Gene: Neu4 (neuraminidase 4) Rattus norvegicus
Symbol: Neu4
Name: neuraminidase 4
Description: ENCODES a protein that exhibits exo-alpha-sialidase activity (ortholog); INVOLVED IN ganglioside catabolic process (ortholog); glycoprotein catabolic process (ortholog); oligosaccharide catabolic process (ortholog); PARTICIPATES IN sphingolipid metabolic pathway; FOUND IN mitochondrion (ortholog); organelle inner membrane (ortholog); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); all-trans-retinoic acid (ortholog)
Type: protein-coding
Also known as: LOC316642; sialidase 4; sialidase-4
Latest Assembly: RGSC Genome Assembly v5.0
NCBI Annotation Information: Note: Neu4 (GeneID: 316642) is annotated incorrectly on Rnor_6.0 but correctly on Rn_Celera. Annotation of Neu4 on Rn_Celera is supported by synteny with human and mouse and is instead annotated as NEWGENE_1308624 (GeneID: 103690047) on Rnor_6.0. Additionally, the locus annotated as Neu4 on Rnor_6.0 likely represents a duplicate placement of this locus that lacks support by the syntenic region in mouse and human. BLASTing Neu4 NM_001108234.1 and NEWGENE_1308624 XM_006245535.2 against the rat genome (Annotation Release 105) shows best hits to NC_005108.4 on Rnor_6.0 (at locations where Neu4 and NEWGENE_1308624 are annotated) and AC_000077.1 on Rn_Celera where Neu4 is annotated. 2-sequence BLAST of Neu4 NM_001108234.1 against NEWGENE_1308624 XM_006245535.2 shows high sequence identity (66% coverage, 100% identity). BLASTing Neu4 underlying component AC118069.8 against the rat genome shows best hit to NC_005108.4 on Rnor_6.0 where Neu4 is annotated (hitting itself) and where NEWGENE_1308624 is annotated. 2-sequence BLAST of Neu4 underlying component AC118069.8 against NEWGENE_1308624 underlying component AABR07068355.1 shows 99% sequence identity across ~96 kb. [27 Mar 2015]
RGSC Genome Assembly v6.09101,284,902 - 101,290,558+NCBI
Rat Cytogenetic Map9q36 NCBI
RGSC Genome Assembly v5.09100,655,816 - 100,661,472+NCBI
RGSC Genome Assembly v3.4993,150,680 - 93,156,336+NCBI
Rat Celera Assembly991,931,048 - 91,936,704+NCBI
Genome Assembly 3.1993,343,347 - 93,360,169+NCBI

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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
RGD Disease Portals


Comparative Map Data
QTLs in Region (RGSC Genome Assembly v5.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Neu4
Entrez Gene
Ensembl Gene
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RGD Object Information
RGD ID: 1308624
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2016-02-02
Status: ACTIVE