Proz (protein Z, vitamin K-dependent plasma glycoprotein) - Rat Genome Database

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Gene: Proz (protein Z, vitamin K-dependent plasma glycoprotein) Rattus norvegicus
Analyze
Symbol: Proz
Name: protein Z, vitamin K-dependent plasma glycoprotein
RGD ID: 1308666
Description: Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein); PARTICIPATES IN coagulation cascade pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC306608; vitamin K-dependent protein Z
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,150,104 - 83,165,688 (-)NCBIGRCr8
mRatBN7.21676,450,013 - 76,463,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,450,013 - 76,463,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,730,561 - 81,744,028 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,183,138 - 85,196,605 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,432,639 - 80,445,876 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,784,348 - 81,797,889 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,784,348 - 81,797,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,269,715 - 81,283,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,311,405 - 81,321,986 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,311,007 - 81,322,132 (-)NCBI
Celera1674,256,045 - 74,269,512 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protein Z, an anticoagulant protein with expanding role in reproductive biology. Almawi WY, etal., Reproduction. 2013 Jun 27;146(2):R73-80. doi: 10.1530/REP-13-0072. Print 2013 Aug.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Protein Z influences the prothrombotic phenotype in Factor V Leiden patients. Kemkes-Matthes B, etal., Thromb Res. 2002 May 15;106(4-5):183-5.
5. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Lichy C, etal., Stroke 2004 Jan;35(1):40-5. Epub 2003 Dec 11.
6. Protein Z in ischemic stroke and its etiologic subtypes. McQuillan AM, etal., Stroke. 2003 Oct;34(10):2415-9. Epub 2003 Sep 11.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Decreased protein Z concentrations complicating the hypercoagulable state of Behcet's disease. Ozturk MA, etal., Clin Appl Thromb Hemost. 2003 Jul;9(3):259-63.
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke. Staton J, etal., Stroke. 2005 Jun;36(6):1123-7. Epub 2005 May 5.
12. Prothrombotic phenotype of protein Z deficiency. Yin ZF, etal., Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6734-8.
Additional References at PubMed
PMID:12477932   PMID:19056867   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Proz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,150,104 - 83,165,688 (-)NCBIGRCr8
mRatBN7.21676,450,013 - 76,463,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,450,013 - 76,463,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,730,561 - 81,744,028 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,183,138 - 85,196,605 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,432,639 - 80,445,876 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,784,348 - 81,797,889 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,784,348 - 81,797,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,269,715 - 81,283,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,311,405 - 81,321,986 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,311,007 - 81,322,132 (-)NCBI
Celera1674,256,045 - 74,269,512 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
PROZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,158,648 - 113,172,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13113,158,648 - 113,172,386 (+)EnsemblGRCh38hg38GRCh38
GRCh3713113,812,962 - 113,826,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613112,860,969 - 112,874,695 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413112,860,968 - 112,874,695NCBI
Celera1394,638,628 - 94,652,355 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,251,393 - 94,264,909 (+)NCBIHuRef
CHM1_113113,781,985 - 113,795,462 (+)NCBICHM1_1
T2T-CHM13v2.013112,406,247 - 112,424,058 (+)NCBIT2T-CHM13v2.0
Proz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,110,583 - 13,126,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,110,914 - 13,126,026 (+)EnsemblGRCm39 Ensembl
GRCm38813,060,584 - 13,076,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,060,914 - 13,076,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv37813,060,908 - 13,075,006 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,060,885 - 13,074,983 (+)NCBIMGSCv36mm8
Celera813,228,680 - 13,241,944 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
Proz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404646,841 - 657,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955404647,217 - 657,256 (-)NCBIChiLan1.0ChiLan1.0
PROZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214114,660,438 - 114,676,729 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,345,218 - 113,363,802 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01394,294,846 - 94,314,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113113,363,530 - 113,383,010 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,364,280 - 113,383,010 (+)Ensemblpanpan1.1panPan2
PROZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,156,880 - 91,171,333 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl391,157,307 - 91,171,042 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604648,193,308 - 48,207,312 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Proz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793745,579 - 755,059 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793745,490 - 757,886 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Proz
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:153
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000026666, ENSRNOT00000064694
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
RH142502  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21676,452,295 - 76,452,405 (+)MAPPERmRatBN7.2
Rnor_6.01681,786,631 - 81,786,740NCBIRnor6.0
Rnor_5.01681,271,998 - 81,272,107UniSTSRnor5.0
RGSC_v3.41681,310,699 - 81,310,808UniSTSRGSC3.4
Celera1674,258,328 - 74,258,437UniSTS
RH 3.4 Map8582.2UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 39 39 39 15
Low 1 12 2 13 2 2 2 11 14 6 7 2
Below cutoff 3 12 6 6 6 7 8 2 19 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026666   ⟹   ENSRNOP00000026666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,450,013 - 76,463,480 (-)Ensembl
Rnor_6.0 Ensembl1681,784,348 - 81,797,815 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,790,946 - 81,791,511 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098453   ⟹   ENSRNOP00000086614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,450,013 - 76,463,480 (-)Ensembl
RefSeq Acc Id: NM_001309433   ⟹   NP_001296362
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,152,152 - 83,165,619 (-)NCBI
mRatBN7.21676,450,013 - 76,463,480 (-)NCBI
Rnor_6.01681,784,348 - 81,797,815 (-)NCBI
Celera1674,256,045 - 74,269,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600160   ⟹   XP_017455649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,150,104 - 83,165,688 (-)NCBI
mRatBN7.21676,452,151 - 76,463,558 (-)NCBI
Rnor_6.01681,784,348 - 81,797,889 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001296362   ⟸   NM_001309433
- Peptide Label: precursor
- UniProtKB: B1H253 (UniProtKB/TrEMBL),   G3V8K8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455649   ⟸   XM_017600160
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2L4 (UniProtKB/TrEMBL),   B1H253 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026666   ⟸   ENSRNOT00000026666
RefSeq Acc Id: ENSRNOP00000086614   ⟸   ENSRNOT00000098453
Protein Domains
EGF-like   Gla   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8K8-F1-model_v2 AlphaFold G3V8K8 1-406 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700236
Promoter ID:EPDNEW_R10759
Type:initiation region
Name:Proz_1
Description:protein Z, vitamin K-dependent plasma glycoprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01681,797,818 - 81,797,878EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308666 AgrOrtholog
BioCyc Gene G2FUF-10699 BioCyc
Ensembl Genes ENSRNOG00000019700 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026666 ENTREZGENE
  ENSRNOT00000026666.10 UniProtKB/TrEMBL
  ENSRNOT00000098453.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  4.10.740.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325485 IMAGE-MGC_LOAD
InterPro Coagulation_fac_subgr_Gla_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  Pept_cys/ser_Trypsin-like UniProtKB/TrEMBL
  Pept_S1A_FX UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
KEGG Report rno:306608 UniProtKB/TrEMBL
MGC_CLONE MGC:188233 IMAGE-MGC_LOAD
NCBI Gene 306608 ENTREZGENE
PANTHER COAGULATION FACTOR UniProtKB/TrEMBL
  VITAMIN K-DEPENDENT PROTEIN Z UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Gla UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PharmGKB PROZ RGD
PhenoGen Proz PhenoGen
PIRSF Factor_X UniProtKB/TrEMBL
PRINTS GLABLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019700 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Pept_Ser_Cys UniProtKB/TrEMBL
  VitK_dep_GLA UniProtKB/TrEMBL
UniProt A0A8I6A2L4 ENTREZGENE, UniProtKB/TrEMBL
  B1H253 ENTREZGENE, UniProtKB/TrEMBL
  G3V8K8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Proz  protein Z, vitamin K-dependent plasma glycoprotein   Proz_predicted  protein Z, vitamin K-dependent plasma glycoprotein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Proz_predicted  protein Z, vitamin K-dependent plasma glycoprotein (predicted)      Symbol and Name status set to approved 70820 APPROVED