Predicted to enable several functions, including cAMP-dependent protein kinase inhibitor activity; oxysterol binding activity; and patched binding activity. Involved in several processes, including negative regulation of hepatocyte proliferation; neuron projection development; and positive regulation of hepatic stellate cell activation. Located in axonal growth cone; dendritic growth cone; and neuronal cell body. Used to study Barrett's esophagus; esophagus adenocarcinoma; liver cirrhosis; and middle cerebral artery infarction. Biomarker of ocular hypertension; pancreatitis; pre-malignant neoplasm; and visual epilepsy. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; malignant pleural mesothelioma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one.
epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA] and epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] and goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein] and goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SMO mRNA] and Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] and Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]
Cisplatin promotes the reaction [jinfukang results in increased expression of SMO mRNA] and jinfukang promotes the reaction [Cisplatin results in increased expression of SMO mRNA]
[Clofibrate co-treated with Acetaminophen] affects the expression of SMO mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SMO mRNA]
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SMO mRNA] and Curcumin inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SMO mRNA] and Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMO mRNA
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] and goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein] and goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein]
hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO mRNA] and hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO protein]
[mono-(2-ethylhexyl)phthalate co-treated with Androgens deficiency] results in increased expression of SMO mRNA and mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of SMO mRNA]
[Clofibrate co-treated with Acetaminophen] affects the expression of SMO mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SMO mRNA]
tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO mRNA] and tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO protein]
hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO mRNA] and hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO protein]
cyclopamine inhibits the reaction [resveratrol results in increased expression of SMO protein] and resveratrol results in increased expression of and affects the localization of SMO protein
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMO mRNA
cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO mRNA] and cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO protein]
GANT 61 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMO mRNA] and GANT 61 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMO protein]
tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO mRNA] and tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO protein]
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA] and theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein]
Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats.
Expression of hedgehog signal pathway in articular cartilage is associated with the severity of cartilage damage in rats with adjuvant-induced arthritis.
Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.
Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier.
Association between donor and recipient smoothened gene polymorphisms and the risk of hepatocellular carcinoma recurrence following orthotopic liver transplantation in a Han Chinese population.
