Gmnc (geminin coiled-coil domain containing) - Rat Genome Database

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Gene: Gmnc (geminin coiled-coil domain containing) Rattus norvegicus
Analyze
Symbol: Gmnc
Name: geminin coiled-coil domain containing
RGD ID: 1563170
Description: Predicted to be involved in DNA replication; negative regulation of DNA replication; and negative regulation of cell cycle. Predicted to act upstream of or within cilium assembly. Predicted to be active in nucleus. Orthologous to human GMNC (geminin coiled-coil domain containing); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: geminin coiled-coil domain-containing protein 1; LOC498102; RGD1563170
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81187,339,617 - 87,352,149 (+)NCBIGRCr8
mRatBN7.21173,836,255 - 73,847,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,814,533 - 73,847,328 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01177,237,033 - 77,247,723 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1177,239,098 - 77,246,315 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,470,179 - 83,480,811 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41175,823,385 - 75,835,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1172,764,269 - 72,774,991 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20383140   PMID:26882546  


Genomics

Comparative Map Data
Gmnc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81187,339,617 - 87,352,149 (+)NCBIGRCr8
mRatBN7.21173,836,255 - 73,847,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,814,533 - 73,847,328 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01177,237,033 - 77,247,723 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1177,239,098 - 77,246,315 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,470,179 - 83,480,811 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41175,823,385 - 75,835,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1172,764,269 - 72,774,991 (+)NCBICelera
Cytogenetic Map11q22NCBI
GMNC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383190,843,271 - 190,862,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3190,852,737 - 190,892,429 (-)EnsemblGRCh38hg38GRCh38
GRCh373190,570,526 - 190,580,483 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363192,055,778 - 192,063,645 (-)NCBINCBI36Build 36hg18NCBI36
Celera3189,000,690 - 189,010,629 (-)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3187,970,135 - 187,980,075 (-)NCBIHuRef
CHM1_13190,534,027 - 190,544,004 (-)NCBICHM1_1
T2T-CHM13v2.03193,659,602 - 193,679,021 (-)NCBIT2T-CHM13v2.0
Gmnc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391626,775,985 - 26,810,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1626,732,303 - 26,810,402 (-)EnsemblGRCm39 Ensembl
GRCm381626,957,235 - 26,991,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1626,913,553 - 26,991,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv371626,957,321 - 26,990,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361626,872,468 - 26,905,207 (-)NCBIMGSCv36mm8
Celera1627,499,106 - 27,531,851 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1618.56NCBI
Gmnc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542017,281,684 - 17,298,001 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542017,286,789 - 17,297,574 (+)NCBIChiLan1.0ChiLan1.0
GMNC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22188,719,559 - 188,728,331 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13188,724,276 - 188,733,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03187,876,545 - 187,931,929 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13196,427,562 - 196,437,385 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3196,426,618 - 196,540,248 (-)Ensemblpanpan1.1panPan2
GMNC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13422,790,364 - 22,800,569 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3422,790,972 - 22,800,852 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3426,884,181 - 26,894,407 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03422,723,660 - 22,733,090 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3422,725,664 - 22,734,744 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13422,746,583 - 22,756,935 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03422,732,689 - 22,743,044 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03422,975,152 - 22,983,061 (-)NCBIUU_Cfam_GSD_1.0
Gmnc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602120,613,222 - 120,650,593 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493690076,581 - 83,550 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GMNC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13128,239,514 - 128,250,707 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113128,239,507 - 128,251,579 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213137,622,779 - 137,631,350 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103241908
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11585,060,719 - 85,070,285 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1585,061,562 - 85,067,339 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604158,682,333 - 58,700,120 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gmnc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473066,288,351 - 66,319,136 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473066,312,153 - 66,322,508 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gmnc
79 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:90
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000058701
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 62 21 11
Below cutoff 6 7 3 2 3 10 7 16

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000058701   ⟹   ENSRNOP00000055495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1173,814,533 - 73,847,328 (+)Ensembl
Rnor_6.0 Ensembl1177,239,098 - 77,246,315 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107893   ⟹   ENSRNOP00000083414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1173,814,564 - 73,847,328 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120173   ⟹   ENSRNOP00000080915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1173,836,451 - 73,847,328 (+)Ensembl
RefSeq Acc Id: XM_006248531   ⟹   XP_006248593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,339,617 - 87,352,149 (+)NCBI
mRatBN7.21173,836,255 - 73,847,698 (+)NCBI
Rnor_6.01177,237,033 - 77,247,723 (+)NCBI
Rnor_5.01183,470,179 - 83,480,811 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088948   ⟹   XP_038944876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,339,617 - 87,352,149 (+)NCBI
mRatBN7.21173,836,255 - 73,847,698 (+)NCBI
Protein Sequences
Protein RefSeqs XP_006248593 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944876 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055495.2
  ENSRNOP00000080915
  ENSRNOP00000080915.1
  ENSRNOP00000083414.1
Reference Protein Sequences
RefSeq Acc Id: XP_006248593   ⟸   XM_006248531
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G7A5 (UniProtKB/TrEMBL),   A0A8I5ZWJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000055495   ⟸   ENSRNOT00000058701
RefSeq Acc Id: XP_038944876   ⟸   XM_039088948
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000083414   ⟸   ENSRNOT00000107893
RefSeq Acc Id: ENSRNOP00000080915   ⟸   ENSRNOT00000120173

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTU7-F1-model_v2 AlphaFold F1LTU7 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563170 AgrOrtholog
BioCyc Gene G2FUF-20944 BioCyc
Ensembl Genes ENSRNOG00000038505 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058701.3 UniProtKB/TrEMBL
  ENSRNOT00000107893.1 UniProtKB/TrEMBL
  ENSRNOT00000120173.1 UniProtKB/TrEMBL
KEGG Report rno:498102 UniProtKB/TrEMBL
NCBI Gene 498102 ENTREZGENE
PANTHER GEMININ UniProtKB/TrEMBL
  PTHR13372:SF2 UniProtKB/TrEMBL
PhenoGen Gmnc PhenoGen
RatGTEx ENSRNOG00000038505 RatGTEx
UniProt A0A8I5ZWJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7A5 ENTREZGENE, UniProtKB/TrEMBL
  F1LTU7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-02 Gmnc  geminin coiled-coil domain containing  RGD1563170  RGD1563170  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563170  RGD1563170   RGD1563170_predicted  RGD1563170 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563170_predicted  RGD1563170 (predicted)  LOC498102  LOC498102  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498102  LOC498102      Symbol and Name status set to provisional 70820 PROVISIONAL