial NeoplasiaDnmt1
Pancreatic NeoplasmsEzh2 , Mtap , Mthfr , Mtr , Mtrr
Panic DisorderComt
Parkinson DiseaseHnmt , Mtrr
Parkinsonian DisordersComt
Peripheral Arterial DiseaseMthfr
Peritoneal FibrosisDnmt1
PheochromocytomaComt
Pick Disease of the BrainHnmt
Polycystic Ovary SyndromeComt
Precursor Cell Lymphoblastic Leukemia-LymphomaDnmt3a , Mthfr , Mtr , Mtrr
Precursor T-Cell Lymphoblastic Leukemia-LymphomaDnmt3a , Ezh2
Primary MyelofibrosisEzh2
Prostatic Intraepithelial NeoplasiaCarm1 , Dnmt1
Prostatic NeoplasmsCarm1 , Comt , Dnmt1 , Dnmt3b , Ezh2 , Gnmt , Kmt5a , Mtap , Mthfr , Setdb1
ProstatitisDnmt3a , Dnmt3b
PsoriasisCarm1 , Comt
Pulmonary Alveolar ProteinosisMars
Pulmonary EmbolismMthfr
Purpura, Thrombocytopenic, IdiopathicDnmt3a , Dnmt3b
Rectal NeoplasmsMthfr
Renal InsufficiencyMthfr
Renal Insufficiency, ChronicMthfr
Renal Vascular DiseasesMthfr
Reperfusion InjuryPnmt
Retinal DiseasesMthfr
Retinal Vein OcclusionMthfr
RetinoblastomaMtr
Rett SyndromeSetdb1
RhinitisHnmt
SchizophreniaComt , Dnmt1 , Dnmt3b , Hnmt , Mthfr , Setdb1
Sciatic NeuropathyDnmt3a
SeizuresGamt
SeminomaPrmt5
Sezary SyndromeDnmt3a
SHORT STATURE, BRACHYDACTYLY, INTELLECTUAL DEVELOPMENTAL DISABILITY, AND SEIZURESPrmt7
Sinus Thrombosis, IntracranialMthfr
Skin DiseasesMthfr
Skin/Hair/Eye Pigmentation, Variation In, 9Ahcy
Small Cell Lung CarcinomaDnmt3b , Mthfr
Smith-Magenis SyndromePnmt , Shmt1 , Sms
Snyder Robinson SyndromeSms
Spinal Cord DiseasesMthfr
Spinal DysraphismMthfr , Mtr , Mtrr , Pcmt1
Stomach NeoplasmsDnmt1 , Dnmt3a , Dnmt3b , Mthfr
Stomatitis, AphthousMthfr
Striatonigral Degeneration InfantileIl4i1
StrokeMthfr
TATTON-BROWN-RAHMAN SYNDROMEDnmt3a
Temporomandibular Joint DisordersComt , Mtrr
Tetralogy of FallotMthfr
ThrombocytopeniaMthfr
ThrombophiliaMthfr
ThrombosisMthfr
Thrombotic MicroangiopathiesMthfr
ThymomaDnmt3b
ThyrotoxicosisMthfr
Transposition of Great VesselsMthfr
Upper Extremity Deformities, CongenitalEzh2
UremiaComt
Urinary Bladder NeoplasmsAs3mt , Comt , Dnmt1 , Mthfr , Mtr
UrticariaHnmt
Uterine Cervical NeoplasmsDnmt1 , Dnmt3b , Mthfr
Vascular CalcificationMthfr
Vascular DiseasesMthfr
Venous ThromboembolismMthfr
Venous ThrombosisComt , Mthfr
Vitamin B 12 DeficiencyMtr
Vitamin B 6 DeficiencyAhcy
VitiligoComt
Weaver SyndromeEzh2
Wet Macular DegenerationMthfr
Wilms TumorMthfr
Pathway Annotations Associated with Genes in the methionine cycle/metabolic pathway
Pathway TermsGene Symbols
5'-end pre-mRNA capping pathwayRnmt
alkaptonuria disease pathwayComt , Pnmt
altered folate cycle metabolic pathwayMthfr , Mtr , Mtrr
altered folate mediated one-carbon metabolic pathwayMthfr , Mtr
aminoacyl-tRNA biosynthetic pathwayMars , Mtfmt
androgen signaling pathwayCarm1 , Prmt1
arginine and proline metabolic pathwayAmd1 , Gamt , Srm
arginine:glycine amidinotransferase deficiency pathwayGamt
aromatic amino acid decarboxylase deficiency pathwayPnmt
beta-alanine metabolic pathwaySrm
Canavan disease pathwayIl4i1
carnitine biosynthetic pathwaySetd7 , Shmt1
catecholamine biosynthetic pathwayPnmt
choline metabolic pathwayAhcy , Bhmt , Chdh , Mat2a , Mat2b , Mtr , Pemt
creatine metabolic pathwayGamt
cyanoamino acid metabolic pathwayShmt1
cysteine and methionine metabolic pathwayAhcy , Amd1 , Bhmt , Cbs , Cth , Dnmt1 , Dnmt3a , Dnmt3b , Mat1a , Mat2a , Mat2b , Mtap , Mtr , Srm , Trdmt1
cysteine metabolic pathwayCbs , Cth
dihydropyrimidine dehydrogenase deficiency pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
dimethylglycine dehydrogenase deficiency pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
disulfiram pharmacodynamics pathwayComt , Pnmt
DNA modification pathwayDnmt1 , Dnmt3a , Dnmt3b
dopamine beta hydroxylase deficiency pathwayComt , Pnmt
epinephrine biosynthetic pathwayPnmt
estrogen signaling pathwayCarm1 , Prmt1
folate cycle metabolic pathwayMthfr , Mtr , Mtrr , Shmt1
folate mediated one-carbon metabolic pathwayGnmt , Mtfmt , Mthfr , Mtr , Mtrr , Shmt1
folate metabolic pathwayGnmt , Mtfmt , Mthfr , Mtr , Mtrr , Shmt1
gamma-cystathionase deficiency pathwayCbs , Cth
glutathione metabolic pathwaySrm
glycerophospholipid metabolic pathwayPemt
glycine metabolic pathwayShmt1
glycine N-methyltransferase deficiency pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
glycine, serine and threonine metabolic pathwayBhmt , Cbs , Chdh , Cth , Gamt , Gnmt , Shmt1
guanidinoacetate methyltransferase deficiency pathwayGamt
gyrate atrophy pathwayGamt
hawkinsinuria disease pathwayComt , Pnmt
hereditary folate malabsorption disease pathwayMtfmt , Mthfr
histidine metabolic pathwayHnmt , Prmt3
histidinemia disease pathwayHnmt , Prmt3
histone modification pathwayCarm1 , Dot1l , Ezh2 , Prmt1 , Prmt2 , Prmt5 , Prmt7 , Setd7 , Smyd2 , Suv39h2
homocysteine metabolic pathwayAhcy , As3mt , Asmt , Carm1 , Comt , Dnmt1 , Dot1l , Gamt , Gnmt , Hnmt , Icmt , Mrm2 , Mthfr , Nnmt , Pcmt1 , Pemt , Pnmt , Prmt1 , Prmt3 , Prmt5 , Prmt6 , Rnmt , Setdb1 , Suv39h2 , Trdmt1
homocystinuria disease pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
hypermethioninemia disease pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
hyperornithinemia-hyperammonemia-homocitrullinemia syndrome pathwayGamt
hyperprolinemia disease pathwayGamt
hyperprolinemia type II disease pathwayGamt
lysine degradation pathwayDot1l , Kmt5a , Setd7 , Setdb1 , Suv39h1l1 , Suv39h2
meracaptolactate cysteine disulfiduria pathwayCth
methionine adenosyltransferase deficiency pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
methionine cycle/metabolic pathwayAhcy , Amd1 , As3mt , Asmt , Bhmt , Carm1 , Cbs , Chdh , Comt , Cth , Dnmt1 , Dnmt3a , Dnmt3b , Dot1l , Ezh2 , Gamt , Gnmt , Hnmt , Icmt , Il4i1 , Kmt5a , Mars , Mat1a , Mat2a , Mat2b , Mrm2 , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Mtrr , Nnmt , Pcmt1 , Pemt , Pnmt , Prmt1 , Prmt2 , Prmt3 , Prmt5 , Prmt6 , Prmt7 , Rnmt , Setd7 , Setdb1 , Shmt1 , Sms , Smyd2 , Srm , Suv39h1l1 , Suv39h2 , Trdmt1
methotrexate pharmacodynamics pathwayMtfmt , Mthfr
methylenetetrahydrofolate reductase deficiency pathwayAhcy , Amd1 , Bhmt , Cbs , Chdh , Cth , Dnmt1 , Il4i1 , Mars , Mat2a , Mat2b , Msrb2 , Msrb3 , Mtap , Mtfmt , Mthfr , Mtr , Shmt1 , Srm
monoterpenoid biosynthetic pathwayNnmt
mRNA decay pathwayRnmt
niacin metabolic pathwayNnmt
nonketotic hyperglycinemia disease pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
Nonketotic hyperglycinemia disease pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
ocular nephropathic cystinosis disease pathwayCth
p53 signaling pathwayPrmt5 , Setd7 , Smyd2
phenylketonuria disease pathwayIl4i1
phenytoin pharmacodynamics pathwayComt
polyamine metabolic pathwayAmd1 , Sms , Srm
prolidase deficiency pathwayGamt
putrescine metabolic pathwayAmd1
remethylation pathway of homocysteine metabolism - cobalamin dependentMthfr , Mtr , Mtrr
remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependentAhcy , Bhmt , Chdh , Mat2a , Mat2b , Mtr , Pemt
RNA transport pathwayPrmt5
sarcosinemia disease pathwayBhmt , Cbs , Cth , Gamt , Gnmt , Shmt1
selenoamino acid metabolic pathwayAhcy , Cbs , Cth , Mars , Mat2a , Mat2b , Mtr
spermidine metabolic pathwayAmd1 , Mat2a , Mat2b , Sms , Srm
spermine metabolic pathwayAmd1 , Mat2a , Mat2b , Sms , Srm
steroid hormone biosynthetic pathwayComt
transsulfuration pathway of homocysteine metabolismCbs , Cth
tryptophan metabolic pathwayAsmt
tyrosine metabolic pathwayComt , Pnmt
tyrosinemia type I disease pathwayComt , Pnmt
tyrosinemia type II disease pathwayIl4i1
tyrosinemia type III disease pathwayIl4i1
Wnt signaling, non-canonical pathwaySetdb1
Phenotype Annotations Associated with Genes in the methionine cycle/metabolic pathway

References Associated with the methionine cycle/metabolic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: