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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of DNMT1 mRNAPMID:29223816
Dnmt1decreases activityISODNMT1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of DNMT1 proteinPMID:20596618
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of DNMT1 mRNA; Arsenic Trioxide results in decreased expression of DNMT1 proteinPMID:16613325 PMID:17490527 PMID:20596618 PMID:21176356 PMID:21687957 PMID:22558281 PMID:23159075 PMID:24993472 PMID:28901456 PMID:29159499
Dnmt1decreases expressionISODnmt1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of DNMT1 mRNA; Arsenic Trioxide results in decreased expression of DNMT1 proteinPMID:19679824 PMID:23159075
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of DNMT1 mRNAPMID:25534098
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]; Arsenic Trioxide promotes the reaction [Azacitidine results in decreased expression of DNMT1 protein]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in decreased expression of DNMT1 protein]PMID:22558281 PMID:28901456
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTD[Arsenic Trioxide co-treated with Tamoxifen] results in decreased expression of DNMT1 mRNA; [Arsenic Trioxide co-treated with Tamoxifen] results in decreased expression of DNMT1 proteinPMID:23159075
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