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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionEXP 6480464CTDlead acetate results in decreased expression of DNMT1 mRNA; lead acetate results in decreased expression of DNMT1 proteinPMID:21117136 PMID:22764079 PMID:23246732
Dnmt1increases expressionEXP 6480464CTDlead acetate results in increased expression of DNMT1 mRNA; lead acetate results in increased expression of DNMT1 proteinPMID:22160880 PMID:23246732
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTD[lead acetate results in increased abundance of Lead] which affects the expression of DNMT1 proteinPMID:29481626
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