Mapk15 (mitogen-activated protein kinase 15) - Rat Genome Database

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Gene: Mapk15 (mitogen-activated protein kinase 15) Rattus norvegicus
Analyze
Symbol: Mapk15
Name: mitogen-activated protein kinase 15
RGD ID: 628675
Description: Predicted to enable MAP kinase activity and chromatin binding activity. Involved in negative regulation of nucleobase-containing compound metabolic process; positive regulation of protein metabolic process; and response to estradiol. Located in nucleus. Orthologous to human MAPK15 (mitogen-activated protein kinase 15); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ERK-7; ERK-8; Erk7; extracellular signal-regulated kinase 7; extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau6
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,575,619 - 109,595,339 (+)NCBIGRCr8
mRatBN7.27107,694,907 - 107,714,640 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,694,964 - 107,714,645 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,448,581 - 109,453,894 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,672,256 - 111,677,569 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,618,237 - 111,623,549 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,041,287 - 117,061,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,055,395 - 117,061,047 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,027,214 - 117,046,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,026,694 - 114,032,007 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,060,919 - 114,066,236 (+)NCBI
Celera7104,066,261 - 104,071,573 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
autophagosome  (IEA,ISO,ISS)
axoneme  (ISO)
bicellular tight junction  (IEA)
cell-cell junction  (IEA,ISO,ISS)
centriole  (IEA,ISO,ISS)
ciliary basal body  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO,ISS)
cytoplasmic vesicle  (IEA)
Golgi apparatus  (IEA,ISO,ISS)
meiotic spindle  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ERK7 is an autoactivated member of the MAPK family. Abe MK, etal., J Biol Chem. 2001 Jun 15;276(24):21272-9. Epub 2001 Apr 3.
2. Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth. Abe MK, etal., Mol Cell Biol 1999 Feb;19(2):1301-12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction. Henrich LM, etal., Mol Cell Biol. 2003 Sep;23(17):5979-88.
5. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. Qian Z, etal., J Biol Chem. 1999 Jan 15;274(3):1621-7.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11875070   PMID:12477932   PMID:15033983   PMID:19166846   PMID:20638370   PMID:20733054   PMID:21190936   PMID:21531765   PMID:21847093   PMID:22948227   PMID:23351492   PMID:24618899  
PMID:25823377   PMID:26595526   PMID:28842414   PMID:29021280  


Genomics

Comparative Map Data
Mapk15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,575,619 - 109,595,339 (+)NCBIGRCr8
mRatBN7.27107,694,907 - 107,714,640 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,694,964 - 107,714,645 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,448,581 - 109,453,894 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,672,256 - 111,677,569 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,618,237 - 111,623,549 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,041,287 - 117,061,799 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,055,395 - 117,061,047 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,027,214 - 117,046,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,026,694 - 114,032,007 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,060,919 - 114,066,236 (+)NCBI
Celera7104,066,261 - 104,071,573 (+)NCBICelera
Cytogenetic Map7q34NCBI
MAPK15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,716,349 - 143,722,458 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8143,716,340 - 143,722,458 (+)EnsemblGRCh38hg38GRCh38
GRCh378144,798,519 - 144,804,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,870,495 - 144,876,621 (+)NCBINCBI36Build 36hg18NCBI36
Celera8141,109,455 - 141,115,595 (+)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,051,333 - 140,057,442 (+)NCBIHuRef
CHM1_18144,838,551 - 144,844,676 (+)NCBICHM1_1
T2T-CHM13v2.08144,872,787 - 144,878,895 (+)NCBIT2T-CHM13v2.0
Mapk15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,865,581 - 75,871,002 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1575,865,618 - 75,871,003 (+)EnsemblGRCm39 Ensembl
GRCm381575,993,732 - 75,999,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1575,993,769 - 75,999,154 (+)EnsemblGRCm38mm10GRCm38
MGSCv371575,824,199 - 75,829,583 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361575,821,024 - 75,826,408 (+)NCBIMGSCv36mm8
Celera1577,494,814 - 77,500,199 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.2NCBI
Mapk15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,413,822 - 2,419,276 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,413,393 - 2,420,703 (+)NCBIChiLan1.0ChiLan1.0
MAPK15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,198,908 - 161,205,165 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18136,716,178 - 136,722,428 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08140,468,365 - 140,474,604 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18143,482,245 - 143,488,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8143,481,567 - 143,492,859 (+)Ensemblpanpan1.1panPan2
MAPK15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,317,061 - 37,322,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,316,424 - 37,322,792 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,273,594 - 37,279,329 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,789,031 - 37,794,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,789,106 - 37,794,731 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,463,171 - 37,468,902 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,580,097 - 37,585,790 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,061,417 - 38,067,119 (+)NCBIUU_Cfam_GSD_1.0
Mapk15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303994,469 - 1,000,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364708,420,732 - 8,425,884 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364708,420,850 - 8,425,996 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4909,268 - 915,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14909,266 - 915,537 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,932,291 - 137,938,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8137,932,364 - 137,938,626 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,942,955 - 1,949,042 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473513,047,125 - 13,056,308 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473513,049,509 - 13,077,509 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapk15
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000012461
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 9 2
Low 1 17 14 5 14 64 20 28 9
Below cutoff 2 17 29 22 12 22 3 4 2 15 4 3

Sequence


RefSeq Acc Id: ENSRNOT00000012461   ⟹   ENSRNOP00000012460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,709,305 - 107,714,639 (+)Ensembl
Rnor_6.0 Ensembl7117,055,623 - 117,060,957 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091960   ⟹   ENSRNOP00000075332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,694,964 - 107,714,645 (+)Ensembl
Rnor_6.0 Ensembl7117,055,395 - 117,061,047 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110168   ⟹   ENSRNOP00000085833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7107,709,305 - 107,714,639 (+)Ensembl
RefSeq Acc Id: NM_173331   ⟹   NP_775453
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,590,026 - 109,595,339 (+)NCBI
mRatBN7.27107,709,327 - 107,714,640 (+)NCBI
Rnor_6.07117,055,645 - 117,060,958 (+)NCBI
Rnor_5.07117,027,214 - 117,046,813 (+)NCBI
RGSC_v3.47114,026,694 - 114,032,007 (+)RGD
Celera7104,066,261 - 104,071,573 (+)RGD
Sequence:
RefSeq Acc Id: XM_006241779   ⟹   XP_006241841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,575,619 - 109,595,339 (+)NCBI
mRatBN7.27107,694,907 - 107,714,640 (+)NCBI
Rnor_6.07117,041,287 - 117,060,958 (+)NCBI
Rnor_5.07117,027,214 - 117,046,813 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078534   ⟹   XP_038934462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,575,619 - 109,595,339 (+)NCBI
mRatBN7.27107,694,907 - 107,714,640 (+)NCBI
RefSeq Acc Id: XM_039078535   ⟹   XP_038934463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,575,619 - 109,595,339 (+)NCBI
mRatBN7.27107,694,907 - 107,714,171 (+)NCBI
RefSeq Acc Id: XM_039078537   ⟹   XP_038934465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,575,619 - 109,594,118 (+)NCBI
mRatBN7.27107,694,907 - 107,713,419 (+)NCBI
RefSeq Acc Id: XM_039078538   ⟹   XP_038934466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,575,619 - 109,594,118 (+)NCBI
mRatBN7.27107,694,907 - 107,713,419 (+)NCBI
RefSeq Acc Id: XM_063263083   ⟹   XP_063119153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,575,619 - 109,595,339 (+)NCBI
RefSeq Acc Id: NP_775453   ⟸   NM_173331
- UniProtKB: Q9Z2A6 (UniProtKB/Swiss-Prot),   A6HS47 (UniProtKB/TrEMBL),   A0A8I6A4Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241841   ⟸   XM_006241779
- Peptide Label: isoform X2
- UniProtKB: Q9Z2A6 (UniProtKB/Swiss-Prot),   A6HS47 (UniProtKB/TrEMBL),   A0A8I6A4Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012460   ⟸   ENSRNOT00000012461
RefSeq Acc Id: ENSRNOP00000075332   ⟸   ENSRNOT00000091960
RefSeq Acc Id: XP_038934462   ⟸   XM_039078534
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A4Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934463   ⟸   XM_039078535
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038934465   ⟸   XM_039078537
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038934466   ⟸   XM_039078538
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000085833   ⟸   ENSRNOT00000110168
RefSeq Acc Id: XP_063119153   ⟸   XM_063263083
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2A6-F1-model_v2 AlphaFold Q9Z2A6 1-547 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628675 AgrOrtholog
BioCyc Gene G2FUF-32965 BioCyc
Ensembl Genes ENSRNOG00000009336 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00060021050 UniProtKB/Swiss-Prot
  ENSRNOG00065009415 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012461 ENTREZGENE
  ENSRNOT00000012461.5 UniProtKB/Swiss-Prot
  ENSRNOT00000091960.2 UniProtKB/TrEMBL
  ENSRNOT00000110168.1 UniProtKB/TrEMBL
  ENSRNOT00060036494 UniProtKB/Swiss-Prot
  ENSRNOT00065015061 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:286997 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 286997 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapk15 PhenoGen
PROSITE MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009336 RatGTEx
  ENSRNOG00060021050 RatGTEx
  ENSRNOG00065009415 RatGTEx
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KAB2_RAT UniProtKB/TrEMBL
  A0A8I6A4Q6 ENTREZGENE, UniProtKB/TrEMBL
  A6HS47 ENTREZGENE, UniProtKB/TrEMBL
  MK15_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mapk15  mitogen-activated protein kinase 15  Erk7  extracellular signal-regulated kinase 7  Symbol and Name updated 1299863 APPROVED
2003-02-27 Erk7  extracellular signal-regulated kinase 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a TEY activation motif and a C-terminal domain which inhibits its growth and nuclear localization 632686
gene_product member of the mAP kinase family 632686
gene_protein 61 kDa in size 632686