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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:16680
Term: S-adenosyl-L-homocysteine
Definition: An organic sulfide that is the S-adenosyl derivative of L-homocysteine.
Chemical ID: MESH:D012435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases activityISODNMT1 (Homo sapiens)6480464CTDS-Adenosylhomocysteine results in decreased activity of DNMT1 proteinPMID:16037419
Dnmt1decreases activityISODnmt1 (Mus musculus)6480464CTDS-Adenosylhomocysteine results in decreased activity of DNMT1 proteinPMID:22064374
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTDS-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]PMID:22064374
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