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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:6651
Term: malathion
Definition: A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.
Chemical ID: MESH:D008294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionEXP 6480464CTDMalathion results in increased expression of TP53 mRNAPMID:21628957
Tp53multiple interactionsEXP 6480464CTD[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of TP53 mRNA]PMID:21628957
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDMalathion results in increased expression of TRP53 proteinPMID:12505448 PMID:32120800
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDMalathion results in increased expression of TP53 mRNA; Malathion results in increased expression of TP53 proteinPMID:12762645 PMID:18204794 PMID:19787260
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTDPlant Extracts inhibits the reaction [Malathion results in increased expression of TRP53 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TRP53 protein]PMID:32120800
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDAtropine inhibits the reaction [Malathion results in increased expression of TP53 protein]PMID:12762645
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