Gene: Tph1 (tryptophan hydroxylase 1) Rattus norvegicus
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Symbol: Tph1
Name: tryptophan hydroxylase 1
Description: ENCODES a protein that exhibits tryptophan 5-monooxygenase activity; INVOLVED IN circadian rhythm; negative regulation of ossification; response to immobilization stress; PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH Depressive Disorder; mental depression; alcohol abuse (ortholog); FOUND IN neuron projection; cytoplasm (ortholog); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 4,4'-sulfonyldiphenol; ammonium chloride
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Tph; tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1; tryptophan hydroxylase
Orthologs:
Homo sapiens (human) : TPH1 (tryptophan hydroxylase 1)  HGNC  AGR
Mus musculus (house mouse) : Tph1 (tryptophan hydroxylase 1)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Tph1 (tryptophan hydroxylase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPH1 (tryptophan hydroxylase 1)
Canis lupus familiaris (dog) : TPH1 (tryptophan hydroxylase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tph1 (tryptophan hydroxylase 1)
more info ...
Allele / Splice: Tph1em1Mcwi   Tph1em3Mcwi  
Genetic Models: WKY-Tph1em3Mcwi WKY-Tph1em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01102,669,868 - 102,699,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,746,878 - 103,774,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,186,071 - 97,207,551 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1197,264,181 - 97,285,662 (-)NCBI
Celera191,404,769 - 91,425,505 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tph1
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3895
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE