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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1increases expressionEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNAPMID:12097258
Dnmt1increases expressionISODnmt1 (Mus musculus)6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA; 9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 proteinPMID:24792773
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTDButyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA]; Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]; Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA]; Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]; Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA]; Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]PMID:24792773
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